Distance matters: barriers to antenatal care and safe childbirth in a migrant population on the Thailand-Myanmar border from 2007 to 2015, a pregnancy cohort study by Eric Steinbrook, Myo Chit Min, Ladda Kajeechiwa, Jacher Wiladphaingern, Moo Kho Paw, Mu Paw Jay Pimanpanarak, Woranit Hiranloetthanyakit, Aung Myat Min, Nay Win Tun, Mary Ellen Gilder, François Nosten, Rose McGready, Daniel M. Parker

“…People with pregnancies complicated by miscarriage travelled 20% farther than those who did not have miscarriages (DR: 1.2; CI 1.1–1.3), and those with Plasmodium falciparum malaria in pregnancy travelled 60% farther than those without P. falciparum (DR: 1.6; CI: 1.6 – 1.8). …”
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Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes by Chiara Andolina, Wouter Graumans, Moussa Guelbeogo, Geert-Jan van Gemert, Jordache Ramijth, Soré Harouna, Zongo Soumanaba, Rianne Stoter, Marga Vegte-Bolmer, Martina Pangos, Photini Sinnis, Katharine Collins, Sarah G Staedke, Alfred B Tiono, Chris Drakeley, Kjerstin Lanke, Teun Bousema

“…It is currently unknown whether all Plasmodium falciparum-infected mosquitoes are equally infectious. …”
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Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya by Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier, Robert W. Snow, Kevin Marsh, Benjamin Tsofa, Norbert Peshu, Mainga Hamaluba, James A. Berkley, Charles R. J. Newton, John Fondo, Anisa Omar, Philip Bejon

“…Abstract Background Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. …”
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Increased Neutrophil Percentage and Neutrophil–T Cell Ratio Precedes Clinical Onset of Experimental Cerebral Malaria by Lucas Freire-Antunes, Uyla Ornellas-Garcia, Marcos Vinicius Rangel-Ferreira, Mônica Lucas Ribeiro-Almeida, Carina Heusner Gonçalves de Sousa, Leonardo José de Moura Carvalho, Cláudio Tadeu Daniel-Ribeiro, Flávia Lima Ribeiro-Gomes

“…This study investigated the dynamics of neutrophil and T cell responses in C57BL/6 and BALB/c mice infected with <i>Plasmodium berghei</i> ANKA, murine models of experimental cerebral malaria (ECM) and non-cerebral experimental malaria, respectively. …”
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Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives by Joyce E. Gutiérrez, Hegira Ramírez, Esteban Fernandez-Moreira, María E. Acosta, Michael R. Mijares, Juan Bautista De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdúch, Liesangerli Labrador-Fagúndez, Bruno G. Stella, Luis José Díaz-Pérez, Gustavo Benaim, Jaime E. Charris

“…A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between quinoline and several benzoyl groups, is synthesized and screened in vitro as an inhibitor of β-hematin formation and in vivo for its antimalarial activity against chloroquine-sensitive strains of <i>Plasmodium berghei</i> ANKA in this study. The compounds significantly reduced haeme crystallization, with IC₅₀ values < 10 µM. …”
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METEMOGLOBINEMIA APÓS USO DE PRIMAQUINA: RELATO DE CASO EM INDÍGENA COM COINFECÇÃO MALARIA E DENGUE by Marielle K.S. Lima, Thiago F. Toledo, Luis Felipe C. Florez, Rafael S. Mazza, Igor J. Souza, Victor C.A. Tonhá, Maiara C.F. Soares, Fellipe R. Pereira, Elza G.B. Pereira, Sérgio de Almeida Basano

“…Laboratoriais do serviço mostraram plaquetopenia de 35.000/mm3 e pesquisa de Plasmodium negativo. Aventada hipótese de associação com dengue, realizada prova do laço negativa, descartados sinais de sangramento espontâneo e realizado expansão volêmica. …”
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Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis by Andrea L. Conroy, Dibyadyuti Datta, Robert O. Opoka, Robert O. Opoka, Robert O. Opoka, Anthony Batte, Anthony Batte, Paul Bangirana, Paul Bangirana, Adnan Gopinadhan, Kagan A. Mellencamp, Ayse Akcan-Arikan, Ayse Akcan-Arikan, Richard Idro, Richard Idro, Richard Idro, Chandy C. John

