Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children by Emily M. Teshome, Pauline E. A. Andang’o, Victor Osoti, Sofie R. Terwel, Walter Otieno, Ayşe Y. Demir, Andrew M. Prentice, Hans Verhoef

“…We assessed haemoglobin concentration (primary outcome), plasma iron markers, plasma inflammation markers and Plasmodium infection in samples collected at baseline and after 30 days of intervention. …”
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Nutrient Deficiencies and Potential Alteration in Plasma Levels of Naturally Acquired Malaria-Specific Antibody Responses in Tanzanian Children by Erasto V. Mbugi, Erasto V. Mbugi, Gerco den Hartog, Jacobien Veenemans, Jaffu O. Chilongola, Hans Verhoef, Hans Verhoef, Huub F. J. Savelkoul

“…Immunoglobulin G (IgG) subclasses have been suggested to confer naturally acquired immunity to Plasmodium falciparum malaria. Cytophilic IgG1 and IgG3 with their potential for opsonization, phagocytosis, and antibody-dependent cellular inhibition in association with monocytes have been suggested to have a critical role in malaria. …”
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Identification of a putative methyltransferase gene of Babesia bigemina as a novel molecular biomarker uniquely expressed in parasite tick stages by Gamila A. R. Bohaliga, Wendell C. Johnson, Naomi S. Taus, Hala E. Hussein, Reginaldo G. Bastos, Carlos E. Suarez, Roberta O’Connor, Massaro W. Ueti

“…Next, transcription analysis of in vitro TCEP-induced B. bigemina culture based on an in silico derived list of homologs of Plasmodium falciparum gamete-specific genes demonstrated differential expression of the gene BBBOND_0204030 in induced cells. …”
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In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of <i>Eriosema montanum Baker f.</i> (Fabaceae) by Jean Claude Didelot Tomani, Olivier Bonnet, Alain Nyirimigabo, William Deschamps, Alembert Tiabou Tchinda, Olivia Jansen, Allison Ledoux, Marie Jeanne Mukazayire, Luc Vanhamme, Michel Frédérich, Raymond Muganga, Jacob Souopgui

“…</i> roots were tested against the 3D7 strain of <i>Plasmodium falciparum</i> and revealed using the SYBR Green, a DNA intercalating compound. …”
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OBSERVACIONES HISTOLÓGICAS DE ESTRUCTURAS CELULARES ASOCIADAS A Spongospora subterranea f sp. subterranea EN PAPA HISTOLOGY OBSERVATIONS OF CELLULAR STRUCTURES ASSOCIATED TO Spongo... by Liliana Hoyos Carvajal, Marcela Villegas Ochoa, Elena Paola González Jaimes

“…It was demostrated that in radicular tissues of potato not always galls are indicative of infection, plants without symptoms can have protozoa structures, beside associated structures to S. subterranea as plasmodium an sporangium aggregate, are commonly found and coincident with some structures frequently reporter in wild hosts; this appreciations, allows to propose that this microorganism is common in soils, associated with wild and cultivate species, causing important disturbs specially on potato plants, where control strategies should be oriented towards the knowledge of ecology of interactions protozoa, its host and soil.…”
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Prediction of species composition ratios in pooled specimens of the Anopheles Hyrcanus group using quantitative sequencing by Do Eun Lee, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Ju Hyeon Kim, Si Hyeock Lee

“…Abstract Background Plasmodium vivax is transmitted by members of the Anopheles Hyrcanus Group that includes six species in the Republic of Korea: Anopheles sinensis sensu stricto (s.s.), Anopheles pullus, Anopheles kleini, Anopheles belenrae, Anopheles lesteri, and Anopheles sineroides. …”
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Long-Lasting Insecticide-Treated Nets Combined or Not with Indoor Residual Spraying May Not Be Sufficient to Eliminate Malaria: A Case-Control Study, Benin, West Africa by Barikissou G. Damien, Thomas Kesteman, Gatien A. Dossou-Yovo, Amal Dahounto, Marie-Claire Henry, Christophe Rogier, Franck Remoué

“…The objective of this study was to assess the effectiveness of LLINs, with or without IRS, protected against <i>Plasmodium falciparum</i> infection and uncomplicated clinical cases (UCC) of malaria in Benin. …”
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Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in <named-content content-type="genus-specie... by Jennifer Timm, Maria Valente, Daniel García-Caballero, Keith S. Wilson, Dolores González-Pacanowska

“…The enzyme is essential for survival in Plasmodium falciparum, where its drug target potential has been suggested. …”
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P2RX7 signaling drives the differentiation of Th1 cells through metabolic reprogramming for aerobic glycolysis by Érika Machado de Salles, Paulo Lisboa Raeder, Claudia Blanes Angeli, Verônica Feijoli Santiago, Cristiane Naffah de Souza, Theresa Ramalho, Niels Olsen Saraiva Câmara, Giuseppe Palmisano, José Maria Álvarez, Maria Regina D'Império Lima

“…IntroductionThis study provides evidence of how Th1 cell metabolism is modulated by the purinergic receptor P2X7 (P2RX7), a cation cannel activated by high extracellular concentrations of adenosine triphosphate (ATP).MethodsIn vivo analysis was performed in the Plasmodium chabaudi model of malaria in view of the great relevance of this infectious disease for human health, as well as the availability of data concerning Th1/Tfh differentiation.ResultsWe show that P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. …”
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Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes by Charlotte Kern, Pie Müller, Carlos Chaccour, Matthias E. Liechti, Felix Hammann, Urs Duthaler

