Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease by Li Zhengyu, Gan Li, Yan Si, Yan Yufang, Huang Wei

“…Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer’s disease (AD). …”
Get full text

Candida Bezoars with Urinary Tract Obstruction in Two Women without Immunocompromising Conditions by Giuseppe Di Paola, Andrea Mogorovich, Girolamo Fiorini, Maria Giuseppa Cuttano, Francesca Manassero, Cesare Selli

“…Preoperative imaging is not pathognomonic; blood clots, radiolucent urinary calculi, air bubbles, and inflammatory debris can mimic urobezoars. …”
Get full text

DIAGNOSIS AND RX-SURGICAL TREATMENT OF THE LIVER HEMANGIOMAS IN CHILDREN by E. I. Petrov, I. V. Kirgizov, Yu. A. Polyaev, R. V. Garbuzov, E. N. Tsygina

“…Of all the known today diagnostic techniques, angiography more precisely reveals the pathognomonic signs of the focus formations in the liver, especially hemangiomas, and allows to make a smooth transition from the stage of diagnosis to the treatment — i.e. endovascular occlusion of the hepatic artery [9]. …”
Get full text

Clinical diagnosis of LGI1 antibody encephalitis in an 83-year-old woman by Attwood, JE, Naseer, S, Michael, S, Riley, J

“…These were clinically recognised as faciobrachial dystonic seizures (FBDS). FBDS are pathognomonic of an autoimmune encephalitis caused by an antibody directed against leucine-rich glioma-inactivated 1 (LGI1). …”

[Alpha-thalassemia/mental retardation syndrome (ATR-X) in two brothers - clinical characteristics, diagnostics and genetic counselling issues]. by Szczałuba, K, Obersztyn, E, Nowakowska, B, Bernaciak, J, Fisher, C, Gibbons, R, Mazurczak, T, Bocian, E

“…Alpha-thalassemia/mental retardation syndrome (ATR-X) is a neurodevelopmental disorder with characteristic clinical picture as well as presence of pathognomonic haemoglobin H inclusions (HbH) on peripheral blood examination. …”

Using Clinical Vignettes to Understand the Complexity of Diagnosing Type 1 Diabetes in Sub-Saharan Africa by Le Bec E, Kam M, Aebischer Perone S, Boulle P, Cikomola JC, Gandur ME, Gehri M, Kehlenbrink S, Beran D

“…The main obstacles to diagnosis were low specificity of non-pathognomonic DKA symptoms and lack of tools to measure blood or urine glucose. …”
Get full text

Amyloidosis: A story of how inframammary erosions eclipsed inconspicuous periorbital ecchymoses by Andrew Kelsey, MD, Diane H. Smith, MD, Joyce Meng, MD, Michael Murphy, MD, Marti J. Rothe, MD

“…She presented with pathognomonic dermatologic findings including pinch purpura and ecchymoses found in the skin folds. …”
Get full text

From exercise intolerance to functional improvement: the second wind phenomenon in the identification of McArdle disease by Renata Siciliani Scalco, Sherryl Chatfield, Richard Godfrey, Jatin Pattni, Charlotte Ellerton, Andrea Beggs, Stefen Brady, Andrew Wakelin, Janice L Holton, Ros Quinlivan

“…A simple exercise test performed in the clinic can however help to identify patients by revealing the second wind phenomenon which is pathognomonic of the condition. Here a patient is reported illustrating the value of using a simple 12 minute walk test.…”
Get full text

Severe rosacea: A case report by Ebrahim Shirzadeh, Abbas Bagheri, Mojtaba Fattahi Abdizadeh, Mozhgan Rezaei Kanavi

“…Conclusion: Rosacea can be extremely severe and disfiguring, and it can be misdiagnosed as the pathognomonic butterfly rash of LE. Demodex carriage in rosacea is consistent and may play a significant role in the severe forms.…”
Get full text

Takayasu's arteritis in a patient with suspected acute coronary syndrome — a literature review and a case report by D. A. Grabovyi, J. V. Dzhinibalaeva, E. V. Adonina, D. V. Duplyakov

“…The true prevalence of this disease is unknown, but it is extremely low, given the rare diagnosis and the absence of pathognomonic symptoms. In clinical practice, the criteria proposed by the American College of Rheumatology are used for making a diagnosis. …”
Get full text

DIFFERENTIAL DIAGNOSTICS OF PROSTATE TUBERCULOSIS by E. V. Brizhatyuk, V. T. Khomyakov, A. A. Baranchukova

