Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia by D. Herbert Opi, Lucy B. Ochola, Metrine Tendwa, Bethsheba R. Siddondo, Harold Ocholla, Harry Fanjo, Ashfaq Ghumra, David J.P. Ferguson, J. Alexandra Rowe, Thomas N. Williams

“…Background: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α+thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both conditions results in a loss of the protection afforded by each, but the biological mechanisms remain unknown. …”
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Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue by Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong

“…The amino-artemisinins artemiside and artemisone display optimal efficacies in vitro against asexual and sexual blood stages of the malaria parasite Plasmodium falciparum and are active against tumour cell lines. …”
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PCR-confirmed malaria among children presenting with a decreased level of consciousness in Angola: a prospective, observational study by Okko Savonius, Cintia F. de Souza, Cláudia Fançony, Manuel Leite Cruzeiro, Miguel Brito, Tuula Pelkonen

“…Results 161 of 345 children (46.7%) had a positive malaria PCR test result. All cases were Plasmodium falciparum species, and 82.6% (133/161) fulfilled the WHO criteria for severe malaria. …”
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Immunological profiles associated with distinct parasitemic states in volunteers undergoing malaria challenge in Gabon by Mikhael D. Manurung, Sanne E. de Jong, Yvonne Kruize, Yoanne D. Mouwenda, Madeleine Eunice Betouke Ongwe, Yabo Josiane Honkpehedji, Jeannot Frézus Zinsou, Jean Claude Dejon-Agobe, Stephen L. Hoffman, Peter G. Kremsner, Ayola Akim Adegnika, Rolf Fendel, Benjamin Mordmüller, Meta Roestenberg, Bertrand Lell, Maria Yazdanbakhsh

“…Abstract Controlled human malaria infection (CHMI) using cryopreserved non-attenuated Plasmodium falciparum sporozoites (PfSPZ) offers a unique opportunity to investigate naturally acquired immunity (NAI). …”
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Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis. by Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning

“…<h4>Background</h4>The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. …”
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Protocol for a cluster randomised placebo-controlled trial of adjunctive ivermectin mass drug administration for malaria control on the Bijagós Archipelago of Guinea-Bissau: the MA... by David Mabey, John Bradley, Amabelia Rodrigues, Chris Drakeley, Eunice Teixeira da Silva, Hristina Vasileva, Umberto d'Alessandro, Cesario Martins, Robert T Jones, James G Logan, Harry Hutchins, Elizabeth Pretorius, Mamadou Ousmane Ndiath, Harouna dit Massire Soumare, Ernesto Jose Nante, Hannah Slater, Anna R Last

“…The trial is being conducted in 24 clusters on the Bijagós Archipelago, Guinea-Bissau, where the peak prevalence of Plasmodium falciparum (Pf) parasitaemia is approximately 15%. …”
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Clustering symptoms of non-severe malaria in semi-immune Amazonian patients by Antonio C. Martins, Felipe M. Araújo, Cássio B. Braga, Maria G.S. Guimarães, Rudi Nogueira, Rayanne A. Arruda, Lícia N. Fernandes, Livia R. Correa, Rosely dos S. Malafronte, Oswaldo G. Cruz, Cláudia T. Codeço, Mônica da Silva-Nunes

“…None of the symptoms showed an association with gender or with species of Plasmodium. The clinical spectrum of malaria in semi-immune individuals can have a broad range of symptoms, the frequency and intensity of which are associated with age, past exposure to malaria, and parasitemia. …”
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Prevalence of malaria and hepatitis B among pregnant women in Northern Ghana: Comparing RDTs with PCR. by Nsoh Godwin Anabire, Paul Armah Aryee, Abass Abdul-Karim, Issah Bakari Abdulai, Osbourne Quaye, Gordon Akanzuwine Awandare, Gideon Kofi Helegbe

“…<h4>Methods</h4>We screened 2071 pregnant women on their first antenatal visit for Plasmodium falciparum and hepatitis B virus (HBV) using HRP2 and HBsAg RDTs, and confirming the infections with PCR. …”
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Identification and characterization of larval and adult anopheline mosquito habitats in the Republic of Korea: potential use of remotely sensed data to estimate mosquito distributi... by Linthicum Kenneth J, Ugsang Donald M, Ja Lee Won, Sithiprasasna Ratana

“…<p>Abstract</p> <p>Background</p> <p><it>Plasmodium vivax </it>malaria reemerged in the Republic of Korea in 1993, with more than 2,000 cases reported in the northwestern part of the country over the last 10 years. …”
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Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. by Nirianne Marie Q Palacpac, Edward Ntege, Adoke Yeka, Betty Balikagala, Nahoko Suzuki, Hiroki Shirai, Masanori Yagi, Kazuya Ito, Wakaba Fukushima, Yoshio Hirota, Christopher Nsereko, Takuya Okada, Bernard N Kanoi, Kohhei Tetsutani, Nobuko Arisue, Sawako Itagaki, Takahiro Tougan, Ken J Ishii, Shigeharu Ueda, Thomas G Egwang, Toshihiro Horii

“…BACKGROUND: Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive Japanese adults. …”
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Malaria patient spectrum representation in therapeutic clinical trials of uncomplicated malaria: a scoping review of the literature by Lorenzo Arena, Mazvita Zanamwe, Christine M. Halleux, Verena Carrara, Brian J. Angus, Proochista Ariana, Georgina S. Humphreys, Caitlin Richmond, Kasia Stepniewska, Philippe J. Guérin, Piero L. Olliaro

