Editorial: Opioids and opioid receptors in pain, addiction, and mood disorders by Yu Qiu, Yu-Jun Wang, Yu-Jun Wang

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Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid... by Christine Robinson, Carly Baehr, Shirdi E. Schmiel, Claudia Accetturo, Daniel L. Mueller, Marco Pravetoni

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May 2023 Medical Image of the Month: Methamphetamine Inhalation Leading to Cavitary Pneumonia and Pleural Complications by Kia Ghiassi DO, Colin Jenkins MD, Prateek Juneja DO

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Retrospective analyses versus RCTs: comparing like with like? by Baron R, Kennes LN, Elling C

Subjects: “…oxycodone/naloxone…”
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Functional expression of a proton-coupled organic cation (H⁺/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model by Shimomura Keita, Okura Takashi, Kato Sayaka, Couraud Pierre-Olivier, Schermann Jean-Michel, Terasaki Tetsuya, Deguchi Yoshiharu

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Republication of “Postoperative Narcotic Prescription Practice in Orthopedic Foot and Ankle Surgery” by Thomas M. Hearty MD, DPT, Paul Butler MD, John Anderson MD, Donald Bohay MD

“…For each scenario, there was variation in the type of pain medication prescribed ( scenario 1 : 17% 5 mg hydrocodone, 22% 10 mg hydrocodone, 52% oxycodone, and 3% oxycodone sustained release [SR]; scenario 2 : 15% 5 mg hydrocodone, 13% 10 mg hydrocodone, 58% oxycodone, and 9% oxycodone SR; scenario 3 : 11% 5 mg hydrocodone, 13% 10 mg hydrocodone, 56% oxycodone, and 14.1% oxycodone SR; scenario 4 : 3% 5 mg hydrocodone, 5% 10 mg hydrocodone, 44% oxycodone, and 45% oxycodone SR) and the number of pills dispensed. …”
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No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury by Rahul Sachdeva, Ali Hosseinzadeh, Aaron Rizzardo, Andrea Maharaj, Michael Berger, Andrei Krassioukov

“…Results Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity. …”
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Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management by Feng XQ, Zhu LL, Zhou Q

“…Circumstances in which opioid is comedicated as an object drug include rifampin–opioids (morphine, tramadol, oxycodone, methadone), quinidine–opioids (morphine, fentanyl, oxycodone, codeine, dihydrocodeine, methadone), antimycotics–opioids (buprenorphine, fentanyl, morphine, oxycodone, methadone, tilidine, tramadol), protease inhibitors–opioids (ritonavir, ritonavir/lopinavir–oxycodone, ritonavir–fentanyl, ritonavir–tilidine), grapefruit juice–opioids (oxycodone, fentanyl, methadone), antidepressants–opioids (paroxetine–tramadol, paroxetine–hydrocodone, paroxetine–oxycodone, escitalopram–tramadol), metoclopramide–morphine, amantadine–morphine, sumatriptan–butorphanol nasal sprays, ticlopidine–tramadol, St John’s wort–oxycodone, macrolides/ketolides–oxycodone, and levomepromazine–codeine. …”
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Opioid Therapy and Implications for Oxidative Balance: A Clinical Study of Total Oxidative Capacity (TOC) and Total Antioxidative Capacity (TAC) by Urszula Kosciuczuk, Piotr Jakubow, Katarzyna Tarnowska, Ewa Rynkiewicz-Szczepanska

“…The TOC did not differ between tramadol and oxycodone. The highest TAC was described for oxycodone, while the TAC for buprenorphine and tramadol was significantly lower in comparison with oxycodone (<i>p</i> = 0.007 and <i>p</i> = 0.016). …”
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Itopride increases the effectiveness of the management of opioid-induced constipation in palliative care patients: an observational non-interventional study by Tomasz Dzierżanowski, Michael Kozlowski

“…Material and methods In a questionnaire-based observational study, all patients received regular laxatives plus one of the following: oxycodone/naloxone (OXN); itopride (ITP); or oxycodone/naloxone + itopride (OXN + ITP). …”
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Increasing utilization of strong opioid analgesics in a UK primary care population by Zin, Che Suraya, Chen, Li-Chia, Knaggs, Roger D

