Structural and immunological characterization of an epitope within the PAN motif of ectodomain I in Babesia bovis apical membrane antigen 1 for vaccine development by Amarin Rittipornlertrak, Boondarika Nambooppha, Anucha Muenthaisong, Veerasak Punyapornwithaya, Saruda Tiwananthagorn, Yang-Tsung Chung, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Nattawooti Sthitmatee

“…Apical membrane antigen-1 (AMA-1) is one of the leading candidates in the development of a vaccine against diseases caused by apicomplexan parasite species. In Plasmodium falciparum (P. falciparum) AMA-1 (PfAMA-1), several antibodies against epitopes in the plasminogen, apple, and nematode (PAN) motif of PfAMA-1 domain I significantly inhibited parasite growth. …”
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Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles by Sayuri Nakamae, Satoshi Miyagawa, Satoshi Miyagawa, Koki Ogawa, Mariko Kamiya, Mayumi Taniguchi, Akari Ono, Maho Kawaguchi, Awet Alem Teklemichael, Jiun-Yu Jian, Tamasa Araki, Yukimi Katagami, Hidefumi Mukai, Takeshi Annoura, Katsuyuki Yui, Kenji Hirayama, Shigeru Kawakami, Shusaku Mizukami, Shusaku Mizukami

“…To examine the protective efficacy, mice were intramuscularly immunized with two doses of circumsporozoite protein mRNA-LNPs at 3-week intervals and challenged with sporozoites of Plasmodium berghei ANKA. Sterile immunity was observed in some of the mice, and the other mice showed a delay in blood-stage development when compared with the control mice. mRNA-LNPs therefore induce memory CD8+ T cells that can protect against sporozoites during liver-stage malaria and may provide a basis for vaccines against the disease.…”
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Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled... by Steve M Taylor, Sarah Korwa, Angie Wu, Cynthia L Green, Betsy Freedman, Sheila Clapp, Joseph Kipkoech Kirui, Wendy P O'Meara, Festus M Njuguna

“…Among secondary outcomes, relative to the daily Proguanil group, the incidence of painful events was not significantly different in the monthly SP-AQ and DP groups, while monthly DP was associated with a reduced rate of dactylitis (IRR: 0.47; 95% CI: 0.23 to 0.96; p = 0.038). The incidence of Plasmodium falciparum infection relative to daily Proguanil was similar in the monthly SP-AQ group (IRR 0.46; 95% CI: 0.17 to 1.20; p = 0.13) but reduced with monthly DP (IRR 0.21; 95% CI: 0.08 to 0.56; p = 0.002). …”
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Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites by Fabien Sindikubwabo, Shuai Ding, Tahir Hussain, Philippe Ortet, Mohamed Barakat, Sebastian Baumgarten, Dominique Cannella, Andrés Palencia, Alexandre Bougdour, Lucid Belmudes, Yohann Couté, Isabelle Tardieux, Cyrille Y Botté, Artur Scherf, Mohamed-ali Hakimi

“…An unusual genome architecture characterizes the two related human parasitic pathogens Plasmodium falciparum and Toxoplasma gondii. A major fraction of the bulk parasite genome is packaged as transcriptionally permissive euchromatin with few loci embedded in silenced heterochromatin. …”
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Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil by Natália S. Ferreira, Jéssica Lorena S. Mathias, Sérgio Roberto L. Albuquerque, Anne Cristine G. Almeida, Ana C. Dantas, Fernanda C. Anselmo, Emerson S. Lima, Marcus Vinicius G. Lacerda, Paulo A. Nogueira, Rajendranath Ramasawmy, Marilda S. Gonçalves, José P. Moura Neto

“…Abstract Background Over a third of the world’s population is at risk of Plasmodium vivax-induced malaria. The unique aspect of the parasite’s biology and interactions with the human host make it harder to control and eliminate the disease. …”
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Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight a... by Alberto Tobón-Castaño, Martha Arismendi Solano, Luis Gonzalo Álvarez Sánchez, Silvia Blair Trujillo

“…Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax) e 1.322 sem malária. …”
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Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia by Joseph Okebe, Edgard Dabira, Fatou Jaiteh, Nuredin Mohammed, John Bradley, Ndey-Fatou Drammeh, Amadou Bah, Yoriko Masunaga, Jane Achan, Joan Muela Ribera, Shunmay Yeung, Julie Balen, Koen Peeters Grietens, Umberto D’Alessandro

