Esketamine Combined with Propofol TCI versus Propofol TCI for Deep Sedation during Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Prospective, Randomized, and... by Sichen Cui, Peiying Huang, Zhanxiong Wei, Ting Guo, Aiyan Zhang, Lining Huang

“…Both groups received midazolam (0.01–0.03 mg/kg) and oxycodone (0.07–0.08 mg/kg). Then, patients in group E received 0.3 mg/kg esketamine, propofol TCI, and 0.2 mg·kg−1·h−1 esketamine for sedative maintenance. …”
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Perceptions in orthopedic surgery on the use of cannabis in treating pain: a survey of patients with spine pain (POSIT Spine) by Marko Gjorgjievski, Kim Madden, Conner Bullen, Frank Koziarz, Alex Koziarz, Aleksa Cenic, Silvia Li, Mohit Bhandari, Herman Johal

“…Nearly three-quarters were prescribed opioids (73.6%, 148/201), with oxycodone/oxycontin (45.9% 68/148) being the most common, and almost half of (49.3%, 73/148) had used an opioid in the last week. …”
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Combining Electrodermal Activity With the Peak-Pain Time to Quantify Three Temporal Regions of Pain Experience by Bhatkar, Viprali, Picard, Rosalind W., Staahl, Camilla

“…We evaluate the measure across two pain models (cold pressor, capsaicin), and four types of treatments (none, A=pregabalin, B=oxycodone, C=placebo). Each of 24 patients made four visits within 8 weeks, for 96 visits total: A training visit (TV), followed by three visits double-blind presenting A, B, or C (randomized order). …”
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Cohort profile: POPPY II – a population-based cohort examining the patterns and outcomes of prescription opioid use in New South Wales, Australia by Natasa Gisev, Sallie-Anne Pearson, Timothy Dobbins, David C Currow, Fiona Blyth, Sarah Larney, Adrian Dunlop, Richard P Mattick, Andrew Wilson, Louisa Degenhardt, Thomas Murphy, Luke Buizen

“…The most commonly initiated opioid was paracetamol/codeine (61.3%), followed by oxycodone (16.3%).Future plans The POPPY II cohort will be updated periodically, both extending the follow-up duration of the existing cohort, and including new individuals initiating opioids. …”
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Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder by Ashish P. Thakrar, Tanya J. Uritsky, Cara Christopher, Anna Winston, Kaitlin Ronning, Anna Lee Sigueza, Anne Caputo, Rachel McFadden, Jennifer M. Olenik, Jeanmarie Perrone, M. Kit Delgado, Margaret Lowenstein, Peggy Compton

“…Methods From August 2021 to March 2022, a pharmacist guided implementation of a pilot sOAT protocol consisting of escalating doses of oxycodone or oral hydromorphone scheduled every four hours, intravenous hydromorphone as needed, and non-opioid adjuvants for withdrawal and pain. …”
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Effect of Intraoperative Multimodal Analgesia on the Early Postoperative Quality of Recovery in End-stage Head and Neck Cancer Patients Undergoing Open Gastrostomy: A Prospective R... by HU Chunhua, ZHAO Xiaoyan, WU Lili, CHEN hongya, XU Xin, WANG Guyan

“…For multimodal analgesia group, the anesthesia method was nerve block + intravenous analgesia: ultrasound-guided left transverse abdominis plane block (0.25% ropivacaine 0.3 mL/kg)+bilateral rectus abdominis sheath block (0.25% ropivacaine 0.3 mL/kg per side)+intravenous injection of oxycodone 0.1 mg/kg, flurbiprofen 1 mg/kg, and dexamethasone 0.2 mg/kg. …”
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A Prospective Evaluation of Opioid Utilization Following Ankle Fracture Surgery by Ayesha Yahya, Christian C. Hall MD, Andrew Wilhelm, Chelsea Bush

“…Conclusion: We found the average patient consumes the equivalent of 34 pills of 5mg oxycodone after undergoing an open reduction internal fixation of an ankle fracture. …”
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Overreporting of adherence to hepatitis C direct-acting antiviral therapy and sustained virologic response among people who inject drugs in the HERO study by Snehal S. Lopes, Irene Pericot-Valverde, Paula J. Lum, Lynn E. Taylor, Shruti H. Mehta, Judith I. Tsui, Judith Feinberg, Arthur Y. Kim, Brianna L. Norton, Kimberly Page, Cristina Murray-Krezan, Jessica Anderson, Alison Karasz, Julia Arnsten, Phillip Moschella, Moonseong Heo, Alain H. Litwin

“…The factors associated with ≥ 25% Δ adherence were unemployment; higher number of days and times/day of injecting drugs; higher proportion of positive urine drug screening for amphetamine, methamphetamine, and oxycodone, and negative urine screening for THC (tetrahydrocannabinol)/cannabis. …”
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CYP2D6 Substrate Dispensing Among Patients Dispensed Mirabegron: An Administrative Claims Analysis by Mary E. Ritchey, Jingjun Wang, Jessica C. Young, Rajat Chandra, Adam Carrera, Noelia Goti, John R. Horn, Cynthia J. Girman

