Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso by Mariama K. Cherif, Oumarou Ouédraogo, Guillaume S. Sanou, Amidou Diarra, Alphonse Ouédraogo, Alfred Tiono, David R. Cavanagh, Theisen Michael, Amadou T. Konaté, Nora L. Watson, Megan Sanza, Tina J. T. Dube, Sodiomon B. Sirima, Issa Nebié

“…Abstract Background High parasite-specific antibody levels are generally associated with low susceptibility to Plasmodium falciparum malaria. This has been supported by several studies in which clinical malaria cases of P. falciparum malaria were reported to be associated with low antibody avidities. …”
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Natural Wolbachia infection in field-collected Anopheles and other mosquito species from Malaysia by Meng Li Wong, Jonathan Wee Kent Liew, Wai Kit Wong, Sandthya Pramasivan, Norzihan Mohamed Hassan, Wan Yusoff Wan Sulaiman, Nantha Kumar Jeyaprakasam, Cherng Shii Leong, Van Lun Low, Indra Vythilingam

“…To our knowledge, this is the first time Wolbachia was detected using 16S rRNA gene amplification, in some Anopheles species (some infected with Plasmodium), Culex sinensis, Culex vishnui, Culex pseudovishnui, Mansonia bonneae and Mansonia annulifera. …”
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Management of imported malaria cases and healthcare institutions in central China, 2012–2017: application of decision tree analysis by Xi-Liang Wang, Jie-Bin Cao, Dan-Dan Li, Dong-Xiao Guo, Cheng-Da Zhang, Xiao Wang, Dan-Kang Li, Qing-Lin Zhao, Xiao-Wen Huang, Wei-Dong Zhang

“…Results From 2012 to 2017, there were 371 imported malaria cases, mostly in males aged between 20 and 50 years, including 319 Plasmodium falciparum cases. First visits of 32.3%, 19.9% and 15.9% malaria cases for treatment were to provincial, municipal and county healthcare institutions, respectively. …”
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Coverage and efficacy of intermittent preventive treatment with sulphadoxine pyrimethamine against malaria in pregnancy in Côte d’Ivoire five years after its implementation by Offianan A Toure, Penali L Kone, M’Lanhoro AA Coulibaly, Berenger AA Ako, Eric A Gbessi, Baba Coulibaly, Landry T N’ Guessan, David Koffi, Sylvain Beourou, Adama Soumahoro, Issiaka Bassinka, Messoun Nogbou, Tidjane Swa, Bernadin Gba, Beugre Esmel, Ernestine M Bokossa

“…Variability in the results was observed depending on the type of area (rural/urban). Plasmodium falciparum was detected in the peripheral blood of 97 women (7.3%) and in the placenta of 119 women (9%). …”
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A dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robust transmission-blocking activity by Wenyan Gao, Yue Qiu, Liying Zhu, Xinxin Yu, Fan Yang, Muyan Chen, Gang He, Yinjie Liu, Liwang Cui, Fei Liu, Xiaotong Zhu, Yaming Cao

“…Methods A chimeric recombinant protein Pb22-Pbg37 (Plasmodium berghei 22-P. berghei G37) composed of 19–218 amino acids (aa) of Pb22 and the N-terminal 26–88 aa of Pbg37 was designed and expressed in the Escherichia coli expression system. …”
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Evaluación del uso de una prueba rápida inmunocromatográfica en promotores de salud para el diagnóstico de la malaria en áreas rurales de la Amazonía peruana* by César Cabezas S, Nancy Arróspide V, Wilmer Marquiño Q, Sonia Gutiérrez S, Ever Álvarez M, Jorge Chuquipiondo R, Tomasa Ruiz A, Martín Daza M, Gladys Chuquipiondo L

“…La prueba utilizada se basa en la detección de la deshidrogenasa láctica del Plasmodium falciparum y del P. vivax, mediante tiras reactivas. …”
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Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru by Catharine Prussing, Marta Moreno, Marlon P. Saavedra, Sara A. Bickersmith, Dionicia Gamboa, Freddy Alava, Carl D. Schlichting, Kevin J. Emerson, Joseph M. Vinetz, Jan E. Conn