“…Using a trans-disciplinary approach, a reactive treatment strategy to reduce Plasmodium falciparum prevalence in participating communities was co-developed and tested. …”
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The impact of gravidity, symptomatology and timing of infection on placental malaria by Erin E. Tran, Morgan L. Cheeks, Abel Kakuru, Mary K. Muhindo, Paul Natureeba, Miriam Nakalembe, John Ategeka, Patience Nayebare, Moses Kamya, Diane Havlir, Margaret E. Feeney, Grant Dorsey, Stephanie L. Gaw

“…While primigravidity has been reported as a risk factor for placental malaria, little is known regarding the relationship between gravidity, symptomatology and timing of Plasmodium falciparum infection and the development of placental malaria. …”
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Viral CNS infections in children from a malaria-endemic area of Malawi: a prospective cohort study by Macpherson Mallewa, PhD, Prof. Pam Vallely, PhD, Brian Faragher, PhD, Dan Banda, MSc, Paul Klapper, PhD, Mavuto Mukaka, MSc, Harriet Khofi, Cert Nur Midwif, Paul Pensulo, Dip Cli Med, Prof. Terrie Taylor, DO, Prof. Malcolm Molyneux, MD, Prof. Tom Solomon, PhD

“…Cerebral malaria, diagnosed when acute Plasmodium falciparum infection and coma are recorded with no other apparent reason, is one important cause. …”
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INCIDÊNCIA DOS CASOS DE MALÁRIA NA REGIÃO NORTE DO BRASIL NO PERÍODO DE 2017 A 2022 by Suzana Ribeiro de Melo Oliveira, Andrea Silvestre Lobão Costa

“…Em relação ao Estado do Tocantins foram notificados 37, 5 e 1 casos entre os anos de 2017 a 2019 e nenhum caso no período de 2020 a 2022, sendo o Plasmodium vivax o responsável por 85.68% dos casos. …”
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Nuevos inhibidores de metaloaminopeptidasas M1 microbianas obtenidos mediante síntesis química by Jorge González Bacerio, Yanira Méndez Gómez, Daniel García Rivera, Maday Alonso del Rivero Antigua, Marcos Gazarini Dutra, María de los Á. Chávez Planes, Adriana K. Carmona

“…En este sentido, las aminopeptidasas ePepN, de la bacteriaEscherichia coli, y PfA-M1, del parásito Plasmodium falciparum, constituyen nuevos blancos en estas enfermedades. …”
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Malaria smear positivity among Kenyan children peaks at intermediate temperatures as predicted by ecological models by Melisa M. Shah, Amy R. Krystosik, Bryson A. Ndenga, Francis M. Mutuku, Jamie M. Caldwell, Victoria Otuka, Philip K. Chebii, Priscillah W. Maina, Zainab Jembe, Charles Ronga, Donal Bisanzio, Assaf Anyamba, Richard Damoah, Kelsey Ripp, Prasanna Jagannathan, Erin A. Mordecai, A. Desiree LaBeaud

“…Abstract Background Ambient temperature is an important determinant of malaria transmission and suitability, affecting the life-cycle of the Plasmodium parasite and Anopheles vector. Early models predicted a thermal malaria transmission optimum of 31 °C, later revised to 25 °C using experimental data from mosquito and parasite biology. …”
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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya by Elly O. Munde, Winnie A. Okeyo, Evans Raballah, Samuel B. Anyona, Tom Were, John M. Ong’echa, Douglas J. Perkins, Collins Ouma

“…Abstract Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. …”
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From high to low malaria transmission in Zanzibar—challenges and opportunities to achieve elimination by A. Björkman, D. Shakely, A. S. Ali, U. Morris, H. Mkali, A. K. Abbas, A-W Al-Mafazy, K. A. Haji, J. Mcha, R. Omar, J. Cook, K. Elfving, M. Petzold, M. C. Sachs, B. Aydin-Schmidt, C. Drakeley, M. Msellem, A. Mårtensson

“…Results The interventions, with sustained high-community uptake, were temporally associated with a major malaria decline, most pronounced between 2004 and 2007 and followed by a sustained state of low transmission. In 2015, the Plasmodium falciparum community prevalence of 0.43% (95% CI 0.23–0.73) by microscopy or rapid diagnostic test represented 96% reduction compared with that in 2003. …”
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Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study. by Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Serge-Brice Assi, Jude D Bigoga, Felix Koukouikila-Koussounda, Nsengi Y Ntamabyaliro, Francine Ntoumi, Selidji T Agnandji, Mirjam Groger, Jangsik Shin, Isabelle Borghini-Fuhrer, Sarah Arbe-Barnes, Stephen J Allen, Peter G Kremsner, Robert Miller, Stephan Duparc, Michael Ramharter, CANTAM study group

