In-Hospital Substance Use and Possession: A Study of Events From 38 Acute Care Hospitals in Pennsylvania by Matthew Taylor, Alexandra Nowalk, Alex Falk

“…We identified 106 reports from 38 acute care hospitals (excluding psychiatric, detox, and behavioral health units and facilities) where a patient possessed and/or misused a substance (e.g., heroin, oxycodone, liquor). We analyzed these reports to better understand how hospital personnel attempt to prevent in-hospital substance use and manage patients who are at risk for using a substance. …”
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Predictors of High-Dose Initial Opioid Prescriptions in Primary Osteoarthritis: A Single Institution Analysis by Charles Johnson, Ryan J. O'Leary, Caroline P. Hoch, Daniel J. Scott MD, MBA, Christopher E. Gross MD

“…The majority of high-dose prescriptions (>=50 OME/d) were given oxycodone (56.1%), while low-dose prescriptions (<50 OME/d) were more commonly prescribed hydrocodone-acetaminophen (34.2%) and tramadol (32.5%). …”
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Gabapentin prevalence: clinical and forensic experience in St. Louis, Missouri, USA by Sarah B. Riley, Kelsie Garbutt, Chelsea Crow, T. Scott Isbell, Anthony J. Scalzo

“…This study found that 30% of urine samples collected from patients with suspected drug intoxication presenting to SSM Health Saint Louis University Hospital, a quaternary care medical center, were positive for gabapentin, and nearly two thirds of those were also positive for oxycodone. Over a 6-month period, the incidence of gabapentin positive postmortem cases increased from 18% to 20%. …”
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Enquête en ligne canadienne relative aux perspectives du personnel infirmier en oncologie sur la gestion de la douleur aiguë liée au cancer (DAC) by Margaret I. Fitch, Alison McAndrew, Stephanie Burlein-Hall

“…Davantage d’infirmières ont rapporté que les patients recevaient de l’hydromorphone (99,5 %), de la morphine (97,0 %), de la codéine (88,1 %) ou de l’oxycodone (88,1 %) pour leur DAC plutôt que des préparations à base de fentanyl (64,7 %). …”
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Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children by Ida Aka, Christiana J. Bernal, Robert Carroll, Angela Maxwell-Horn, Kazeem A. Oshikoya, Sara L. Van Driest

“…Of those, only 10 drugs were commonly used in children (ondansetron, oxycodone, codeine, omeprazole, lansoprazole, sertraline, amitriptyline, citalopram, escitalopram, and risperidone). …”
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A 48-Year-Old Man With a Hip Fracture and Skin Rash: A Case Report by J. Anthony Parker, MD, Runhua Hou, MD

“…Case Report: A 48-year-old man experienced a left femoral neck fracture after a fall. After a dose of oxycodone/hydromorphone postoperatively, he developed an anaphylactic reaction. …”
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Prescription quantity and duration predict progression from acute to chronic opioid use in opioid-naïve Medicaid patients. by Drake G Johnson, Vy Thuy Ho, Jennifer M Hah, Keith Humphreys, Ian Carroll, Catherine Curtin, Steven M Asch, Tina Hernandez-Boussard

“…Initial opioid prescriptions in COU patients had increased morphine milligram equivalents (MME) (33.2 vs. 23.2), tablets per prescription (45.6 vs. 36.54), longer prescriptions (26.63 vs 24.69 days), and higher proportions of tramadol (16.06% vs. 13.44%) and long acting oxycodone (0.24% vs 0.04%) compared to non- COU patients. …”
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Applicability of a Chemiluminescence Immunoassay to Screen Postmortem Bile Specimens and Its Agreement with Confirmation Analysis by Martina Franzin, Rachele Ruoso, Monica Concato, Davide Radaelli, Stefano D’Errico, Riccardo Addobbati

“…Kappa analysis assessed a perfect agreement (0.81–1) between the assays for benzodiazepines, methadone, opiates, cocaine, oxycodone, cannabinoids, buprenorphine and pregabalin; a substantial agreement (0.41–0.6) was reported for barbiturates. …”
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An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats by Colin N. Haile, Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L. Duddupudi, Gregory D. Cuny, Elizabeth B. Norton, Thomas R. Kosten, Therese A. Kosten

“…Cross-reactivity assays showed anti-FEN antibodies bound to FEN and sufentanil but not to morphine, methadone, buprenorphine, or oxycodone. These data support further clinical development of this vaccine to address OUD in humans.…”
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Use of tanezumab for chronic pain treatment by A. E. Karateev, A. M. Lila, L. I. Alekseeva

“…In patients with OA or CNSLBP, it has a pronounced and persistent analgesic effect that exceeds the effect of placebo, and is equal to or superior to the effect of many months of daily intake of naproxen, celecoxib, diclofenac, oxycodone and tramadol. Tanezumab can cause various AE, primarily rapid progression of OA (in 2.6–6.0%) and neurological disorders (paresthesia and hyposthesia, in ≈5%). …”
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Novel Opioids in the Setting of Acute Postoperative Pain: A Narrative Review by Ashley Wang, Jasper Murphy, Lana Shteynman, Neil Daksla, Abhishek Gupta, Sergio Bergese