“…Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A “post-ivermectin effect” has also been reported, in which the survival of mosquitoes remains reduced even after ivermectin is no longer detectable in blood meals. …”
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Clinical-epidemiological characteristics and maternal-foetal outcomes in pregnant women hospitalised with COVID-19 in Venezuela: a retrospective study by Fhabián S. Carrión-Nessi, Mercedes P. Castro, Diana C. Freitas-De Nobrega, Augusto Moncada-Ortega, Óscar D. Omaña-Ávila, Daniela L. Mendoza-Millán, María V. Marcano-Rojas, Nayren J. Trejo, Isabella V. Virriel, Melynar Chavero, Natasha A. Camejo-Ávila, Alfonso J. Rodriguez-Morales, David A. Forero-Peña

“…Interestingly, four (5%) pregnant women were co-infected with malaria by Plasmodium vivax and three (3.8%) with syphilis. The most frequent symptoms were fever (75%; n = 60), dry cough (68.8%; n = 55), dyspnoea (55%; n = 44), and headache (53.8%; n = 43). …”
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The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of... by David Kwame Dosoo, Jeffrey A Bailey, Kwaku Poku Asante, Felix Boakye Oppong, Karamoko Niaré, Jones Opoku-Mensah, Seth Owusu-Agyei, Brian Greenwood, Daniel Chandramohan

“…Effectiveness of IPTp-SP is, however, threatened by mutations in the Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes which confer resistance to pyrimethamine and sulfadoxine, respectively. …”
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Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity by Jennifer I. Brown, Peng Wang, Alan Y. L. Wong, Boryana Petrova, Rosanne Persaud, Sepideh Soukhtehzari, Melanie Lopez McDonald, Danielle Hanke, Josephine Christensen, Petar Iliev, Weiyuan Wang, Daniel K. Everton, Karla C. Williams, David A. Frank, Naama Kanarek, Brent D. G. Page

“…Cycloguanil was proposed as a DHFR inhibitor in the 1950s and is the active metabolite of clinically approved <i>plasmodium</i> DHFR inhibitor Proguanil. The Cycloguanil scaffold was explored to generate potential cancer therapies in the 1970s. …”
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Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women by Elvin Lufele, Alexandra Umbers, Jaume Ordi, Maria Ome-Kaius, Regina Wangnapi, Holger Unger, Nandao Tarongka, Peter Siba, Ivo Mueller, Leanne Robinson, Stephen Rogerson

“…Abstract Background Plasmodium falciparum in pregnancy results in substantial poor health outcomes for both mother and child, particularly in young, primigravid mothers who are at greatest risk of placental malaria (PM) infection. …”
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SKRINING MALARIA PADA REMAJA DI SURABAYA DENGAN MENGGUNAKAN METODE HAPUSAN DARAH by Firdaus ., Handayani ., M. Yusuf Alamudi

“… Abstrak: Malaria adalah penyakit infeksi disebabkan oleh parasit Plasmodium yang hidup dan berkembang biak dalam sel darah merah manusia yang ditularkan oleh nyamuk malaria (Anopheles) betina. …”
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Tick-Borne Pathogens Shape the Native Microbiome Within Tick Vectors by Abdulsalam Adegoke, Deepak Kumar, Cailyn Bobo, Muhammad Imran Rashid, Aneela Zameer Durrani, Muhammad Sohail Sajid, Shahid Karim

“…We also identify the presence of <i>Plasmodium falciparum</i>, the causative agent of human malaria from the microbiome of both <i>H. anatolicum</i> and <i>R. microplus</i> ticks. …”
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Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials. by Guido J H Bastiaens, Alfred B Tiono, Joseph Okebe, Helmi E Pett, Sam A Coulibaly, Bronner P Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C Bougouma, Guillaume S Sanou, Issa Nébié, John Bradley, Kjerstin H W Lanke, Mikko Niemi, Sodiomon B Sirima, Umberto d'Alessandro, Teun Bousema, Chris Drakeley

“…Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. …”
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Monitoring of malaria vectors at the China-Myanmar border while approaching malaria elimination by Shao-sen Zhang, Shui-sen Zhou, Zheng-bin Zhou, Tian-mu Chen, Xue-zhong Wang, Wen-qi Shi, Wei-kang Jiang, Ju-lin Li, Xiao-nong Zhou, Roger Frutos, Sylvie Manguin, Aneta Afelt

“…Both An. sinensis and An. minimus (s.l.) were found zoophilic with human blood index as 0.21 and 0.26, respectively. No Plasmodium positive Anopheles specimens were found by PCR among 4,000 trapped mosquitoes. …”
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Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study. by Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell

“…<h4>Background</h4>In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America, and the Horn of Africa. …”
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<i>Breynia cernua</i>: Chemical Profiling of Volatile Compounds in the Stem Extract and Its Antioxidant, Antibacterial, Antiplasmodial and Anticancer Activity In Vitro and In Silic... by Hesti Lina Wiraswati, Nisa Fauziah, Gita Widya Pradini, Dikdik Kurnia, Reza Abdul Kodir, Afiat Berbudi, Annisa Retno Arimdayu, Amila Laelalugina, Supandi, Ilma Fauziah Ma'ruf

“…Further analysis revealed that the extract with a concentration of 1–2 ppm protects erythrocytes from the ring formation stage of <i>Plasmodium falciparum</i>, while the extract with a concentration of 1600 ppm induced apoptosis in the MCF-7 breast cancer cell line. …”
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