“…Adverse events of any cause occurred in 20.8% (1,490/7,154) of patients, most frequently pyrexia (5.1% [366/7,154]) and vomiting (4.2% [303/7,154]). Adjusting for Plasmodium falciparum reinfection, clinical effectiveness at day 28 was 98.6% ([7,369/7,746] 95% confidence interval (CI) 98.3 to 98.9) in the per-protocol population. …”
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Prioritization of Microorganisms Isolated from the Indian Ocean Sponge <i>Scopalina hapalia</i> Based on Metabolomic Diversity and Biological Activity for the Discovery of Natural... by Alexandre Le Loarer, Rémy Marcellin-Gros, Laurent Dufossé, Jérôme Bignon, Michel Frédérich, Allison Ledoux, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Anne Gauvin-Bialecki, Mireille Fouillaud

“…The biological activities targeted in the study were cytotoxicity against the HCT-116 and MDA-MB-231 cell lines and antiplasmodial activity against <i>Plasmodium falciparum</i> 3D7. <i>Chaetomium globosum</i> SH-123 and <i>Salinispora arenicola</i> SH-78 strains actually showed remarkable cytotoxic and antiplasmodial activities, while <i>Micromonospora fluostatini</i> SH-82 demonstrated promising antiplasmodial effects. …”
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Unraveling the Complexity of the Rhomboid Serine Protease 4 Family of <i>Babesia bovis</i> Using Bioinformatics and Experimental Studies by Romina Gallenti, Hala E. Hussein, Heba F. Alzan, Carlos E. Suarez, Massaro Ueti, Sebastián Asurmendi, Daniel Benitez, Flabio R. Araujo, Peter Rolls, Kgomotso Sibeko-Matjila, Leonhard Schnittger, Mónica Florin-Christensen

“…In the apicomplexans <i>Toxoplasma gondii</i> and <i>Plasmodium falciparum</i>, rhomboid serine protease 4 (ROM4) fulfills an essential role in host cell invasion. …”
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Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens by Benjamin Amoani, Ben Gyan, Samuel Asamoah Sakyi, Emmanuel Kwasi Abu, Samuel Victor Nuvor, Precious Barnes, Tracy Sarkodie-Addo, Benjamin Ahenkorah, Christian Sewor, Duah Dwomoh, Michael Theisen, Michael Cappello, Michael D. Wilson, Bright Adu

“…The GMZ2 malaria vaccine candidate is a fusion protein of Plasmodium falciparum merozoite surface protein 3 (MSP3) and glutamate rich protein (GLURP R0). …”
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Disentangling the intersection of inequities with health and malaria exposure: key lessons from rural communities in Northern Borneo by Nurul Athirah Naserrudin, Pauline Yong Pau Lin, April Monroe, Sara Elizabeth Baumann, Bipin Adhikari, Anna Cohen Miller, Shigeharu Sato, Kimberly M. Fornace, Richard Culleton, Phaik Yeong Cheah, Rozita Hod, Mohammad Saffree Jeffree, Kamruddin Ahmed, Mohd Rohaizat Hassan

“…Abstract Background The increasing incidence of Plasmodium knowlesi malaria poses a significant challenge to efforts to eliminate malaria from Malaysia. …”
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The bionomics of the malaria vector Anopheles rufipes Gough, 1910 and its susceptibility to deltamethrin insecticide in North Cameroon by Parfait H. Awono-Ambene, Josiane Etang, Christophe Antonio-Nkondjio, Cyrille Ndo, Wolfgang Ekoko Eyisap, Michael C. Piameu, Elysée S. Mandeng, Ranaise L. Mbakop, Jean Claude Toto, Salomon Patchoke, Abraham P. Mnzava, Tessa B. Knox, Martin Donnelly, Etienne Fondjo, Jude D. Bigoga

“…Adult anophelines collected using outdoor clay pots, window exit traps and indoor spray catches were checked for feeding status, blood meal origin and Plasmodium circumsporozoite protein. The susceptibility of field-collected An. rufipes to deltamethrin was assessed using WHO standard procedures. …”
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