Evaluation of adaptive feedback in a smartphone-based serious game on health care providers’ knowledge gain in neonatal emergency care: Protocol for a randomized controlled trial by Tuti, T, Winters, N, Muinga, N, Wanyama, C, English, M, Paton, C

“…</p> <p><strong>Trial Registration:</strong> Pan African Clinical Trials Registry PACTR201901783811130; https://pactr.samrc.ac.za/TrialDisplay. aspx?…”

Determinants of glycaemic control among type 2 diabetes mellitus patients in Northern State of Kedah, Malaysia: a cross-sectional analysis of 5 years national diabetes registry 201... by Mohd Rohaizat Hassan, Mohd Nazrin Jamhari, Firdaus Hayati, Norfazilah Ahmad, Mohd 'Ammar Ihsan Ahmad Zamzuri, Azmawati Mohammed Nawi, Khaironi Yatim Sharif, Muhammad Sufri, Shahrul Bariyah Ahmad, Norhizan Ismail, Syed Sharizman Syed Abdul Rahim, Mohammad Saffree Jeffree

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An Unstructured Supplementary Service Data–Based mHealth App Providing On-Demand Sexual Reproductive Health Information for Adolescents in Kibra, Kenya: Randomized Controlled Trial... by Paul Macharia, Antoni Pérez-Navarro, Betsy Sambai, Irene Inwani, John Kinuthia, Ruth Nduati, Carme Carrion

“…Adolescents in the study valued the information provided because it helped them identify SRH topics on which they needed more information. Trial RegistrationPan African Clinical Trial Registry PACTR202204774993198; https://pactr.samrc.ac.za/TrialDisplay.aspx?…”
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Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled... by Steve M Taylor, Sarah Korwa, Angie Wu, Cynthia L Green, Betsy Freedman, Sheila Clapp, Joseph Kipkoech Kirui, Wendy P O'Meara, Festus M Njuguna

“…<h4>Trial registration</h4>clinicaltrials.gov (NCT03178643). Pan-African Clinical Trials Registry: PACTR201707002371165.…”
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Effect of Short, Animated Video Storytelling on Maternal Knowledge and Satisfaction in the Perinatal Period in South Africa: Randomized Controlled Trial by Maya Adam, Zwannda Kwinda, Mithilesh Dronavalli, Elizabeth Leonard, Vān Kính Nguyễn, Vusani Tshivhase, Till Bärnighausen, Yogan Pillay

“…Future studies should explore the effect of SAS videos on maternal knowledge in hard-to-reach populations with limited access to antenatal care, although real-world logistical challenges persist when implementing studies in underresourced South African populations. Trial RegistrationPan African Clinical Trials Registry PACTR202203673222680; https://tinyurl.com/362cpuny…”
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Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial. by Selidji T Agnandji, José F Fernandes, Emmanuel B Bache, Régis M Obiang Mba, Jessica S Brosnahan, Lumeka Kabwende, Paul Pitzinger, Pieter Staarink, Marguerite Massinga-Loembe, Verena Krähling, Nadine Biedenkopf, Sarah Katharina Fehling, Thomas Strecker, David J Clark, Henry M Staines, Jay W Hooper, Peter Silvera, Vasee Moorthy, Marie-Paule Kieny, Akim A Adegnika, Martin P Grobusch, Stephan Becker, Michael Ramharter, Benjamin Mordmüller, Bertrand Lell, VEBCON Consortium, Sanjeev Krishna, Peter G Kremsner

“…<h4>Trial registration</h4>Pan African Clinical Trials Registry PACTR201411000919191.…”
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The evaluation of five serological assays in determining seroconversion to peste des petits ruminants virus in typical and atypical hosts by Matthew Tully, Carrie Batten, Martin Ashby, Mana Mahapatra, Krupali Parekh, Satya Parida, Felix Njeumi, Brian Willett, Arnaud Bataille, Genevieve Libeau, Olivier Kwiatek, Alexandre Caron, Francisco J. Berguido, Charles E. Lamien, Giovanni Cattoli, Gerald Misinzo, Julius Keyyu, Daniel Mdetele, Francis Gakuya, Sanne Charles Bodjo, Fatima Abdelazeem Taha, Husna Mohamed Elbashier, Abdelmalik Ibrahim Khalafalla, Abdinasir Y. Osman, Richard Kock

