Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance by Nnamani PO, Ugwu AA, Ibezim EC, Kenechukwu FC, Akpa PA, Ogbonna JD, Obitte NC, Odo AN, Windbergs M, Lehr CM, Attama AA

“…Subsequent AL liquisolid tablets were tested for in vitro drug release and in vivo antiplasmodial activity in mice infected with Plasmodium berghei berghei (NK 65). Results showed that optimized LUM-NLC were stable, spherical, polydispersed but nanometric. …”
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Entomological impact of indoor residual spraying with pirimiphos-methyl: a pilot study in an area of low malaria transmission in Senegal by Ousmane Sy, El Hadji Amadou Niang, Magatte Ndiaye, Lassana Konaté, Abdoulaye Diallo, Elhadji Conco Ciré Ba, Fassiath Tairou, Elhadji Diouf, Badara Cissé, Oumar Gaye, Ousmane Faye

“…Females caught through HLC were tested by ELISA for the detection of Plasmodium falciparum circumsporozoite protein and Anopheles gambiae complex was identified using PCR. …”
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Identification of a novel thrombospondin-related anonymous protein (BoTRAP2) from Babesia orientalis by Xueyan Zhan, Junwei He, Long Yu, Qin Liu, Yali Sun, Zheng Nie, Jiaying Guo, Yangnan Zhao, Muxiao Li, Xiaoying Luo, Lan He, Junlong Zhao

“…Abstract Background The thrombospondin-related anonymous protein (TRAP) was first discovered in the sporozoite of Plasmodium falciparum and TRAP family proteins are secreted by micronemes and transported to the parasite surface to participate in the invasion process. …”
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Infant and child mortality in relation to malaria transmission in KEMRI/CDC HDSS, Western Kenya: validation of verbal autopsy by Nyaguara O. Amek, Annemieke Van Eijk, Kim A. Lindblade, Mary Hamel, Nabie Bayoh, John Gimnig, Kayla F. Laserson, Laurence Slutsker, Thomas Smith, Penelope Vounatsou

“…These were linked to household-specific estimates of the Plasmodium falciparum entomological inoculation rate (EIR) based on high resolution spatio-temporal geostatistical modelling of entomological data. …”
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Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized... by Aaron M. Samuels, Nobert Awino, Wycliffe Odongo, Benard Abong’o, John Gimnig, Kephas Otieno, Ya Ping Shi, Vincent Were, Denise Roth Allen, Florence Were, Tony Sang, David Obor, John Williamson, Mary J. Hamel, S. Patrick Kachur, Laurence Slutsker, Kim A. Lindblade, Simon Kariuki, Meghna Desai

“…Abstract Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. …”
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Exploring the heterogeneity of human exposure to malaria vectors in an urban setting, Bouaké, Côte d’Ivoire, using an immuno-epidemiological biomarker by Dipomin F. Traoré, André B. Sagna, Akré M. Adja, Dounin D. Zoh, Kouassi A. Adou, Kouassi N. Lingué, Issa Coulibaly, N’Cho Bertin Tchiekoi, Serge B. Assi, Anne Poinsignon, Mamadou Dagnogo, Franck Remoue

“…Data on insecticide-treated net (ITN) use and blood samples were collected from children aged between 6 months and 15 years to determine the parasite density and the prevalence of Plasmodium falciparum and the level of IgG against the Anopheles gSG6-P1 salivary peptide, used as the biomarker of Anopheles bite exposure. …”
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Malaria en poblaciones con ocupación minera, Colombia, 2012-2018 by Daniela Salas, Dora Yurany Sánchez, Germán Achury, Fabio Escobar-Díaz

“…Entre el 2012 y el 2018, se notificaron 44.032 casos de malaria en la población minera, 43.900 de malaria no complicada y 132 de malaria complicada, así como tres muertes, dos por Plasmodium vivax y una por infección mixta. Hubo una disminución del 44,7 % de los casos en el período evaluado. …”
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Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito by Victoria A. Balta, Deborah Stiffler, Abeer Sayeed, Abhai K. Tripathi, Rubayet Elahi, Godfree Mlambo, Rahul P. Bakshi, Amanda G. Dziedzic, Anne E. Jedlicka, Elizabeth Nenortas, Keyla Romero-Rodriguez, Matthew A. Canonizado, Alexis Mann, Andrew Owen, David J. Sullivan, Sean T. Prigge, Photini Sinnis, Theresa A. Shapiro

“…Laboratory studies have indicated that atovaquone resistance disadvantages parasites in mosquitoes, but lack of data on clinically relevant Plasmodium falciparum has hampered integration of these variable findings into drug development decisions. …”
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Convolutional neural networks to automate the screening of malaria in low-resource countries by Oliver S. Zhao, Nikhil Kolluri, Anagata Anand, Nicholas Chu, Ravali Bhavaraju, Aditya Ojha, Sandhya Tiku, Dat Nguyen, Ryan Chen, Adriane Morales, Deepti Valliappan, Juhi P. Patel, Kevin Nguyen

“…Malaria is an infectious disease caused by Plasmodium parasites, transmitted through mosquito bites. …”
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Potential Epha2 Receptor Blockers Involved in Cerebral Malaria from <i>Taraxacum officinale</i>, <i>Tinospora cordifolia</i>, <i>Rosmarinus officinalis</i> and <i>Ocimum basilicum<... by Mohd Sayeed Shaikh, Fahadul Islam, Parag P. Gargote, Rutuja R. Gaikwad, Kalpana C. Dhupe, Sharuk L. Khan, Falak A. Siddiqui, Ganesh G. Tapadiya, Syed Sarfaraz Ali, Abhijit Dey, Talha Bin Emran