“…Eligible children were infected with Plasmodium falciparum and had unexplained coma. Acute kidney injury (AKI) on admission was defined using the Kidney Disease: Improving Global Outcomes criteria. …”
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Molecular Detection and Characterization of Intestinal and Blood Parasites in Wild Chimpanzees (<i>Pan troglodytes verus</i>) in Senegal by Pamela C. Köster, Justinn Renelies-Hamilton, Laia Dotras, Manuel Llana, Celia Vinagre-Izquierdo, Petras Prakas, Donatas Sneideris, Alejandro Dashti, Begoña Bailo, Marta Lanza, Alejandra Jiménez-Mejías, Carlota Muñoz-García, Aly S. Muadica, David González-Barrio, José M. Rubio, Isabel Fuentes, Francisco Ponce-Gordo, Rafael Calero-Bernal, David Carmena

“…Blood protists including <i>Plasmodium malariae</i> (0.4%), <i>Trypanosoma brucei</i> (1.3%), and <i>Mansonella perstans</i> (9.8%) were also identified. …”
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Identification of vaccine targets in pathogens and design of a vaccine using computational approaches by Kamal Rawal, Robin Sinha, Bilal Ahmed Abbasi, Amit Chaudhary, Swarsat Kaushik Nath, Priya Kumari, P. Preeti, Devansh Saraf, Shachee Singh, Kartik Mishra, Pranjay Gupta, Astha Mishra, Trapti Sharma, Srijanee Gupta, Prashant Singh, Shriya Sood, Preeti Subramani, Aman Kumar Dubey, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi

“…The system incorporates reverse vaccinology and immuno-informatics tools to screen genomic and proteomic datasets of several pathogens such as Trypanosoma cruzi, Plasmodium falciparum, and Vibrio cholerae to identify potential vaccine candidates (PVC). …”
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DENGUE COM LESÃO RENAL AGUDA E MIOGLOBINÚRIA: RELATO DE CASO by Marielle K.S. Lima, Caroline N. Maia, Maiara C.F. Soares, Sergio A. Basano, Thiago F. Toledo, Luís F.C. Flórez, Rafael S. Mazza, Igor J. Souza, Victor C.A. Tonhá, Elza G.B. Pereira

“…Laboratoriais do serviço com Plaquetas 119.000 mm3, CPK 102062 U/L, DHL 21880, PCR 25 mg/L, TGO 42500 U/L, TGP 8400 U/L, Ureia 183 mg/dl, Creatinina 3.16 mg/dl, Fosfatase Alcalina 188 U/L, Gama GT 502 U/L, Proteína Totais Urina 480,79 mg/24h, Pesquisa de Plasmodium negativa, sem dismorfismo eritrocitário no exame sumário de urina. …”
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Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi by Wongani Nyangulu, Randy G. Mungwira, Titus H. Divala, Nginache Nampota-Nkomba, Osward M. Nyirenda, Andrea G. Buchwald, Jernelle Miller, Dominique E. Earland, Matthew Adams, Christopher V. Plowe, Terrie E. Taylor, Jane E. Mallewa, Joep J. van Oosterhout, Sunil Parikh, Matthew B. Laurens, Miriam K. Laufer, the TSCQ Study Team

“…After diagnosis of uncomplicated Plasmodium falciparum malaria, a therapeutic efficacy monitoring was conducted with PCR-correction according to WHO guidelines. …”
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From control to elimination: a spatial-temporal analysis of malaria along the China-Myanmar border by Fang Huang, Li Zhang, Jing-Bo Xue, Hong-Ning Zhou, Aung Thi, Jun Zhang, Shui-Sen Zhou, Zhi-Gui Xia, Xiao-Nong Zhou

“…The number of townships with an API between 0 and 1 increased to 15 in 2018, compared to only five in 2014, while still four townships had API > 10. Plasmodium vivax was the predominant species along the border. …”
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Biochemical Studies of Mitochondrial Malate: Quinone Oxidoreductase from <em>Toxoplasma gondii</em> by Rajib Acharjee, Keith K. Talaam, Endah D. Hartuti, Yuichi Matsuo, Takaya Sakura, Bundutidi M. Gloria, Shinya Hidano, Yasutoshi Kido, Mihoko Mori, Kazuro Shiomi, Masakazu Sekijima, Tomoyoshi Nozaki, Kousuke Umeda, Yoshifumi Nishikawa, Shinjiro Hamano, Kiyoshi Kita, Daniel K. Inaoka

“…Ferulenol, the only known MQO inhibitor, also inhibited TgMQO at IC₅₀ of 0.822 μM, and displayed different inhibition kinetics compared to <i>Plasmodium falciparum</i> MQO. Furthermore, our analysis indicated the presence of a third binding site for ferulenol that is distinct from the ubiquinone and malate sites.…”
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Malaria incidence and prevalence during the first year of life in Nanoro, Burkina Faso: a birth-cohort study by Hamtandi Magloire Natama, Eduard Rovira-Vallbona, M. Athanase Somé, Serge Henri Zango, Hermann Sorgho, Pieter Guetens, Maminata Coulibaly-Traoré, Innocent Valea, Petra F. Mens, Henk D. F. H. Schallig, Luc Kestens, Halidou Tinto, Anna Rosanas-Urgell