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The Effectiveness of Interactive Text Messaging and Structured Psychosocial Support Groups on Developmental Milestones of Children From Adolescent Pregnancies in Kenya: Quasi-Exper... by Valerian Mwenda, Ireen Makena, Vincent Ogweno, James Obonyo, Vincent Were

“…Such platforms offer a convenient avenue for providing reproductive health information to adolescents. Trial RegistrationPan African Clinical Trials Registry PACTR201806003369302; https://tinyurl.com/kkxvzjse…”
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Validation of KASP-SNP markers in cassava germplasm for marker-assisted selection of increased carotenoid content and dry matter content by Adenike D. Ige, Adenike D. Ige, Bunmi Olasanmi, Guillaume J. Bauchet, Ismail S. Kayondo, Edwige Gaby Nkouaya Mbanjo, Ruth Uwugiaren, Ruth Uwugiaren, Sharon Motomura-Wages, Joanna Norton, Chiedozie Egesi, Chiedozie Egesi, Elizabeth Y. Parkes, Peter Kulakow, Hernán Ceballos, Ibnou Dieng, Ismail Y. Rabbi

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Development of a rapid and highly sensitive nucleic acid-based diagnostic test for schistosomes, leveraging on identical multi-repeat sequences by Ombeni Ally, Ombeni Ally, Bernard N. Kanoi, Shwetha Kamath, Clement Shiluli, Eric M. Ndombi, Eric M. Ndombi, Maurice Odiere, Gerald Misinzo, Steven Ger Nyanjom, Chunduri Kiran Kumar, Lucy Ochola, Srinivasa Raju Lolabattu, Jesse Gitaka

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Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. by Williams, D, Gutiérrez, J, Calvete, J, Wüster, W, Ratanabanangkoon, K, Paiva, O, Brown, N, Casewell, N, Harrison, R, Rowley, P, O'Shea, M, Jensen, S, Winkel, K, Warrell, D

“…We propose two mechanisms through which the Global Snakebite Initiative might seek to end the antivenom drought in Africa and Asia: first by establishing a multidisciplinary, multicentre, international collaboration to evaluate currently available antivenoms against the venoms of medically important snakes from specific nations in Africa and Asia using a combination of proteomic, antivenomic and WHO-endorsed preclinical assessment protocols, to provide a validated evidence base for either recommending or rejecting individual products; and secondly by bringing the power of proteomics to bear on the design of new immunising mixtures to raise Pan-African and Pan-Asian polyvalent antivenoms of improved potency and quality. …”

Tracking Demographic Movements and Immunization Status to Improve Children’s Access to Immunization: Field-Based Randomized Controlled Trial by Jérôme Ateudjieu, Ketina Hirma Tchio-Nighie, André Pascal Goura, Martin Yakum Ndinakie, Miltiade Dieffi Tchifou, Lapia Amada, Marcelin Tsafack, Frank Forex Kiadjieu Dieumo, Etienne Guenou, Charlette Nangue, Bruno Kenfack

“…This strategy should be adopted to improve access to vaccination for EPI target populations and the consistency verified in other contexts. Trial RegistrationPan African Clinical Trials Registry PACTR201808527428720; https://pactr.samrc.ac.za/TrialDisplay.aspx?…”
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Safety and efficacy of pyronaridine–artesunate paediatric granules in the treatment of uncomplicated malaria in children: insights from randomized clinical trials and a real-world... by Michael Ramharter, Abdoulaye A. Djimde, Isabelle Borghini-Fuhrer, Robert Miller, Jangsik Shin, Adam Aspinall, Naomi Richardson, Martina Wibberg, Lawrence Fleckenstein, Sarah Arbe-Barnes, Stephan Duparc

“…Trial registration Clinicaltrials.gov: SP-C-003-05: identifier NCT00331136; SP-C-007-07: identifier NCT0541385; SP-C-021-15: identifier NCT03201770. Pan African Clinical Trials Registry: SP-C-013-11: identifier PACTR201105000286876…”
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Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial. by Peter G Kremsner, Akim A Adegnika, Aurore B Hounkpatin, Jeannot F Zinsou, Terrie E Taylor, Yamikani Chimalizeni, Alice Liomba, Maryvonne Kombila, Marielle K Bouyou-Akotet, Denise P Mawili Mboumba, Tsiri Agbenyega, Daniel Ansong, Justice Sylverken, Bernhards R Ogutu, Godfrey A Otieno, Anne Wangwe, Kalifa A Bojang, Uduak Okomo, Frank Sanya-Isijola, Charles R Newton, Patricia Njuguna, Michael Kazungu, Reinhold Kerb, Mirjam Geditz, Matthias Schwab, Thirumalaisamy P Velavan, Christian Nguetse, Carsten Köhler, Saadou Issifou, Stefanie Bolte, Thomas Engleitner, Benjamin Mordmüller, Sanjeev Krishna

