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Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway
Published 2022-01-01“…Mechanistically, the results showed that pyruvate dehydrogenase complex E1ɑ subunit (PDHA1) and the pyruvate dehydrogenase complex (PDC) activator pyruvate dehydrogenase phosphatase 1 (PDP1) did not noticeable change after intermittent hypoxia. …”
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C-terminal binding protein (CtBP) activates the expression of E-box clock genes with CLOCK/CYCLE in Drosophila.
Published 2013-01-01“…In vivo overexpression of dCtBP in clock cells lengthened or abolished circadian locomotor rhythm with up-regulation of a subset of the E-box clock genes, period (per), vrille (vri), and PAR domain protein 1ε (Pdp1ε). Co-expression of dCtBP with CLK in vitro also increased the promoter activity of per, vri, Pdp1ε and cwo depending on the amount of dCtBP expression, whereas no effect was observed without CLK. …”
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Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method
Published 2023-07-01“…ROC curves of eight LMDEGs (LDHA, GSR, STAT3, CDKN3, FOXM1, GCKR, PDP1, and LDHB) with consistent expression patterns in two datasets had an area under the curve (AUC) ranging from 0.662 to 0.889. …”
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Music Playing on the PDP-6
Published 2004“…Attached is a copy of the original specifications for the coding (a PDP-1 memo by Peter Samson).…”
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Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer
Published 2022-05-01“…There are four kinases, PDK1, PDK2, PDK3 and PDK4, which can phosphorylate and inactivate PDH; and two phosphatases, PDP1 and PDP2, that dephosphorylate and activate PDH.MethodsWe have analyzed by immunohistochemistry the expression and clinicopathological correlations of PDHA1, PDP1, PDP2, PDK1, PDK2, PDK3, and PDK4, as well as of androgen receptor (AR), in a retrospective PCa cohort of patients. …”
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DERIVATOR I: A Program for Visual Inspection of Solutions to First-Order Non-Linear Differential Equations
Published 2004“…Derivator is a PDP-1 program for examining the solutions to differential equations by inspection of a visual display of trajectories. …”
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The emergence of circadian timekeeping in the intestine
Published 2024-02-01“…As the intestine develops, the circadian clock is first consolidated in intestinal stem cells with changes in Ecdysone and Hnf4 signalling influencing the transcriptional activity of Clk/cyc to drive the expression of tim, Pdp1, and vri. In the mature intestine, stem cell lineage commitment transiently disrupts clock activity in differentiating progeny, mirroring early developmental clock-less transitions. …”
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Skeletal-Muscle-Specific Overexpression of Chrono Leads to Disruption of Glucose Metabolism and Exercise Capacity
Published 2022-08-01“…In addition, the Chrono TG mice also showed a significant increase in the amount of Chrono bound to Bmal1 according to a co-IP analysis; a remarkable decrease in mRNA expression of <i>Tbc1d1</i>, <i>Glut4</i>, <i>Hk2</i>, <i>Pfkm</i>, <i>Pdp1</i>, <i>Gbe1</i>, and <i>Phka1</i>, as well as in activity of Hk and protein expression of Ldhb; but higher mRNA expression of <i>Pdk4</i> and protein expression of Ldha compared with those of WT mice. …”
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SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells
Published 2022-10-01“…The SERBP1-regulated alternative splicing of ME3, LPIN3, CROT, PDP1, SLC27A1 and ALKBH7 was validated by RT-qPCR analysis. …”
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Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products
Published 2023-07-01“…Interestingly, tricarboxylic acid cycle (TCA)-related genes, such as pyruvate dehydrogenase phosphatase 1 (PDP1), PDP2, aconitate hydratase 1 (ACO1) and oxoglutarate dehydrogenase (OGDH) were upregulated by ML-ESPs. …”
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Clarifying Relationship between PM<sub>2.5</sub> Concentrations and Spatiotemporal Predictors Using Multi-Way Partial Dependence Plots
Published 2023-01-01“…However, there are two key shortcomings in the original PDP. (1) it calculates the marginal effect of feature(s) on the predicted outcome of a machine learning model, therefore some local effects might be hidden. (2) it requires that the feature(s) for which the partial dependence is computed are not correlated with other features, otherwise the estimated feature effect has a great bias. …”
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ADHD medications use and risk of mortality and unintentional injuries: a population-based cohort study
Published 2024-02-01“…Exposure was defined as mutually exclusive episodes of ADHD medication use and/or coverage under the public provincial drug plan (PDP): 1) covered and not treated with ADHD medication; 2) covered and treated with ADHD medication; and 3) not covered under the PDP. …”
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Identification of candidate single nucleotide polymorphic markers in brown-marbled grouper Epinephelus fuscoguttatus (Forsskal, 1775)
Published 2021“…Sequencing using the novel ddRAD Seq revealed four genes: acss2, abhd15, lrp2 and pdp1 as potential candidate markers that could assist in the selection of broodstock fish with superior traits. …”
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Transcriptome Analysis Reveals Differences in Gene Expression in the Muscle of the Brown-Marbled Grouper (<i>Epinephelus fuscoguttatus</i>) with Different Growth Rates
Published 2023-06-01“…Our findings suggest that up-regulated genes such as <i>ghr</i> and <i>tnni2</i>, as well as down-regulated genes such as <i>stc2</i> and <i>pdp1</i>, are associated with growth advantages in brown-marbled grouper. …”
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A Highly Unstable and Elusive Plasmid That Encodes the Type III Secretion System Is Necessary for Full Virulence in the Marine Fish Pathogen <i>Photobacterium damselae</i> subsp. <...
Published 2022-04-01“…<i>piscicida</i> (<i>Pdp</i>) causes photobacteriosis in fish and important financial losses in aquaculture, but knowledge of its virulence factors is still scarce. …”
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Design of low-power high-speed truncation-error-tolerant adder and its application in digital signal processing
Published 2010“…When compared to its conventional counterparts, the proposed ETA is able to attain more than 65% improvement in the Power-Delay Product (PDP). One important potential application of the proposed ETA is in digital signal processing systems that can tolerate certain amount of errors.…”
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Mining Of Text In The Product Development Process
Published 2003“…The research direction is to study real-life cases where textual databases can be mined to obtain valuable information for PDP. One suitable candidate identified for this is “voice of the customer” databases.…”
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On the Stationarity Time of a Vehicle-to-Infrastructure Massive Radio Channel in a Line-of-Sight Suburban Environment
Published 2022-11-01“…The generalized local scattering function (GLSF), computed from the sampled channels, was used to derive (1) the spatial distribution of the stationarity time using the channel correlation function (CCF) and empirical collinearity methods and (2) the root mean square delay/angular spread and coherence time/bandwidth values from the projected power delay profile (<i>PDP</i>) and Doppler power spectra (<i>DPS</i>). The results highlight the high degree of correlation between the spatial distribution of the stationarity time and the scattering properties along the measurement route.…”
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Enhanced device and circuit-level performance benchmarking of graphene nanoribbon field-effect transistor against a nano-MOSFET with interconnects
Published 2014“…GNRFET provides reduced EDP and PDP one order of magnitude that is lower than that of a MOSFET. …”
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