A conversation with Aaron Richterman, MD, MPH, Assistant Professor of Medicine (Infectious Diseases), Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania by Clinical Research Forum

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Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis by Isabel Song, Elizabeth W. Thompson, Anurag Verma, Matthew T. MacLean, Jeffrey Duda, Ameena Elahi, Richard Tran, Pavan Raghupathy, Sophia Swago, Mohamad Hazim, Abhijit Bhattaru, Carolin Schneider, Marijana Vujkovic, Drew A. Torigian, Charles E. Kahn, James C. Gee, Arijitt Borthakur, Colleen M. Kripke, Christopher C. Carson, Rotonya Carr, Qasim Jehangir, Yi-An Ko, Harold Litt, Mark Rosen, David A. Mankoff, Mitchell D. Schnall, Haochang Shou, Julio Chirinos, Scott M. Damrauer, Marina Serper, Jinbo Chen, Daniel J. Rader, Penn Medicine BioBank, Walter R. T. Witschey, Hersh Sagreiya

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T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma by Alfred L. Garfall, Ehren K. Dancy, Adam D. Cohen, Wei-Ting Hwang, Joseph A. Fraietta, Megan M. Davis, Bruce L. Levine, Don L. Siegel, Edward A. Stadtmauer, Dan T. Vogl, Adam Waxman, Aaron P. Rapoport, Michael C. Milone, Carl H. June, J. Joseph Melenhorst

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Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction by Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens

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Personalized circuit-targeted deep brain stimulation for obsessive compulsive disorder by Robert Seilheimer, Liming Qiu, Gustavo Campos, Younghoon Nho, Daniel Barbosa, Lily Brown, Mario Cristancho, Bijan Pesaran, Casey Halpern, Katherine Scangos

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BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers by Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, John Pluta, Lyndsey Emery, Amanda Barrett, Adam A. Kraya, Ioannis N. Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole Hackman, Kurt D’Andrea, Robert Daber, Jennifer J. D. Morrissette, Nandita Mitra, Michael Feldman, Susan M. Domchek, Katherine L. Nathanson

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Sokratis A. Apostolidis, Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Amy E. Baxter, Allison R. Greenplate, Allison R. Greenplate, Cécile Alanio, Cécile Alanio, Cécile Alanio, Mohamed Abdel-Hakeem, Mohamed Abdel-Hakeem, Derek A. Oldridge, Derek A. Oldridge, Derek A. Oldridge, Josephine R. Giles, Josephine R. Giles, Josephine R. Giles, Jennifer E. Wu, Jennifer E. Wu, Jennifer E. Wu, Zeyu Chen, Zeyu Chen, Yinghui Jane Huang, Yinghui Jane Huang, Jonathan Belman, Jonathan Belman, Ajinkya Pattekar, Ajinkya Pattekar, Sasikanth Manne, Sasikanth Manne, Oliva Kuthuru, Oliva Kuthuru, Jeanette Dougherty, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Alexander C. Huang, Alexander C. Huang, Laura A. Vella, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Scott E. Hensley, Lubica Rauova, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Mortimer Poncz, Charles S. Abrams, E. John Wherry, E. John Wherry, E. John Wherry, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck

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Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level by Thomas F. Tropea, Whitney Hartstone, Noor Amari, Dylan Baum, Jacqueline Rick, Eunran Suh, Hanwen Zhang, Rachel A. Paul, Noah Han, Rebecca Zack, Eliza M. Brody, Isabela Albuja, Justin James, Meredith Spindler, Andres Deik, Whitley W. Aamodt, Nabila Dahodwala, Ali Hamedani, Aaron Lasker, Howard Hurtig, Matthew Stern, Daniel Weintraub, Pavan Vaswani, Allison W. Willis, Andrew Siderowf, Sharon X. Xie, Vivianna Van Deerlin, Alice S. Chen-Plotkin

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Ideas for how informaticians can get involved with COVID-19 research by Jason H. Moore, Ian Barnett, Mary Regina Boland, Yong Chen, George Demiris, Graciela Gonzalez-Hernandez, Daniel S. Herman, Blanca E. Himes, Rebecca A. Hubbard, Dokyoon Kim, Jeffrey S. Morris, Danielle L. Mowery, Marylyn D. Ritchie, Li Shen, Ryan Urbanowicz, John H. Holmes

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Iron imaging in myocardial infarction reperfusion injury by Brianna F. Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P. Solomon, Anya T. Hall, Rishabh Kumar, Nicholas J. Josselyn, Elizabeth M. Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Cory Tschabrunn, Samuel J. Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W. Wehrli, Haochang Shou, Victor A. Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai, Walter R. Witschey

