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Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate
Published 2018-09-01“…We also adapted proximity biotinylation assay for use in Xenopus embryos and show that Par3 functions by enhancing the formation of the anterior apical PCP complex. These findings describe a mechanistic link between the apical localization of PCP components and morphogenetic movements underlying neurulation.…”
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Synthesis and characterization of para-pyridinyl PCP pincer complexes
Published 2015“…Furthermore, the N-methylated Pd(PCP) complex was synthesized from the reaction between Pd(PCP) complex and iodomethane. …”
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Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment.
Published 2018-05-01“…Our results therefore demonstrate a mechanism to maintain low levels of the minor Pk isoform, allowing PCP complexes to form correctly and specify cell fate.…”
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