The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study by Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast, Andre J. van der Ven

“…Methods Sixteen healthy, malaria-naive CHMI participants were challenged with five Plasmodium falciparum-infected mosquitoes. Blood was sampled daily for XN-30, blood smear microscopy, and malaria qPCR. …”
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High opsonic phagocytosis activity and growth inhibition of merozoites are associated with RON4 antibody levels and protect against febrile malaria in Ghanaian children by Eric Kyei-Baafour, Eric Kyei-Baafour, Kwadwo Asamoah Kusi, Fareed K.N. Arthur, Regis W. Tiendrebeogo, Regis W. Tiendrebeogo, Eunice Owusu-Yeboa, Susheel K. Singh, Susheel K. Singh, Sarah Friedrich, Sarah Friedrich, Thomas A. Gerds, Daniel Dodoo, Michael Theisen, Michael Theisen, Bright Adu

“…Here, we assessed the roles of opsonic phagocytosis and antibody-mediated merozoite growth inhibition in Plasmodium falciparum (P. falciparum) infection outcomes in Ghanaian children.MethodsThe levels of merozoite opsonic phagocytosis, growth inhibition activities and six P. falciparum antigen-specific IgG of plasma samples from children (n=238, aged 0.5 to 13 years) were measured at baseline prior to the malaria seasons in southern Ghana. …”
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Antimalarial dihydrochalcone isolated from Artocarpus sericicarpus Jarret leaves and in silico investigation against falcipain-2 protein by Lidya Tumewu, Hilkatul Ilmi, Ratih Dewi Saputri, Defi Kartika Sari, Adita Ayu Permanasari, Hanifah Khairun Nisa, Saipul Maulana, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung, Che Puteh Osman, Nor Hadiani Ismail, Aty Widyawaruyanti, Achmad Fuad Hafid

“…The compound was tested for its antimalarial activity against Plasmodium falciparum and evaluated for cytotoxicity using several cell lines, including Huh7, HepG2, BHK-21, and Vero cells. …”
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Training-of-trainers program for community health workers involved in an innovative and community-based intervention against malaria among goldminers in the Guiana shield: a qualit... by Carlotta Carboni, Irene Jimeno Maroto, Muriel Galindo, Lorraine Plessis, Yann Lambert, Teddy Bardon, Stephen Vreden, Martha Suárez-Mutis, Jane Miller Bordalo, Maylis Douine, Alice Sanna

“…The intervention consists of the distribution of malaria self-management kits to goldminers and the presumptive treatment for individuals at risk of carrying Plasmodium vivax hypnozoites. The intervention is possible owing to community health workers (CHWs) who are previously trained to master all intervention procedures, including health education activities and goldmining training. …”
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3... by Esperanca Sevene, Anifa Vala, Salésio Macuacua, Kassoum Kayentao, Issaka Sagara, Halidou Tinto, Clara Menendez, Raquel González, Umberto d'Alessandro, Hamadoun Diakite, Moussa Djimde, Hypolite Mavoko Muhindo, Mireia Piqueras, Petra Mens, Henk Schallig, Japhet Kabalu Tshiongo, Maminata Traore, Berenger Kabore, Edgard Diniba Dabira, Annette Erhart, Mohamed Keita, Thomas PC Dorlo

“…The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. …”
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Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa by Luyi Zhao, Liang Pi, Yucheng Qin, Yuxin Lu, Weilin Zeng, Zheng Xiang, Pien Qin, Xi Chen, Cuiying Li, Yanmei Zhang, Siqi Wang, Yu Si, Gongchao Yang, Benjamin M. Rosenthal, Yaming Huang, Zhaoqing Yang

“…Keywords: Africa, Anti-malarial drug resistance, Sulfadoxine–pyrimethamine, Plasmodium falciparum…”
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To spray or target mosquitoes another way: focused entomological intelligence guides the implementation of indoor residual spraying in southern Mozambique by Celso Alafo, Helena Martí-Soler, Mara Máquina, Arlindo Malheia, Ayesha S. Aswat, Lizette L. Koekemoer, James Colborn, Neil F. Lobo, Allison Tatarsky, Yasmin A. Williams, Dulcisária Marrenjo, Nelson Cuamba, Regina Rabinovich, Pedro Alonso, Pedro Aide, Francisco Saúte, Krijn P. Paaijmans

