A study of malaria vector surveillance as part of the Malaria Elimination Demonstration Project in Mandla, Madhya Pradesh by Ashok K. Mishra, Praveen K. Bharti, Anup Vishwakarma, Sekh Nisar, Harsh Rajvanshi, Ravendra K. Sharma, Kalyan B. Saha, Man Mohan Shukla, Himanshu Jayswar, Aparup Das, Harpreet Kaur, Suman L. Wattal, Altaf A. Lal

“…One An.culicifacies (sibling species C) was found positive for Plasmodium falciparum by PCR tests in the mosquitoes sampled from the test areas. …”
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Comparing the Infection Biology of Plasmodiophora brassicae in Clubroot Susceptible and Resistant Hosts and Non-hosts by Lijiang Liu, Lijiang Liu, Li Qin, Xiaohui Cheng, Yi Zhang, Li Xu, Fan Liu, Chaobo Tong, Junyan Huang, Shengyi Liu, Yangdou Wei

“…However, during the secondary infection phase, no secondary plasmodium was detected in the cortical cells of both resistant hosts in contrast to massive secondary plasmodia present in the cortex tissue of two susceptible hosts leading to root swelling at 15 dpi. …”
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Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi by Guilherme Curty Lechuga, Júlio Cesar Borges, Claudia Magalhães Calvet, Humberto Pinheiro de Araújo, Aline Araujo Zuma, Samara Braga do Nascimento, Maria Cristina Machado Motta, Alice Maria Rolim Bernardino, Mirian Claudia de Souza Pereira, Saulo Cabral Bourguignon

“…The potency of 1g in combination with heme was enhanced against epimastigotes and trypomastigotes, suggesting a similar mechanism of action that occurs in Plasmodium spp. The addition of hemin to the culture medium increased trypanocidal activity of analog 1g without changing the cytotoxicity of the host cell, reaching an IC50 of 11.7 μM for trypomastigotes. …”
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Transcriptional variation in Babesia gibsoni (Wuhan isolate) between in vivo and in vitro cultures in blood stage by Zhen Han, Yaxin Zheng, Yu Shi, Fangwei Chen, Chenglong Wu, Lingna Wang, Shiyu Lu, Dongfang Li, Xingai Guan, Lan He, Junlong Zhao

“…The development of in vitro culture technology has driven research progress in various kinds of omics studies, including transcriptomic analysis of Plasmodium spp. between in vitro and in vivo environments, which has prompted the observation of diagnostic antigens and vaccine development. …”
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An innovative three-layer strategy in response to a quartan malaria outbreak among forest goers in Hainan Island, China: a retrospective study by Yuchun Li, Yingjuan Huang, Renqiang Chen, Weizhen Huang, Huanzhi Xu, Rongshen Ye, Shaoling Huang, Ji Zhen, Xiaodan Wen, Guoyi Wang, Yong Liu, Haishan Li, Zaichun Zheng, Jian Wang, Guoshen Wang, Chong Chen, Wen Zeng, Feng Meng, Xiaoming Huang, Guangze Wang, Bing Yang, Yan Chen

“…Abstract Background An outbreak of Plasmodium malariae infection among forest goers in Sanya City of Hainan Island, China was reported in 2015. …”
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Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa by A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker, Kathryn Maitland

“…Results Of 3170 children in the FEAST trial, including 1719 children (57%) with Plasmodium falciparum malaria, 3008 (95%) had a baseline lactate measurement, 2127 (71%) had HL (lactate ≥ 2.5 mmol/L), and 1179 (39%) had severe HL (≥ 5 mmol/L). …”
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Kinetics of monocyte subpopulations during experimental cerebral malaria and its resolution in a model of late chloroquine treatment by Jade Royo, Aissata Camara, Aissata Camara, Benedicte Bertrand, Philippe Batigne, Agnes Coste, Bernard Pipy, Agnes Aubouy, the NeuroCM Group, Dissou Affolabi, Jules Alao, Daniel Ajzenberg, Linda Ayédadjou, Gwladys Bertin, Bibiane Biokou, Farid Boumédiène, Josselin Brisset, Michel Cot, Jean-Eudes Degbelo, Philippe Deloron, Ida Dossou-Dagba, Latifou Dramane, Jean François Faucher, Sandrine Houzé, Sayeh Jafari-Guemouri, Claire Kamaliddin, Elisée Kinkpé, Anaïs Labrunie, Yélé Ladipo, Thomas Lathiere, Achille Massougbodji, Audrey Mowendabeka, Jade Papin, Pierre-Marie Preux, Marie Raymondeau, Darius Sossou, Brigitte Techer, Bertin Vianou, Laurence Watier

