Dual-action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery by Catriona McCallion, Anna D. Peters, Andrew Booth, Karen Rees-Unwin, Julie Adams, Raisa Rahi, Alain Pluen, Claire V. Hutchinson, Simon J. Webb, John Burthem

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Comparative effectiveness of interventions for preventing tuberculosis: systematic review and network meta-analysis of interventional studiesResearch in context by Alemneh Mekuriaw Liyew, Beth Gilmour, Archie C.A. Clements, Kefyalew Addis Alene

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Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery by Jia L. Stevens, Helen T. McKenna, Helder Filipe, Laurie Lau, Bernadette O. Fernandez, Andrew J. Murray, Martin Feelisch, Daniel S. Martin

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Implementation of large, multi-site hospital interventions: a realist evaluation of strategies for developing capability by Janet C Long, Natalie Roberts, Emilie Francis-Auton, Mitchell N Sarkies, Hoa Mi Nguyen, Johanna I Westbrook, Jean-Frederic Levesque, Diane E Watson, Rebecca Hardwick, Kate Churruca, Peter Hibbert, Jeffrey Braithwaite

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Audit and feedback to reduce unwarranted clinical variation at scale: a realist study of implementation strategy mechanisms by Mitchell Sarkies, Emilie Francis-Auton, Janet Long, Natalie Roberts, Johanna Westbrook, Jean-Frederic Levesque, Diane E. Watson, Rebecca Hardwick, Kim Sutherland, Gary Disher, Peter Hibbert, Jeffrey Braithwaite

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Identification of risk factors associated with prolonged hospital stay following primary knee replacement surgery: a retrospective, longitudinal observational study by Martin Pitt, Andrew Judge, Tim Jones, Rebecca Wilson, Chris Penfold, Andrew Elliott, Ruta Margelyte, Ashley Blom, Maria Theresa Redaniel, Alison Harper, Emily Eyles, Tim Keen

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Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): stud... by Ann Hutchinson, Victoria Allgar, Judith Cohen, David C. Currow, Susan Griffin, Simon Hart, Kelly Hird, Andrew Hodge, Suzanne Mason, Matthew Northgraves, Joanne Reeve, Flavia Swan, Miriam J. Johnson

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Interventions to prevent post-tuberculosis sequelae: a systematic review and meta-analysisResearch in context by Kefyalew Addis Alene, Lucas Hertzog, Beth Gilmour, Archie C.A. Clements, Megan B. Murray

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The MATE trial: a multicentre, mixed-methodology, pilot, randomised controlled trial in neovascular age-related macular degeneration by Archana Airody, Heidi A. Baseler, Julie Seymour, Victoria Allgar, Rajarshi Mukherjee, Louise Downey, Sushma Dhar-Munshi, Sajjad Mahmood, Konstantinos Balaskas, Theo Empeslidis, Rachel L. W. Hanson, Tracey Dorey, Tom Szczerbicki, Sobha Sivaprasad, Richard P. Gale

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Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review by Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Madden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson, Joanne Reeve

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Guiding principles for effective collaborative implementation strategies for multisite hospital improvement initiatives: a mixed-method realist evaluation of collaborative strategi... by Frances Rapport, Jeffrey Braithwaite, Peter D Hibbert, Janet C Long, Johanna Westbrook, Jean-Frédéric Levesque, Mitchell N Sarkies, Emilie Francis-Auton, Hoa Mi Nguyen, Diane E Watson, Rebecca Hardwick, Natalie Roberts

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Systematic review of the effectiveness and cost-effectiveness of weight management schemes for the under fives: a short report by M Bond, K Wyatt, J Lloyd, K Welch, R Taylor

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Assessing the impact of a new delivery method of insulin on glycemic control using a novel trial design by Thomas Strack, Luc Martinez, Stefano Del Prato, Larry Blonde, Burkhard Göke, et al

