Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014–2015 by YuYen Chan, Diana Martin, Kimberly E. Mace, Samuel E. Jean, Gillian Stresman, Chris Drakeley, Michelle A. Chang, Jean F. Lemoine, Venkatachalam Udhayakumar, Patrick J. Lammie, Jeffrey W. Priest, Eric William Rogier

“…Filter paper blood samples (n = 4,438) were collected from participants in 117 locations and assayed for IgG antibodies on a multiplex bead assay containing 15 different antigens from 11 pathogens: Plasmodium falciparum, Toxoplasma gondii, lymphatic filariasis roundworms, Strongyloides stercoralis, chikungunya virus, dengue virus, Chlamydia trachomatis, Treponema pallidum, enterotoxigenic Escherichia coli, Entamoeba histolytica, and Cryptosporidium parvum.ResultsDifferent proportions of the Haiti study population were IgG seropositive to the different targets, with antigens from T. gondii, C. parvum, dengue virus, chikungunya virus, and C. trachomatis showing the highest rates of seroprevalence. …”
Get full text

The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians by Lek Dysoley, Saorin Kim, Sergio Lopes, Nimol Khim, Steven Bjorges, Samphornarann Top, Chea Huch, Huy Rekol, Nelli Westercamp, Mark M. Fukuda, Jimee Hwang, Arantxa Roca-Feltrer, Mavuto Mukaka, Didier Menard, Walter R. Taylor

“…Abstract Background The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body weight) in falciparum-infected patients to block malaria transmission and contribute to eliminating multidrug resistant Plasmodium falciparum from the Greater Mekong Sub region (GMS). …”
Get full text

Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite by Linyan Cheng, Yuan Tian, Yan Wang, Tingting Wang, Yinning Yao, Helin Yu, Xiaozi Zheng, Mimi Wu, Wei Zhao, Qianqian Hua, Xin Hu, Feng Tan

“…Intriguingly, autophagy-related protein 8 (Atg8), a highly conserved eukaryotic protein, can localize to the outermost membrane of the apicoplast and modulate its inheritance in both Toxoplasma and Plasmodium parasites. The Atg8-Atg3 interaction plays a key role in Atg8 lipidation and localization, and our previously work in Toxoplasma has suggested that the core Atg8-family interacting motif (AIM) in TgAtg3, 239FADI242, and the R27 residue of TgAtg8 contribute to TgAtg8-TgAtg3 interaction in vitro. …”
Get full text

The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control strategies in Malawi: a cluster-ran... by Robert S. McCann, Alinune N. Kabaghe, Paula Moraga, Steven Gowelo, Monicah M. Mburu, Tinashe Tizifa, Michael G. Chipeta, William Nkhono, Aurelio Di Pasquale, Nicolas Maire, Lucinda Manda-Taylor, Themba Mzilahowa, Henk van den Berg, Peter J. Diggle, Dianne J. Terlouw, Willem Takken, Michèle van Vugt, Kamija S. Phiri

“…Secondary outcomes included mosquito density, Plasmodium falciparum prevalence, and haemoglobin levels. …”
Get full text

Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia by Gisela Henriques, Koukeo Phommasone, Rupam Tripura, Thomas J. Peto, Shristi Raut, Coco Snethlage, Im Sambo, Nou Sanann, Chea Nguon, Bipin Adhikari, Tiengkham Pongvongsa, Mallika Imwong, Lorenz von Seidlein, Nicholas P. Day, Nicholas J. White, Arjen M. Dondorp, Paul Newton, Benedikt Ley, Mayfong Mayxay

“…Primaquine is the only licensed drug that effectively removes Plasmodium vivax hypnozoites from the human host and prevents relapse. …”
Get full text

Blockage of mechanosensitive Piezo1 channel alleviates the severity of experimental malaria-associated acute lung injury by Min Zhang, Qian Ru Wang, Xinpeng Hou, Qi Wang, Xiaoyan Yang, Tingting Zhou, Xiaobo Liu, Lirong Wu, Jie Wang, Xiaobao Jin, Zhenlong Liu, Bo Huang

“…Methods Here, we utilized a widely accepted murine model of MA-ALI using C57BL/6 mice with Plasmodium berghei ANKA infection and then added a Piezo1 inhibitor (GsMTx4) to the model. …”
Get full text

Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, d... by Alassane Dicko, Abdoulbaki I Diallo, Intimbeye Tembine, Yahia Dicko, Niawanlou Dara, Youssoufa Sidibe, Gaoussou Santara, Halimatou Diawara, Toumani Conaré, Abdoulaye Djimde, Daniel Chandramohan, Simon Cousens, Paul J Milligan, Diadier A Diallo, Ogobara K Doumbo, Brian Greenwood