“…C57BL/6 mice were infected with the Plasmodium berghei ANKA strain and treated or not with chloroquine (CQ) on the first day of the onset of neurological symptoms (day 6) for 4 days and followed until day 12 to mimic neuroinflammation and its resolution during experimental CM. …”
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Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl) by Thuy-Tien Thi Trinh, Su-Yeon Yun, Gum-Ju Bae, Kwonmo Moon, Hyelee Hong, Tae Hui Eum, Young-ah Kim, Soon-Ai Kim, Hyun Park, Hak Sung Kim, Seon-Ju Yeo

“…The selective index indicated that SKM13-2HCl showed the same effectiveness with SKM13 in Plasmodium falciparum in in-vitro. Even though, in vivo mouse study demonstrated that SKM13 (20 mg/kg) at single dose could not completely inhibit P. berghei growth in blood. …”
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TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ by Jiajie Li, Lin Liu, Junmin Xing, Dianhui Chen, Chao Fang, Feng Mo, Yumei Gong, Zhengrong Tan, Guikuan Liang, Wei Xiao, Shanni Tang, Haixia Wei, Shan Zhao, Hongyan Xie, Xingfei Pan, Xiaomao Yin, Jun Huang, Jun Huang, Jun Huang

“…Here, when mice were infected with rodent parasites, Plasmodium yoelii NSM, TLR7 expression in splenocytes was increased. …”
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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 by Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

“…Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito vectors, is safe in rats, and pharmacokinetic-pharmacodynamic modeling informs about a potential oral human dosing regimen.…”
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BIRC6 modifies risk of invasive bacterial infection in Kenyan children by James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams

“…Here, we utilise probabilistic diagnostic models to identify children with a high probability of invasive bacterial disease among critically unwell Kenyan children with Plasmodium falciparum parasitaemia. We construct a joint dataset including 1445 bacteraemia cases and 1143 severe malaria cases, and population controls, among critically unwell Kenyan children that have previously been genotyped for human genetic variation. …”
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Improving the efficiency of reactive case detection for malaria elimination in southern Zambia: a cross-sectional study by Fiona R. P. Bhondoekhan, Kelly M. Searle, Harry Hamapumbu, Mukuma Lubinda, Japhet Matoba, Michael Musonda, Ben Katowa, Timothy M. Shields, Tamaki Kobayashi, Douglas E. Norris, Frank C. Curriero, Jennifer C. Stevenson, Philip E. Thuma, William J. Moss, for the Southern and Central Africa International Centers of Excellence for Malaria Research

“…Methods Between January 12, 2015 and July 26, 2017, 4170 individuals residing in 158 index and 531 secondary households were enrolled and completed a baseline questionnaire in the catchment area of Macha Hospital in Choma District, Southern Province, Zambia. Plasmodium falciparum prevalence was measured using PfHRP2 RDTs and quantitative PCR (qPCR). …”
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Repeatability and reproducibility of a handheld quantitative G6PD diagnostic by Benedikt Ley, Ari Winasti Satyagraha, Mohammad Golam Kibria, Jillian Armstrong, Germana Bancone, Amy K. Bei, Greg Bizilj, Marcelo Brito, Xavier C. Ding, Gonzalo J. Domingo, Michael E. von Fricken, Gornpan Gornsawun, Brandon Lam, Didier Menard, Wuelton Monteiro, Stefano Ongarello, Sampa Pal, Lydia Visita Panggalo, Sunil Parikh, Daniel A. Pfeffer, Ric N. Price, Alessandra da Silva Orfano, Martina Wade, Mariusz Wojnarski, Kuntawunginn Worachet, Aqsa Yar, Mohammad Shafiul Alam, Rosalind E. Howes

“…<h4>Background</h4> The introduction of novel short course treatment regimens for the radical cure of Plasmodium vivax requires reliable point-of-care diagnosis that can identify glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. …”
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Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria by Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman

“…A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite. …”
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Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization by Giulia Manzoni, Rady Try, Jean Olivier Guintran, Céline Christiansen-Jucht, Elodie Jacoby, Siv Sovannaroth, Zaixing Zhang, Vilasack Banouvong, Matthew Scott Shortus, Rita Reyburn, Chitsavang Chanthavisouk, Nay Yi Yi Linn, Badri Thapa, San Kyawt Khine, Prayuth Sudathip, Deyer Gopinath, Nguyen Quang Thieu, Mya Sapal Ngon, Dai Tran Cong, Liu Hui, James Kelley, Neena Nee Kesar Valecha, Maria Dorina Bustos, Charlotte Rasmussen, Luciano Tuseo

