Spatiotemporal dynamics of malaria in Banmauk Township, Sagaing region of Northern Myanmar: characteristics, trends, and risk factors by Pyae Linn Aung, Myat Thu Soe, Thit Lwin Oo, Kyaw Thu Aung, Kyaw Kyaw Lin, Aung Thi, Lynette Menezes, Daniel M. Parker, Liwang Cui, Myat Phone Kyaw

“…Results During 2016–2018, 2,402 malaria cases were reported, with Plasmodium falciparum accounting for 83.4% of infections. …”
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Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso by Jean Bosco Ouédraogo, Alassane Dicko, Ranju Baral, Clint Pecenka, Halimatou Diawara, Fadima Yaya Bocoum, Ann Levin, Cynthia Lee, Fatoumata Koita, Rosemonde Guissou, Seydou Yabré, Seydou Traoré, Winthrop Morgan

“…Background The WHO recommends use of the RTS,S/AS01E (RTS,S) malaria vaccine for young children living in areas of moderate to high Plasmodium falciparum malaria transmission and suggests countries consider seasonal vaccination in areas with highly seasonal malaria. …”
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Blockade of LAG-3 in PD-L1-Deficient Mice Enhances Clearance of Blood Stage Malaria Independent of Humoral Responses by Raquel Furtado, Laurent Chorro, Natalie Zimmerman, Erik Guillen, Emily Spaulding, Shu Shien Chin, Johanna P. Daily, Johanna P. Daily, Grégoire Lauvau

“…While blockade or lack of PD-1/PD-L1 and/or LAG-3 was reported to promote better clearance of Plasmodium parasites in various mouse models, how exactly blockade of these pathways contributes to enhanced protection is not known. …”
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New Dihydroisocoumarin Root Growth Inhibitors From the Sponge-Derived Fungus Aspergillus sp. NBUF87 by Liming Huang, Lijian Ding, Xiaohui Li, Ning Wang, Wei Cui, Xiao Wang, C. Benjamin Naman, C. Benjamin Naman, J. Enrico H. Lazaro, Xiaojun Yan, Shan He

“…Meanwhile, 1−11 were all found to be inactive in vitro against acetylcholinesterase (AChE) (IC50 > 100 μM), four different types of human-derived cancer cell lines (IC50 > 50 μM), as well as methicillin-resistant Staphylococcus aureus and Escherichia coli (MIC > 50 μg/mL), and Plasmodium falciparum W2 (EC50 > 100 μg/mL), in phenotypic tests.…”
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The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth by Anaïs Lalève, Cindy Vallières, Marie-Pierre Golinelli-Cohen, Cécile Bouton, Zehua Song, Grzegorz Pawlik, Sarah M. Tindall, Simon V. Avery, Jérôme Clain, Brigitte Meunier

“…The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. …”
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Household-level and surrounding peri-domestic environmental characteristics associated with malaria vectors Anopheles arabiensis and Anopheles funestus along an urban–rural continu... by Nicole F. Dear, Chifundo Kadangwe, Themba Mzilahowa, Andy Bauleni, Don P. Mathanga, Chifundo Duster, Edward D. Walker, Mark L. Wilson

“…Thus, dichotomous designations of “urban” or “rural” can obscure important heterogeneity in the landscape of Plasmodium transmission, suggesting the need for more nuanced assessment of urban malaria risk and prevention efforts.…”
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Spatial-temporal heterogeneity in malaria receptivity is best estimated by vector biting rates in areas nearing elimination by Thomas R. Burkot, Hugo Bugoro, Allan Apairamo, Robert D. Cooper, Diego F. Echeverry, Danyal Odabasi, Nigel W. Beebe, Victoria Makuru, Honglin Xiao, Jenna R. Davidson, Nicholas A. Deason, Hedrick Reuben, James W. Kazura, Frank H. Collins, Neil F. Lobo, Tanya L. Russell