“…A total of 672 episodes of clinical malaria defined as fever or a history of fever and the presence of at least 5,000 asexual forms of Plasmodium falciparum per microlitre (incidence rate of 1.90; 95% confidence interval [CI] 1.76-2.05 episodes per person year) were observed in the control arm versus 126 (incidence rate of 0.34; 95% CI 0.29-0.41 episodes per person year) in the intervention arm, indicating a protective effect (PE) of 82% (95% CI 78%-85%) (p<0.001) on the primary endpoint. …”
Get full text

Imported malaria cases in former endemic and non-malaria endemic areas in China: are there differences in case profile and time to response? by Shao-Sen Zhang, Jun Feng, Li Zhang, Xiang Ren, Elizabeth Geoffroy, Sylvie Manguin, Roger Frutos, Shui-Sen Zhou

“…Variables used in the comparative analysis between cases in former endemic and former non-endemic areas, included age, gender and occupation, destination of overseas travel, Plasmodium species and patient health outcome. Monthly aggregated data was used to compare seasonal and spatial characteristics. …”
Get full text

Identification and characterization of novel chemical scaffolds to overcome drug resistance in malaria by Tay, Donald Wen Jun

“…By comparison of pharmacokinetic properties in humans against their efficacy against Plasmodium falciparum, this allowed us to shortlist the two candidates which were documented to achieve doses in excess of their minimum inhibitory concentrations for at least 24hrs post administration in a single dose. …”
Get full text

Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, random... by Peto, TJ, Tripura, R, Callery, JJ, Lek, D, Nghia, HDT, Nguon, C, Thuong, NTH, van der Pluijm, RW, Dung, NTP, Sokha, M, Luong, VV, Long, LT, Sovann, Y, Duanguppama, J, Waithira, N, Hoglund, RM, Chotsiri, P, Chau, NH, Ruecker, A, Amaratunga, C, Dhorda, M, Miotto, O, Maude, RJ, Rekol, H, Chotivanich, K, Tarning, J, von Seidlein, L, Imwong, M, Mukaka, M, Day, NPJ, Hien, TT, White, NJ, Dondorp, AM

“…Eligible participants were male and female patients aged 2–65 years with uncomplicated <i>Plasmodium falciparum</i> malaria. Patients were randomly allocated (1:1 in blocks of eight to 12) to either artemether–lumefantrine alone (dosed according to WHO guidelines) or artemether–lumefantrine plus amodiaquine (10 mg base per kg/day), both given orally as six doses over 3 days. …”

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patie... by Abdulla, S, Adam, I, Adjei, G, Adjuik, M, Alemayehu, B, Allan, R, Arinaitwe, E, Ashley, E, Ba, MS, Barennes, H, Barnes, K, Bassat, Q, Baudin, E, Berens-Riha, N, Bjoerkman, A, Bompart, F, Bonnet, M, Borrmann, S, Bousema, T, Brasseur, P, Bukirwa, H, Checchi, F, Dahal, P, D'Alessandro, U, Desai, M, Dicko, A, Djimde, A, Dorsey, G, Doumbo, O, Drakeley, C, Duparc, S, Eshetu, T, Espie, E, Etard, J, Faiz, A, Falade, C, Fanello, C, Faucher, J, Faye, B, Faye, O, Filler, S, Flegg, J, Fofana, B, Fogg, C, Gadalla, N, Gaye, O, Genton, B, Gething, P, Gil, J, Gonzalez, R, Grandesso, F, Greenhouse, B, Greenwood, B, Grivoyannis, A, Guerin, P, Guthmann, J, Hamed, K, Hamour, S, Hay, S, Hodel, E, Humphreys, G, Hwang, J, Ibrahim, M, Jima, D, Jones, J, Jullien, V, Juma, E, Kachur, P, Kager, P, Kamugisha, E, Kamya, MR, Karema, C, Kayentao, K, Kiechel, J, Kironde, F, Kofoed, P, Kremsner, P, Krishna, S, Lameyre, V, Lell, B, Lima, A, Makanga, M, Malik, E, Marsh, K, Martensson, A, Massougbodji, A, Menan, H, Menard, D, Menendez, C, Mens, P, Meremikwu, M, Moreira, C, Nabasumba, C, Nambozi, M, Ndiaye, J, Ngasala, B, Nikiema, F, Nsanzabana, C, Ntoumi, F, Oguike, M, Ogutu, B, Olliaro, P, Omar, SA, Ouedraogo, J, Owusu-Agyei, S, Penali, L, Pene, M, Peshu, J, Piola, P, Plowe, C, Premji, Z, Price, R, Randrianarivelojosia, M, Rombo, L, Roper, C, Rosenthal, P, Sagara, I, Same-Ekobo, A, Sawa, P, Schallig, H, Schramm, B, Seck, A, Shekalaghe, SA, Sibley, C, Sinou, V, Sirima, S, Som, F, Sow, D, Staedke, S, Stepniewska, K, Sutherland, C, Swarthout, T, Sylla, K, Talisuna, A, Taylor, W, Temu, E, Thwing, J, Tine, R, Tinto, H, Tommasini, S, Toure, O, Ursing, J, Vaillant, M, Valentini, G, Van den Broek, I, Van Vugt, M, Ward, SA, Winstanley, P, Yavo, W, Yeka, A, Zolia, Y, Zongo, I, Based, W

