Analysis of prehospital delay in acute ischaemic stroke and its influencing factors: a multicentre prospective case registry study in China by Lijie Ren, Jinyan Chen, Dan Gao, Qin Liu, Yan Yang, Ying Su, Xiaoxiang Peng, Xin Shi, Feng Chi, Liming Cao, Yanni Yu, Wenwei Qi, Jiaqian Zhu, Xiaohong Wu, Runyu Xia, Limin Qin, Guobing Huang, Yidong Xue, Wenbiao Guan, Bin Ye

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Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation by Meng Wei, Meng Wei, Yunhai Mo, Yunhai Mo, Jialong Liu, Jingtong Zhai, Huilong Li, Huilong Li, Yixin Xu, Yixin Xu, Yumeng Peng, Yumeng Peng, Zhihong Tang, Zhihong Tang, Tao Wei, Tao Wei, Xiaopan Yang, Linfei Huang, Xiao Shao, Jingfei Li, Li Zhou, Hui Zhong, Congwen Wei, Qiaosheng Xie, Min Min, Feixiang Wu, Feixiang Wu

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A case–case study on the effect of primary and booster immunization with China-produced COVID-19 vaccines on prevention of pneumonia and viral load among vaccinated persons infecte... by Dan Wu, Ying Ye, Lin Tang, Ai-Bin Wang, Rui Zhang, Zhao-Hui Qian, Fu-Zhen Wang, Hui Zheng, Chang Huang, Xiao-Ya Lv, Hai-Feng Wang, Yan-Yang Zhang, Jing-Jing Pan, Ya-Fei Li, Ming-Xia Lu, Chang-Shuang Wang, Ya-Ting Ma, Zhi-Jie An, Lance Everett Rodewald, Zun-Dong Yin, Xuan-Yi Wang, Zhi-Yin Wu, Yi-Ming Shao

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Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants by Hong Lei, Aqu Alu, Jingyun Yang, Xi He, Cai He, Wenyan Ren, Zimin Chen, Weiqi Hong, Li Chen, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Wei Wang, Yuquan Wei, Shuaiyao Lu, Guangwen Lu, Xiangrong Song, Xiawei Wei

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The associations of radiological features of high-resolution computed tomography with the outcomes of transbronchial cryobiopsy in interstitial lung diseases: A cohort study by Guowu Zhou, Yanhong Ren, Jun Li, Ting Yang, Nan Su, Ling Zhao, Shumeng Wang, Dan Wang, Ying Li, Zheng Tian, Ruihong Liu, Huaping Dai, Chen Wang, Chen Wang

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The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing by Chengdi Wang, Qiuxiao Yu, Tingting Song, Zhoufeng Wang, Lujia Song, Ying Yang, Jun Shao, Jingwei Li, Yinyun Ni, Ningning Chao, Li Zhang, Weimin Li

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Gene-Focused Networks Underlying Phenotypic Convergence in a Systematically Phenotyped Cohort With Heterogeneous Intellectual Disability by Yan Wang, Yan Wang, Yan Wang, Li-Na Zhu, Li-Na Zhu, Li-Na Zhu, Xiu-Wei Ma, Xiu-Wei Ma, Xiu-Wei Ma, Fang Yang, Xi-Lin Xu, Yao Yang, Yao Yang, Yao Yang, Xiao Yang, Xiao Yang, Xiao Yang, Wei Peng, Wei Peng, Wei Peng, Wan-Qiao Zhang, Wan-Qiao Zhang, Wan-Qiao Zhang, Jin-Yu Liang, Wei-Dong Zhu, Tai-Jiao Jiang, Tai-Jiao Jiang, Xin-Lei Zhang, Zhi-Chun Feng, Zhi-Chun Feng, Zhi-Chun Feng

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Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i by Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jialing Huang, Siyu Han, Martina Rommel, Markus Rotter, Margit Heier, Robert P. Mohney, Jan Krumsiek, Gabi Kastenmüller, Wolfgang Rathmann, Zhongmei Zou, Sven Zukunft, Markus F. Scheerer, Susanne Neschen, Jerzy Adamski, Christian Gieger, Annette Peters, Donna P. Ankerst, Thomas Meitinger, Tanya L. Alderete, Martin Hrabe de Angelis, Karsten Suhre, Rui Wang-Sattler

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Real-World Safety and Effectiveness of Omalizumab in Moderate to Severe Allergic Asthma Patients in China: A Post-Authorization Study by Su N, Zhi L, Liu F, Wang Y, Zhang Q, Liu X, Wang X, Hao G, Zhang X, Hu Q, Ligueros-Saylan M, Uddin A, Yang J, Liang T, Ding L, Li R, Wang C