“…Commonly codispensed CYP2D6 substrates included hydrocodone, oxycodone, tramadol, metoprolol, and tamsulosin. Findings were similar for patients in the older cohort (≥ 65 years old), with 72.1% receiving overlapping CYP2D6 substrates. …”
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4326 Effects of Single-dose Preoperative Pregabalin on Postoperative Pain and Opioid Consumption in Cleft Orthognathic Surgery by Abdullah Said, Ema Zubovic, Austin Y Ha, Gary B Skolnic, Jacob AuBuchon, Erika Waters, Kamlesh B Patel

“…Postoperative pain control during admission consisted of oral oxycodone and intravenous (IV) hydromorphone or morphine. …”
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Non-medical use of pharmaceutical opioids with and without other illicit substance use: Trends from two repeated nationally representative Australian surveys by Janni Leung, Daniel Stjepanovic, Giang Vu, Carmen Lim, Aathavan Shanmuga Anandan, Wayne Hall, Jason Connor, Gary Chan

“…No significant changes were observed in the use of other types of painkillers (e.g. oxycodone and fentanyl) between 2016 and 2019. The overall decrease in NMUPO primarily occurred among people who used NMUPO only and did not use other illicit drugs. …”
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Liberal vs. restricted opioid prescribing following midurethral sling dataset by Brianne M. Morgan, Jaime B. Long, Sarah S. Boyd, Matthew F. Davies, Allen R. Kunselman, Christy M. Stetter, Michael H. Andreae

“…Participants were randomized to either receive a standard prescription of ten 5 mg tablets oxycodone provided preoperatively (standard) or opioid prescription provided only upon patient request postoperatively (restricted). …”
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Analysis of pharmacovigilance databases for spontaneous reports of adverse drug reactions related to substandard and falsified medical products: A descriptive study by Kevin Pozsgai, Gergő Szűcs, Anikó Kőnig-Péter, Orsolya Balázs, Péter Vajda, Lajos Botz, Róbert György Vida

“…In the FAERS database, we identified 138 signals with 95% confidence interval including sildenafil (n = 314; PRR, 12.99; ROR, 13.04; RRR, 11.97), tadalafil (n = 200; PRR, 11.51; ROR, 11.55; RRR, 10.94), and oxycodone (n = 190; PRR, 2.47; ROR, 2.14; RRR, 2.47). …”
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The past, present, and future of opioid prescribing: Perioperative opioid use in gynecologic oncology patients after laparotomy at a single institution from 2012 to 2021 by Allison H. Kay, Alisha Othieno, John Boscardin, Lee-lynn Chen, Edwin A. Alvarez, Megan Swanson, Stefanie Ueda, Lee-may Chen, Jocelyn S. Chapman

“…Patients had an excess of opioids equivalent to 1331 doses of 5-milligram oxycodone tablets per 100 patients. Conclusion: Inpatient opioid use in our gynecologic oncology open surgical patients and post-discharge opioid prescription size significantly decreased over the last decade. …”
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A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues by Alessandra Manca, Amedeo De Nicolò, Elisa Delia De Vivo, Micol Ferrara, Sharon Oh, Sahar Khalili, Niamh Higgins, Robert G. Deiss, Stefano Bonora, Jessica Cusato, Alice Palermiti, Jacopo Mula, Sara Gianella, Antonio D’Avolio

“…Methods: We describe an ultra-high-performance liquid chromatography coupled with tandem mass spectrometry method for the simultaneous quantification of methadone, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone and fentanyl in several tissues: liver, brain, kidney, abdominal adipose tissue, lung and blood plasma. …”
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Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Single dose oral analgesics for acute postoperative pain in adults. by Moore, R, Derry, S, McQuay, H, Wiffen, P

“…Long duration of action (≥ 8 hours) was found for etoricoxib 120 mg, diflunisal 500 mg, oxycodone 10 mg + paracetamol 650 mg, naproxen 500/550 mg, and celecoxib 400 mg.Not all participants had good pain relief and for many drug/dose combinations 50% or more did not achieve at last 50% maximum pain relief over four to six hours. …”

Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry by Gregory G Grecco, Briana E Mork, Jui-Yen Huang, Corinne E Metzger, David L Haggerty, Kaitlin C Reeves, Yong Gao, Hunter Hoffman, Simon N Katner, Andrea R Masters, Cameron W Morris, Erin A Newell, Eric A Engleman, Anthony J Baucum, Jiuen Kim, Bryan K Yamamoto, Matthew R Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L Sheets, Brady K Atwood

“…We developed a translational mouse model of prenatal methadone exposure (PME) that resembles the typical pattern of opioid use by pregnant women who first use oxycodone then switch to methadone maintenance pharmacotherapy, and subsequently become pregnant while maintained on methadone. …”
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The Ethics of Prescription Drug Monitoring Programs by Ryan Ravanpak

“…If we monitor other opioid drugs like oxycodone so closely, we could monitor medications that manage addiction, such as Suboxone. …”
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3447 Effects of intranasal ketamine on uncontrolled cancer related pain by Vinita Singh, Donald Harvey

“…Failed other pain medications such non-steroidal anti-inflammatories such as ibuprofen, acetaminophen, opioids such as tramadol, hydrocodone, oxycodone etc. and antineuropathics such as gabapentin. 2. …”
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