“…Background: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. …”

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study by Ndila, C, Uyoga, S, Macharia, A, Nyutu, G, Peshu, N, Ojal, J, Shebe, M, Awuondo, K, Mturi, N, Tsofa, B, Sepúlveda, N, Clark, T, Band, G, Clarke, G, Rowlands, K, Hubbart, C, Jeffreys, A, Kariuki, S, Marsh, K, Mackinnon, M, Maitland, K, Kwiatkowski, D, Rockett, K, Williams, T, Malariagen Consortium

“…We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.We did a case-control study in Kilifi County, Kenya. …”

Mass drug administration for the acceleration of malaria elimination in a region of Myanmar with artemisinin-resistant falciparum malaria: a cluster-randomised trial by McLean, ARD, Indrasuta, C, Khant, ZS, Phyo, AK, Maung, SM, Heaton, J, Aung, H, Aung, Y, Soe, K, Swe, MMM, von Seidlein, L, Tun, NN, Tun, KM, Day, NPJ, Ashley, EA, Hlaing, T, Kyaw, TT, Dondorp, AM, Imwong, M, White, NJ, Smithuis, FM

“…<p><strong>Background:</strong> To contain multidrug-resistant Plasmodium falciparum, malaria elimination in the Greater Mekong subregion needs to be accelerated while current antimalarials remain effective. …”

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: Cross-sectional and case-control studies by Ngugi, A, Bottomley, C, Kleinschmidt, I, Wagner, R, Kakooza-Mwesige, A, Ae-Ngibise, K, Owusu-Agyei, S, Masanja, H, Kamuyu, G, Odhiambo, R, Chengo, E, Sander, J, Newton, C

“…Blood samples were taken from a randomly selected subgroup of 300 participants with epilepsy and 300 control individuals from each centre and were screened for antibodies to Toxocara canis, Toxoplasma gondii, Onchocerca volvulus, Plasmodium falciparum, Taenia solium, and HIV. We estimated odds ratios (ORs) with logistic regression, adjusted for age, sex, education, employment, and marital status. …”

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data by Adjuik, M, Allan, R, Anvikar, A, Ashley, E, Ba, MS, Barennes, H, Barnes, K, Bassat, Q, Baudin, E, Bjorkman, A, Bompart, F, Bonnet, M, Borrmann, S, Brasseur, P, Bukirwa, H, Checchi, F, Cot, M, Dahal, P, D'Alessandro, U, Deloron, P, Desai, M, Diap, G, Djimde, A, Dorsey, G, Doumbo, O, Espie, E, Etard, J, Fanello, C, Faucher, J, Faye, B, Flegg, J, Gaye, O, Gething, P, Gonzalez, R, Grandesso, F, Guerin, P, Guthmann, J, Hamour, S, Hasugian, A, Hay, S, Humphreys, G, Jullien, V, Juma, E, Kamya, MR, Karema, C, Kiechel, JR, Kremsner, P, Krishna, S, Lameyre, V, Ibrahim, L, Lee, S, Lell, B, Martensson, A, Massougbodji, A, Menan, H, Menard, D, Menendez, C, Meremikwu, M, Moreira, C, Nabasumba, C, Nambozi, M, Ndiaye, J, Nikiema, F, Nsanzabana, C, Ntoumi, F, Ogutu, B, Olliaro, P, Osorio, L, Ouedraogo, J, Penali, L, Pene, M, Pinoges, L, Piola, P, Price, R, Roper, C, Rosenthal, P, Rwagacondo, C, Same-Ekobo, A, Schramm, B, Seck, A, Sharma, B, Sibley, C, Sinou, V, Sirima, S, Smith, J, Smithuis, F, Some, F, Sow, D, Staedke, S, Stepniewska, K, Swarthout, T, Sylla, K, Talisuna, A, Tarning, J, Taylor, W, Temu, E, Thwing, J, Tjitra, E, Tine, R, Tinto, H, Vaillant, M, Valecha, N, Van den Broek, I, White, N, Yeka, A, Zongo, I, Resistance, W

