Molecular characterisation of beta thalassaemia in patients from Sabah, Malaysia by Teh, Lai Kuan

“…This may be related to the natural selection and protection for survival from severe malaria (Plasmodium Falciparum). Only type I of -α3.7 deletion was observed in this study population, indicating that the population has a single origin. …”
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Clinical outcome of malaria cases and malarial acute kidney injury in Hospital Serdang. A single center experience from 2007 till 2016 by Thevandran, Kalaiselvam, Premila, A. A., Lim, Christopher Thiam Seong, Goh, Bak Leong

“…Methods: All registered malaria cases with positive Plasmodium (P) sp from blood smears patients from hospital infection control database, were included in this study. …”
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Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody by Paola Favuzza, Elena Guffart, Marco Tamborrini, Bianca Scherer, Anita M Dreyer, Arne C Rufer, Johannes Erny, Joerg Hoernschemeyer, Ralf Thoma, Georg Schmid, Bernard Gsell, Araceli Lamelas, Joerg Benz, Catherine Joseph, Hugues Matile, Gerd Pluschke, Markus G Rudolph

“…Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. …”
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Aspectos sócio-econômicos dos indivíduos com malária importada na região metropolitana de São Paulo, Brasil: I - Caracterização da população e conhecimento sobre a doença Social an... by Maria José Chinelatto Pinheiro Alves, Luiz Carlos Barradas Barata, Rita de Cássia Barradas Barata, Maria do Carmo R. Rodrigues de Almeida, Eliana B. Gutierrez, Dalva Marli Valério Wanderley, José Carlos Rehder de Andrade

“…Of the population studied, 345 (61.0%) lived in the endemic area; 479 (84.6%) were males, 513 (90.7%) were between 15 and 55 years old and 307 (54.2%) presented positive plasmodium haemoscopia. The analysis by educational level indicated that 486 (85.9%) had primary or secondary education; 109 (19.3%) worked in mineral extraction; 74 (13.2%) were farmers, and 46 (8.1%) were related to terrestrial transportation activities. …”
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Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 4; peer review: 2 approved] by Victor Chaumeau, Bénédicte Fustec, Saw Nay Hsel, Céline Montazeau, Saw Naw Nyo, Selma Metaane, Sunisa Sawasdichai, Prapan Kittiphanakun, Phabele Phatharakokordbun, Nittipha Kwansomboon, Chiara Andolina, Dominique Cerqueira, Theeraphap Chareonviriyaphap, François H. Nosten, Vincent Corbel

“…Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. …”
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Target-Based 6-5 Fused Ring Heterocyclic Scaffolds Display Broad Antiparasitic Potency In Vitro by Darline Dize, Mariscal Brice Tchatat Tali, Cyrille Armel Njanpa Ngansop, Rodrigue Keumoe, Eugenie Aimée Madiesse Kemgne, Lauve Rachel Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Boniface Pone Kamdem, Katsura Hata, Fabrice Fekam Boyom

“…In this study, a series of three DHFR inhibitors (6-5 fused heterocyclic derivatives X, Y, and Z) and one K⁺ channel blocker (E4031) were screened for their inhibitory effects on <i>Leishmania donovani</i>, <i>Plasmodium falciparum</i>, and <i>Trypanosoma brucei</i>. …”
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Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection by Manuela C. Aguirre-Botero, Lawrence T. Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J. Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W. Bowyer, Fidel Zavala, Azza H. Idris, Joseph R. Francica, Robert A. Seder, Rogerio Amino

“…Summary: Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for preventing malaria infection. …”
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Cytokine profiles in adults with imported malaria by Charles de Roquetaillade, Cédric Laouenan, Jean-Paul Mira, Carine Roy, Marie Thuong, Élie Azoulay, Didier Gruson, Frédéric Jacobs, Juliette Chommeloux, François Raffi, Laurent Hocqueloux, Patrick Imbert, Vincent Jeantils, Jean-Luc Delassus, Sophie Matheron, Catherine Fitting, Jean-François Timsit, Fabrice Bruneel

“…This study reports cytokine profiles in adults with Plasmodium falciparum malaria included in the PALUREA prospective study conducted between 2006 and 2010. …”
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A eletropirexia no tratamento da neurossífilis by Iracy Doyle

“…If it is finally ascertained that short ware diathermy is of equal or superior efficiency to malariotherapy, there will be no further defense for the theory of the specific action of the Plasmodium; if this is true, as it would seem to be, we shall have to believe that therapeutic results depend on the fever factor alone. …”
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Estimated impact of RTS,S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: A modelling study. by Alexandra B Hogan, Peter Winskill, Azra C Ghani

“…<h4>Background</h4>The RTS,S/AS01 vaccine against Plasmodium falciparum malaria infection completed phase III trials in 2014 and demonstrated efficacy against clinical malaria of approximately 36% over 4 years for a 4-dose schedule in children aged 5-17 months. …”
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Estudos sôbre índice de siclemia by Ernani Martins da Silva

“…O parasitismo da hemátia pelo Plasmodium vivax não impede o fenômeno da siclisação. …”
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Entomological determinants of malaria transmission in Kayin state, Eastern Myanmar: A 24-month longitudinal study in four villages [version 3; peer review: 2 approved] by Victor Chaumeau, Bénédicte Fustec, Saw Nay Hsel, Céline Montazeau, Saw Naw Nyo, Selma Metaane, Sunisa Sawasdichai, Prapan Kittiphanakun, Phabele Phatharakokordbun, Nittipha Kwansomboon, Chiara Andolina, Dominique Cerqueira, Theeraphap Chareonviriyaphap, François H. Nosten, Vincent Corbel

