In vitro antiplasmodial activity, cytotoxicity, and gas chromatography – flame ionization detector metabolites fingerprint of extracts and fractions from Tetrorchidium didymostemon... by Osamudiamen Ebohon, Francis Irabor, Nekpen Erhunse, Abigail Omagene, Ehimwenma Sheena Omoregie

“…Materials and methods: Plasmodium falciparum 3D7 (Pf3D7) strain was cultured and maintained in fresh O+ human erythrocytes. …”
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Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in <named-content content-type="genus-species">Toxoplasma gondii</named-content> by Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew I. Webb, Christopher J. Tonkin

“…All identified ASP5 substrates are dense granule proteins, and interestingly, none appear to be exported, thus differing from the analogous system in related Plasmodium spp. Instead we show that the majority of substrates reside within the parasitophorous vacuole (PV), and its membrane (the PVM), including two kinases and one phosphatase. …”
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Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect mod... by Xiaoyan Yin, Ying Li, Wilhelmina Bagchus, Özkan Yalkinoglu, Deon Bezuidenhout, Aliona Tappert, James McCarthy, Louise Marquart, Claude Oeuvray

“…Conclusions All three statistical approaches are effective tools to characterize the bi-phasic clearance of M5717 in the phase 1b experimental Plasmodium falciparum malaria human infection study. …”
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Do we need to go further to train healthcare providers in the targeted regions for malaria elimination in Myanmar? A mixed-methods study by Zar Ni Min Hein, Thae Maung Maung, Poe Poe Aung, Nwe Oo Mon, Wai Wai Han, Tin Oo, Nay Yi Yi Linn, Aung Thi, Khin Thet Wai

“…Abstract Background The National Malaria Control Programme (NMCP) in Myanmar trained health staff at the township level starting in mid-2016 in order to achieve the Plasmodium falciparum malaria elimination target by 2020. …”
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In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis. by Oliver Van Hecke, Meriel Raymond, Joseph J Lee, Philip Turner, Clare R Goyder, Jan Y Verbakel, Ann Van den Bruel, Gail Hayward

“…Pooled estimates showed that malarial-POCTs (Plasmodium falciparum) better targeted antimalarial treatment by reducing over-treatment by a third compared to usual care (RR 0.67; 95% CI [0.58 to 0.77], n = 36,949). …”
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A Synthetic Nanoparticle Based Vaccine Approach Targeting MSP4/5 Is Immunogenic and Induces Moderate Protection Against Murine Blood-Stage Malaria by Kirsty L. Wilson, Kirsty L. Wilson, Dodie Pouniotis, Jennifer Hanley, Sue D. Xiang, Charles Ma, Ross L. Coppel, Magdalena Plebanski, Magdalena Plebanski

“…Herein, we explore the ability of a model nanoparticle delivery system (polystyrene nanoparticles; PSNPs), previously proven to not induce conventional inflammation, Treg or MDSC, to induce immunity to MSP4/5 from Plasmodium yoelii, a member of the MSP4 and MSP5 family of proteins which are highly conserved across diverse malaria species including P. falciparum. …”
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Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms by Momen M. Lotfy, Hossam M. Hassan, Hossam M. Hassan, Rabab Mohammed, Mona Hetta, Ahmed O. El-Gendy, Mostafa E. Rateb, Mostafa E. Rateb, Mohamed A. Zaki, Noha M. Gamaleldin, Noha M. Gamaleldin

“…The in vitro antimalarial activities against D6 (chloroquine sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum were evaluated.ResultsSeven isolated microorganisms were identified as Streptomyces indiaensis, Bacillus safensis, B. anthracis, Bacillus sp., and Aspergillus awamori. …”
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In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies by Prapaporn Chaniad, Arnon Chukaew, Prasit Na-ek, Gorawit Yusakul, Litavadee Chuaboon, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Abdi Wira Septama, Chuchard Punsawad

“…Mice were intraperitoneally injected with Plasmodium berghei ANKA strain and given HTX daily for 4 days. …”
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Annual variations in the number of malaria cases related to two different patterns of <it>Anopheles darlingi </it>transmission potential in the Maroni area of French Guiana by Issaly Jean, Carinci Romuald, Gaborit Pascal, Fouque Florence, Girod Romain

“…The mosquitoes were sorted by species, sex, date, hour and place of collection and processed for <it>Plasmodium sp</it>. parasite detection. The data were compiled to provide the following variables: human biting rates (HBR), parity rates (PR), numbers of infective bites (IB), entomological inoculation rates (EIR) and numbers of infected mosquitoes surviving enough to transmit (IMT). …”
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G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients by Sara Avalos, Rosa E. Mejia, Engels Banegas, Cesar Salinas, Lester Gutierrez, Marcela Fajardo, Suzeth Galo, Alejandra Pinto, Angel Mejia, Gustavo Fontecha

