Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway by Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv, Fang Han

“…Mechanistically, the results showed that pyruvate dehydrogenase complex E1ɑ subunit (PDHA1) and the pyruvate dehydrogenase complex (PDC) activator pyruvate dehydrogenase phosphatase 1 (PDP1) did not noticeable change after intermittent hypoxia. …”
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Functional characterization of the second feedback loop in the circadian clock of the Antarctic krill Euphausia superba by Chiara Stefanelli, Davide Colaianni, Gabriella M. Mazzotta, Gabriele Sales, Cristiano Bertolucci, Bettina Meyer, Alberto Biscontin, Cristiano De Pittà

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Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1 by Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A DeBose-Boyd

“…Conversely, these reactions are enhanced in the absence of PDP1. Our findings indicate PDP1-mediated hydrolysis of GGpp significantly contributes to a feedback mechanism that maintains optimal intracellular levels of the nonsterol isoprenoid.…”
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C-terminal binding protein (CtBP) activates the expression of E-box clock genes with CLOCK/CYCLE in Drosophila. by Taichi Q Itoh, Akira Matsumoto, Teiichi Tanimura

“…In vivo overexpression of dCtBP in clock cells lengthened or abolished circadian locomotor rhythm with up-regulation of a subset of the E-box clock genes, period (per), vrille (vri), and PAR domain protein 1ε (Pdp1ε). Co-expression of dCtBP with CLK in vitro also increased the promoter activity of per, vri, Pdp1ε and cwo depending on the amount of dCtBP expression, whereas no effect was observed without CLK. …”
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Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method by Huimin Jiang, Yun Ren, Jiale Yu, Sheng Hu, Jihui Zhang, Jihui Zhang

“…ROC curves of eight LMDEGs (LDHA, GSR, STAT3, CDKN3, FOXM1, GCKR, PDP1, and LDHB) with consistent expression patterns in two datasets had an area under the curve (AUC) ranging from 0.662 to 0.889. …”
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Music Playing on the PDP-6 by Sordillo, Donald

“…Attached is a copy of the original specifications for the coding (a PDP-1 memo by Peter Samson).…”
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Predicting and Investigating the Permeability Coefficient of Soil with Aided Single Machine Learning Algorithm by Van Quan Tran

“…To identify and quantify the feature importance on the permeability coefficient of soil, sensitivity studies using permutation importance, SHapley Additive exPlanations (SHAP), and Partial Dependence Plot 1D (PDP 1D) are performed with the aided best performance and reliable ML model GB. …”
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KIAA0753 promotes glucose and energy metabolism in osteoblasts inhibited by diabetes by LI Mengxue, LI Mengxue, WANG Jichun, WANG Jichun, LI Letai

“…High glucose resulted in inhibited protein expression of GYS1, ACACA, PFKM, GluT4, PGC-1α, TFAM and NRF1, enhanced protein levels of PDP1 and PYGL, reduced glycogen generation and consumption of extracellular glucose, and promoted production of lactic acid (P < 0.05). …”
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DERIVATOR I: A Program for Visual Inspection of Solutions to First-Order Non-Linear Differential Equations by Minsky, Marvin

“…Derivator is a PDP-1 program for examining the solutions to differential equations by inspection of a visual display of trajectories. …”
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Staf teknikal UMP hasil video tutorial bantu PdP by Mohd Khairul Anam, Md Khairudin

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The emergence of circadian timekeeping in the intestine by Kathyani Parasram, Amy Zuccato, Minjeong Shin, Reegan Willms, Brian DeVeale, Edan Foley, Phillip Karpowicz

“…As the intestine develops, the circadian clock is first consolidated in intestinal stem cells with changes in Ecdysone and Hnf4 signalling influencing the transcriptional activity of Clk/cyc to drive the expression of tim, Pdp1, and vri. In the mature intestine, stem cell lineage commitment transiently disrupts clock activity in differentiating progeny, mirroring early developmental clock-less transitions. …”
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Comparative study on the prediction of the unconfined compressive strength of the one-part geopolymer stabilized soil by using different hybrid machine learning models by Qinyi Chen, Guo Hu, Jun Wu