“…Prescribing of oxycodone increased the most (10960%) compared with buprenorphine (1707%), fentanyl (1135%) and morphine (394%). …”
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Comparison between multimodal and intraoperative opioid free anesthesia for laparoscopic sleeve gastrectomy: a prospective, randomized study by Piotr Mieszczański, Grzegorz Górniewski, Paweł Ziemiański, Radosław Cylke, Wojciech Lisik, Janusz Trzebicki

“…There were no significant differences in NRS scores or total 24-h oxycodone requirements. In the first postoperative hour, OFA group patients needed an average of 4.6 mg of oxycodone while the MMA group 7.72 mg (p = 0.008, p < 0.05 statistically significant). …”
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Tapentadol in acute pain: a review of the results of international studies by V. V. Nikoda

“…The incidence of adverse events on this drug is lower than on oxycodone or morphine.…”
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Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases by Miho Takemura, Kazuyuki Niki, Yoshiaki Okamoto, Hiroshi Tamura, Tomohiro Kawamura, Makie Kohno, Yoshinobu Matsuda, Kenji Ikeda

“…Conclusions: Tapentadol and methadone may be more effective than hydromorphone, oxycodone, and fentanyl for cancer pain due to spinal metastasis with numbness.…”
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Multimodal Pain Management After Outpatient Orthopedic Hand Surgery: A Prospective Randomized Trial by Asif M. Ilyas, MD, MBA, Padmaja Sundaram, BA, Kyle Plusch, BA, Alexis Kasper, BS, Christopher M. Jones, MD

“…However, study group patients reported fewer average daily oxycodone intake and total oxycodone pill count (7.0 vs 2.4 total pills, P <.005). …”
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Housing conditions and microbial environment do not affect the efficacy of vaccines for treatment of opioid use disorders in mice and rats by Bethany Crouse, Li Zhang, Christine Robinson, Yuguang Ban, Jennifer R Vigliaturo, Sabita Roy, Marco Pravetoni

“…Results showed that housing mice and rats in either conventional (non-controlled) or specific pathogen-free (SPF, sterile barrier maintained) environment did not affect vaccine-induced antibody responses against oxycodone and fentanyl, nor their efficacy against oxycodone- and fentanyl-induced antinociception, respiratory depression, and bradycardia. …”
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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users by Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo

“…Each study utilized a randomized, double-blind, active-, and placebo-controlled crossover design to assess esmethadone compared with oxycodone (Oxycodone Study) or ketamine (Ketamine Study) in healthy recreational drug users. …”
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Comparing the effects of decreasing prescription opioid shipments and the release of an abuse deterrent OxyContin formulation on opioid overdose fatalities in WV: an interrupted ti... by Eric W. Lundstrom, Zheng Dai, Caroline P. Groth, Brian Hendricks, Erin L. Winstanley, Marie Abate, Gordon S. Smith

“…Similarly, the majority of opioid tablets shipped to the state for 2006–2014 were generic oxycodone or hydrocodone. This may indicate that diminishing prescription supplies had a larger impact on opioid overdose patterns than the ADF OxyContin release in WV.…”
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Opioid‐limiting legislation and prescribing habits of otolaryngologists among Medicare beneficiaries by Yun Ji Kim, Ian Kim, Ido Badash, Jonathan West, Kevin Hur

“…Methods Through the Centers for Medicare and Medicaid Services (CMS) database, we retrieved data on Medicare enrollment and on the total days prescribed and total number of beneficiaries for the drugs codeine/acetaminophen, hydrocodone/acetaminophen, oxycodone HCl, oxycodone/acetaminophen, and tramadol HCl, by each otolaryngologist prescriber in 13 states from January 2013 to December 2019. …”
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Opioids alter paw placement during walking, confounding assessment of analgesic efficacy in a postsurgical pain model in mice by Victoria E. Brings, Maria A. Payne, Robert W. Gereau, IV

“…Surprisingly, oxycodone caused a tiptoe-like gait in mice, reducing the paw print area of both hind paws. …”
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