“…Thomas Strack1, Luc Martinez2, Stefano Del Prato3, Larry Blonde4, Burkhard Göke5, Vincent Woo6, Ann Millward7, Ramon Gomis8, Bill Canovatchel1, David Lawrence1, Nick Freemantle9 on behalf of the EXPERIENCE Trial Team1Pfizer Inc., New York, NY, USA; 2Société Française de Médecine Générale, Issy les Moulineaux, France; 3University of Pisa, Pisa, Italy; 4Ochsner Medical Center, New Orleans, LO, USA; 5University of Munich, Munich, Germany; 6Health Sciences Centre, Winnipeg, Canada; 7Peninsula Medical School, Plymouth, UK; 8University of Barcelona, Barcelona, Spain; 9University of Birmingham, Birmingham, UKObjective: The purpose of the trial was to examine the impact of inhaled human insulin (INH) on patient or physician willingness to adopt insulin after oral diabetes agent failure.Research design and methods: The EXPERIENCE trial was a one-year randomized controlled trial conducted at primary, secondary and tertiary care facilities in Europe and North America. …”
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Anti-cholinergic drug burden in patients with dementia increases after hospital admission: a multicentre cross-sectional study by Annabelle Hook, Jessica L. Randall, Carla M. Grubb, Natalie Ellis, Jack Wellington, Aayushi Hemmad, Agisilaos Zerdelis, Andrew R. D. Winnett, Benjamin D. W. Geers, Bethany Sykes, Charlotte N. Auty, Cecilia Vinchenzo, Christiane E. Thorburn, Daniella Asogbon, Emily Granger, Heather Boagey, Juliet Raphael, Kajal Patel, Kartik Bhargava, Mary-Kate M. Dolley, Matthew J. Maden, Mehdin M. Shah, Qao M. Lee, Ratnaraj Vaidya, Simran Sehdev, Sneha Barai, Sophie Roche, Uzair Khalid, David A. Codling, Judith R. Harrison

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Prevalence of chronic obstructive pulmonary disease and associated risk factors in Uganda (FRESH AIR Uganda): a prospective cross-sectional observational study by Frederik van Gemert, MD, Bruce Kirenga, MMED, Niels Chavannes, PhD, Prof. Moses Kamya, PhD, Simon Luzige, MMED, Patrick Musinguzi, MMED, John Turyagaruka, MPH, Rupert Jones, MD, Ioanna Tsiligianni, PhD, Sian Williams, MSc, Corina de Jong, PhD, Prof. Thys van der Molen, PhD

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Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activi... by Rachael L Murray, Paul Aveyard, Helen Hancocks, Jane Horrell, Siobhan Creanor, Michael Ussher, Sarah Campbell, Charlotte Wahlich, Tess Harris, Adrian Taylor, Wendy Ingram, Lisa Price, Tom P Thompson, Colin Green, Adam Justin Streeter, Jade Chynoweth, Colin J Greaves, Tristan Snowsill, Lynne Callaghan, Jennie King, Alex Gude, Mary George, Louisa Hamilton, Kelisha Cheema, Dan Preece

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Psychotropic medicines’ prevalence, patterns and effects on cognitive and physical function in older adults with intellectual disability in Ireland: longitudinal cohort study, 2009... by Marina Odalović, Ashleigh Gorman, Aviejay Paul, Philip McCallion, Éilish Burke, Malcolm MacLachlan, Mary McCarron, Martin C. Henman, Maeve Moran, Juliette O'Connell, Michael Walsh, Rohit Shankar, Caitriona Ryan, Máire O'Dwyer

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Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution by Hunter, David J., Peltonen, Leena, Guiducci, Candace, Crawford, Gabriel, Hirschhorn, Joel N., Lyon, Helen N., Speliotes, Elizabeth K.

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Prevalence of long-term physical sequelae among patients treated with multi-drug and extensively drug-resistant tuberculosis: a systematic review and meta-analysisResearch in conte... by Temesgen Yihunie Akalu, Archie C.A. Clements, Haileab Fekadu Wolde, Kefyalew Addis Alene

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Implementing large-system, value-based healthcare initiatives: a realist study protocol for seven natural experiments by Frances Rapport, Jeffrey Braithwaite, Peter D Hibbert, Chiara Pomare, Yvonne Tran, Robyn Clay-Williams, Janet C Long, Virginia Mumford, Johanna Westbrook, Gaston Arnolda, Rebecca Mitchell, Jean-Frédéric Levesque, Richard O Day, Kim Sutherland, Mitchell N Sarkies, Emilie Francis-Auton, Andrew Partington, Hoa Mi Nguyen, Wendy Wu, Henry Cutler, Diane E Watson, Reidar Lystad, George Leipnik, Rebecca Hardwick

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