Effects of erythropoietin on osteoblast in the tooth extraction socket in mice periodontitis model by Ju-Eun Bae, Sung-Min Hwang, Yam Prasad Aryal, Tae-Young Kim, Wern-Joo Sohn, Seo-Young An, Ji-Youn Kim, Chang-Hyeon An, Youngkyun Lee, Yong-Gun Kim, Jin-Woo Park, Jae-Mok Lee, Jae-Young Kim, Jo-Young Suh

Get full text

Lnc-C2orf63-4-1 Confers VSMC Homeostasis and Prevents Aortic Dissection Formation via STAT3 Interaction by Song Zhang, Shiqi Zhao, Xuejie Han, Yun Zhang, Xuexin Jin, Yue Yuan, Xinbo Zhao, Yingchun Luo, Yun Zhou, Yunlong Gao, Hui Yu, Danghui Sun, Wei Xu, Sen Yan, Yongtai Gong, Yue Li, Yue Li, Yue Li, Yue Li, Yue Li, Yue Li

Get full text

Efficacy and Safety of the MDM2–p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced Biliary Tract Cancer: A Case Series by Yamamoto N, Tolcher A, Hafez N, Lugowska I, Ramlau R, Macarulla T, Geng J, Li J, Teufel M, Märten A, LoRusso P

“…Noboru Yamamoto,1 Anthony Tolcher,2 Navid Hafez,3,4 Iwona Lugowska,5 Rodryg Ramlau,6 Teresa Macarulla,7,8 Junxian Geng,9 Jian Li,9 Michael Teufel,9 Angela Märten,10 Patricia LoRusso3 1Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan; 2NEXT Oncology, San Antonio, TX, USA; 3Yale Comprehensive Cancer Center, Yale School of Medicine, New Haven, CT, USA; 4The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, CA, USA; 5Early Phase Clinical Trials Unit, Maria Skłodowska Curie National Research Institute of Oncology, Warsaw, Poland; 6Institute of Oncology, Poznan University of Medical Sciences, Poznan, Poland; 7Vall d’Hebrón University Hospital, Barcelona, Spain; 8Vall d’Hebrón Institute of Oncology (VHIO), Barcelona, Spain; 9Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 10Boehringer Ingelheim International GmbH, Ingelheim am Rhein, GermanyCorrespondence: Noboru Yamamoto, Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan, Tel + 81-3-3542-2511 ext 7319, Email nbryamam@ncc.go.jpBackground: In patients with advanced biliary tract cancer (BTC), first-line chemotherapy plus immunotherapy has improved outcomes; however, second-line options that reflect the disease’s molecular heterogeneity are still needed. …”
Get full text

Bioactive Bibenzyl Enantiomers From the Tubers of Bletilla striata by Mei Zhou, Mei Zhou, Sai Jiang, Sai Jiang, Changfen Chen, Jinyu Li, Jinyu Li, Huayong Lou, Huayong Lou, Mengyun Wang, Gezhou Liu, Hanfei Liu, Hanfei Liu, Ting Liu, Weidong Pan, Weidong Pan

Get full text

Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Schistosoma mansoni Infection by Felipe F. Dias, Kátia B. Amaral, Kássia K. Malta, Thiago P. Silva, Gabriel S. C. Rodrigues, Florence M. Rosa, Gisele O. L. Rodrigues, Vivian V. Costa, Vivian V. Costa, Hélio Chiarini-Garcia, Peter F. Weller, Rossana C. N. Melo, Rossana C. N. Melo

Get full text

Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs by Tianqi Duo, Xiaohong Liu, Delin Mo, Yu Bian, Shufang Cai, Min Wang, Ruiqiang Li, Qi Zhu, Xian Tong, Ziyun Liang, Weilun Jiang, Shiyi Chen, Yaosheng Chen, Zuyong He