“…Three criteria account for about 70% of malaria-positive patients excluded: mixed-species malaria infections or other specific Plasmodium species, parasite counts outside the set study ranges, and refusal of consent. …”
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Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade by Jaymin C. Patel, Nicholas J. Hathaway, Christian M. Parobek, Kyaw L. Thwai, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Achille Massougbodji, Nadine Fievet, Jeffery A. Bailey, Feiko O. ter Kuile, Philippe Deloron, Stephanie M. Engel, Steve M. Taylor, Jonathan J. Juliano, Nicaise Tuikue Ndam, Steven R. Meshnick

“…Abstract Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the placenta. …”
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Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening by Ayleen Kosasih, Robert James, Nguyen Hoang Chau, Michelle M. Karman, Lydia Visita Panggalo, Lyndes Wini, Ngo Viet Thanh, Thomas Obadia, Ari Winasti Satyagraha, Puji Budi Setia Asih, Din Syafruddin, Walter R. J. Taylor, Ivo Mueller, Inge Sutanto, Harin Karunajeewa, Ayodhia Pitaloka Pasaribu, J. Kevin Baird

“…Primaquine for radical cure of <i>Plasmodium vivax</i> malaria poses a potentially life-threatening risk of haemolysis in G6PD-deficient patients. …”
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Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy. by Johannes Mischlinger, Rella Zoleko Manego, Ghyslain Mombo-Ngoma, Dorothea Ekoka Mbassi, Nina Hackbarth, Franck-Aurelien Ekoka Mbassi, Saskia Dede Davi, Ruth Kreuzmair, Luzia Veletzky, Jennifer Hergeth, Wilfrid Nzebe Ndoumba, Paul Pitzinger, Mirjam Groger, Pierre Blaise Matsiegui, Ayôla Akim Adegnika, Selidji Todagbe Agnandji, Bertrand Lell, Michael Ramharter

“…It was recently established that the odds for detecting Plasmodium spp. is higher in capillary (CAP) blood than in venous (VEN) blood. …”
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Perfil da malária em crianças atendidas no Hospital Pediátrico do Lobito by Leonel Mendes, Maria José, Mariele Luís

“…A espécie predominante foi o Plasmodium falciparum. Os casos de malária mantiveram-se estáveis em quase todos os meses do ano de 2019, porém, no ano de 2020 houve um aumento nos meses de setembro a dezembro. …”
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Análisis de concordancia de tres pruebas para el diagnóstico de malaria en la población sintomática de los municipios endémicos de Colombia by Liliana Jazmín Cortés, Ángela Patricia Guerra

“…Los resultados de este estudio respaldan el uso de las pruebas de diagnóstico rápido en Colombia, aunque se requiere un mejor entrenamiento del personal para diferenciar eficientemente las especies de Plasmodium.…”
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Structural and Biochemical Features of <i>Eimeria tenella</i> Dihydroorotate Dehydrogenase, a Potential Drug Target by Dan Sato, Endah Dwi Hartuti, Daniel Ken Inaoka, Takaya Sakura, Eri Amalia, Madoka Nagahama, Yukina Yoshioka, Naotoshi Tsuji, Tomoyoshi Nozaki, Kiyoshi Kita, Shigeharu Harada, Makoto Matsubayashi, Tomoo Shiba

“…Although, DHODHs from <i>E. tenella</i> (EtDHODH), <i>Plasmodium falciparum</i> (PfDHODH), and human (HsDHODH) show distinct sensitivities to classical DHODH inhibitors, in this paper, we identify ferulenol as a potent inhibitor of both EtDHODH and HsDHODH. …”
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Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation by Ella Larissa Ndoricyimpaye, Jacques Van Snick, Jean de Dieu Niyoyita, Philbert Kanimba, Jean Bosco Mbonimpa, Robert Rutayisire, Réverien Rutayisire, Vedaste Ndahindwa, Paméla Cheou, Jean Paul Coutelier, Nadine Rujeni

“…The proper control of Plasmodium infection requires a finely balanced immune response. …”
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Anopheles vector distribution and malaria transmission dynamics in Gbêkê region, central Côte d’Ivoire by Alphonsine A. Koffi, Soromane Camara, Ludovic P. Ahoua Alou, Welbeck A. Oumbouke, Rosine Z. Wolie, Innocent Z. Tia, Eleanore D. Sternberg, Florent H. A. Yapo, Fernand M. Koffi, Serge B. Assi, Jackie Cook, Matthew B. Thomas, Raphael N’Guessan

“…Anopheles gambiae was the predominant malaria vector responsible for 84.8% of Plasmodium parasite transmission in the area. An unprotected individual living in Gbêkê region received an average of 260 [222–298], 43.5 [35.8–51.29] and 3.02 [1.96–4] infected bites per year from An. gambiae, An. funestus and An. nili, respectively. …”
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Resting behaviour of malaria vectors in highland and lowland sites of western Kenya: Implication on malaria vector control measures. by Maxwell G Machani, Eric Ochomo, Fred Amimo, Jackline Kosgei, Stephen Munga, Guofa Zhou, Andrew K Githeko, Guiyun Yan, Yaw A Afrane

“…This study was designed to investigate the resting behavior, host preference and rates of Plasmodium falciparum infection in relation to insecticide resistance of malaria vectors in different ecologies of western Kenya.…”
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