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ModelArray: An R package for statistical analysis of fixel-wise data by Chenying Zhao, Tinashe M. Tapera, Joëlle Bagautdinova, Josiane Bourque, Sydney Covitz, Raquel E. Gur, Ruben C. Gur, Bart Larsen, Kahini Mehta, Steven L. Meisler, Kristin Murtha, John Muschelli, David R. Roalf, Valerie J. Sydnor, Alessandra M. Valcarcel, Russell T. Shinohara, Matthew Cieslak, Theodore D. Satterthwaite

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Protocol to evaluate sequential electronic health record-based strategies to increase genetic testing for breast and ovarian cancer risk across diverse patient populations in gynec... by Heather Symecko, Robert Schnoll, Rinad S. Beidas, Justin E. Bekelman, Daniel Blumenthal, Anna-Marika Bauer, Peter Gabriel, Leland Boisseau, Abigail Doucette, Jacquelyn Powers, Jacqueline Cappadocia, Danielle B. McKenna, Robert Richardville, Lauren Cuff, Ryan Offer, Elizabeth G. Clement, Alison M. Buttenheim, David A. Asch, Katharine A. Rendle, Rachel C. Shelton, Oluwadamilola M. Fayanju, E. Paul Wileyto, Martina Plag, Sue Ware, Lawrence N. Shulman, Katherine L. Nathanson, Susan M. Domchek

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Protocol for a pragmatic stepped wedge cluster randomized clinical trial testing behavioral economic implementation strategies to increase supplemental breast MRI screening among p... by Anne Marie McCarthy, Claudia Fernandez Perez, Rinad S. Beidas, Justin E. Bekelman, Daniel Blumenthal, Elizabeth Mack, Anna-Marika Bauer, Sarah Ehsan, Emily F. Conant, Bernadette C. Wheeler, Carmen E. Guerra, Linda W. Nunes, Peter Gabriel, Abigail Doucette, E. Paul Wileyto, Alison M. Buttenheim, David A. Asch, Katharine A. Rendle, Rachel C. Shelton, Oluwadamilola M. Fayanju, Sue Ware, Martina Plag, Steven Hyland, Tracy Gionta, Lawrence N. Shulman, Robert Schnoll

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Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity by Takeshi Katsuda, Jonathan H. Sussman, Kenji Ito, Andrew Katznelson, Salina Yuan, Naomi Takenaka, Jinyang Li, Allyson J. Merrell, Hector Cure, Qinglan Li, Reyaz Ur Rasool, Irfan A. Asangani, Kenneth S. Zaret, Ben Z. Stanger

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Anemia in a young Guinean male by Nicholas S. Wilcox, Chantal Tapé, Anthony J. Cordisco, Minh T. Than, Leah Zuroff, Jane Dobkin, Ryan C. Massa, Andrew G. Lytle, Adam Bagg, Htun Min, Laurel J. Glaser, Laura M. Kosseim

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Using the Translational Science Benefits Model to assess the impact of the Penn Implementation Science Center in Cancer Control by Robert Schnoll, Justin E. Bekelman, Daniel Blumenthal, David A. Asch, Alison M. Buttenheim, Krisda H. Chaiyachati, Susan M. Domchek, Oluwadamilola M. Fayanju, Peter Gabriel, Brian P. Jenssen, Frank T. Leone, Anne Marie McCarthy, Katherine L. Nathanson, Ravi B. Parikh, Katharine A. Rendle, Rachel C. Shelton, Lawrence N. Shulman, Samuel U. Takvorian, Susan Ware, E. Paul Wileyto, Rinad S. Beidas

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The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity by Edward Z. Song, Xin Wang, Benjamin I. Philipson, Qian Zhang, Radhika Thokala, Logan Zhang, Charles-Antoine Assenmacher, Zev A. Binder, Guo-li Ming, Donald M. O’Rourke, Hongjun Song, Michael C. Milone

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WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation by Mingang Xu, Jeremy Horrell, Melinda Snitow, Jiawei Cui, Heather Gochnauer, Camille M. Syrett, Staci Kallish, John T. Seykora, Fei Liu, Dany Gaillard, Jonathan P. Katz, Klaus H. Kaestner, Brooke Levin, Corinne Mansfield, Jennifer E. Douglas, Beverly J. Cowart, Michael Tordoff, Fang Liu, Xuming Zhu, Linda A. Barlow, Adam I. Rubin, John A. McGrath, Edward E. Morrisey, Emily Y. Chu, Sarah E. Millar

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Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers by Jennifer B. Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D’Andrea, Anna P. Hubert, Jake S. Shilan, Wenting Zhou, Adam A. Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J. Morin, Anupma Nayak, Kara N. Maxwell, Susan M. Domchek, Katherine L. Nathanson

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p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism by Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser

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