Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine by Thayne H. Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D. Salinas, Jen C. C. Hume, Lynn E. Lambert, Patrick E. Duffy, Niraj H. Tolia

“…Pfs48/45 is a promising antigen in development as a transmission blocking vaccine (TBV) against the deadliest malaria parasite Plasmodium falciparum. The third domain of Pfs48/45 (D3) is an established TBV candidate, but production challenges have hampered development. …”
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Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives by Mohd Asyraf Shamsuddin, Amatul Hamizah Ali, Nur Hanis Zakaria, Mohd Fazli Mohammat, Ahmad Sazali Hamzah, Zurina Shaameri, Kok Wai Lam, Wun Fui Mark-Lee, Hani Kartini Agustar, Mohd Ridzuan Mohd Abd Razak, Jalifah Latip, Nurul Izzaty Hassan

“…Widespread resistance of <i>Plasmodium falciparum</i> to current artemisinin-based combination therapies necessitate the discovery of new medicines. …”
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High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure by Rajeev K. Tyagi, Patrick J. Gleeson, Ludovic Arnold, Rachida Tahar, Eric Prieur, Laurent Decosterd, Jean-Louis Pérignon, Piero Olliaro, Pierre Druilhe

“…Abstract Background Humanity has become largely dependent on artemisinin derivatives for both the treatment and control of malaria, with few alternatives available. A Plasmodium falciparum phenotype with delayed parasite clearance during artemisinin-based combination therapy has established in Southeast Asia, and is emerging elsewhere. …”
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The resting behavior of malaria vectors in different ecological zones of Ghana and its implications for vector control by Akua Obeng Forson, Isaac A. Hinne, Shittu B. Dhikrullahi, Isaac Kwame Sraku, Abdul Rahim Mohammed, Simon K. Attah, Yaw Asare Afrane

“…This study was carried out to investigate the resting behavior, host preference and infection with Plasmodium falciparum of malaria vectors in Ghana in the context of the increasing insecticide resistance of malaria vectors in sub-Saharan Africa. …”
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PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses by Jun Wang, Jun Wang, Yue Li, Yan Shen, Jiao Liang, Yinghui Li, Yuxiao Huang, Xuewu Liu, Dongbo Jiang, Shuya Yang, Ya Zhao, Kun Yang

“…Cerebral malaria (CM), mainly caused by Plasmodium falciparum (P. f.), is one of the most lethal complications of severe malaria. …”
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A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection by Benjamin Mordmüller, Zita Sulyok, Mihály Sulyok, Zsofia Molnar, Albert Lalremruata, Carlos Lamsfus Calle, Patricia Granados Bayon, Meral Esen, Markus Gmeiner, Jana Held, Henri-Lynn Heimann, Tamirat Gebru Woldearegai, Javier Ibáñez, Judith Flügge, Rolf Fendel, Andrea Kreidenweiss, Natasha KC, Tooba Murshedkar, Sumana Chakravarty, Pouria Riyahi, Peter F. Billingsley, L. W. Preston Church, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner

“…Abstract Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria infection (CHMI) with the same parasites as in the vaccine (homologous) than with genetically distant parasites (heterologous). …”
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New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model by Keith Limbach, Maureen Stefaniak, Ping Chen, Noelle B. Patterson, Grant Liao, Shaojie Weng, Svetlana Krepkiy, Greg Ekberg, Holly Torano, Damodar Ettyreddy, Kalpana Gowda, Sharvari Sonawane, Arnel Belmonte, Esteban Abot, Martha Sedegah, Michael R. Hollingdale, Ann Moormann, John Vulule, Eileen Villasante, Thomas L. Richie, Douglas E. Brough, Joseph T. Bruder

“…In mice, a single administration of GC44, GC45 and GC46 vectors expressing a murine malaria gene, Plasmodium yoelii circumsporozoite protein (PyCSP), induced robust PyCSP-specific T cell and antibody responses that were at least as high as a comparable HuAd5-PyCSP vector. …”
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Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target by Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis

“…Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol. …”
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Structural variation of the malaria-associated human glycophorin A-B-E region by Sandra Louzada, Walid Algady, Eleanor Weyell, Luciana W. Zuccherato, Paulina Brajer, Faisal Almalki, Marilia O. Scliar, Michel S. Naslavsky, Guilherme L. Yamamoto, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz, Fengtang Yang, Edward J. Hollox

“…They are receptors for the invasion of the protist parasite Plasmodium falciparum, a causative agent of malaria. …”
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Deferiprone–resveratrol hybrid attenuates iron accumulation, oxidative stress, and antioxidant defenses in iron-loaded human Huh7 hepatic cells by Jin Li, Jin Li, Pimpisid Koonyosying, Woranontee Korsieporn, Narisara Paradee, Nuntouchaporn Hutachok, Honghong Xu, Honghong Xu, Yongmin Ma, Hataichanok Chuljerm, Somdet Srichairatanakool

“…The deferiprone–resveratrol hybrid (DFP–RVT) is a synthetic iron chelator possessing anti-β-amyloid peptide aggregation, anti-malarial activity, and hepatoprotection in plasmodium-infected mice. The study focuses on investigating the antioxidant, cytotoxicity, iron-chelating, anti-lipid peroxidation, and antioxidant defense properties of DFP–RVT in iron-loaded human hepatocellular carcinoma (Huh7) cells. …”
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Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study by Khatib Rashid A, Skarbinski Jacek, Njau Joseph D, Goodman Catherine A, Elling Berty F, Kahigwa Elizeus, Roberts Jacquelin M, MacArthur John R, Gutman Julie R, Kabanywanyi Abdunoor M, Smith Ernest E, Somi Masha F, Lyimo Thomas, Mwita Alex, Genton Blaise, Tanner Marcel, Mills Anne, Mshinda Hassan, Bloland Peter B, Abdulla Salim M, Kachur S

“…Population-level prevalence of <it>Plasmodium falciparum</it> asexual parasitaemia and gametocytaemia were assessed using light microscopy from samples collected during representative household surveys in 2001, 2002, 2004, 2005 and 2006.…”
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Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases by Kadarkarai Murugan, Chellasamy Panneerselvam, Jayapal Subramaniam, Manickam Paulpandi, Rajapandian Rajaganesh, Murugan Vasanthakumaran, Jagannathan Madhavan, S. Syed Shafi, Mathath Roni, Johan S. Portilla-Pulido, Stelia C. Mendez, Jonny E. Duque, Lan Wang, Al Thabiani Aziz, Balamurugan Chandramohan, Devakumar Dinesh, Shanmughavel Piramanayagam, Jiang-Shiou Hwang

“…In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC50 values of 6.7 nM (CQ-s) and 8.5 nM (CQ-r). …”
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Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells by Marcos J. Araúzo-Bravo, Denis Delic, Daniela Gerovska, Frank Wunderlich

“…Here, we investigate the effect of vaccination on NK cell-associated genes induced in the liver by blood-stage malaria of <i>Plasmodium chabaudi.</i> Female Balb/c mice were vaccinated at weeks 3 and 1 before being infected with 10⁶<i>P. chabaudi</i>-parasitized erythrocytes. …”
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Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration by Yifat Ofir-Birin, Hila Ben Ami Pilo, Abel Cruz Camacho, Ariel Rudik, Anna Rivkin, Or-Yam Revach, Netta Nir, Tal Block Tamin, Paula Abou Karam, Edo Kiper, Yoav Peleg, Reinat Nevo, Aryeh Solomon, Tal Havkin-Solomon, Alicia Rojas, Ron Rotkopf, Ziv Porat, Dror Avni, Eli Schwartz, Thomas Zillinger, Gunther Hartmann, Antonella Di Pizio, Neils Ben Quashie, Rivka Dikstein, Motti Gerlic, Ana Claudia Torrecilhas, Carmit Levy, Esther N. M. Nolte-‘t Hoen, Andrew G. Bowie, Neta Regev-Rudzki