“…Anopheles mosquitoes were identified by morphology, and molecular assays were used in order to discriminate between closely related sibling species of malaria vectors. Plasmodium infection rate was determined using quantitative real-time PCR. …”
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Sequestration and Cyanobacterial Diet Preferences in the Opisthobranch Molluscs Dolabrifera nicaraguana and Stylocheilus rickettsi by Kasey E. Clark, Kasey E. Clark, Angela Capper, Wei-Ting Liu, Amanda M. Fenner, Alejandro Almanza, Alejandro Almanza, Gina Della Togna, Liuris Herrera, Timothy Johns, Valerie J. Paul, Pieter C. Dorrestein, Todd L. Capson, Todd L. Capson, Marcy J. Balunas, Marcy J. Balunas, Marcy J. Balunas

“…Veraguamides M (1) and N (2) showed in vitro activity toward the malaria-causing parasite Plasmodium falciparum with GI50 values of 4.2 and 4.3 μM, respectively, and therapeutic windows of 7.0–8.0 (based on moderate cytotoxicities to mammalian Vero cells with GI50 values of 29.3 and 34.1 μM, respectively). …”
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Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria by Pamela Rosa-Gonçalves, Pamela Rosa-Gonçalves, Luciana Pereira de Sousa, Luciana Pereira de Sousa, Aline Barbosa Maia, Aline Barbosa Maia, Flávia Lima Ribeiro-Gomes, Flávia Lima Ribeiro-Gomes, Caroline Cristhiani Tavares de Lima Gress, Caroline Cristhiani Tavares de Lima Gress, Guilherme Loureiro Werneck, Diogo Onofre Souza, Roberto Farina Almeida, Cláudio Tadeu Daniel-Ribeiro, Cláudio Tadeu Daniel-Ribeiro

“…Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of non-severe rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. …”
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PD-1+ CD4 T cell immune response is mediated by HIF-1α/NFATc1 pathway after P. yoelii infection by Haixia Wei, Haixia Wei, Anqi Xie, Jiajie Li, Chao Fang, Lin Liu, Junmin Xing, Feihu Shi, Feng Mo, Dianhui Chen, Dianhui Chen, Hongyan Xie, Quan Yang, Xingfei Pan, Xiaoping Tang, Jun Huang, Jun Huang

“…The C57BL/6 mice were injected with Plasmodium yoelii (P. yoelii) in this study. Expressions of PD-1, activation markers, and cytokines were tested. …”
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CpG Oligodeoxinucleotides and Flagellin Modulate the Immune Response to Antigens Targeted to CD8α+ and CD8α− Conventional Dendritic Cell Subsets by Renan Antonialli, Fernando Bandeira Sulczewski, Kelly Nazaré da Silva Amorim, Bianca da Silva Almeida, Natália Soares Ferreira, Márcio Massao Yamamoto, Irene Silva Soares, Luís Carlos de Souza Ferreira, Daniela Santoro Rosa, Daniela Santoro Rosa, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin

“…A chimeric antigen containing the Plasmodium vivax 19 kDa portion of the merozoite surface protein (MSP119) linked to the Pan-allelic DR epitope was fused to each mAb. …”
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The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria by Sha Joe Zhu, Jason A Hendry, Jacob Almagro-Garcia, Richard D Pearson, Roberto Amato, Alistair Miles, Daniel J Weiss, Tim CD Lucas, Michele Nguyen, Peter W Gething, Dominic Kwiatkowski, Gil McVean, for the Pf3k Project

“…Individual malaria infections can carry multiple strains of Plasmodium falciparum with varying levels of relatedness. …”
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The association between gold mining and malaria in Guyana: a statistical inference and time-series analysis by Pablo M De Salazar, MD, Horace Cox, MD, Helen Imhoff, MD, Jean S F Alexandre, PhD, Caroline O Buckee, PhD

“…We aimed to investigate the association between the international gold price and Plasmodium falciparum malaria transmission in Guyana between 2007 and 2019. …”
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Identification of the PfK13 mutations R561H and P441L in the Democratic Republic of Congo by Gauthier Mesia Kahunu, Sarah Wellmann Thomsen, Louise Wellmann Thomsen, Hypolite Muhindo Mavoko, Patrick Mitashi Mulopo, Emma Filtenborg Hocke, Papy Mandoko Nkoli, Vito Baraka, Daniel T.R. Minja, Andria Mousa, Cally Roper, Destin Mbongi Moke, Dieudonné Mumba Ngoyi, Eric Mukomena Sompwe, Jean Jacques Muyembe Tanfum, Helle Hansson, Michael Alifrangis

“…Objectives: Partial artemisinin resistance, mediated by Plasmodium falciparum K13 (PfK13) mutations, has been confirmed in certain areas of East Africa that are historically associated with high-level antimalarial resistance. …”
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KARAKTERISASI SENYAWA PENGHAMBAT POLIMERISASI HEME DARI BATANG BROTOWALI (Tinospora crispa (L.)) (Characterization of Inhibitor Compounds in Heme Polymerization from Brotowali Stem... by Lilik Sulastri, . Syamsudin, Partomuan Simanjuntak

“…</em></p><p> </p><p><strong>ABSTRAK</strong></p><p>Malaria adalah penyakit yang disebabkan oleh parasit <em>Plasmodium falcifarum</em> dan ditularkan oleh nyamuk Anopheles betina. …”
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