Get full text

Calix[n]arene-based immunogens: A new non-proteic strategy for anti-cocaine vaccine by Leonardo da Silva Neto, Angélica Faleiros da Silva Maia, Adriana Martins Godin, Paulo Sérgio de Almeida Augusto, Raissa Lima Gonçalves Pereira, Sordaini Maria Caligiorne, Rosemeire Brondi Alves, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Gisele Assis Castro Goulart, Felipe Terra Martins, Maila de Castro Lourenço das Neves, Frederico Duarte Garcia, Ângelo de Fátima

Get full text

Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: Post-hoc analyses of the phase II adrenomedullin and outcome in septic shock 2 trial by Dirk van Lier, Adrien Picod, Gernot Marx, Pierre-François Laterre, Oliver Hartmann, Claudia Knothe, Feriel Azibani, Joachim Struck, Karine Santos, Jens Zimmerman, Andreas Bergmann, Andreas Bergmann, Alexandre Mebazaa, Alexandre Mebazaa, Peter Pickkers

Get full text

The friagem event in the central Amazon and its influence on micrometeorological variables and atmospheric chemistry by G. F. Camarinha-Neto, J. C. P. Cohen, J. C. P. Cohen, C. Q. Dias-Júnior, M. Sörgel, M. Sörgel, J. H. Cattanio, J. H. Cattanio, A. Araújo, S. Wolff, S. Wolff, P. A. F. Kuhn, R. A. F. Souza, L. V. Rizzo, P. Artaxo

Get full text

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice by Rebekka Fendt, Ahmed Ghallab, Ahmed Ghallab, Maiju Myllys, Ute Hofmann, Reham Hassan, Reham Hassan, Zaynab Hobloss, Daniela González, Lisa Brackhagen, Rosemarie Marchan, Karolina Edlund, Abdel-Latif Seddek, Noha Abdelmageed, Lars M. Blank, Jan-Frederik Schlender, Christian H. Holland, Jan G. Hengstler, Lars Kuepfer

Get full text

miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC by Tomohiro Shibata, Duo-Yao Cao, Tahir B. Dar, Faizan Ahmed, Shabir A. Bhat, Luciana C. Veiras, Ellen A. Bernstein, Abdul Arif Khan, Manita Chaum, Stephen L. Shiao, Warren G. Tourtellotte, Jorge F. Giani, Kenneth E. Bernstein, Xiaojiang Cui, Eric Vail, Zakir Khan

Get full text

Characterization of the acetylation of cyclooxygenase-isozymes and targeted lipidomics of eicosanoids in serum and colon cancer cells by the new aspirin formulation IP1867B versus... by Ulrika Hofling, Ulrika Hofling, Stefania Tacconelli, Stefania Tacconelli, Annalisa Contursi, Annalisa Contursi, Annalisa Bruno, Annalisa Bruno, Matteo Mucci, Matteo Mucci, Patrizia Ballerini, Patrizia Ballerini, Simon Cohen, Paola Patrignani, Paola Patrignani

Get full text

Differential resting-state patterns across networks are spatially associated with Comt and Trmt2a gene expression patterns in a mouse model of 22q11.2 deletion by Natalia Gass, Zeru Peterson, Jonathan Reinwald, Alexander Sartorius, Wolfgang Weber-Fahr, Markus Sack, Junfang Chen, Han Cao, Michael Didriksen, Tine Bryan Stensbøl, Gabrielle Klemme, Adam J. Schwarz, Emanuel Schwarz, Andreas Meyer-Lindenberg, Thomas Nickl-Jockschat

Get full text

Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients by Costanza Paoletti, Meredith M. Regan, Samuel M. Niman, Emily M. Dolce, Elizabeth P. Darga, Minetta C. Liu, P. Kelly Marcom, Lowell L. Hart, John W. Smith, Karen L. Tedesco, Eitan Amir, Ian E. Krop, Angela M. DeMichele, Pamela J. Goodwin, Margaret Block, Kimberly Aung, Martha E. Brown, Robert T. McCormack, Daniel F. Hayes

Get full text

Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer by A. W. Adamson, Y. C. Ding, L. Steele, L. A. Leong, R. Morgan, M. T. Wakabayashi, E. S. Han, T. H. Dellinger, P. S. Lin, A. A. Hakim, S. Wilczynski, C. D. Warden, S. Tao, V. Bedell, M. C. Cristea, S. L. Neuhausen

