Possibilities of ultrasonography in the diagnosis of pigmented villonodular synovitis. Clinical case by V.M. Zhdan, I.V. Ivanytskyi, M.Y. Babanina, T.A. Ivanytska, Y.M. Kitura, H.V. Volchenko, M.V. Tkachenko, O.A. Kyrian, V.H. Lebid

“…It demonstrated a significant increase in the stiffness of the synovial membrane, which can be a patho­gnomonic symptom of this pathology. The diagnosis of villonodular synovitis was confirmed histologically after surgical treatment. …”
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Evaluation of the HFA‐PEFF Score: results from the prospective DIAST‐CHF cohort by Djawid Hashemi, Meinhard Mende, Tobias D. Trippel, Johannes Petutschnigg, Gerd Hasenfuss, Kathleen Nolte, Christoph Herrmann‐Lingen, Anna Feuerstein, Romy Langhammer, Carsten Tschöpe, Burkert Pieske, Rolf Wachter, Frank Edelmann

“…In the absence of a pathognomonic sign for HFpEF or specific treatment strategies, a prognosis‐based characterization of suspected patients remains promising for both the risk stratification of the patients and a disease definition. …”
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Novel Roles of the Nipah Virus Attachment Glycoprotein and Its Mobility in Early and Late Membrane Fusion Steps by Victoria Ortega, J. Lizbeth Reyes Zamora, I. Abrrey Monreal, Daniel T. Hoffman, Shahrzad Ezzatpour, Gunner P. Johnston, Erik M. Contreras, Fernando J. Vilchez-Delgado, Hector C. Aguilar

“…Paramyxoviral entry into cells requires viral-cell membrane fusion, and formation of paramyxoviral pathognomonic syncytia requires cell-cell membrane fusion. …”
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Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications by Daria V. Babushok, Jamie L. Duke, Hongbo M. Xie, Natasha Stanley, Jamie Atienza, Nieves Perdigones, Peter Nicholas, Deborah Ferriola, Yimei Li, Hugh Huang, Wenda Ye, Jennifer J.D. Morrissette, Jane Kearns, David L. Porter, Gregory M. Podsakoff, Laurence C. Eisenlohr, Jaclyn A. Biegel, Stella T. Chou, Dimitrios S. Monos, Monica Bessler, Timothy S. Olson

“…We hypothesized that HLA class I mutations are pathognomonic for autoimmunity in aAA, but were previously underappreciated because the major histocompatibility complex (MHC) region is notoriously difficult to analyze by WES. …”
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A Baseline Algorithm for Molecular Diagnosis of Genetic Eye Diseases: Ophthalmologist’s Perspective by Hande Taylan Şekeroğlu, Gülen Eda Utine, Mehmet Alikaşifoğlu

“…If the phenotype is pathognomonic, Sanger sequencing is preferred for confirmation.1 A previously established genotype-phenotype correlation may add to the value, either by providing accurate prognostic information or by indicating which particular mutation to look for. …”
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Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer by Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi, Sabine Colnot, Thierry André, Julien Taieb, Jean-Luc Vilotte, Béatrice Romagnolo, Pierre Laurent-Puig

“…Conclusions An unleashed PrPC-dependent vicious circle is pathognomonic of poor prognosis, mesenchymal CRC. Patients from this aggressive subtype of CRC may benefit from therapies targeting the PRNP-CTNNB1-NR3C1 axis.…”
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Oral-Gut Microbiome Analysis in Patients With Metabolic-Associated Fatty Liver Disease Having Different Tongue Image Feature by Chenxia Lu, Hui Zhu, Dan Zhao, Jia Zhang, Kai Yang, Yi Lv, Miao Peng, Xi Xu, Jingjing Huang, Zuoyu Shao, Zuoyu Shao, Zuoyu Shao, Zuoyu Shao, Mingzhong Xiao, Mingzhong Xiao, Mingzhong Xiao, Mingzhong Xiao, Xiaodong Li, Xiaodong Li, Xiaodong Li, Xiaodong Li