“…Although traditional opioids such as morphine and oxycodone are commonly used in the management of acute postoperative pain, novel opioids may play a role as alternatives that provide potent pain relief while minimizing adverse effects. …”
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Potential Cytochrome P450 Drug-Drug Interaction Among Adult and Adolescent Patients Undergoing Tonsillectomy by Sai Nimmagadda, Stephanie Jung-ying Wong MD, Madlin Faria PharmD, Paul Allen PhD, John Faria MD

“…Approximately 70% of patients were taking 2 medications in addition to the standard postoperative analgesics (acetaminophen, hydrocodone, oxycodone, morphine, and/or ibuprofen). The 5 most commonly prescribed medications excluding the posttonsillectomy medications were oral contraceptives, ondansetron, amoxicillin, albuterol, and methylprednisolone. …”
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Global, regional, and national consumption of controlled opioids: a cross-sectional study of 214 countries and non-metropolitan territories by Richards, GC, Aronson, JK, Mahtani, KR, Heneghan, C

“…Consumption was the highest in Germany (480 mg/person), followed by Iceland (428 mg/person), the United States (398 mg/person) and Canada (333 mg/person). Oxycodone (35%) was the most heavily consumed controlled opioid globally, followed by morphine (15.9%), methadone (15.8%) and tilidine (14%). …”

In silico molecular understanding of opioid receptor activation by Velgy, N

“…Enhanced sampling simulations of the δ OR bound to four ligands (the antagonists naltrindole and naltrexone, and the agonists morphine and oxycodone), however, failed to elucidate the differences between agonists and antagonists, likely due to poor phase space sampling borne from umbrella sampling. …”

Misuse of prescription and illicit drugs among high-risk young adults in Los Angeles and New York by Stephen E. Lankenau, Sheree M. Schrager, Karol Silva, Alex Kecojevic, Jennifer Jackson Bloom, Carolyn Wong, Ellen Iverson

“…NY participants more frequently misused oxycodone, heroin, and cocaine, and LA participants more frequently misused codeine, marijuana, and methamphetamine. …”
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Impact of a Community Pharmacy Pharmacotherapy Follow-up (PTF) service in patients using opioid analgesic by V. Hernández-García, C. Rubio-Armendáriz, D. Alberto-Armas, A. Hardisson-de la Torre

“…The use of prescribed major opioid analgesics (fentanyl, tapentadol, morphine and oxycodone and combinations) for non-cancer chronic pain is fraught with risks that may generate Negative Medicine Outcomes (NMO). …”
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Transversus Abdominis Plane Block as a Strategy for Effective Pain Management in Patients with Pain during Laparoscopic Cholecystectomy: A Systematic Review by Abdalkarem Fedgash Alsharari, Faud Hamdi Abuadas, Yaser Salman Alnassrallah, Dauda Salihu

“…Ten different drug solutions (i.e., esmolol, Dexamethasone, Magnesium Sulfate, Ketorolac, Oxycodone, Epinephrine, Sufentanil, Tropisetron, normal saline, and Dexmedetomidine) were used as adjuvants. …”
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Opioid Consumption Following Foot and Ankle Surgery: A Systematic Review by Christian DeMaio BS, Rob Nayfa BS, Ty D. Reasnor BS, Jake A. Fox MD, Samuel Thompson MD, Amgad Haleem Amin MD, PhD

“…Five studies standardized opioids prescribed and consumed to a 5-milligram oxycodone "pill." Of the three studies reporting mean pill consumption by region of surgery, 16.1, 27.8, and 26.4 pills were consumed by forefoot, midfoot, and hindfoot patients, respectively. …”
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Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition by Parsshava Mehta, Amira Soliman, Leyanis Rodriguez-Vera, Stephan Schmidt, Paula Muniz, Monica Rodriguez, Marta Forcadell, Emili Gonzalez-Perez, Valvanera Vozmediano

“…Data from the literature on the plasma and CNS of rats and humans regarding acetaminophen, oxycodone, lacosamide, ibuprofen, and levetiracetam were collected. …”
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Analysis of Wastewater Samples to Explore Community Substance Use in the United States: Pilot Correlative and Machine Learning Study by Marie A Severson, Sathaporn Onanong, Alexandra Dolezal, Shannon L Bartelt-Hunt, Daniel D Snow, Lisa M McFadden

“…Results revealed a higher use of methamphetamine (z=–2.27, P=.02) and opioids-to-methadone ratios (oxycodone-to-methadone: z=–1.95, P=.05; hydrocodone-to-methadone: z=–1.95, P=.05) in states west of the Mississippi River compared to the east. …”
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