A conversation with Aaron Richterman, MD, MPH, Assistant Professor of Medicine (Infectious Diseases), Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania by Clinical Research Forum

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BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers by Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, Daniel De Sloover, John Pluta, Lyndsey Emery, Amanda Barrett, Adam A. Kraya, Ioannis N. Anastopoulos, Shun Yu, Yuchao Jiang, Hao Chen, Nancy R. Zhang, Nicole Hackman, Kurt D’Andrea, Robert Daber, Jennifer J. D. Morrissette, Nandita Mitra, Michael Feldman, Susan M. Domchek, Katherine L. Nathanson

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Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level by Thomas F. Tropea, Whitney Hartstone, Noor Amari, Dylan Baum, Jacqueline Rick, Eunran Suh, Hanwen Zhang, Rachel A. Paul, Noah Han, Rebecca Zack, Eliza M. Brody, Isabela Albuja, Justin James, Meredith Spindler, Andres Deik, Whitley W. Aamodt, Nabila Dahodwala, Ali Hamedani, Aaron Lasker, Howard Hurtig, Matthew Stern, Daniel Weintraub, Pavan Vaswani, Allison W. Willis, Andrew Siderowf, Sharon X. Xie, Vivianna Van Deerlin, Alice S. Chen-Plotkin

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Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers by Jennifer B. Shah, Dana Pueschl, Bradley Wubbenhorst, Mengyao Fan, John Pluta, Kurt D’Andrea, Anna P. Hubert, Jake S. Shilan, Wenting Zhou, Adam A. Kraya, Alba Llop Guevara, Catherine Ruan, Violeta Serra, Judith Balmaña, Michael Feldman, Pat J. Morin, Anupma Nayak, Kara N. Maxwell, Susan M. Domchek, Katherine L. Nathanson

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P853: Racial, ethnic, and socioeconomic disparities in general genetics evaluation and testing in the adult population* by Jessica Gold, Yehuda Elkaim, Stephanie Asher, Anna Raper, Courtney Condit, Isaac Elysee, Zoe Bogus, Laura Hennessy, Emma Kennedy, Colleen Kripke, Anurag Verman, Latrice Landry, Katherine Nathanson, Staci Kallish, Theodore Drivas

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Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism by Elizabeth Nunn, Natasha Jaiswal, Matthew Gavin, Kahealani Uehara, Megan Stefkovich, Karima Drareni, Ryan Calhoun, Michelle Lee, Corey D. Holman, Joseph A. Baur, Patrick Seale, Paul M. Titchenell

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NPM1 mutation is associated with leukemia cutis in acute myeloid leukemia with monocytic features by Marlise R. Luskin, Auris O. Huen, Sarah A. Brooks, Campbell Stewart, Christopher D. Watt, Jennifer J.D. Morrissette, David B. Lieberman, Adam Bagg, Misha Rosenbach, Alexander E. Perl

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Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos by Amanda D Yzaguirre, Arun Padmanabhan, Eric D de Groh, Kurt A Engleka, Jun Li, Nancy A Speck, Jonathan A Epstein

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Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes by Astero Klampatsa, Shaun M. O’Brien, Jeffrey C. Thompson, Abhishek S. Rao, Jason E. Stadanlick, Marina C. Martinez, Maria Liousia, Edward Cantu, Keith Cengel, Edmund K. Moon, Sunil Singhal, Evgeniy B. Eruslanov, Steven M. Albelda

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442-B IL-18-enhanced non-activated CAR T-cells for improved metabolic function and therapeutic efficacy by Carl H June, Joseph A Fraietta, Xiaoling Jin, Saba Ghassemi, Joseph Durgin, Ashwin Sannecy, Nandana Mukherjee, Andre Kelly, Alexander Shestov, Jakub Svoboda, Roddy O’Connor

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion by Jarrett R. Remsberg, Benjamin N. Ediger, Wesley Y. Ho, Manashree Damle, Zhenghui Li, Christopher Teng, Cristina Lanzillotta, Doris A. Stoffers, Mitchell A. Lazar

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Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design by Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Carl H. June, Roddy S. O’Connor

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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity by Amber Tariq, JiaBei Lin, Meredith E. Jackrel, Christina D. Hesketh, Peter J. Carman, Korrie L. Mack, Rachel Weitzman, Craig Gambogi, Oscar A. Hernandez Murillo, Elizabeth A. Sweeny, Esin Gurpinar, Adam L. Yokom, Stephanie N. Gates, Keolamau Yee, Saurabh Sudesh, Jacob Stillman, Alexandra N. Rizo, Daniel R. Southworth, James Shorter

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Assessing ChatGPT’s Ability to Reply to Queries Regarding Colon Cancer Screening Based on Multisociety Guidelines by S. Mukherjee, C. Durkin, A.M. PeBenito, N.D. Ferrante, I.C. Umana, M.L. Kochman

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Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells by Kevin R. Zhang, Connor S. R. Jankowski, Rayna Marshall, Rohini Nair, Néstor Más Gómez, Ahab Alnemri, Yingrui Liu, Elizabeth Erler, Julia Ferrante, Ying Song, Brent A. Bell, Bailey H. Baumann, Jacob Sterling, Brandon Anderson, Sierra Foshe, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Jen-Zen Chuang, Ching-Hwa Sung, Anuradha Dhingra, Kathleen Boesze-Battaglia, Venkata R. M. Chavali, Joshua D. Rabinowitz, Claire H. Mitchell, Joshua L. Dunaief

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The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally by Jordan C. Harris, Natalie A. Trigg, Bruktawit Goshu, Yuichi Yokoyama, Lenka Dohnalová, Ellen K. White, Adele Harman, Sofía M. Murga-Garrido, Jamie Ting-Chun Pan, Preeti Bhanap, Christoph A. Thaiss, Elizabeth A. Grice, Colin C. Conine, Taku Kambayashi

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Unlock the potential: Auditory-evoked event-related potential (ERP) as a treatment-responsive biomarker for Rett syndrome by Joanna Medina, Zhaolan Zhou

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A sleep state in Drosophila larvae required for neural stem cell proliferation by Milan Szuperak, Matthew A Churgin, Austin J Borja, David M Raizen, Christopher Fang-Yen, Matthew S Kayser

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Identification of a molecular basis for the juvenile sleep state by Leela Chakravarti Dilley, Milan Szuperak, Naihua N Gong, Charlette E Williams, Ricardo Linares Saldana, David S Garbe, Mubarak Hussain Syed, Rajan Jain, Matthew S Kayser

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Therapeutic genetic variation revealed in diverse Hsp104 homologs by Zachary M March, Katelyn Sweeney, Hanna Kim, Xiaohui Yan, Laura M Castellano, Meredith E Jackrel, JiaBei Lin, Edward Chuang, Edward Gomes, Corey W Willicott, Karolina Michalska, Robert P Jedrzejczak, Andrzej Joachimiak, Kim A Caldwell, Guy A Caldwell, Ophir Shalem, James Shorter

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