Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma by Shijia Lu, Mingming Zhao, Limei Zhao, Guofei Li

“…In hepatocellular carcinoma treatment, sorafenib, oxaliplatin, 5-fluorouracil, capecitabine, lenvatinib, and donafenib are first-line drugs; regorafenib, apatinib, and cabozantinib are second-line drugs; and oxycodone, morphine, and fentanyl are commonly used analgesics. …”
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REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats by Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram, August Buchhalter, Judy Ashworth, Ryan Lanier, Marco Pappagallo, Charles Inturrisi, Franco Folli, Sergio Traversa, Paolo L. Manfredi

“…We evaluated lack of reinforcing effect, physical dependence, and withdrawal of REL-1017 in Sprague Dawley rats. (1) Self-administration Study Rats were trained to self-administer oxycodone intravenously (IV) and then were subjected to 3-day substitution tests where saline, oxycodone, and REL-1017 were self-delivered IV by a fixed number of lever presses; (2) Drug Discontinuation Study Rats were treated for 30 days by oral gavage with vehicle, REL-1017, ketamine or morphine and evaluated for withdrawal with functional observational batteries (FOBs). …”
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Analgesic effect of the ultrasound-guided thoracolumbar paravertebral block in patients undergoing robot-assisted laparoscopic nephrectomy: a randomized controlled trial by Guojiang Yin, Yue Li, Pengxiao Wei, Xuyuan Ma, Bixi Li, Guosheng Gan, Xiaoyang Song

“…Results Compared to the NO-PVB group, the amount of remifentanil used during surgery in patients with TL-PVB group was significantly reduced (1.78 ± 0.37 mg vs. 3.09 ± 0.48 mg, p < 0.001), the amount of oxycodone used 24 h after surgery was significantly reduced (8.70 ± 1.70 mg vs. 13.79 ± 2.74 mg, p < 0.001), and the amount of oxycodone used 48 h after surgery was remarkably reduced (21.83 ± 4.28 mg vs. 27.27 ± 4.76 mg, p < 0.001). …”
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Dynamic changes in prescription opioids from 2006 to 2017 in Texas by Ebuwa O. Ighodaro, Kenneth L. McCall, Daniel Y. Chung, Stephanie D. Nichols, Brian J. Piper

“…Methadone in 2017 accounted for a greater portion (39.5%) of the total MME than hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, and meperidine, combined. …”
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Analgesic effects of ultrasound-guided fourquadrant transversus abdominis plane in patients with cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a prospective... by Jaegyok Song, Nayoung Choi, Minji Kang, Sung Mi Ji, Dong-wook Kim, Min A Kwon

“…Secondary endpoints included oxycodone requirement in PACU, fentanyl doses of IV PCA, morphine milligram equivalent (MME) of total opioid use, hospital stay, and postoperative complications. …”
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Opioids and frequency counts in the US Food and Drug Administration Adverse Event Reporting System (FAERS) database: a quantitative view of the epidemic by Veronin MA, Schumaker RP, Dixit RR, Elath H

“…The highest frequency count value was 158,181 for oxycodone, which represents approximately 20.2% of the frequency counts for the opioids. …”
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Changes in trends and pattern of strong opioid prescribing in primary care by Zin, Che Suraya, Chen, Li-Chia, Knaggs, Roger D

“…Prescriptions ofbuprenorphine, fentanyl, morphine and oxycodone issued to adult patients were included in this study. …”
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Opioid-Sparing Multimodal Analgesia Efficacy in Hispanic Patients Undergoing Total Knee Arthroplasty by Gerardo Olivella, MD, MPH, Eduardo Natal-Albelo, MD, Edwin Rosado, MD, Lenny Rivera, MD, Rubén Tresgallo, MD, José Vidal-Figueroa, MD, Norberto J. Torres-Lugo, MD, Norman Ramírez, MD, Fernando Zayas-Torres, MD, Antonio Otero-López, MD

“…The experimental group had the option to use morphine and oxycodone combined with acetaminophen as a rescue therapy. …”
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Implementation of a Standardized Post-Cesarean Delivery Order Set with Multimodal Combination Analgesia Reduces Inpatient Opioid Usage by Eran Bornstein, Gregg Husk, Erez Lenchner, Amos Grunebaum, Therese Gadomski, Cristina Zottola, Sarah Werner, Jamie S. Hirsch, Frank A. Chervenak

“…<b>Methods:</b> Our health system’s post-cesarean pain management electronic medical record (EMR) order set was changed from standing NSAIDs (Ibuprofen 600 mg every 6 h) and additional acetaminophen and opioid medications (Oxycodone 5 mg/acetaminophen 325 mg every 3 h or Oxycodone 10 mg/acetaminophen 650 mg every 6 h for moderate and severe pain, respectively) as needed (PRN) to a multimodal combination therapy with acetaminophen (975 mg every 6 h) and NSAIDs (Ibuprofen 600 mg every 6 h) as primary analgesics and opioids PRN (Oxycodone immediate release (IR) 5 mg every 3 h for moderate to severe pain). …”
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Opioids for cancer pain - an overview of Cochrane reviews. by Wiffen, P, Wee, B, Derry, S, Bell, R, Moore, R