“…Cerebral malaria (CM) is a severe manifestation of parasite infection caused by <i>Plasmodium</i> species. In 2018, there were approximately 228 million malaria cases worldwide, resulting in about 405,000 deaths. …”
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Seasonal malaria chemoprevention in Africa and China’s upgraded role as a contributor: a scoping review by Ming Xu, Yun-Xuan Hu, Shen-Ning Lu, Muhammad Abdullahi Idris, Shu-Duo Zhou, Jian Yang, Xiang-Ning Feng, Yang-Mu Huang, Xian Xu, Ying Chen, Duo-Quan Wang

“…Abstract Background Children under five are the vulnerable population most at risk of being infected with Plasmodium parasites, especially in the Sahel region. …”
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Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose by Wei-Chiao Huang, Bingbing Deng, Moustafa T. Mabrouk, Amal Seffouh, Joaquin Ortega, Carole Long, Kazutoyo Miura, Yimin Wu, Jonathan F. Lovell

“…Abstract Background The Plasmodium falciparum sexual-stage surface proteins Pfs25 and Pfs230 are antigen candidates for a malaria transmission-blocking vaccine (TBV), and have been widely investigated as such. …”
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Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria by María Álvarez-Bardón, Yolanda Pérez-Pertejo, César Ordóñez, Daniel Sepúlveda-Crespo, Nestor M. Carballeira, Babu L. Tekwani, Sankaranarayanan Murugesan, Maria Martinez-Valladares, Carlos García-Estrada, Rosa M. Reguera, Rafael Balaña-Fouce

“…Malaria, caused by the apicomplexan parasite <i>Plasmodium falciparum</i>, is responsible for thousands of deaths each year. …”
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How useful are malaria risk maps at the country level? Perceptions of decision-makers in Kenya, Malawi and the Democratic Republic of Congo by Ludovica Ghilardi, George Okello, Linda Nyondo-Mipando, Chawanangwa Mahebere Chirambo, Fathy Malongo, Jenna Hoyt, Jieun Lee, Yovitha Sedekia, Justin Parkhurst, Jo Lines, Robert W. Snow, Caroline A. Lynch, Jayne Webster

“…Abstract Background Declining malaria prevalence and pressure on external funding have increased the need for efficiency in malaria control in sub-Saharan Africa (SSA). Modelled Plasmodium falciparum parasite rate (PfPR) maps are increasingly becoming available and provide information on the epidemiological situation of countries. …”
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Reducing malaria transmission in forest-going mobile and migrant populations in Lao PDR and Cambodia: protocol for stepped-wedge cluster-randomised controlled trial by Win Htike, Win Han Oo, Thet Lynn, Lun Sovanda, Paul A. Agius, May Chan Oo, Naw Hkawng Galau, Kaung Myat Thu, Aung Khine Zaw, Ei Phyu Htwe, Julia C. Cutts, Ellen A. Kearney, Nick Scott, Katherine O’Flaherty, Bangyuan Wang, Boualam Khamlome, Phoutnalong Vilay, Sovannaroth Siv, Freya J. I. Fowkes

“…The primary outcome of the trial is the prevalence of Plasmodium spp. infection diagnosed by rapid diagnostic test. …”
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A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models by Winter A. Okoth, Mei-Fong Ho, Mehfuz Zaman, Emily Cooper, Priyanka Som, Mark Burgess, Maddison Walton, Reshma J. Nevagi, Lynette Beattie, Declan Murphy, Danielle I. Stanisic, Michael F. Good

“…Here, we evaluate the immunogenicity and protective efficacy of a whole-parasite Plasmodium yoelii 17X blood-stage vaccine formulated with the clinically tested cationic adjuvant formulation, CAF01. …”
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Regulation of Mitochondrial Energy Metabolism by Glutaredoxin 5 in the Apicomplexan Parasite Neospora caninum by Xingju Song, Xu Yang, Zhu Ying, Kaijian Wu, Jing Liu, Qun Liu

“…The intracellular parasites in the phylum Apicomplexa, including Plasmodium, Toxoplasma gondii, and Neospora caninum, harbor the ISC pathway involved in the biosynthesis of [Fe-S] clusters in mitochondria. …”
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Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine by Anyse P. Essoh, Gustavo Capatti Cassiano, Filipa Mandim, Lillian Barros, Isildo Gomes, Márcia Melo Medeiros, Mónica Moura, Pedro Vitor Lemos Cravo, Maria M. Romeiras

“…Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) <i>Plasmodium falciparum</i> strains using the SYBR Green detection method. …”
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Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials by Duparc Stephan, Pamba Allan, Carter Nick, Waitumbi John N

“…</p> <p>Methods</p> <p>Study participants, aged > 1 year, with microscopically confirmed uncomplicated <it>Plasmodium falciparum </it>malaria, and haemoglobin ≥ 70 g/L or haematocrit ≥ 25%, were recruited into two clinical trials conducted in six African countries (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, Mali). …”
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<it>Anopheles gambiae</it>: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya by Kamau Luna, Mutuku Francis M, Odiere Maurice R, Mathias Derrick K, Bayoh M Nabie, Gimnig John E, Vulule John M, Hawley William A, Hamel Mary J, Walker Edward D

“…Data of blood host choice, parity rate, and infection rate for <it>Plasmodium falciparum </it>in <it>A. gambiae s.s. </it>and <it>A. arabiensis </it>were obtained for a sample from Asembo and Seme from 2005.…”
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