Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems by Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M

“…We asked whether this mechanism of directing secretory lysosome release is unique to CTL or whether natural killer (NK) and invariant NKT (iNKT) cytolytic cells of the innate immune system use a similar mechanism to focus perforin-bearing lysosome release.</p> <p>Results</p> <p>NK cells were conjugated with B-cell targets lacking major histocompatibility complex class I 721.221 cells, and iNKT cells were conjugated with glycolipid-pulsed CD1-bearing targets, then prepared for thin-section electron microscopy. …”
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Climate condition affects foliar nutrition in main European tree species by Inken Krüger, Andreas Schmitz, Tanja GM Sanders

“…Only Ca content in spruce shows weak effects of climate as changes in foliar mass are entirely counterbalanced by opposing changes in Ca concentrations.For spruce, pine, and oak significant climate effects on nutrient ratios were found. In general, N:P, N:K, and P:K are less sensitive to climate variations than ratios including Mg or Ca. …”
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Periodic Flooding Decoupled the Relations of Soil C, N, P, and K Ecological Stoichiometry in a Coastal Shelterbelt Forest of Eastern China by Binghui Bao, Mengyuan Chang, Songheng Jin, Xueqin Li, Hongtao Xie

“…Soil C:N ratio increased significantly in 0–10 cm layer, while soil C:P, C:K, N:P, N:K, and P:K ratios decreased notably in both 0–10 cm and 20–30 cm layers following the flooding. …”
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The State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility by Azam Azargoon, Yasaman Mirrasouli, Mahdieh Shokrollahi Barough, Mehdi Barati, Parviz Kokhaei

“…Background The prognostic value of peripheral natural killer (pNK) cells, as a screening test in women with recur- rent pregnancy loss (RPL) and unexplained infertility, is still a matter for discussion. …”
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Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure by Ee Von Woon, Ee Von Woon, Dimitrios Nikolaou, Kate MacLaran, Julian Norman-Taylor, Priya Bhagwat, Antonia O. Cuff, Mark R. Johnson, Victoria Male

“…We report that KIR2DL1/S1 and LILRB1 expression is lower in the reproductive failure group for both uNK (total uNK, uNK 2 and 3) and pNK. We also show that degranulation activity is significantly reduced in total uNK, and that TNF-α production is lower in all uNK subsets in the reproductive failure group. …”
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Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor by Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang

“…In A549 cells with receptors deleted and reconstituted, NK2 exerted a negative effect on substance P/NK1-mediated cell migration. Conclusion Our study has provided the first direct evidence of an interaction between NK1 and NK2, which highlights the functional relevance of their heterodimerization in cellular responses. …”
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Intrathecally Administered D-Cycloserine Produces Nociceptive Behavior Through the Activation of N-Methyl-D-aspartate Receptor Ion-Channel Complex Acting on the Glycine Recognition... by Koichi Tan-No, Akihisa Esashi, Osamu Nakagawasai, Fukie Niijima, Seiichi Furuta, Takumi Sato, Susumu Satoh, Hajime Yasuhara, Takeshi Tadano

“…However, [D-Phe7,D-His9]-substance P(6 – 11), a specific antagonist for substance P (NK1) receptors, and MEN-10,376, a tachykinin NK2-receptor antagonist, had no effect on D-cycloserine-induced nociceptive behavior. …”
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Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People by Vishwal Indravadan Patel, Kinjal Prahaladbhai Patel, Mayur Goradhanbhai Makadia, Aashna Darshanbhai Shah, Kaushik Salubhai Chaudhari, Haridas Neelakandan Nilayangode

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Activation of TRPV1 by capsaicin induces functional Kinin B₁receptor in rat spinal cord microglia by Talbot Sébastien, Dias Jenny, Lahjouji Karim, Bogo Maurício, Campos Maria, Gaudreau Pierrette, Couture Réjean

“…Des-Arg⁹-BK-induced thermal hyperalgesia was blocked by capsazepine, SB-366791 and by antagonists/inhibitors of B₁R (SSR240612, 10 mg/kg, p.o.), glutamate NMDA receptor (DL-AP5, 10 μg/site, i.t.), substance P NK-1 receptor (RP-67580, 10 μg/site, i.t.) and nitric oxide synthase (L-NNA, 10 μg/site, i.t.). …”
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A Novel Mechanism of Endoplasmic Reticulum Stress‐ and c‐Myc‐Degradation‐Mediated Therapeutic Benefits of Antineurokinin‐1 Receptor Drugs in Colorectal Cancer by Yue Shi, Xi Wang, Yueming Meng, Junjie Ma, Qiyu Zhang, Gang Shao, Lingfei Wang, Xurui Cheng, Xiangyu Hong, Yong Wang, Zhibin Yan, Yihai Cao, Jian Kang, Caiyun Fu

“…The emerging role of the substance P‐NK‐1R system in oncogenesis raises the possibility of repurposing well‐tolerated NK‐1R antagonists for cancer treatment. …”
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Biogeographic Patterns of Leaf Element Stoichiometry of <i>Stellera chamaejasme</i> L. in Degraded Grasslands on Inner Mongolia Plateau and Qinghai-Tibetan Plateau by Lizhu Guo, Li Liu, Huizhen Meng, Li Zhang, Valdson José Silva, Huan Zhao, Kun Wang, Wei He, Ding Huang

“…The results showed that mean leaf C, N, P, and K concentrations were 498.60, 19.95, 2.15, and 6.57 g kg⁻¹; the average C:N, C:P, N:P, N:K and K:P ratios were 25.20, 245.57, 9.81, 3.13, and 3.21, respectively. …”
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Surgical Outcome of Epicanthus and Telecanthus Correction by Double Z-Plasty and Trans-Nasal Fixation with Prolene Suture in Blepharophimosis Syndrome by Salil Kumar Mandal, Aparna Mandal, James Christian Fleming, Tara Goecks, Andrew Meador, Brian T Fowler

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Decidual CXCR4+CD56brightNK cells as a novel NK subset in maternal–foetal immune tolerance to alleviate early pregnancy failure by Yu Tao, Yan‐Hong Li, Di Zhang, Ling Xu, Jia‐Jia Chen, Yi‐Fei Sang, Hai‐Lan Piao, Xue‐Ling Jing, Min Yu, Qiang Fu, Sheng‐Tao Zhou, Da‐Jin Li, Mei‐Rong Du

“…In this report, we analysed RNA sequencing on peripheral NK (pNK) and decidual NK cells during early pregnancy; we identified an immunomodulatory dNK subset CXCR4+CD56brightdNK and investigated its origin and phenotypic and functional characteristics. …”
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