“…Clinical malaria episodes were determined by passive case detection at peripheral health centres while asymptomatic malaria infections were identified during  4 cross-sectional surveys at 3, 6, 9 and 12 months of age. Plasmodium falciparum infections were detected by rapid diagnostic test and/or light microscopy (LM) and quantitative PCR (qPCR). …”
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Advances and challenges in automated malaria diagnosis using digital microscopy imaging with artificial intelligence tools: A review by Carles Rubio Maturana, Carles Rubio Maturana, Allisson Dantas de Oliveira, Sergi Nadal, Besim Bilalli, Francesc Zarzuela Serrat, Mateu Espasa Soley, Mateu Espasa Soley, Elena Sulleiro Igual, Elena Sulleiro Igual, Elena Sulleiro Igual, Mercedes Bosch, Anna Veiga Lluch, Alberto Abelló, Daniel López-Codina, Tomàs Pumarola Suñé, Tomàs Pumarola Suñé, Elisa Sayrol Clols, Joan Joseph-Munné

“…Malaria is an infectious disease caused by parasites of the genus Plasmodium spp. It is transmitted to humans by the bite of an infected female Anopheles mosquito. …”
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Biting behaviour, spatio-temporal dynamics, and the insecticide resistance status of malaria vectors in different ecological zones in Ghana by Osei K. Akuoko, Shittu B. Dhikrullahi, Isaac A. Hinne, Abdul R. Mohammed, Christopher M. Owusu-Asenso, Sylvester Coleman, Samuel K. Dadzie, Rosina Kyerematen, Daniel A. Boakye, Michael D. Wilson, Yaw A. Afrane

“…Genotyping of insecticide-resistant markers was done using the TaqMan SNP genotyping probe-based assays. Detection of Plasmodium falciparum sporozoites was determined using PCR. …”
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A Review of Major Patents on Potential Malaria Vaccine Targets by Reysla Maria da Silveira Mariano, Ana Alice Maia Gonçalves, Diana Souza de Oliveira, Helen Silva Ribeiro, Diogo Fonseca Soares Pereira, Ingrid Soares Santos, Daniel Ferreira Lair, Augusto Ventura da Silva, Alexsandro Sobreira Galdino, Miguel Angel Chávez-Fumagalli, Denise da Silveira-Lemos, Walderez Ornelas Dutra, Rodolfo Cordeiro Giunchetti

“…After more than four decades of basic research and clinical trials, the World Health Organization (WHO) has recommended the pre-erythrocytic Plasmodium falciparum (RTS, S) malaria vaccine for widespread use among children living in malaria-endemic areas. …”
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First Description of Marinoquinoline Derivatives’ Activity against <i>Toxoplasma gondii</i> by Luiza Tamie Hirata Diethelm, Amanda Bruno da Silva Bellini Ramos, Giovanna Braga de Lorena, Bruna Inácio Trajano, Rafael Dias do Espírito Santo, Renata Priscila Barros de Menezes, Marcus Tullius Scotti, Fabio Antonio Colombo, Marcos José Marques, Carlos Roque Duarte Correia, Juliana Quero Reimão

“…The exploration of marine bacteria-derived natural products has led to marinoquinolines, which feature a pyrroloquinoline core and demonstrate in vitro and in vivo anti-<i>Plasmodium</i> activity. This study investigates the in vitro anti-<i>Toxoplasma gondii</i> potential of six marinoquinoline derivatives. …”
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Seroprevalence of SARS-CoV-2 antibodies among children and adolescents recruited in a malariometric survey in north-eastern Tanzania July 2021 by Eric Lyimo, Cyrielle Fougeroux, Anangisye Malabeja, Joyce Mbwana, Paul M. Hayuma, Edwin Liheluka, Louise Turner, Samwel Gesase, Thomas Lavstsen, John P. A. Lusingu, Daniel T. R. Minja, Christian W. Wang

“…Besides a younger population and potential pre-existing immunity to a SARS-CoV-2-like virus, it has been hypothesized that co-infection or recent history of Plasmodium falciparum malaria may be protective of COVID-19 severity and mortality. …”
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Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans by Marija Zaric, Arianna Marini, Carolyn M. Nielsen, Gaurav Gupta, David Mekhaiel, Thao P. Pham, Sean C. Elias, Iona J. Taylor, Hans de Graaf, Ruth O. Payne, Yuanyuan Li, Sarah E. Silk, Chris Williams, Adrian V. S. Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas

“…Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. …”
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