Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women by Ritah F. Mutagonda, Appolinary A. R. Kamuhabwa, Omary M. S. Minzi, Siriel N. Massawe, Muhammad Asghar, Manijeh V. Homann, Anna Färnert, Eleni Aklillu

“…Abstract Background Pregnancy has considerable effects on the pharmacokinetic properties of drugs used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic variation on anti-malarial drug disposition and efficacy during pregnancy is not well investigated. …”
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Statistical prediction of immunity to placental malaria based on multi-assay antibody data for malarial antigens by Chathura Siriwardhana, Rui Fang, Ali Salanti, Rose G. F. Leke, Naveen Bobbili, Diane Wallace Taylor, John J. Chen

“…Abstract Background Plasmodium falciparum infections are especially severe in pregnant women because infected erythrocytes (IE) express VAR2CSA, a ligand that binds to placental trophoblasts, causing IE to accumulate in the placenta. …”
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Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations by Mary A. Oboh, Tolla Ndiaye, Khadim Diongue, Yaye D. Ndiaye, Mouhamad Sy, Awa B. Deme, Mamadou A. Diallo, Mamadou S. Yade, Sarah K. Volkman, Aida S. Badiane, Alfred Amambua-Ngwa, Daouda Ndiaye

“…This study compared Plasmodium falciparum parasite population diversity from two sites with low (pre-elimination) and high transmission in Senegal and Nigeria, respectively. …”
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Implementing radical cure diagnostics for malaria: user perspectives on G6PD testing in Bangladesh by Nora Engel, Cristian Ghergu, Mohammad Abdul Matin, Mohammad Golam Kibria, Kamala Thriemer, Ric N. Price, Xavier C. Ding, Rosalind E. Howes, Benedikt Ley, Sandra Incardona, Mohammad Shafiul Alam

“…Abstract Background The radical cure of Plasmodium vivax requires treatment with an 8-aminoquinoline drug, such as primaquine and tafenoquine, to eradicate liver hypnozoite stages, which can reactivate to cause relapsing infections. …”
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Intermittent preventive treatment and malaria amongst pregnant women who give birth at the Centre Hospitalier Régional Paul Moukambi de Koula-Moutou in southeastern Gabon by Jean Claude Biteghe-Bi-Essone, Roméo Karl Imboumy-Limoukou, Jean Jordan Ekogha-Ovono, Sydney Maghendji-Nzondo, Pater Noster Sir-Ondo-Enguier, Lydie Sandrine Oyegue, Jean Bernard Lekana-Douki

“…In the second sub-set of data, the prevalence of plasmodial infection was 3.10% (95% IC [1.21–5]) and Plasmodium falciparum was responsible for 100% of infections. …”
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Risk associations of submicroscopic malaria infection in lakeshore, plateau and highland areas of Kisumu County in western Kenya. by Wilfred Ouma Otambo, Collince J Omondi, Kevin O Ochwedo, Patrick O Onyango, Harrysone Atieli, Ming-Chieh Lee, Chloe Wang, Guofa Zhou, Andrew K Githeko, John Githure, Collins Ouma, Guiyun Yan, James Kazura

“…Finger prick blood smears and dry blood spots (DBS) on filter paper were collected from 1,777 healthy volunteers for microscopic inspection and real time-PCR (RT-PCR) diagnosis of Plasmodium infection. Persons who were PCR positive but blood smear negative were considered to harbor submicroscopic infections. …”
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Antiprotozoal and Antibacterial Activity of Ravenelin, a Xanthone Isolated from the Endophytic Fungus <i>Exserohilum rostratum</i> by Jeferson Rodrigo Souza Pina, João Victor Silva-Silva, Josiwander Miranda Carvalho, Heriberto Rodrigues Bitencourt, Luciano Almeida Watanabe, Juan Matheus Pereira Fernandes, Guilherme Eduardo de Souza, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Fernando Almeida-Souza, Kátia da Silva Calabrese, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho

“…SYBR Green I-based assay was used in the asexual stages of <i>Plasmodium falciparum</i>. Trypanocidal activity was tested against the epimastigote and intracellular amastigote forms of <i>Trypanosoma cruzi</i>. …”
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High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota by Ting Liu, Xue Liang, Chao Lei, Qinhong Huang, Weiqi Song, Rong Fang, Chen Li, Xiaomei Li, Hui Mo, Ning Sun, Ning Sun, Haoran Lv, Zhihua Liu

“…Among ND gut microbiota, relative abundance of Bacteroides, Lactobacillus, Butyricimonas, and Dorea was significantly increased by arsenic (As) exposure; relative abundance of Faecoccus and Lactobacillus was significantly increased by Cd exposure; relative abundance of Desulfovibrio, Plasmodium, and Roseburia were significantly increased by Pb exposure. …”
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Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines by Andreas Masch, Abed Nasereddin, Arne Alder, Megan J. Bird, Sandra I. Schweda, Lutz Preu, Christian Doerig, Ron Dzikowski, Tim W. Gilberger, Conrad Kunick

“…All derivatives were tested for inhibition of asexual erythrocytic stages of transgenic NF54-luc Plasmodium falciparum. Selected compounds with promising antiplasmodial activity were further evaluated for inhibition of HEK293 cells as well as inhibition of isolated PfGSK-3 and HsGSK-3. …”
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Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana by Ebenezer A. Ofori, John K. A. Tetteh, Augustina Frimpong, Harini Ganeshan, Maria Belmonte, Bjoern Peters, Eileen Villasante, Martha Sedegah, Michael F. Ofori, Kwadwo A. Kusi

“…This study compared the influence of allelic polymorphisms in Plasmodium falciparum apical membrane antigen 1 (PfAMA1) peptide sequences from three strains of P. falciparum (3D7, 7G8 and FVO) on their function as immunodominant targets of T cell responses in high and low malaria transmission communities in Ghana. …”
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High-resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences by Marilou Boddé, Alex Makunin, Diego Ayala, Lemonde Bouafou, Abdoulaye Diabaté, Uwem Friday Ekpo, Mahamadi Kientega, Gilbert Le Goff, Boris K Makanga, Marc F Ngangue, Olaitan Olamide Omitola, Nil Rahola, Frederic Tripet, Richard Durbin, Mara KN Lawniczak

“…NNoVAE presents an approach that may be of value to other targeted sequencing panels, and is a method that will be used to survey Anopheles species diversity and Plasmodium transmission patterns through space and time on a large scale, with plans to analyse half a million mosquitoes in the next five years.…”
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Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling by Ellen A Kearney, Paul A Agius, Victor Chaumeau, Julia C Cutts, Julie A Simpson, Freya JI Fowkes

“…Seroprevalence was also significantly positively associated with established epidemiological measures of malaria transmission: entomological inoculation rate, Plasmodium spp. prevalence, and malarial endemicity class. …”
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Efficacy of two artemisinin-based combinations for the treatment of malaria in pregnancy in India: a randomized controlled trial by Anupkumar R. Anvikar, Irene Kuepfer, Vinitkumar Mishra, Jane Bruce, Tushar Arya, Deb Ranjan Mishra, Sanjib Mohanty, Rajesh Mohanty, Bina Srivastava, Suryakant Sharma, Neelima Mishra, Brian Greenwood, Daniel Chandramohan, Neena Valecha

“…This study assessed the safety and efficacy of AS+SP and artesunate + mefloquine (AS+MQ) for treatment of Plasmodium falciparum in pregnancy in India. Methods This open-label, randomized clinical trial was conducted from October 2010 to December 2013 at three sites in India (Ranchi and Jamshedpur in Jharkhand state, and Rourkela in Odisha state). …”
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Effects of community-level bed net coverage on malaria morbidity in Lilongwe, Malawi by Veronica Escamilla, Alisa Alker, Leonard Dandalo, Jonathan J. Juliano, William C. Miller, Portia Kamthuza, Tapiwa Tembo, Gerald Tegha, Francis Martinson, Michael Emch, Irving F. Hoffman