“…Unexpectedly, there was evidence of a rainy season population decline in An. darlingi. Plasmodium-infected An. darlingi were detected indoors and outdoors throughout the night, and the monthly An. darlingi human biting rate was correlated with the number of malaria cases. …”
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Prioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries by Jennifer Osborn, Teri Roberts, Ethan Guillen, Oscar Bernal, Paul Roddy, Stefano Ongarello, Armand Sprecher, Anne-Laure Page, Isabela Ribeiro, Erwan Piriou, Abiy Tamrat, Roberto de la Tour, V. Bhargavi Rao, Laurence Flevaud, Tomas Jensen, Lachlan McIver, Cassandra Kelly, Sabine Dittrich

“…Results The expert ranked prioritized pathogen list generated as part of this two-pronged approach included typhoidal Salmonella, Plasmodium species and Mycobacterium tuberculosis as the top 3 pathogens. …”
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Profiling the Targets of Protective CD8+ T Cell Responses to Infection by Joseph T. Bruder, Ping Chen, Greg Ekberg, Emily C. Smith, Christopher A. Lazarski, Bennett A. Myers, Jessica Bolton, Martha Sedegah, Eileen Villasante, Thomas L. Richie, C. Richter King, Joao C. Aguiar, Denise L. Doolan, Douglas E. Brough

“…We generated an adenovirus array by cloning 312 highly expressed pre-erythrocytic Plasmodium yoelii antigens into adenovirus vectors using high-throughput methodologies. …”
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First Molecular Detection of <i>Polychromophilus</i> Parasites in Brazilian Bat Species by Guilherme Augusto Minozzo, Bruno da Silva Mathias, Irina Nastassja Riediger, Lilian de Oliveira Guimarães, Carolina Clares dos Anjos, Eliana Ferreira Monteiro, Andrea Pires dos Santos, Alexander Welker Biondo, Karin Kirchgatter

“…Blood parasites of the Haemosporida order, such as the <i>Plasmodium</i> spp. responsible for malaria, have become the focus of many studies in evolutionary biology. …”
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Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa by Amélé Nyedzie Wotodjo, Mary Aigbiremo Oboh, Souleymane Doucoure, Nafissatou Diagne, Fatoumata Diène-Sarr, Makhtar Niang, Jean-François Trape, Cheikh Sokhna, Alfred Amambua-Ngwa, Umberto D’Alessandro

“…Methods Samples from both malaria patients and Plasmodium falciparum asymptomatic carriers were analysed with high resolution melting (HRM) technique to genotype P. falciparum chloroquine resistance transporter (Pfcrt) gene haplotypes and multidrug-resistant protein 1 (Pfmdr1) gene at codons N86 and Y184. …”
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A combination of metabolic resistance and high frequency of the 1014F kdr mutation is driving pyrethroid resistance in Anopheles coluzzii population from Guinea savanna of Cameroon by Amen N. Fadel, Sulaiman S. Ibrahim, Magellan Tchouakui, Ebai Terence, Murielle J. Wondji, Micareme Tchoupo, Samuel Wanji, Charles S. Wondji

“…Analysis of infection with TaqMan assays using heads/thoraces of indoor collected females of An. coluzzii revealed a low Plasmodium falciparum parasite rate of 4.7%. Bioassays conducted with female An. coluzzii revealed extreme resistance, with low mortalities of only 3.75 ± 1.25%, 3.03 ± 1.59% and 1.45 ± 1.45%, respectively, for permethrin, deltamethrin and DDT. …”
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Application of mathematical modelling to inform national malaria intervention planning in Nigeria by Ifeoma D. Ozodiegwu, Monique Ambrose, Beatriz Galatas, Manuela Runge, Aadrita Nandi, Kamaldeen Okuneye, Neena Parveen Dhanoa, Ibrahim Maikore, Perpetua Uhomoibhi, Caitlin Bever, Abdisalan Noor, Jaline Gerardin