“…Sporozoite rates provided evidence for continued transmission of Plasmodium falciparum, P. vivax and P. ovale by An. farauti and for incriminating An. hinesorum, as a minor vector, but were unreliable as indicators of transmission intensity. …”
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UM RARO E DESAFIADOR CASO DE LEISHMANIOSE VISCERAL E COINFECÇÃO POR MALÁRIA by Pedro Antônio Passos Amorim, Luiz Felipe Silveira Sales, João Pedro da Rocha Santos, Rafaela Fernandes Nascimento, Juliana Moreira Ribeiro

“…Em exames iniciais foram evidenciados as seguintes alterações: pancitopenia, inversão albumina-globulina, aumento discreto de transaminases, teste rápido para malária e pesquisa de hematozoários em sangue periférico positivos sugestivas de Plasmodium vivax. Sinalizado imediatamente pelo laboratório do nosso hospital presença de corpos intracelulares em macrófagos compatíveis com amastigotas de Leishmania spp. …”
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Ready for malaria elimination: zero indigenous case reported in the People’s Republic of China by Jun Feng, Li Zhang, Fang Huang, Jian-Hai Yin, Hong Tu, Zhi-Gui Xia, Shui-Sen Zhou, Ning Xiao, Xiao-Nong Zhou

“…While in 2017, for the first time, zero indigenous case was reported in China, and only 7 of imported cases were in individuals who died of Plasmodium falciparum infection. Conclusion Malaria elimination in China is a country-led and country-owned endeavour. …”
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Role of <italic toggle="yes">Toxoplasma gondii</italic> Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance by Geetha Kannan, Manlio Di Cristina, Aric J. Schultz, My-Hang Huynh, Fengrong Wang, Tracey L. Schultz, Matteo Lunghi, Isabelle Coppens, Vern B. Carruthers

“…Although proteolytic degradation within the parasite lysosome-like vacuolar compartment (VAC) is critical for bradyzoite viability, whether other aspects of the VAC are important for parasite persistence remains unknown. An ortholog of Plasmodium falciparum chloroquine resistance transporter (CRT), TgCRT, has previously been identified in T. gondii. …”
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Stable transfection system for Babesia sp. Xinjiang by Jinming Wang, Xiaoxing Wang, Guiquan Guan, Jifei Yang, Junlong Liu, Aihong Liu, Youquan Li, Jianxun Luo, Hong Yin

“…Abstract Background Stable transfection systems have been described in many protozoan parasites, including Plasmodium falciparum, Cryptosporidium parvum, Babesia bovis, Babesia ovata, and Babesia gibsoni. …”
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Isoprenoid alcohols utilization by malaria parasites by Ignasi Bofill Verdaguer, Rodrigo A. C. Sussmann, Rodrigo A. C. Sussmann, Verônica Feijoli Santiago, Giuseppe Palmisano, Gabriel Cândido Moura, Juliana Tonini Mesquita, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Alejandro Miguel Katzin, Marcell Crispim

“…Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. …”
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Investment case for malaria elimination in South Africa: a financing model for resource mobilization to accelerate regional malaria elimination by Joseph Njau, Sheetal P. Silal, Aparna Kollipara, Katie Fox, Ryleen Balawanth, Anthony Yuen, Lisa J. White, Mandisi Moya, Yogan Pillay, Devanand Moonasar

“…The model simulated a range of malaria interventions and estimated their impact on the transmission of Plasmodium falciparum malaria between 2018 and 2030 in the three endemic provinces of Limpopo, Mpumalanga and KwaZulu-Natal. …”
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Anopheles gambiae s.l (Diptera: Culicidae) seasonal abundance, abdominal status and parity rates in Metema-Armachiho lowland, Northwest Ethiopia by Yibeltal Aschale, Animen Ayehu, Ligabaw Worku, Ayenew Addisu, Ayalew Jejaw Zeleke, Abebe Genetu Bayih, Wossenseged Lemma