“…Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. …”

Fern-synthesized nanoparticles in the fight against malaria: LC/MS analysis of Pteridium aquilinum leaf extract and biosynthesis of silver nanoparticles with high mosquitocidal and... by Panneerselvam, Chellasamy, Murugan, Kadarkarai, Roni, Mathath, Aziz, Al Thabiani, Suresh, Udaiyan, Rajaganesh, Rajapandian, Madhiyazhagan, Pari, Subramaniam, Jayapal, Dinesh, Devakumar, Nicoletti, Marcello, Higuchi, Akon, Alarfaj, Abdullah A., Munusamy, Murugan A., Kumar, Suresh, Desneux, Nicolas, Benelli, Giovanni

“…Malaria remains a major public health problem due to the emergence and spread of Plasmodium falciparum strains resistant to chloroquine. …”
Get full text

Fern-synthesized nanopeprintss in the fight against malaria: LC/MS analysis of Pteridium aquilinum leaf extract and biosynthesis of silver nanopeprintss with high mosquitocidal and... by Panneerselvam, Chellasamy, Murugan, Kadarkarai, Roni, Mathath, Aziz, Al Thabiani, Suresh, Udaiyan, Rajaganesh, Rajapandian, Madhiyazhagan, Pari, Subramaniam, Jayapal, Dinesh, Devakumar, Nicoletti, Marcello, Higuchi, Akon, Alarfaj, Abdullah A., Munusamy, Murugan A., Kumar, Suresh, Desneux, Nicolas, Benelli, Giovanni

“…Malaria remains a major public health problem due to the emergence and spread of Plasmodium falciparum strains resistant to chloroquine. …”
Get full text

The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial by Kamala Thriemer, Robert James Commons, Megha Rajasekhar, Tamiru Shibiru Degaga, Krisin Chand, Nguyen Hoang Chau, Ashenafi Assefa, Mohammad Nader Naddim, Ayodhia Pitaloka Pasaribu, Awab Ghulam Rahim, Inge Sutanto, Tran Tinh Hien, Asrat Hailu, Mohammad Anwar Hasanzai, Lenny L. Ekawati, Adugna Woyessa, Tedla Teferi, Naomi Waithira, Walter R. J. Taylor, Benedikt Ley, Arjen Dondorp, J. Kevin Baird, Nicholas J. White, Nicholas P. Day, Ric N. Price, Julie A. Simpson, Lorenz von Seidlein

“…Methods Data were derived from the IMPROV trial, a randomised, placebo-controlled double blinded trial of high dose primaquine to prevent Plasmodium vivax recurrence conducted in eight study sites in Afghanistan, Ethiopia, Indonesia and Vietnam. …”
Get full text

New strains of Japanese encephalitis virus circulating in Shanghai, China after a ten-year hiatus in local mosquito surveillance by Yuan Fang, Yi Zhang, Zheng-Bin Zhou, Shang Xia, Wen-Qi Shi, Jing-Bo Xue, Yuan-Yuan Li, Jia-Tong Wu

“…Alphaviruses, orthobunyaviruses, Plasmodium and filariasis were not found in this study. …”
Get full text

Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique by Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel González, Raquel González, M. Nelia Manaca, Chenjerai Jairoce, Miquel Vázquez-Santiago, Reyes Balcells, Reyes Balcells, Anifa Vala, María Rupérez, María Rupérez, Pau Cisteró, Laura Fuente-Soro, Laura Fuente-Soro, Marta Cova, Evelina Angov, Arsenio Nhacolo, Esperança Sevene, Esperança Sevene, John J. Aponte, John J. Aponte, Eusebio Macete, Ruth Aguilar, Alfredo Mayor, Alfredo Mayor, Clara Menéndez, Clara Menéndez, Carlota Dobaño, Carlota Dobaño, Gemma Moncunill, Gemma Moncunill

“…We analyzed the association of maternal HIV infection, Plasmodium falciparum exposure, maternal variables and pregnancy outcomes on cord antibody levels and transplacental transfer. …”
Get full text