“…Methods An agent-based model of Plasmodium falciparum transmission was used to simulate malaria morbidity and mortality in Nigeria’s 774 LGAs under four possible intervention strategies from 2020 to 2030. …”
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Identification of fungal natural products with potent inhibition in Toxoplasma gondii by Tiantian Jiang, Karla P. Godinez-Macias, Jennifer E. Collins, Jin Woo Lee, Karen L. Wendt, Krypton Carolino, Debopam Chakrabarti, Robert H. Cichewicz, Elizabeth A. Winzeler

“…By leveraging the resources available for the malaria drug discovery campaign, we conducted a phenotypic screen utilizing a set of natural products previously screened against Plasmodium falciparum. Our study revealed 18 compounds with high potency and low cytotoxicity in T. gondii, including four novel scaffolds with no previously reported activity in T. gondii. …”
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Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi by Hany Sady, David Chaima, Lotta Hallamaa, Emma Kortekangas, Ulla Ashorn, Jomo Banda, Charles Mangani, Kenneth Maleta, Per Ashorn, Yue-Mei Fan

“…The prevalence rate of asymptomatic Plasmodium falciparum was determined by real-time PCR from the participant’s dried blood spots (DBS) collected at the baseline and every 3 months. …”
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Hatsusamides A and B: Two New Metabolites Produced by the Deep-Sea-Derived Fungal Strain <i>Penicillium steckii</i> FKJ-0213 by Hirotaka Matsuo, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Mayuka Higo, Kenichi Nonaka, Yuriko Nagano, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

“…Compounds <b>1</b> and <b>3</b> exhibited weak anti-malarial activity at half-maximal inhibitory concentration (IC₅₀) values of 27.2 and 78.5 µM against the K1 strain, and 27.9 and 79.2 µM against the FCR3 strain of <i>Plasmodium falciparum</i>, respectively. Furthermore, <b>1</b> exhibited cytotoxicity against HeLa S3, A549, Panc1, HT29 and H1299 cells, with IC₅₀ values of 15.0, 13.7, 12.9, 6.8, and 18.7 μM, respectively.…”
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Phytochemical Investigation and Biological Activities of <i>Lantana rhodesiensis</i> by Fatimata Nea, Michel Boni Bitchi, Manon Genva, Allison Ledoux, Alembert Tiabou Tchinda, Christian Damblon, Michel Frederich, Zanahi Félix Tonzibo, Marie-Laure Fauconnier

“…The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of <i>Plasmodium falciparum</i>, chloroquine-sensitive strain 3D7. …”
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Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats by Xiaobo Li, Yueming Yuan, Yingyi Chen, Li Ru, Zheng Yuan, Zhiyong Xu, Qin Xu, Jianping Song, Guoming Li, Changsheng Deng

“…Abstract Background: The WHO recommends artemisinin-based combination regimens for uncomplicated Plasmodium falciparum malaria. One such combination is artemisinin-piperaquine tablets (ATQ). …”
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Impact of vector control interventions on malaria transmission intensity, outdoor vector biting rates and Anopheles mosquito species composition in Tororo, Uganda by Alex K. Musiime, David L. Smith, Maxwell Kilama, John Rek, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses R. Kamya, Melissa D. Conrad, Grant Dorsey, Anne M. Akol, Sarah G. Staedke, Steve W. Lindsay, James P. Egonyu

“…Female Anopheles were tested for the presence of Plasmodium falciparum sporozoites and species identification performed using gross dissection and polymerase chain reaction (PCR). …”
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Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis by Weam Siheri, Godwin U. Ebiloma, John O. Igoli, Alexander I. Gray, Marco Biddau, Pilaslak Akrachalanont, Samya Alenezi, Mohammad A. Alwashih, RuAngelie Edrada-Ebel, Sylke Muller, Catherine E. Lawrence, James Fearnley, David G. Watson, Harry P. De Koning

“…Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two helminth species, Trichinella spiralis and Caenorhabditis elegans, showing various degrees of activity. …”
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