“…Upon analyzing the microorganisms in the tongue coating, 66 and 62 pathognomonic bacterial genera were found in the White and Yellow Coating Groups, respectively. …”
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Pathology of acute and subchronic nitrate poisening in reindeer (Rangifer tarandus L) by M. Nordkvist, C. Rehbinder, S. C. Mukherjee, K. Erne

“…The constant finding of these pleural and muscular haemorrhages may indicate almost pathognomonic lesions, in reindeer, in connection with nitrate poisoning of subchronic and chronic nature. …”
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Case report: A novel ACTA1 variant in a patient with nemaline rods and increased glycogen deposition by Daniela Piga, Martina Rimoldi, Martina Rimoldi, Francesca Magri, Simona Zanotti, Laura Napoli, Michela Ripolone, Serena Pagliarani, Patrizia Ciscato, Daniele Velardo, Adele D’Amico, Enrico Bertini, Giacomo Pietro Comi, Giacomo Pietro Comi, Dario Ronchi, Dario Ronchi, Stefania Corti, Stefania Corti

“…Muscle biopsy analysis is crucial for the identification of pathognomonic morphological features, such as core areas, nemaline bodies or rods, nuclear centralizations and congenital type 1 fibers disproportion. …”
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A Comparison of Clinical and Radiographic Signs of Nontuberculous Mycobacterial Pulmonary Disease, Destructive Drug-Resistant Pulmonary Tuberculosis and a Combination of Nontubercu... by Dmitrii Giller, Galina Scherbakova, Inga Enilenis, Ivan Martel, Oleg Kesaev, Vadim Koroev, Anna Popova, Alexandr Ilyukhin, Valeria Basangova, Sergey Smerdin, Shokirjon Mayusupov, Sergey Saenko, Olga Frolova, Veronika Vinarskaya, Lyudmila Severova

“…Thus, upon clinically observing the combination of pTB and NTMPD, there are no pathognomonic clinical and radiographic detected symptoms. …”
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A percutaneous treatment strategy of an adult patient with a bicuspid aortic valve, coarctation of the aorta, and an exceptionally large aneurysm of a collateral artery: Case repor... by D. B. H. Verheijen, D. B. H. Verheijen, J. Lauran Stöger, F. van der Kley, F. van der Kley, M. J. Schalij, M. J. Schalij, M. R. M. Jongbloed, M. R. M. Jongbloed, M. R. M. Jongbloed, H. W. Vliegen, H. W. Vliegen, P. Kiès, P. Kiès, A. D. Egorova, A. D. Egorova

“…Echocardiography showed a narrowing of the aorta distal from the origin of the left subclavian artery with the antegrade diastolic flow with a pathognomonic “sawtooth” pattern and an estimated pressure gradient of >70 mmHg. …”
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Methods to Measure the Broncho-Arterial Ratio and Wall Thickness in the Right Lower Lobe for Defining Radiographic Reversibility of Bronchiectasis by Abhijith Reddy Beeravolu, Ian Brent Masters, Mirjam Jonkman, Kheng Cher Yeo, Spyridon Prountzos, Rahul J. Thomas, Eva Ignatious, Sami Azam, Gabrielle B. Mccallum, Efthymia Alexopoulou, Anne B. Chang, Friso De Boer

“…It is confirmed radiologically using a chest tomography (C.T.). scan where the pathognomonic feature is increased broncho-arterial ratio (BAR) (>0.8 in children) and, often accompanied by other features such as bronchial wall thickening (W.T.). …”
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mNGS helped diagnose scrub typhus-associated HLH in children: a report of two cases by Hui Jian, Hui Jian, Qiu-xia Yang, Qiu-xia Yang, Jia-xin Duan, Jia-xin Duan, Shu-yu Lai, Shu-yu Lai, Guang-lu Che, Guang-lu Che, Jie Teng, Jie Teng, Li Chang, Li Chang, Xiao-juan Liu, Xiao-juan Liu, Li-li Luo, Li-li Luo, Fang Liu, Fang Liu