“…Participants with malaria were recruited. Plasmodium vivax infection was treated with 0.25 mg/kg of PQ daily for 14 days. …”
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Liver injury in malaria infected patients in Douala-Cameroon and its association with poor medical practice by Arnaud Fondjo Kouam, Noé Auguste Nseké Ngoumé, Armelle Gaelle Kwesseu Fepa, Zerubabel Wainfen, Eléonore Ngounou, Borris Rosnay Tietcheu Galani, Nembu Erastus Nembo, Pascal Dieudonné Djamen Chuisseu, Fréderic Nico Njayou, Paul Fewou Moundipa

“…Methods Over 10 weeks, 150 febrile patients and 28 healthy individuals serving as the control group were enrolled and their blood samples screened for Plasmodium species by Giemsa Staining and liver injury evaluated by measuring the serum level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. …”
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Dynamic behavior of healthy and malaria infected human red blood cells by Quinn, David John, Sc. D. Massachusetts Institute of Technology

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Geosentinel surveillance of illness in returned travelers, 2007–2011 by Toressi, Joseph, Leder, Karin, Libman, Michael D., Cramer, Jakob P., Castelli, Francesco, Schlagenhauf, Patricia, Wilder-Smith, Annelies, Wilson, Mary E., Keystone, Jay S., Schwartz, Eli, Barnett, Elizabeth D., Sonnenburg, Frank von, Brownstein, John S., Cheng, Allen C., Sotir, Mark J., Esposito, Douglas H., Freedman, David O.

“…Life-threatening diseases, such as Plasmodium falciparum malaria, melioidosis, and African trypanosomiasis, were reported. …”
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P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC by Aniweh, Yaw, Gao, Xiaohong, Hao, Piliang, Meng, Wei, Lai, Soak-Kuan, Gunalan, Karthigayan, Chu, Trang T., Sinha, Ameya, Lescar, Julien, Chandramohanadas, Rajesh, Li, Hoi-Yeung, Sze, Siu Kwan, Preiser, Peter Rainer

“…The successful invasion of Plasmodium is an essential step in their life cycle. …”
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Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target by Wagner, Matthias Paulus, Formaglio, Pauline, Gorgette, Olivier, Dziekan, Jerzy Michal, Huon, Christèle, Berneburg, Isabell, Rahlfs, Stefan, Barale, Jean-Christophe, Feinstein, Sheldon I., Fisher, Aron B., Ménard, Didier, Bozdech, Zbynek, Amino, Rogerio, Touqui, Lhousseine, Chitnis, Chetan E.

“…Here, we demonstrate that Plasmodium falciparum imports a host antioxidant enzyme, peroxiredoxin 6 (PRDX6), during hemoglobin uptake from the red blood cell cytosol. …”
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Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria by Grigg, Matthew J., Parameswaran, Uma, Piera, Kim A., Price, Ric N., Yeo, Tsin W., Anstey, Nicholas M., Barber, Bridget E., William, Timothy

“…Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. …”
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A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells by Claessens, Antoine, Adams, Yvonne, Ghumra, Ashfaq, Lindergard, Gabriella, Andisi, Cheryl, Mok, Sachel, Turner, Louise, Arman, Mònica, Raza, Ahmed, Bozdech, Zbynek, Rowe, J. Alexandra, Buchan, Caitlin C., Bull, Peter C., Gupta, Archna P., Wang, Christian W.

“…Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvascular endothelial cells. …”
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SINTESIS SENYAWA (1)-N-(4-BENZILOKSI-3-METOKSIBENZIL)-1,10-FENANTROLINIUM KLORIDA SEBAGAI ANTIMALARIA by Hadanu, Ruslin, Matsjeh, Sabirin, Jumina, Jumina, Mustafa, Mustafa, AW, Mahardika, Nurwening Sholikhah, Eti

“…Hasil uji aktivitas in vitro antiplasmodial pada sel Plasmodium falciparum 5:-3in FCR3 dan D10 resisten klorokuin terhadap senyawa (1)-N-(4-benziloksi-3--etoksibenzil)-1,10-fenantrolinium klorida bertutut-turut diperoleh hasil IC50 sebesar 8-0,30 (jM dan 2,68-1,03 pM ada waktu inkubasi selama 24 dan 72 jam …”
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Antiplasmodial phytochemicals from Rennellia elliptica korth. and their synthetic analogues / Che Puteh Osman by Osman, Che Puteh

“…The dichloromethane extract showed potent antiplasmodial activity against Plasmodium falciparum (3D7) with an IC50 value of 4.04 μg/ml. …”
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Investigating protective mechanisms of anti-sporozoite vaccines by Bellamy, DG

“…R21 is a virus-like particle-based (VLP-based) vaccine displaying the immunodominant NANP repeat region of the circumsporozoite protein (CSP) of <em>Plasmodium falciparum</em>. R21 is biosimilar to the current leading malaria vaccine candidate, RTS,S, in that CSP epitopes are found on the VLP surface. …”