A Comparison of Multimodal Analgesic Regimens for Opioid Reduction in Elective Plastic Surgery: A Randomized Study by Katherine L. Long-Lijoi, MS, Hrijeeta Mukherjee, MS, Ximena A. Pinell, MD, Karl Grimmer, MD, Steven P. Davison, MD, DDS, FACS

“…Patients were randomly assigned to a multimodal regimen of postoperative acetaminophen, gabapentin, and oxycodone with an acetaminophen and gabapentin preload or postoperative ibuprofen and oxycodone-acetaminophen protocol without a preload. …”
Get full text

Reported adverse events related to use of hepatitis C virus direct-acting antivirals with opioids: 2017–2021 by Anthony Martinez, Tipu Khan, Douglas E. Dylla, John Marcinak, Michelle Collins, Brad Saget, Brian Conway

“…The number of AE reports containing opioids (fentanyl, hydrocodone, oxycodone) as co-suspect products/concomitant products were counted and summarized by severity, reporting country and whether an outcome of death was reported. …”
Get full text

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose by Sachiko Fukui, Hideki Yano, Shuichi Yada, Tsuyoshi Mikkaichi, Hidemi Minami

“…Hypromellose acetate succinate (HPMCAS) and hydroxypropylcellulose (HPC) were selected as ER polymers for the ER matrix tablet (HPMCAS/HPC ER matrix tablet). Oxycodone hydrochloride was employed as a model drug. …”
Get full text

Impact of state legislation and institutional protocols on opioid prescribing practices following pediatric tonsillectomy by Lisa M. Einhorn, Congwen Zhao, Benjamin A. Goldstein, Sudha R. Raman, Jeffrey Cheng

“…Conclusion Legislative and institution specific opioid interventions was associated with a 40% decrease in oxycodone doses per prescription following pediatric tonsillectomy. …”
Get full text

Six-year follow-up of impact of co-proxamol withdrawal in England and Wales on prescribing and deaths: time-series study. by Hawton, K, Bergen, H, Simkin, S, Wells, C, Kapur, N, Gunnell, D

“…The reduction in prescribing of co-proxamol following its withdrawal in 2005 was accompanied by increases in prescribing of several other analgesics (co-codamol, paracetamol, codeine, co-dydramol, tramadol, oxycodone, and morphine) during 2005-2010 compared with 1998-2004. …”

Economic Trends in Commonly Used Drugs for Spinal Fusion and Brain Tumor Resection: An Analysis of the Medicare Part D Database by Jagroop Doad, Nithin Gupta, Lydia Leavitt, Alexandra Hart, Andrew Nguyen, Shawn Kaura, Frank DeStefano, Edwin McCray, Brandon Lucke-Wold

“…The results showed a significant negative correlation between the number of spinal procedure beneficiaries and the cost of methocarbamol, as well as between the annual percent change in spinal beneficiaries and the annual percent change in oxycodone cost. Linear regression revealed that oxycodone cost was the only parameter with a statistically significant model. …”
Get full text

Patient-controlled intravenous analgesia with opioids after thoracoscopic lung surgery: a randomized clinical trial by Hong Yu, Wei Tian, Zhao Xu, Rongjuan Jiang, Liang Jin, Wenjie Mao, Ying Chen, Hai Yu

“…Methods This randomized clinical trial enrolled patients scheduled for thoracoscopic lung surgery randomized to receive 1 of 3 opioids for PCIA: oxycodone (group O), hydromorphone (group H), and sufentanil (group S). …”
Get full text

International Comparison in Opiate Prescribing for New Users in Primary Care using Electronic Medical Record Data by Robyn Tamblyn, Nadyne Girard, Bettina Habib, William Dixon, Meghna Jani, David Bates, Jennifer Haas

“…In the U.S 65.0\% were started on oxycodone (MME:1.5), and 10.9% on hydrocodone (MME:1). …”
Get full text

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT_1A) Receptors Heterodimerization and Cellular Effectors (Ca²⁺, ERK1/2 and p38)... by Vlad Radoi, Gerd Jakobsson, Vinko Palada, Andrej Nikosjkov, Henrik Druid, Lars Terenius, Eva Kosek, Vladana Vukojević

“…Using fluorescence cross-correlation spectroscopy (FCCS), a quantitative method with single-molecule sensitivity, we characterized in live cells MOP and 5-HT_1A interactions and the effects of prolonged (18 h) exposure to selected non-peptide opioids: morphine, codeine, oxycodone and fentanyl, on the extent of these interactions. …”
Get full text

Prescription quantity and duration predict progression from acute to chronic opioid use in opioid-naïve Medicaid patients by Drake G. Johnson, Vy Thuy Ho, Jennifer M. Hah, Keith Humphreys, Ian Carroll, Catherine Curtin, Steven M. Asch, Tina Hernandez-Boussard

“…Initial opioid prescriptions in COU patients had increased morphine milligram equivalents (MME) (33.2 vs. 23.2), tablets per prescription (45.6 vs. 36.54), longer prescriptions (26.63 vs 24.69 days), and higher proportions of tramadol (16.06% vs. 13.44%) and long acting oxycodone (0.24% vs 0.04%) compared to non- COU patients. …”
Get full text