“…The diagnosis of scrub typhus-associated HLH may be overlooked due to the non-specific clinical characteristics and the absence of pathognomonic eschar.Case presentationWe obtained clinical data from two patients in the South of Sichuan, China. …”
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Development of a Multiplex qPCR Assay for Fast Detection and Differentiation of Paracoccidioidomycosis Agents by Breno Gonçalves Pinheiro, Ana Paula Pôssa, Giannina Ricci, Angela Satie Nishikaku, Ferry Hagen, Rosane Christine Hahn, Zoilo Pires de Camargo, Anderson Messias Rodrigues

“…The laboratorial diagnosis of PCM relies on observing pathognomonic structures such as the “steering wheel” or “Mickey Mouse” shape in the direct mycological examination, fresh biopsied tissue in 10% KOH, histopathological analysis, and/or the isolation of the fungus in culture. …”
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case report by Rawaa Dawood Aljanabi

“…Diagnosis of rupture RAA during pregnancy is very difficult i.e. no pathognomonic presentation. When rupture occurs during pregnancy the clinical presentation is confused with those more common conditions e.g. placenta abruption or rupture uterus. …”
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Functional Neuroimaging in Psychiatry—Aiding in Diagnosis and Guiding Treatment. What the American Psychiatric Association Does Not Know by Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Muriel J. van Lierop, Muriel J. van Lierop, Mary McLean, Mary McLean, John Michael Uszler, John Michael Uszler, John Michael Uszler, John F. Thornton, John F. Thornton, Yin-Hui Siow, Yin-Hui Siow, Dan G. Pavel, Dan G. Pavel, Joe Cardaci, Joe Cardaci, Joe Cardaci, Joe Cardaci, Phil Cohen, Phil Cohen, Phil Cohen

“…Using the diagnosis of depression as a model, we illustrate how setting aside the unrealistic expectation of a pathognomonic “fingerprint” for categorical diagnoses, we can avoid missing the biological and, therefore, treatable contributors to psychopathology which can and are visualized using functional neuroimaging. …”
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Vaccination with an in vitro culture attenuated Babesia bovis strain safely protects highly susceptible adult cattle against acute bovine babesiosis by Reginaldo G. Bastos, Reginaldo G. Bastos, Janaina Capelli-Peixoto, Jacob M. Laughery, Carlos E. Suarez, Carlos E. Suarez, Massaro W. Ueti, Massaro W. Ueti

“…In contrast, control adult cattle (n=5) showed pathognomonic symptoms of acute babesiosis, and significant decrease (P<0.05) in lymphocytes, monocytes, and neutrophils, starting on day 7 post-challenge. …”
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Clinical characteristics and prognostic factor in juvenile dermatomyositis: data of the Spanish registry by Sonia Carriquí-Arenas, Juan Manuel Mosquera, Estefanía Quesada-Masachs, Mireia López, Daniel Clemente, Alina Boteanu, Clara Udaondo, Jaime de Inocencio, Juan Carlos Nieto, Leyre Riancho, Esmeralda Núñez, Judith Sánchez-Manubens, María José Lirola, Rosa Roldán, Marisol Camacho, Melania Martínez, Marta Medrano, Paula Alcañiz, Jordi Antón, Estíbaliz Iglesias

“…Median age at diagnosis was 7.3 years (Interquartile range (IQR) 4.5–10.2). All patients had pathognomonic skin lesions at the beginning of the disease. …”
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Molecular characterization and experimental infection of infectious spleen and kidney necrosis virus from ornamental fish in Peninsular Malaysia by Subramaniam, Kuttichantran

“…The inclusion body-bearing cells (IBCs) which are pathognomonic for Megalocytivirus infection were present in the liver and spleen. …”
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Mutational topography reflects clinical neuroblastoma heterogeneity by Elias Rodriguez-Fos, Mercè Planas-Fèlix, Martin Burkert, Montserrat Puiggròs, Joern Toedling, Nina Thiessen, Eric Blanc, Annabell Szymansky, Falk Hertwig, Naveed Ishaque, Dieter Beule, David Torrents, Angelika Eggert, Richard P. Koche, Roland F. Schwarz, Kerstin Haase, Johannes H. Schulte, Anton G. Henssen

“…We demonstrate that clinical neuroblastoma heterogeneity is associated with differences in the mutational processes driving these scenarios, linking risk-defining pathognomonic variants to distinct molecular processes. …”
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