“…Furthermore, the interpretable method including SHAP and PDP (1D and 2D), was employed to investigate the precise mechanisms by which input parameters influenced the output label. …”
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Skeletal-Muscle-Specific Overexpression of Chrono Leads to Disruption of Glucose Metabolism and Exercise Capacity by Shiyi He, Lu Yan, Rongxin Zhu, Hao Wei, Jianxiong Wang, Lan Zheng, Ying Zhang

“…In addition, the Chrono TG mice also showed a significant increase in the amount of Chrono bound to Bmal1 according to a co-IP analysis; a remarkable decrease in mRNA expression of <i>Tbc1d1</i>, <i>Glut4</i>, <i>Hk2</i>, <i>Pfkm</i>, <i>Pdp1</i>, <i>Gbe1</i>, and <i>Phka1</i>, as well as in activity of Hk and protein expression of Ldhb; but higher mRNA expression of <i>Pdk4</i> and protein expression of Ldha compared with those of WT mice. …”
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Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine learning by Xiaoli Zhou, Lina Zhao, Zepei Zhang, Yang Chen, Guangdong Chen, Jun Miao, Xiaohui Li

“…Conclusion We identified 7 candidate hub genes (PDP1, ALS2CL, VLDLR, PLEKHA6, PPP1CB, MOSPD2, METTL9) and constructed column line plots for osteoporosis combined with sarcopenia. …”
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SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells by Junjie Zhou, Wenhao Chen, Qianwen He, Dong Chen, Chunguang Li, Congqing Jiang, Zhao Ding, Qun Qian

“…The SERBP1-regulated alternative splicing of ME3, LPIN3, CROT, PDP1, SLC27A1 and ALKBH7 was validated by RT-qPCR analysis. …”
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Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products by Haoxuan Wang, Yingying Zhu, Meichen Li, Jingdan Pan, Dan Li, Wen-Ping Guo, Guangcheng Xie, Luanying Du

“…Interestingly, tricarboxylic acid cycle (TCA)-related genes, such as pyruvate dehydrogenase phosphatase 1 (PDP1), PDP2, aconitate hydratase 1 (ACO1) and oxoglutarate dehydrogenase (OGDH) were upregulated by ML-ESPs. …”
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Clarifying Relationship between PM_2.5 Concentrations and Spatiotemporal Predictors Using Multi-Way Partial Dependence Plots by Haoze Shi, Naisen Yang, Xin Yang, Hong Tang

“…However, there are two key shortcomings in the original PDP. (1) it calculates the marginal effect of feature(s) on the predicted outcome of a machine learning model, therefore some local effects might be hidden. (2) it requires that the feature(s) for which the partial dependence is computed are not correlated with other features, otherwise the estimated feature effect has a great bias. …”
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ADHD medications use and risk of mortality and unintentional injuries: a population-based cohort study by Helen-Maria Vasiliadis, Carlotta Lunghi, Elham Rahme, Louis Rochette, Martin Gignac, Victoria Massamba, Fatoumata Binta Diallo, Alvine Fansi, Samuele Cortese, Alain Lesage

“…Exposure was defined as mutually exclusive episodes of ADHD medication use and/or coverage under the public provincial drug plan (PDP): 1) covered and not treated with ADHD medication; 2) covered and treated with ADHD medication; and 3) not covered under the PDP. …”
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Identification of candidate single nucleotide polymorphic markers in brown-marbled grouper Epinephelus fuscoguttatus (Forsskal, 1775) by Mohamad Tahir, Nur Diyana

“…Sequencing using the novel ddRAD Seq revealed four genes: acss2, abhd15, lrp2 and pdp1 as potential candidate markers that could assist in the selection of broodstock fish with superior traits. …”
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Transcriptome Analysis Reveals Differences in Gene Expression in the Muscle of the Brown-Marbled Grouper (<i>Epinephelus fuscoguttatus</i>) with Different Growth Rates by Tong Wang, Yang Yang, Shirui Gong, Xi Wu, Leilei Zeng, Yuhao Tao, Chaoyue Zhong, Leling Song, Xiaochun Liu

“…Our findings suggest that up-regulated genes such as <i>ghr</i> and <i>tnni2</i>, as well as down-regulated genes such as <i>stc2</i> and <i>pdp1</i>, are associated with growth advantages in brown-marbled grouper. …”
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