“…From the perspective of the World Health Organization (WHO), this article considers the collaborative efforts in the GMS, to contain Plasmodium falciparum artemisinin partial resistance and multi-drug resistance and to advance malaria elimination. …”
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Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa by Shehu S. Awandu, Jaishree Raman, Takalani I. Makhanthisa, Philip Kruger, John Frean, Teun Bousema, Jandeli Niemand, Lyn-Marie Birkholtz

“…Abstract Background Primaquine (PQ) is recommended as an addition to standard malaria treatments in pre-elimination settings due to its pronounced activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for onward transmission to mosquitoes. …”
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Impact of Mothers’ Schistosomiasis Status During Gestation on Children’s IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses b... by Bartholomew N. Ondigo, Bartholomew N. Ondigo, Erick M. O. Muok, John K. Oguso, Sammy M. Njenga, Henry M. Kanyi, Eric M. Ndombi, Eric M. Ndombi, Jeffrey W. Priest, Nupur Kittur, William Evan Secor, Diana M. S. Karanja, Daniel G. Colley, Daniel G. Colley

“…To provide additional data to these discussions, we have enrolled 99 close-to-term pregnant women in western Kenya and determined their Schistosoma mansoni and Plasmodium falciparum infection status. At 2 years of age, when the initial immunization schedule was complete, we determined their children’s IgG antibody levels to tetanus toxoid, diphtheria toxoid, and measles nucleoprotein (N-protein) antigens using a multiplex assay. …”
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Seasonal Malaria Chemoprevention Therapy in Children Up To 9 Years of Age: Protocol for a Cluster-Randomized Trial Study by Mahamoudou Toure, Jeffrey G Shaffer, Daouda Sanogo, Soumba Keita, Moussa Keita, Fousseyni Kane, Bourama Traore, Djeneba Dabitao, Aissata Kone, Cheick Oumar Doumbia, Joseph Keating, Joshua Yukich, Helle H Hansson, Alyssa E Barry, Mahamadou Diakité, Michael Alifrangis, Seydou Doumbia

“…ObjectiveThe primary goal of the study is to compare 2 SMC regimens (SP-AQ and dihydroartemisinin-piperaquine [DHA-PQ]) in preventing uncomplicated Plasmodium falciparum malaria in children 3 months to 9 years old. …”
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Design, synthesis, and biological evaluation of multiple targeting antimalarials by Yiqing Yang, Tongke Tang, Xiaolu Li, Thomas Michel, Liqin Ling, Zhenghui Huang, Maruthi Mulaka, Yue Wu, Hongying Gao, Liguo Wang, Jing Zhou, Brigitte Meunier, Hangjun Ke, Lubin Jiang, Yu Rao

“…Here, we performed a structure-based drug design on mitochondrial respiratory chain of Plasmodium falciparum and identified an extremely potent molecule, RYL-581, which binds to multiple protein binding sites of P. falciparum simultaneously (allosteric site of type II NADH dehydrogenase, Qo and Qi sites of cytochrome bc1). …”
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Antiplasmodial, Trypanocidal, and Genotoxicity <i>In Vitro</i> Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives by Carlos Fernando Araujo-Lima, Rita de Cassia Castro Carvalho, Sandra Loureiro Rosario, Debora Inacio Leite, Anna Caroline Campos Aguiar, Lizandra Vitoria de Souza Santos, Julianna Siciliano de Araujo, Kelly Salomão, Carlos Roland Kaiser, Antoniana Ursine Krettli, Monica Macedo Bastos, Claudia Alessandra Fortes Aiub, Maria de Nazaré Correia Soeiro, Nubia Boechat, Israel Felzenszwalb

“…Methods: Considering the anti-inflammatory activity of phenylacetamides and the potential microbicidal action of statins against obligate intracellular parasites, the objective of this work was to synthesize eight new hybrid compounds of α,α-difluorophenylacetamides with the moiety of statins and assess their phenotypic activity against <i>in vitro</i> models of <i>Plasmodium falciparum</i> and <i>Trypanosoma cruzi</i> infection besides exploring their genotoxicity safety profile. …”
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