Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study by Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cisteró, Henriques Mbeve, Anna Escoda, Judice Miguel, Elena Buetas, Ianthe de Jong, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Gemma Porras, Haily Chen, Kevin K. A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Beatriz Galatas, Eusébio Macete, Alfredo Mayor

“…Abstract Background Low-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minimal, suggesting an immune-independent effect on parasite densities. …”
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Prevalence of malaria-helminth co-infections among children living in a setting of high coverage of standard interventions for malaria and helminths: Two population-based studies i... by Muhammed O. Afolabi, Doudou Sow, Ibrahima Mbaye, Marie Pierre Diouf, Mor Absa Loum, Elhadji Babacar Fall, Amadou Seck, Isaac A. Manga, Cheikh Cissé, Baba Camara, Awa Diouf, Ndéye Aida Gaye, Aminata Colle Lo, Brian Greenwood, Jean Louis A. Ndiaye

“…BackgroundConcurrent infections of Plasmodium falciparum with Soil Transmitted Helminths (STH) and Schistosoma spp are still a major public health problem among children living in Sub-Saharan Africa. …”
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Effectiveness and safety of intermittent preventive treatment for malaria using either dihydroartemisinin-piperaquine or artesunate-amodiaquine in reducing malaria related morbidit... by Geofrey Makenga, Vito Baraka, Filbert Francis, Swabra Nakato, Samwel Gesase, George Mtove, Rashid Madebe, Edna Kyaruzi, Daniel T.R. Minja, John P.A. Lusingu, Jean-Pierre Van geertruyden

“…Thus, epidemiologically, school aged children act as a substantial reservoir for malaria transmission. Asymptomatic Plasmodium infections induce inflammation leading to iron deficiency anaemia. …”
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Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment by Amirah Hani Ramli, Puspanjali Swain, Muhammad Syafiq Akmal Mohd Fahmi, Faridah Abas, Sze Wei Leong, Bimo Ario Tejo, Khozirah Shaari, Amatul Hamizah Ali, Hani Kartini Agustar, Rusdam Awang, Yee Ling Ng, Yee Ling Lau, Mohammad Aidiel Md Razali, Siti Nurulhuda Mastuki, Norazlan Mohmad Misnan, Siti Munirah Mohd Faudzi, Cheol-Hee Kim

“…Here we report on a virtual screening of ∼300 diarylpentanoids and derivatives, in search of potential Plasmodium falciparum lactate dehydrogenase (PfLDH) inhibitors with acceptable drug-like properties. …”
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Uptake of intermittent preventive treatment of malaria in pregnancy and risk factors for maternal anaemia and low birthweight among HIV-negative mothers in Dschang, West region of... by Sabrina Lynda Simo Kamga, Innocent Mbulli Ali, Ghislain Romeo Ngangnang, Mehmet Can Ulucesme, Leonard T. D. Keptcheu, Eva Mai Keming, Valery-Pacome Kom Tchuenkam, Juluis Visnel Foyet, Münir Aktas, Michel Noubom, Vincent K. Payne

“…Nested PCR based on amplification of the Plasmodium 18S sRNA was carried out to detect submicroscopic infection. …”
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Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii by Cyrille Botté, Nadia Saïdani, Ricardo Mondragon, Mónica Mondragón, Giorgis Isaac, Ernest Mui, Rima McLeod, Jean-François Dubremetz, Henri Vial, Ruth Welti, Marie-France Cesbron-Delauw, Corinne Mercier, Eric Maréchal

“…DGLE was detected in other Apicomplexa (i.e., Neospora, Plasmodium, Babesia, and Cryptosporidium).…”
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Prevalence, probability, and outcomes of typhoidal/non-typhoidal Salmonella and malaria co-infection among febrile patients: a systematic review and meta-analysis by Polrat Wilairatana, Wanida Mala, Wiyada Kwanhian Klangbud, Kwuntida Uthaisar Kotepui, Pongruj Rattaprasert, Manas Kotepui