Get full text

Dupilumab Efficacy in Patients with Uncontrolled Moderate-to-Severe Type 2 Asthma Regardless of Perennial Aeroallergen Sensitization by Corren J, Jackson DJ, Casale TB, Borish L, Rabe KF, Busse WW, Maspero JF, Jackson DJ, Daizadeh N, Altincatal A, Radwan A, Khodzhayev A, Djandji M, Jacob-Nara JA, Rowe PJ, Deniz Y

“…Jonathan Corren,1 David J Jackson,2,3 Thomas B Casale,4 Larry Borish,5,6 Klaus F Rabe,7,8 William W Busse,9 Jorge F Maspero,10 Daniel J Jackson,11 Nadia Daizadeh,12 Arman Altincatal,12 Amr Radwan,13 Angela Khodzhayev,13 Michel Djandji,12 Juby A Jacob-Nara,12,14 Paul J Rowe,14 Yamo Deniz13 1David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2King’s College London, London, UK; 3Guy’s and St Thomas’ NHS Foundation Trust, London, UK; 4Division of Allergy and Immunology, University of South Florida, Tampa, FL, USA; 5Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA; 6Carter Immunology Center, University of Virginia Health System, Charlottesville, VA, USA; 7LungenClinic Grosshansdorf (Member of the German Center for Lung Research [DZL]), Airway Research Center North (ARCN), Grosshansdorf, Germany; 8Christian-Albrechts University (Member of the German Center for Lung Research [DZL]), Airway Research Center North (ARCN), Kiel, Germany; 9UW Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; 10Fundación CIDEA, Buenos Aires, Argentina; 11University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; 12Sanofi, Cambridge, MA, USA; 13Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 14Sanofi, Bridgewater, NJ, USACorrespondence: Jonathan Corren, David Geffen School of Medicine at UCLA, 10780 Santa Monica Blvd., Suite 280, Los Angeles, CA, 90025, USA, Email jcorren@ucla.eduPurpose: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukins-4/-13, key and central drivers of type 2 (T2) inflammation in multiple diseases. …”
Get full text

Cardiovascular and mortality benefits of sodium–glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus: CVD-Real Catalonia by Jordi Real, Bogdan Vlacho, Emilio Ortega, Joan Antoni Vallés, Manel Mata-Cases, Esmeralda Castelblanco, Eric T. Wittbrodt, Peter Fenici, Mikhail Kosiborod, Dídac Mauricio, Josep Franch-Nadal

Get full text

Anticorrosive Effects of Essential Oils Obtained from White Wormwood and Arâr Plants by Ghada Beniaich, Mustapha Beniken, Rajae Salim, Nadia Arrousse, Elhachmia Ech-chihbi, Zakia Rais, Asmae Sadiq, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia, Mustapha Taleb

Get full text

Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro by Loren L. Flynn, Loren L. Flynn, Loren L. Flynn, Loren L. Flynn, Ruohan Li, Ruohan Li, Ianthe L. Pitout, Ianthe L. Pitout, May T. Aung-Htut, May T. Aung-Htut, May T. Aung-Htut, Leon M. Larcher, Jack A. L. Cooper, Kane L. Greer, Kane L. Greer, Kane L. Greer, Alysia Hubbard, Lisa Griffiths, Charles S. Bond, Steve D. Wilton, Steve D. Wilton, Steve D. Wilton, Archa H. Fox, Archa H. Fox, Sue Fletcher, Sue Fletcher, Sue Fletcher

Get full text

ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastatic castration‐resistant prostate cancer patients: A phase Ib study by Marit A. C. Vermunt, Debbie G. J. Robbrecht, Lot A. Devriese, Julie M. Janssen, Bas Thijssen, Marianne Keessen, Maarten vanEijk, Rob Kessels, Ferry A. L. M. Eskens, Jos H. Beijnen, Niven Mehra, Andries M. Bergman

Get full text