“…The article analyses the experience of differential diagnostics of prostate tuberculosis based on the data of examination of 84 patients. 45 of them were diagnosed with prostate tuberculosis, and 39 patients were diagnosed with chronic bacterial prostatitis. Pathognomonic diagnostics criteria of prostate tuberculosis were the following: detection of tuberculous mycobacteria in the prostatic fluid or ejaculate, signs of granulomatous prostatitis with areas of cavernous necrosis in prostate biopsy samples, and prostate cavities visualized by X-ray or ultrasound examinations. …”
Get full text

Cutaneous signs in dermatological diseases; An overview by Surabhi Sharma, Binod K Khaitan, Sujith Prasad Kumarasinghe

“…Cutaneous signs in dermatology are pathognomonic or diagnostic for certain conditions. A knowledge of these signs is a useful skill, which must not be forgotten in the recent trend towards relying on molecular biology and other investigative tools including histological findings to make a diagnosis. …”
Get full text

Primary angiitis of the central nervous system presenting with subacute and fatal course of disease: a case report by Börnke Christian, Keyvani Kathy, Lukas Carsten

“…This rare but treatable disease provides a diagnostic challenge owing to the lack of pathognomonic tests and the necessity of a histological confirmation.…”
Get full text

THE SUFFERING OF PATIENTS WITH RESPIRATORY DISORDERS DURING SLEEP by Jacek Lech

“…Summary : The problem of sleep apnoea is most often diagnosed and treated too late due to the number of symptoms with a simultaneous absence of pathognomonic symptoms. Despite its commonness, recognition of this disease is still insufficient.…”
Get full text

CASE REPORT OF A PATIENT WITH CYSTINURIA by Matej Kemperle, Robert Kordič, Rina Rus

“…The diagnosis is made by a positive family his- tory of cystinuria, if pathognomonic hexagonal crystals of cystine are identified in the urine, or if the analysed stone contains cystine. …”
Get full text

HEMOLYTIC ANEMIA IMUNNE-MEDIATED IN DOGS by R. C. Castilho, M. O. Lima, M. F. R. Cruz, E. S. Marquez, C. Calderón

“…Due to the reduction in the number of red blood cells, caused by the immune system, the immune-mediated hemolytic anemia (IMHA) is the most common disease among the hemolytic anemias and occurs more frequently in dogs (Nelson & Couto, 2010), wherein the most affected breeds are Cocker Spaniel, Poodle, Doberman and Collie (ETTINGER; FELDMAN 2004; THRALL et al 2007.). There is no pathognomonic sign for the diagnosis of the immune-mediated hemolytic anemia; however, laboratory findings show regenerative anemia, spherocytosis, positive results in Coombs' test and rarely, monocytes with hemosiderin or erythrocytes phagocytosis, but even with these findings, the primary and secondary IMHA can not be differentiate from each other. …”
Get full text

Pulmonary alveolar microlithiasis: Lungs of stone! by N Neenu, Ketaki Utpat, Unnati Desai, Gautam Sarawade

“…Even though PAM has pathognomonic unique chest radiographic findings, it always poses a diagnostic challenge for physicians as it closely resembles other diseases including miliary tuberculosis, pneumoconiosis, and sarcoidosis. …”
Get full text

Hallervorden-Spatz Syndrome: A Case Report by Anita Soundarapandian, Samai Puhazhendhi, Cheppala Rajan Seena, Saveetha Veeraiyan

“…Though, the definitive diagnosis of the disease is by histopathological examination, radiological investigations by detecting certain near pathognomonic features play an important role in narrowing down to the diagnosis in patients who present with vague symptoms, signs and thus vast clinical differential diagnoses.…”
Get full text

Intramuscular Chondroid Lipoma: Magnetic Resonance Imaging Diagnosis by ‘Fat Ring Sign’ by Adalet Elçin Yıldız, Üstün Aydıngöz, Muşturay Karçaaltıncaba, Cenk Sökmensüer

“…Although benign lipomatous lesions are the most common soft tissue tumors and imaging findings are often pathognomonic, there have been few reports describing the imaging features of chondroid lipoma. …”
Get full text

The mechanism: how dental resorptions occur in ameloblastoma by Giovana Gonçalves Martins, Ingrid Araújo de Oliveira, Alberto Consolaro

“…ABSTRACT Knife-edge or blunt root resorptions characterize ameloblastomas and are pathognomonic for this tumor, because they differentiate ameloblastomas from simple bone cysts, odontogenic keratocysts and nasopalatine duct cysts, which do not lead to resorption of involved teeth. …”
Get full text