“…Ltd, Shanghai, People’s Republic of China; 18National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of China; 19Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 20Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 21Department of Respiratory Medicine, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Chen Wang, China- Japan Friendship Hospital, No. 2, East Yinghua Road, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel +86 10-6510 5565, Fax +86 10-6510 5567, Email wangchen@pumc.edu.cnPurpose: Omalizumab was first approved in China in 2017 for the treatment of moderate to severe allergic asthma for adult and adolescent patients aged ≥ 12 years. …”
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Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias by Chen-Chen Hu, Xin Wei, Jin-Min Liu, Lin-Lin Han, Cheng-Kun Xia, Jing Wu, Tao You, A.-Fang Zhu, Shang-Long Yao, Shi-Ying Yuan, Hao-Dong Xu, Zheng-Yuan Xia, Ting-Ting Wang, Wei-Ke Mao

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ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses by Liping Li, Jia Wang, Xincheng Zhong, Yaoyao Jiang, Gaofeng Pei, Xikang Yang, Kaixiang Zhang, Siqi Shen, Xue Jin, Gaoge Sun, Chaofei Su, Shuzhen Chen, Hang Yin

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Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children by Nina Li, Nina Li, XueYun Li, XueYun Li, Jiani Wu, Jiani Wu, Shengze Zhang, Shengze Zhang, Lin Zhu, Lin Zhu, Qiqi Chen, Qiqi Chen, Ying Fan, Ying Fan, Zhengyu Wu, Zhengyu Wu, Sidian Xie, Sidian Xie, Qi Chen, Qi Chen, Ning Wang, Nan Wu, Chuming Luo, Chuming Luo, Yuelong Shu, Yuelong Shu, Yuelong Shu, Yuelong Shu, Huanle Luo, Huanle Luo, Huanle Luo

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Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep by Mingming Chen, Yue Zhao, Yao Li, Tiantian Chen, Wendi Zhou, Xiaosheng Zhang, Shoulong Deng, Xueling Xu, Sujun Wu, Zhimei Liu, Shiyu Qi, Luyu Wang, Yan Li, Kun Yu, Zhengxing Lian

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Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism by Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou

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Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea by Salma Nabila, Ji-Yeob Choi, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Aesun Shin, Melissa A. Merritt, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Hui Cai, Shoichiro Tsugane, Takashi Kimura, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

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Real-World Utilization, Barriers, and Factors Associated With the Targeted Treatment of Metastatic Colorectal Cancer Patients in China: A Multi-Center, Hospital-Based Survey Study by Yin Liu, Xi Zhang, Hui-Fang Xu, Ji-Hai Shi, Yu-Qian Zhao, Ling-Bin Du, Yun-Yong Liu, Wen-Jun Wang, He-Lu Cao, Li Ma, Juan-Xiu Huang, Ji Cao, Li Li, Yan-Ping Fan, Xiao-Fen Gu, Chang-Yan Feng, Qian Zhu, Xiao-Hui Wang, Jing-Chang Du, Jian-Gong Zhang, Shao-Kai Zhang, You-Lin Qiao, You-Lin Qiao

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Nosocomial Infections After Pediatric Congenital Heart Disease Surgery: Data from National Center for Cardiovascular Diseases in China by Wang X, Li S, Huo D, Zhu Z, Wang W, He H, Zhang Q, Li J, Wang X

“…Xiaofeng Wang,1,2,* Shuo Li,3,* Da Huo,4,* Zhiyuan Zhu,1,2,* Wenlong Wang,1,2 Hongxia He,1,2 Qian Zhang,1,2 Jiantao Li,2,5 Xu Wang1,2 1Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Beijing, People’s Republic of China; 2School of Clinical Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Infection Control, Peking University First Hospital, Beijing, People’s Republic of China; 4Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of China; 5Department of Infection Control, National Center for Cardiovascular Disease and Fuwai Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu Wang, Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, No. 167 North Lishi Road, Xicheng District, Beijing, 100037, People’s Republic of China, Email fwpicu@163.comPurpose: Infection prevention and control (IPC) has a significant impact on the prognosis after pediatric cardiac surgery. …”
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Effectiveness and safety of ivabradine in Chinese patients with chronic heart failure: an observational study by Jingmin Zhou, Yamei Xu, Zhaofen Zheng, Shuyang Zhang, Jiefu Yang, Yuhui Zhang, Baopeng Tang, Huiyuan Han, Qing Zhang, Fan Liu, Wenhui Ding, Caizhen Qian, Guohai Su, Xiaohui Liu, Yuansheng Shen, Bei Shi, Xiangqing Kong, Zhiming Ge, Ping Zhang, Xiaomei Guo, Hong Zhang, Yuemin Sun, Yugang Dong, Guosheng Fu, Lei Feng, Junbo Ge, the POSITIVE investigators

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Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia by Guo-Tian Ruan, Li Deng, Hai-Lun Xie, Jin-Yu Shi, Xiao-Yue Liu, Xin Zheng, Yue Chen, Shi-Qi Lin, He-Yang Zhang, Chen-An Liu, Yi-Zhong Ge, Meng-Meng Song, Chun-Lei Hu, Xiao-Wei Zhang, Ming Yang, Wen Hu, Ming-Hua Cong, Li-Chen Zhu, Kun-Hua Wang, Han-Ping Shi

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Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau by Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, Dan Li

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