“…Anopheles funestus sensu stricto (s.s.) was the major vector among its sibling species, and 1.9% were positive for Plasmodium falciparum infections. Anopheles arabiensis was the most abundant vector species within the An. gambiae complex, but none tested positive for P. falciparum infections. …”
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Acute oral toxicity and antimalarial studies of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-o... by David O Oladejo, Titilope M Dokunmu, Mercy E Tebamifor, Mercy B Omunagbe, Esther O Okafor, Emeka EJ Iweala

“…From our molecular docking study, the small molecule 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5 a]pyrido[4,3-d]pyrimidin-9(1H)-one (MCL) was identified to be capable of inhibiting an essential protein in Plasmodium falciparum (Apetala 2-invasion transcription factor) involved in red blood cell invasion. …”
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Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C... by Ho Ning Wong, Vivian Padín-Irizarry, Mariëtte E. van der Watt, Janette Reader, Wilna Liebenberg, Lubbe Wiesner, Peter Smith, Korina Eribez, Elizabeth A. Winzeler, Dennis E. Kyle, Lyn-Marie Birkholtz, Dina Coertzen, Richard K. Haynes

“…We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities in vitro against the asexual blood stages of Plasmodium falciparum (Pf). In particular, the compounds are active against late blood stage Pf gametocytes, and are strongly synergistic in combination with the redox active drug methylene blue. …”
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Expanded geographic distribution and host preference of Anopheles gibbinsi (Anopheles species 6) in northern Zambia by Mary E. Gebhardt, Rachel S. Krizek, Maureen Coetzee, Lizette L. Koekemoer, Yael Dahan-Moss, David Mbewe, James Sichivula Lupiya, Mbanga Muleba, Jennifer C. Stevenson, William J. Moss, Douglas E. Norris, For the Southern Africa International Centers of Excellence for Malaria Research

“…No specimens were positive for Plasmodium falciparum sporozoites. Animal pens and inland households > 3 km from Lake Mweru were both associated with increased An. gibbinsi abundance. …”
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In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized co... by Moussa Lingani, Léa Nadège Bonkian, Isidore Yerbanga, Adama Kazienga, Innocent Valéa, Hermann Sorgho, Jean Bosco Ouédraogo, Petronella Francisca Mens, Henk D. F. H. Schallig, Raffaella Ravinetto, Umberto d’Alessandro, Halidou Tinto

“…Methods In total, 440 children with uncomplicated Plasmodium falciparum malaria were randomized to receive either AL or ASAQ for 3 days and were followed up weekly for 42 days. …”
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The Effects of HIV Infection on the Immune Response to Malaria Among Pregnant Women in Kumba, Southwest Cameroon: Protocol for a Cross-sectional Study by Bekindaka Ngemani Obase, Zeukeng Francis, Esemu Livo Forgu, Awanakam Honore, Jude Daiga Bigoga, Dickson S Nsagha

“…The study aims to determine the prevalence of malaria infection, assess the occurrence of Plasmodium falciparum genetic diversity, and evaluate the antibody (immunoglobulin [Ig]G and IgM: apical membrane antigen-1 [AMA1], merozoite surface protein [MSP]1, MSP2, MSP3, and erythrocyte-binding antigen [EBA]175) and cytokine (interleukin [IL]-10, tumor necrosis factor alpha [TNF-α], and interferon gamma [IFNγ]) response to malaria infection among pregnant women with and without HIV in Kumba. …”
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Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate by Bárbara Fernandes, Bárbara Fernandes, Marcos Sousa, Marcos Sousa, Rute Castro, Anja Schäfer, Anja Schäfer, Julia Hauser, Julia Hauser, Kai Schulze, Mario Amacker, Mario Amacker, Marco Tamborrini, Marco Tamborrini, Gerd Pluschke, Gerd Pluschke, Paula M Alves, Paula M Alves, Sylvain Fleury, António Roldão, António Roldão

“…Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) has been identified as a promising blood-stage candidate antigen to include in a broadly cross-reactive malaria vaccine. …”
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Behavioural plasticity of Anopheles coluzzii and Anopheles arabiensis undermines LLIN community protective effect in a Sudanese-savannah village in Burkina Faso by Eleonora Perugini, Wamdaogo Moussa Guelbeogo, Maria Calzetta, Sara Manzi, Chiara Virgillito, Beniamino Caputo, Verena Pichler, Hilary Ranson, N’Fale Sagnon, Alessandra della Torre, Marco Pombi