Low-Level Laser and Light Therapy After Total Knee Arthroplasty Improves Postoperative Pain and Functional Outcomes: A Three-Arm Randomized Clinical Trial by Homa Bahrami, PhD, Alireza Moharrami, MD, Peyman Mirghaderi, Seyed Mohammad Javad Mortazavi, MD

“…Range of motion (ROM), visual analog scale pain, opiate consumption (oxycodone in milligrams), knee swelling, and the Knee Society Score (KSS) were assessed before the surgery and on postoperative day 2, postoperative day 3, month 3, and month 12 after the operation. …”
Get full text

Kratom use disorder as a gateway to an opioid use disorder by A. C. Borges, D. Machado

“…Knowing that this substance has opioid effects, the patient started to consume opioids like oxycodone in order to obtain Kraton-like effects. Kraton’s use was thus quickly replaced by oxycodone consumption and dependence. …”
Get full text

Synergism between metformin and analgesics/vitamin B12 in a model of painful diabetic neuropathy by Uroš Pecikoza, Maja Tomić, Katarina Nastić, Ana Micov, Radica Stepanović-Petrović

“…Additionally, it synergizes with duloxetine/oxycodone/ESL/vitamin B12 in reducing hyperalgesia. …”
Get full text

The prescription drug monitoring program in a multifactorial approach to the opioid crisis: PDMP data, Pennsylvania, 2016–2020 by Jenna R. Adalbert, Amit Syal, Karan Varshney, Brandon George, Jeffrey Hom, Asif M. Ilyas

“…Results For total prescriptions dispensed, the number of oxycodone, hydrocodone, and morphine prescriptions decreased by 34.4, 44.6, and 22.3% respectively (p < 0.0001). …”
Get full text

Narcotic Use and Prescribing Trends Among Workers Compensation Patients Undergoing Foot and Ankle Surgery by Tyler Goodwin MD, Richard D. Murray MD, Jesse F. Doty MD

“…WC patients were prescribed in total 1,125 oxycodone MME and 871.8 hydrocodone MME (P < 0.001), versus 750 oxycodone MME and 450 hydrocodone MME among the non-WC group (p < .008). …”
Get full text

Complete opioid transition to sublingual Buprenorphine after abdominal surgery is associated with significant reductions in opioid requirements, but not reduction in hospital lengt... by Charlotte Heldreich, Sameer Ganatra, Zheng Lim, Ilonka Meyer, Raymond Hu, Laurence Weinberg, Chong O. Tan

“…We hypothesized that complete opioid transition to SLBup rather than oral oxycodone (OOxy) in the early postoperative period after major abdominal surgery would reduce hospital length of stay, and acute pain and total OMEDD (Oral Morphine Equivalent Daily Dose) requirements in the first 24 h from post-parenteral opioid transition. …”
Get full text

Characteristics of Suicides Caused by Drug Overdose in the State of Maryland by Ling Li, Xinbiao Liao, Guozhong Zhang, Daming Sun, Tiantong Yang, Keming Yun, Rebecca Phipps, Xiang Zhang, Mary G Ripple, David Fowler

“…Among single-type prescription drugs, analgesic (N = 76), antidepressant (N = 45), and neuroleptic (N = 35) classes were the three leading type of drugs used in suicidal deaths. Oxycodone, morphine, quetiapine, and amitriptyline were the most common prescription drugs in suicidal overdose. …”
Get full text

Reason analysis for unplanned discontinuation of patient-controlled intravenous analgesia after thoracic surgery by WANG Jing-yi, CHEN Si, ZHANG Yue-lun, WANG Ying-li, REN Li-ying, SHEN Le

“…In PCIA, patients who used morphine were more likely to stop using postoperative PCIA within 24 hours than those who used oxycodone and sufentanil, and patients who used oxycodone were more likely to stop using PCIA within 24 hours than those who used sufentanil (60%/40.5%/25.3%). …”
Get full text

Opioid prescribing patterns after arthroplasty of the knee and hip: a Dutch nationwide cohort study from 2013 to 2018 by Heather E van Brug, Rob G H H Nelissen, Willem M Lijfering, Liza N van Steenbergen, Frits R Rosendaal, Eveline L A van Dorp, Marcel L Bouvy, Albert Dahan, Maaike G J Gademan

“…In KAs the prescription rates increased from 13.1 DDD/PY to 14.4 DDD/PY, mainly due to oxycodone prescriptions (2.9 DDD/PY to 7.3 DDD/PY), while tramadol decreased (7.3 DDD/PY to 4.6 DDD/PY). …”
Get full text

Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surge... by Yin Zhou, Peng Yuan, Qi Xing, Wenjie Jin, Chonglong Shi

“…Intraoperative sufentanil and postoperative oxycodone consumption, the first time to press analgesic pump, the times of effective and total compressions of patient- controlled analgesia (PCA) were lower than those of the Group C and Group T. …”
Get full text