Demethylzeylasteral reduces the level of proteinuria in diabetic nephropathy: Screening of network pharmacology and verification by animal experiment by Lengnan Xu, Ban Zhao, Liping Yang, Xinyi Dong, Xue Yang, Yonghui Mao

“…Pharmacology Research & Perspectives…”
Get full text

CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation by Satoshi Shimizu, Atsuko Shiraki

“…Pharmacology Research & Perspectives…”
Get full text

Population pharmacokinetic of paracetamol and atorvastatin with co‐administration of semaglutide by Emilie K. Langeskov, Kim Kristensen

“…Pharmacology Research & Perspectives…”
Get full text

The preclinical pharmacokinetics of Tolinapant—A dual cIAP1/XIAP antagonist with in vivo efficacy by Vanessa Martins, George Ward, Tomoko Smyth, Mike Reader, Gianni Chessari, Chris Johnson, Nicola Wilsher

“…Pharmacology Research & Perspectives…”
Get full text

Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant by Ishani Landry, Jagadeesh Aluri, Nancy Hall, Gleb Filippov, Satish Dayal, Margaret Moline, Larisa Reyderman

“…Pharmacology Research & Perspectives…”
Get full text

Experimental training in molecular pharmacology education based on drug–target interactions by Luna Ge, Kai Cheng, Yuang Zhang, Junling Li, Wei Chen, Guanhua Song, Lin Wang

“…Pharmacology Research & Perspectives…”
Get full text

In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions by Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye, Brian W. Ogilvie, Steven Smith, Brooks Boyd

“…Pharmacology Research & Perspectives…”
Get full text

Experimental pharmacology in precision medicine by Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H. Martin, David N. Sheppard, Michael F. Jarvis

“…Pharmacology Research & Perspectives…”
Get full text

Effect of tenofovir containing ART on renal function in patients with moderate/severe reduced creatinine clearance at baseline: A retrospective study at two referral hospitals in N... by Francis Kalemeera, Brian Godman, Andy Stergachis, Tim Rennie

“…Pharmacology Research & Perspectives…”
Get full text

NMDA Receptor–Mediated Ca2+ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin by Jordan Casby, Benjamin M. Gansemer, Stanley A. Thayer

“…Pharmacology Research & Perspectives…”
Get full text

Asciminib, a novel allosteric inhibitor of BCR‐ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance by Naoki Okamoto, Kenta Yagi, Sayaka Imawaka, Mayu Takaoka, Fuka Aizawa, Takahiro Niimura, Mitsuhiro Goda, Koji Miyata, Kei Kawada, Yuki Izawa‐Ishizawa, Satoshi Sakaguchi, Keisuke Ishizawa

“…Pharmacology Research & Perspectives…”
Get full text

Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol by Long‐Bo Bai, Lee‐Fong Yau, Tian‐Tian Tong, Wai‐Him Chan, Wei Zhang, Zhi‐Hong Jiang

“…Pharmacology Research & Perspectives…”
Get full text

Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia by Yoshihiro Konno, Shunsuke Kamigaso, Hidetoh Toki, Shuichi Terasaka, Hirohiko Hikichi, Hiromi Endo, Jun‐Ichi Yamaguchi, Akiko Mizuno‐Yasuhira

“…Pharmacology Research & Perspectives…”
Get full text

Phase 1 pharmacokinetic and safety study of soticlestat in participants with mild or moderate hepatic impairment or normal hepatic function by Wei Yin, Pranab Mitra, Veronique Copalu, Thomas C. Marbury, Juan Carlos Rondon, Eric J. Lawitz, Valerie Lloyd, Mike Baratta, Mahnaz Asgharnejad, Tom Hui, Yasir Khan

“…Pharmacology Research & Perspectives…”
Get full text

Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt–mTOR pathway by Huaqing Chen, Tong Zhu, Xiaojie Huang, Wenshuang Xu, Zemin Di, Yuyang Ma, Min Xue, Sixing Bi, Yujun Shen, Yongqiang Yu, Yuxian Shen, Lijie Feng

“…Pharmacology Research & Perspectives…”
Get full text

Docosahexaenoic acid and eicosapentaenoic acid strongly inhibit prostanoid TP receptor‐dependent contractions of guinea pig gastric fundus smooth muscle by Keyue Xu, Miyuki Shimizu, Chika Murai, Miki Fujisawa, Daichi Ito, Noboru Saitoh, Yutaka Nakagome, Mio Yamashita, Azusa Murata, Shunya Oikawa, Guanghan Ou, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka

“…Pharmacology Research & Perspectives…”
Get full text

In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether by Sophie Werner, Lucie Hegg, Nancy B. Hopf, Myriam Borgatta, Laura Suter‐Dick

“…Pharmacology Research & Perspectives…”
Get full text

Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic by Ian Albert Clark

“…Pharmacology Research & Perspectives…”
Get full text

In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study by Fangfei Liu, Lampson M. Fan, Nicholas Michael, Jian‐Mei Li

“…Pharmacology Research & Perspectives…”
Get full text

The role of plasma concentrations and drug characteristics of beta‐blockers in fall risk of older persons by K. J. Ploegmakers, E. P. vanPoelgeest, L. J. Seppala, S. C. vanDijk, L. C. P. G. M. deGroot, S. Oliai Araghi, N. M. vanSchoor, B. Stricker, K. M. A. Swart, A. G. Uitterlinden, R. A. A. Mathôt, N. van derVelde

“…Pharmacology Research & Perspectives…”
Get full text