“…The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL10 protein translation.…”
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Comparison of immunogenicity and safety outcomes of a malaria vaccine FMP013/ALFQ in rhesus macaques (Macaca mulatta) of Indian and Chinese origin by Monica L. Martin, Alexis A. Bitzer, Andrew Schrader, Elke S. Bergmann-Leitner, Kim Soto, Xiaoyan Zou, Zoltan Beck, Gary R. Matyas, Sheetij Dutta

“…The most advanced malaria vaccine, RTS,S (GlaxoSmithKline), is based on the circumsporozoite protein (CSP) of Plasmodium falciparum. The efficacy of RTS,S vaccine in the field remains low and short-lived; efforts are underway to improve CSP-based vaccines. …”
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Molecular Characterization of <i>Anopheles algeriensis</i> Theobald, 1903 (Diptera: Culicidae) Populations from Europe by Michela Menegon, Alexandru Tomazatos, Francesco Severini, Donato Antonio Raele, Tobias Lilja, Doreen Werner, Daniela Boccolini, Luciano Toma, Ilaria Vasco, Renke Lühken, Helge Kampen, Maria Assunta Cafiero, Marco Di Luca

“…<i>Anopheles algeriensis</i> Theobald, 1903, considered a competent vector of <i>Plasmodium</i> parasites, is a mosquito species widely distributed in the Mediterranean area but rare in Northern and Central Europe. …”
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Defining malaria risks among forest workers in Aceh, Indonesia: a formative assessment by Lenny L. Ekawati, Kelly C. Johnson, Jerry O. Jacobson, Carmen A. Cueto, Iska Zarlinda, Iqbal R. F. Elyazar, Abdul Fatah, Maria E. Sumiwi, Rintis Noviyanti, Chris Cotter, Jennifer L. Smith, Farah N. Coutrier, Adam Bennett

“…While RACD detected few cases in households surrounding index cases, engaging in forest work was identified as a risk factor for malaria and infections from Plasmodium knowlesi—a non-human primate malaria parasite—were more common than expected. …”
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Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum by Valeria Lodde, Valeria Lodde, Matteo Floris, Matteo Floris, Isabel Beerman, Rachel Munk, Rajan Guha, Maristella Steri, Valeria Orrù, Kotb Abdelmohsen, Peter D. Crompton, Myriam Gorospe, Maria Laura Idda, Francesco Cucca, Francesco Cucca

“…Lysates of erythrocytes infected with Plasmodium falciparum (iRBCs) or left uninfected (uRBCs, control) were used to treat peripheral blood mononuclear cells (PBMCs) with distinct BAFF genotypes. …”
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Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo by Simon Marie Peko, Francine Ntoumi, Christevy Vouvoungui, David Nderu, Simon Charles Kobawila, Thirumalaisamy P. Velavan, Félix Koukouikila-Koussounda

“…This study investigated the distribution of the CYP2C8*2 allele in Brazzaville, Republic of Congo, where artesunate + amodiaquine is used as the second-line treatment for uncomplicated Plasmodium falciparum malaria. Methods: A total of 285 febrile children visiting the Marien Ngouabi paediatric hospital were genotyped for CYP2C8*2 using PCR-restriction fragment length polymorphism (PCR-RFLP). …”
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Blood-feeding patterns of Anopheles vectors of human malaria in Malawi: implications for malaria transmission and effectiveness of LLIN interventions by Rex B. Mbewe, John B. Keven, Themba Mzilahowa, Don Mathanga, Mark Wilson, Lauren Cohee, Miriam K. Laufer, Edward D. Walker

“…Anopheles species, their blood-meal host, and infection with Plasmodium falciparum were determined using PCR methods. …”
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