“…</p> <h4> <p>Reviews on buprenorphine, codeine with or without paracetamol, hydromorphone,methadone, tramadol with or without paracetamol, tapentadol, and oxycodone did not have information about the primary outcome of mild or no pain at 14 days, although that on oxycodone indicated that average pain scores were within that range. …”

Pharmacovigilance Signals of the Opioid Epidemic over 10 Years: Data Mining Methods in the Analysis of Pharmacovigilance Datasets Collecting Adverse Drug Reactions (ADRs) Reported... by Stefania Chiappini, Rachel Vickers-Smith, Amira Guirguis, John M. Corkery, Giovanni Martinotti, Daniel R. Harris, Fabrizio Schifano

“…Compared with other opioids, abuse concerns were mostly recorded in relation to fentanyl and oxycodone, while tramadol and oxycodone were more strongly associated with drug dependence and withdrawal. …”
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55 If you don't use it, lose it: reducing over prescription of opioids at discharge by Alison McGough-Maduena, Allyson Jang, Allison Kay, Natalia Dematteo, Melissa Mark, Edwin Alvarez, Stephanie Cham, Jocelyn Chapman, Katherine Fuh, Megan Swanson, Lee-may Chen, Stefanie Ueda

“…We utilized the post-discharge opioid calculator, which recommends a discharge prescription of 1–2 tabs of 5mg oxycodone (or equivalent alternative opioid) for 0-OME patients. …”
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Trends in dispensing of individual prescription opioid formulations, Canada 2005–2020 by Wayne Jones, Ridhwana Kaoser, David Rudoler, Benedikt Fischer

“…Among the five interrupted trend models for individual formulations, four (fentanyl, morphine, oxycodone, codeine but not hydromorphone) indicated their initial breakpoint during 2011–2014 introducing a downward dispensing trend. …”
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Interpectoral and Pectoserratus Plane Block vs. Local Anesthetic Infiltration for Partial Mastectomy: A Prospective Randomized Trial by Patryk Eisler, Stephan Zimmermann, Ragnar Henningsson

“…The difference in postoperative use of oxycodone in the PACU (p value 0.7) and the use of oxycodone within 24 hours postoperatively (p value 0.87) was not statistically significant. …”
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Use of oral osmotic hydromorphone in opioid switch for cancer pain by Rosa Palomba, Cristiano Minucci, Marco Graffi, Ilaria Santoriello, Emiliana Matania

“…The aim of this study was to assess effectiveness and safety of a protocol for the switch from transdermic fentanyl - controlled release morphine - controlled release oxycodone to oral osmotic hydromorphone. Twentyeight patients with uncontrolled cancer pain (VAS≥7), taking high doses of fentanyl, morphine or oxycodone were included in the study. …”
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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids by Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, José Miguel Vela

“…Despite its partial MOR agonism, WLB-73502 exerted full antinociceptive efficacy, with potency superior to morphine and similar to oxycodone against nociceptive, inflammatory and osteoarthritis pain, and superior to both morphine and oxycodone against neuropathic pain. …”
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Analysis of postoperative pulmonary complications after gastrectomy for gastric cancer: development and validation of a nomogram by Ling Zhou, Yuanna Li, Yuanbo Ni, Cunming Liu

“…Binary logistic analysis showed that age &gt; 65 years, higher total cholesterol level, longer duration of surgery, total gastrectomy, and the dose of oxycodone &gt; 5.5 mg were independent risk factors for the occurrence of PPCs, which were contained in the nomogram. …”
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Central and Peripheral Mechanisms Underlying Physiological and Drug-Induced Fluctuations in Brain Oxygen in Freely-Moving Rats by Eugene A. Kiyatkin

“…While respiratory depression was evident for all tested drugs, heroin was ~6-fold more potent than oxycodone, and fentanyl was 10-20-fold more potent than heroin. …”
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Melatonin Interaction Resulting in Severe Sedation by Brian C Foster, Kosta Cvijovic, Heather S Boon, Teresa W Tam, Rui Liu, Mano Murty, Duc Vu, Walter Jaeger, Ross T Tsuyuki, Joanne Barnes, Sunita Vohra

“…Key words: Melatonin, citalopram, nortriptyline, oxycodone, drug interaction.   This article is open to POST-PUBLICATION REVIEW. …”
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Quadratus Lumborum Block Reduces Postoperative Opioid Consumption and Decreases Persistent Postoperative Pain Severity in Patients Undergoing Both Open and Laparoscopic Nephrectomi... by Michał Borys, Patrycja Szajowska, Mariusz Jednakiewicz, Grzegorz Wita, Tomasz Czarnik, Marcin Mieszkowski, Bułat Tuyakov, Piotr Gałkin, Mansur Rahnama-Hezavah, Mirosław Czuczwar, Paweł Piwowarczyk

“…Results: Patients undergoing QLB needed less oxycodone than those in the CON group (34.5 mg (interquartile range 23 to 40 mg) vs. 47.5 mg (35–50 mg); <i>p</i> < 0.001). …”
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