“…Abstract Background Malaria is a life threating vector borne disease caused by different Plasmodium parasites. Metema and Armachiho are two of the top five malaria endemic areas among the districts of Amhara region in Ethiopia. …”
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Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations by Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte

“…Thus, in our present work, we sought to prepare micro/large nano-scale (> 100 nm) and yet kinetically stable lumefantrine lipid self-emulsifying system (that would not require an external drug dissolution enhancing agent in the dissolution medium) and palm kernel oil-based 100 nm kinetically stable artemether lipid self-emulsifying system with rapid emulsification time. COVID-19 and Plasmodium falciparum-infected Africans with previous long exposure to malaria have manifested attenuated inflammatory cytokines more than malaria-naive patients. …”
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PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury by Xinyue Du, Baiyang Ren, Chang Li, Qi Li, Shuo Kan, Xin Wang, Wenjuan Bai, Chenyun Wu, Kokouvi Kassegne, Huibo Yan, Xiaoyin Niu, Min Yan, Wenyue Xu, Samuel C. Wassmer, Jing Wang, Guangjie Chen, Zhaojun Wang

“…In the absence of PRL2 in myeloid cells, Plasmodium berghei infection results in augmented lung injury, leading to significantly increased mortality. …”
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Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2. by Odilon Nouatin, Juliana Boex Mengue, Jean Claude Dejon-Agobé, Rolf Fendel, Javier Ibáñez, Ulysse Ateba Ngoa, Jean Ronald Edoa, Bayodé Roméo Adégbité, Yabo Josiane Honkpéhédji, Jeannot Fréjus Zinsou, Aurore Bouyoukou Hounkpatin, Kabirou Moutairou, Andreas Homoet, Meral Esen, Andrea Kreidenweiss, Stephen L Hoffman, Michael Theisen, Adrian J F Luty, Bertrand Lell, Selidji Todagbe Agnandji, Ghyslain Mombo-Ngoma, Michael Ramharter, Peter Kremsner, Benjamin Mordmüller, Ayôla Akim Adegnika

“…<h4>Background</h4>Helminths can modulate the host immune response to Plasmodium falciparum and can therefore affect the risk of clinical malaria. …”
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Prevalence and factors associated with anaemia in children aged 6-24 months living a high malaria transmission setting in Burundi. by Jean Claude Nkurunziza, Nicolette Nabukeera-Barungi, Joan Nakayaga Kalyango, Aloys Niyongabo, Mercy Muwema Mwanja, Ezekiel Mupere, Joaniter I Nankabirwa

“…A physical exam was conducted, and a blood sample was collected to: 1) assess for presence of plasmodium infection using a rapid diagnosis test; 2) estimate the haemoglobin levels using a portable haemocue machine. …”
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A Coccidia-Specific Phosphate Transporter Is Essential for the Growth of Toxoplasma gondii Parasites by Jianmin Cui, Xuke Yang, Jichao Yang, Ruilian Jia, Yaoyu Feng, Bang Shen

“…TgPiT and TgmPT are widely present and conserved in apicomplexan parasites that include Plasmodium and Eimeria species. Nonetheless, they are dispensable for the growth and virulence of Toxoplasma. …”
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Perturbations in the T cell receptor β repertoire during malaria infection in children: A preliminary study by Augustina Frimpong, Augustina Frimpong, Augustina Frimpong, Michael Fokuo Ofori, Michael Fokuo Ofori, Abdoelnaser M. Degoot, Kwadwo Asamoah Kusi, Kwadwo Asamoah Kusi, Buri Gershom, Jacob Quartey, Eric Kyei-Baafour, Nhi Nguyen, Wilfred Ndifon, Wilfred Ndifon

“…We profiled the complementarity-determining region 3 (CDR3) of the TCRβ chain sequences from children with Plasmodium falciparum infections (asymptomatic, uncomplicated and severe malaria) and compared these with sequences from healthy children. …”
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