“…<h4>Trial registration</h4>Pan African Clinical Trials Registry PACTR201102000277177.…”
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Oral pre-exposure prophylaxis uptake, adherence, and adverse events among South African men who have sex with men and transgender women by Linda-Gail Bekker, Danielle Giovenco, Stefan Baral, Karen Dominguez, Rachel Valencia, Travis Sanchez, A.D. McNaghten, Ryan Zahn, Clarence S. Yah, Zinhle Sokhela, Richard Kaplan, Refliwe N. Phaswana-Mafuya, Chris Beyrer, Patrick S. Sullivan

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Effect of index HIV self-testing for sexual partners of clients enrolled in antiretroviral therapy (ART) programs in Malawi: A randomized controlled trial. by Kathryn Dovel, Kelvin Balakasi, Khumbo Phiri, Frackson Shaba, Ogechukwu Agatha Offorjebe, Sundeep K Gupta, Vincent Wong, Eric Lungu, Brooke E Nichols, Tobias Masina, Anteneh Worku, Risa Hoffman, Mike Nyirenda

“…<h4>Trial registration</h4>ClinicalTrials.gov, NCT03271307, and Pan African Clinical Trials, PACTR201711002697316.…”
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Increased interleukin-6 is associated with long COVID-19: a systematic review and meta-analysis by Jing-Xian Yin, Yannick Luther Agbana, Zhi-Shan Sun, Si-Wei Fei, Han-Qing Zhao, Xiao-Nong Zhou, Jun-Hu Chen, Kokouvi Kassegne

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Genetic analyses of tropical maize lines under artificial infestation of fall armyworm and foliar diseases under optimum conditions by Isaac Kamweru, Isaac Kamweru, Yoseph Beyene, Anani Y. Bruce, Dan Makumbi, Victor O. Adetimirin, Paulino Pérez-Rodríguez, Paulino Pérez-Rodríguez, Fernando Toledo, Jose Crossa, Boddupalli M. Prasanna, Manje Gowda

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Intramuscular artesunate for severe malaria in African children: a multicenter randomized controlled trial by Kremsner, PG, Adegnika, AA, Hounkpatin, AB, Zinsou, JF, Taylor, TE, Chimalizeni, Y, Liomba, A, Kombila, M, Bouyou-Akotet, MK, Mboumba, DP, Agbenyega, T, Ansong, D, Sylverken, J, Ogutu, BR, Otieno, GA, Wangwe, A, Bojang, KA, Okomo, U, Sanya-Isijola, F, Newton, CR, Njuguna, P, Kazungu, M, Kerb, R, Geditz, M, Schwab, M, Velavan, TP, Nguetse, C, Köhler, C, Issifou, S, Bolte, S, Engleitner, T, Mordmüller, B, Krishna, S

“…</p> <p><strong>Trial registration</strong> Pan African Clinical Trials Registry PACTR201102000277177.…”

Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysi... by Madhi, SA, Kwatra, G, Richardson, SI, Koen, AL, Baillie, V, Cutland, CL, Fairlie, L, Padayachee, SD, Dheda, K, Barnabas, SL, Bhorat, QE, Briner, C, Ahmed, K, Aley, PK, Bhikha, S, Bhorat, AE, Esmail, A, Horne, E, Kaldine, H, Mukendi, CK, Madzorera, VS, Manamela, NP, Masilela, M, Hermanus, ST, Motlou, T, Mzindle, N, Oelofse, S, Patel, F, Rhead, S, Rossouw, L, Taoushanis, C, van Eck, S, Lambe, T, Gilbert, SC, Pollard, AJ, Moore, PL, Izu, A

“…This trial is registered with ClinicalTrials.gov, NCT04444674, and the Pan African Clinicals Trials Registry, PACTR202006922165132.…”