Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications by Jin Feng, Xiaohui Wang, Xiaochun Ye, Irma Ares, Bernardo Lopez-Torres, Marta Martínez, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, María-Aránzazu Martínez

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NSD2 modulates Drp1-mediated mitochondrial fission in chronic renal allograft interstitial fibrosis by methylating STAT1 by Jianjian Zhang, Weibin Xie, Bin Ni, Zhuohang Li, Dengyuan Feng, Yao Zhang, Qianguang Han, Hai Zhou, Min Gu, Ruoyun Tan

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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

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Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial by Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo

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PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer by Yulu Zhang, Annan Ming, Junyan Wang, Wenmin Chen, Zhiqing Fang

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Natural-source payloads used in the conjugated drugs architecture for cancer therapy: Recent advances and future directions by Cuiping Li, Kourong Shi, Siyuan Zhao, Juan Liu, Qiaoli Zhai, Xiaoli Hou, Jie Xu, Xinyu Wang, Jiahui Liu, Xin Wu, Wei Fan

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Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions by Veronica Marabitti, Elisabetta Vulpis, Francesca Nazio, Silvia Campello

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Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment? by Ellis Nelissen, Melissa Schepers, Laura Ponsaerts, Sébastien Foulquier, Annelies Bronckaers, Tim Vanmierlo, Peter Sandner, Jos Prickaerts

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CSF-1R: A promising therapeutic target for various diseases by Chen-Yueh Wen, Po-Hung Chen, Feng-Renn Hsieh, Renin Chang, Meng-Yu Wu, Su-Boon Yong, Chia-Jung Li

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Nrf2 mediated signaling axis in heart failure: Potential pharmacological receptor by Pei-pei Cheng, Xin-ting Wang, Qian Liu, Yi-ran Hu, En-rui Dai, Ming-hao Zhang, Tian-shu Yang, Hui-yan Qu, Hua Zhou

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Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales by Andrey D. Bondarev, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Francisco Alejandro Lagunas-Rangel, Helgi B. Schiöth

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Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update by Robert Roskoski, Jr.

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Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems by Xi Wang, Yixuan Li, Xueyu Pu, Guiquan Liu, Honglin Qin, Weimin Wan, Yuying Wang, Yan Zhu, Jian Yang

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Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay by Hadi Mansour, Hasan Slika, Suzanne A. Nasser, Gianfranco Pintus, Maha Khachab, Amirhossein Sahebkar, Ali H. Eid

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Autoantibodies against the glial glutamate transporter GLT1/EAAT2 in Type 1 diabetes mellitus—Clues to novel immunological and non-immunological therapies by Carla Perego, Eliana S. Di Cairano, Alessandra Galli, Stefania Moretti, Elena Bazzigaluppi, Victoria Frolich Centonze, Amalia Gastaldelli, Emma Assi, Paolo Fiorina, Massimo Federici, Ottavia Porzio, Federico Bertuzzi, Alberto M. Davalli, Franco Folli

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Quenching thirst with poison? Paradoxical effect of anticancer drugs by Kaiyuan Chai, Chuanlei Wang, Jianpeng Zhou, Wentao Mu, Menghan Gao, Zhongqi Fan, Guoyue Lv

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IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia by Brian Dean

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Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies? by Lucia La Sala, Valentina Carlini, Caterina Conte, Maria Belen Macas-Granizo, Elham Afzalpour, Jimmy Martin-Delgado, Marco D’Anzeo, Roberto F.E. Pedretti, Angelo Naselli, Antonio E. Pontiroli, Riccardo Cappato

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IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications by Abdullah Al Mamun, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao

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Adhesion between EVs and tumor cells facilitated EV-encapsulated doxorubicin delivery via ICAM1 by Shibo Wang, Chenxiao Qiao, Xianghui Kong, Jie Yang, Fei Guo, Jiming Chen, Wenhui Wang, Bei Zhang, Huiqing Xiu, Yuzhou He, Jianli Wang, Huajun Feng, Zhijian Cai

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