“…Collected specimens were morphologically and molecularly identified and processed for Plasmodium detection and L1014F insecticide-resistance allele genotyping. …”
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A New Hope for CD56negCD16pos NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases by Catherine S. Forconi, Cliff I. Oduor, Cliff I. Oduor, Peter O. Oluoch, Peter O. Oluoch, John M. Ong'echa, Christian Münz, Jeffrey A. Bailey, Ann M. Moormann

“…Recently, using a strict flow cytometry gating strategy to exclude monocytes, we reported an accumulation of CD56negCD16pos NK cells in Plasmodium falciparum malaria-exposed children and pediatric cancer patients diagnosed with endemic Burkitt lymphoma (eBL). …”
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Cluster-randomized trial of monthly malaria prophylaxis versus focused screening and treatment: a study protocol to define malaria elimination strategies in Cambodia by Jessica Manning, Chanthap Lon, Michele Spring, Mariusz Wojnarski, Sok Somethy, Soklyda Chann, Panita Gosi, Kin Soveasna, Sabaithip Sriwichai, Worachet Kuntawunginn, Mark M Fukuda, Philip L Smith, Huy Rekol, Muth Sinoun, Mary So, Jessica Lin, Prom Satharath, David Saunders

“…The continued spread of multi-drug-resistant Plasmodium falciparum has led to calls for malaria elimination on the Thai-Cambodian border. …”
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Profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria: a retrospective study in China, 2014–2021 by Tao Zhang, Duoquan Wang, Yingjun Qian, Wei Ruan, Ying Liu, Jing Xia, Hui Yan, Yuan Sui, Shenning Lu, Xian Xu, Jingjing Jiang, Xiaofeng Lyu, Shuqi Wang, Shizhu Li, Weidong Li

“…In multivariate analysis, independent risk factors associated with delayed care-seeking include PLADs (Guangxi as reference), consultations in high-level facilities for the first medical visit, infections with non-Plasmodium falciparum species, and older age. However, PLADs (Guangxi as reference), the purpose of traveling (labour as reference), and infections with non-P. falciparum species increased the risk of delayed diagnosis. …”
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ANÁLISE DO PERFIL EPIDEMIOLÓGICO DOS CASOS DE MALÁRIA NO ESTADO DA BAHIA ENTRE OS ANOS DE 2013 E 2022 by Stéfany Lima Prado, Bruna de Jesus Prata, Geisy Menezes Nascimento, Gustavo Henrique de Santana Fontes, Ana Carla Ferreira Silva dos Santos, Leticia Maria de Araujo Ferreira, Izabela Oliveira Araujo

“…Introdução/Objetivo: A malária é uma doença febril infectoparasitária causada, pelos protozoários Plasmodium, principalmente P. falciparum, P. malariae, P. vivax e P. ovale. …”
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l-Lactic acid production from glucose and xylose with engineered strains of Saccharomyces cerevisiae: aeration and carbon source influence yields and productivities by Vera Novy, Bernd Brunner, Bernd Nidetzky

“…We have recently presented two xylose-to-lactic acid converting strains, IBB14LA1 and IBB14LA1_5, which have the l-lactic acid dehydrogenase from Plasmodium falciparum (pfLDH) integrated at the pdc1 (pyruvate decarboxylase) locus. …”
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The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analys... by Andria Mousa, Abdullah Al-Taiar, Nicholas M Anstey, Cyril Badaut, Bridget E Barber, Quique Bassat, Joseph D Challenger, Aubrey J Cunnington, Dibyadyuti Datta, Chris Drakeley, Azra C Ghani, Victor R Gordeuk, Matthew J Grigg, Pierre Hugo, Chandy C John, Alfredo Mayor, Florence Migot-Nabias, Robert O Opoka, Geoffrey Pasvol, Claire Rees, Hugh Reyburn, Eleanor M Riley, Binal N Shah, Antonio Sitoe, Colin J Sutherland, Philip E Thuma, Stefan A Unger, Firmine Viwami, Michael Walther, Christopher J M Whitty, Timothy William, Lucy C Okell

“…<h4>Methods and findings</h4>A search using Ovid MEDLINE and Embase was initially conducted to identify studies on severe Plasmodium falciparum malaria that included information on treatment delay, such as fever duration (inception to 22nd September 2017). …”
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