“…Participant blood samples were tested for Plasmodium falciparum presence. The percentage of people sleeping under a bed net within 400-m and 1-km radii of all participants was measured. …”
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Magnetic Bead Handling Using a Paper-Based Device for Quantitative Point-of-Care Testing by Kevin Arias-Alpízar, Ana Sánchez-Cano, Judit Prat-Trunas, Elena Sulleiro, Pau Bosch-Nicolau, Fernando Salvador, Inés Oliveira, Israel Molina, Adrián Sánchez-Montalvá, Eva Baldrich

“…As a proof-of-concept, the μPAD has been applied to the quantitative detection of <i>Plasmodium falciparum</i> lactate dehydrogenase (Pf-LDH), a biomarker of malaria infection. …”
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Prediction of malaria positivity using patients’ demographic and environmental features and clinical symptoms to complement parasitological confirmation before treatment by Taiwo Adetola Ojurongbe, Habeeb Abiodun Afolabi, Kehinde Adekunle Bashiru, Waidi Folorunso Sule, Sunday Babatunde Akinde, Olusola Ojurongbe, Nurudeen A. Adegoke

“…Therefore, this study used a machine-learning model to predict Plasmodium falciparum (Pf) antigen positivity (presence of malaria) based on sociodemographic behaviour, environment, and clinical features. …”
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Efficacy and safety of pyronaridine–artesunate versus artemether–lumefantrine in the treatment of acute uncomplicated malaria in children in South-West Nigeria: an open-labelled ra... by Catherine O. Falade, Adebola E. Orimadegun, Fiyinfoluwa I. Olusola, Obaro S. Michael, Oluwafunmibi E. Anjorin, Roland I. Funwei, Aduragbenro D. Adedapo, Abiola L. Olusanya, Bose E. Orimadegun, Olugbenga A. Mokuolu

“…Methods In an open-labelled, randomized, controlled clinical trial, 172 children aged 3–144 months with a history of fever and microscopically confirmed uncomplicated Plasmodium falciparum malaria were enrolled in southwest Nigeria. …”
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Wolbachia introduction into Lutzomyia longipalpis (Diptera: Psychodidae) cell lines and its effects on immune-related gene expression and interaction with Leishmania infantum by Daniela da Silva Gonçalves, Iñaki Iturbe-Ormaetxe, Andrea Martins-da-Silva, Erich Loza Telleria, Marcele Neves Rocha, Yara M. Traub-Csekö, Scott L. O’Neill, Maurício Roberto Viana Sant’Anna, Luciano Andrade Moreira

“…The bacterium Wolbachia pipientis is being used to control viruses transmitted by mosquitoes, such as dengue and Zika, and its introduction in disease vectors has been effective against parasites such as Plasmodium. Here we show the first successful establishment of Wolbachia into two different embryonic cell lines from L. longipalpis, LL-5 and Lulo, and analysed its effects on the sand fly innate immune system, followed by in vitro Leishmania infantum interaction. …”
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Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000–2012 by Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo, Erin Eckert

“…In 2010, 23% of febrile children under 5 received ACT, as opposed to 19% in 2012. The prevalence of Plasmodium falciparum infection increased from 2010 (38.6%) to 2012 (51.6%), followed by a decrease in 2015 (35.8%). …”
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Transdermal Immunization of Elastic Liposome-Laden Recombinant Chimeric Fusion Protein of <i>P. falciparum</i> (<i>Pf</i>MSP-Fu₂₄) Mounts Protective Immune Response by Ramesh Chaudhari, Nikunj Tandel, Kiran Sahu, Sushmita Negi, Hilal Bashir, Arzu Rupareliya, Ravi PN Mishra, Sarat K. Dalai, Rajeev K. Tyagi

“…Elastic liposome-mediated subcutaneous delivery of chimeric fusion protein (<i>Pf</i>MSP-Fu₂₄) of <i>Plasmodium falciparum</i> exhibited improved immunogenic responses. …”
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