“…Additionally, the case fatality rate and mean difference of malarial parasitemia between typhoidal/NTS and malaria co-infection and Plasmodium monoinfection were also determined. The subgroup analyses of typhoidal/NTS, regions (Africa and Asia), countries, time (publication year), characteristics of participants, and diagnostic tests for identifying Salmonella spp. were also conducted. …”
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Vectorial capacity and TEP1 genotypes of Anopheles gambiae sensu lato mosquitoes on the Kenyan coast by Brian Bartilol, Donwilliams Omuoyo, Jonathan Karisa, Kelly Ominde, Charles Mbogo, Joseph Mwangangi, Marta Maia, Martin Kibet Rono

“…The thioester-containing protein 1 (TEP1) gene, which mediates the killing of Plasmodium falciparum in the mosquito midgut, has recently been identified as a promising target for gene drive systems. …”
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Effectiveness of the innovative 1,7-malaria reactive community-based testing and response (1, 7-mRCTR) approach on malaria burden reduction in Southeastern Tanzania by Yeromin P. Mlacha, Duoquan Wang, Prosper P. Chaki, Tegemeo Gavana, Zhengbin Zhou, Mihayo G. Michael, Rashid Khatib, Godlove Chila, Hajirani M. Msuya, Exavery Chaki, Christina Makungu, Kangming Lin, Ernest Tambo, Susan F. Rumisha, Sigsbert Mkude, Muhidin K. Mahende, Frank Chacky, Penelope Vounatsou, Marcel Tanner, Honorati Masanja, Maru Aregawi, Ellen Hertzmark, Ning Xiao, Salim Abdulla, Xiao-Nong Zhou

“…The 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) which is a locally-tailored approach for reporting febrile malaria cases in endemic villages was developed to stop transmission and Plasmodium life-cycle. The (1,7-mRCTR) utilizes existing health facility data and locally trained community health workers to conduct community-level testing and treatment. …”
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Molecular Investigation Confirms <i>Myotis</i> Genus Bats as Common Hosts of <i>Polychromophilus</i> in Brazil by Bruno da Silva Mathias, Guilherme Augusto Minozzo, Alexander Welker Biondo, Jaciara de Oliveira Jorge Costa, Herbert Sousa Soares, Arlei Marcili, Lilian de Oliveira Guimarães, Carolina Clares dos Anjos, Andrea Pires Dos Santos, Irina Nastassja Riediger, Alan Fecchio, Marina Galvão Bueno, João Batista Pinho, Karin Kirchgatter

“…<i>Plasmodium</i> spp. and some other blood parasites belonging to the order Haemosporida are the focus of many epidemiological studies worldwide. …”
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Large-scale field trial of attractive toxic sugar baits (ATSB) for the control of malaria vector mosquitoes in Mali, West Africa by Mohamad M. Traore, Amy Junnila, Sekou F. Traore, Seydou Doumbia, Edita E. Revay, Vasiliy D. Kravchenko, Yosef Schlein, Kristopher L. Arheart, Petrányi Gergely, Rui-De Xue, Axel Hausmann, Robert Beck, Alex Prozorov, Rabiatou A. Diarra, Aboubakr S. Kone, Silas Majambere, John Bradley, John Vontas, John C. Beier, Günter C. Müller

“…Female samples of the catch were tested for age by examination of the ovarioles in dissected ovaries and identification of Plasmodium falciparum sporozoite infection by ELISA. …”
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Apart From Rhoptries, Identification of Toxoplasma gondii's O-GlcNAcylated Proteins Reinforces the Universality of the O-GlcNAcome by Moyira Osny Aquino-Gil, Moyira Osny Aquino-Gil, Moyira Osny Aquino-Gil, Mattis Kupferschmid, Hosam Shams-Eldin, Jörg Schmidt, Nao Yamakawa, Marlène Mortuaire, Frédéric Krzewinski, Stéphan Hardivillé, Edgar Zenteno, Christian Rolando, Fabrice Bray, Eduardo Pérez Campos, Eduardo Pérez Campos, Jean-François Dubremetz, Yobana Perez-Cervera, Yobana Perez-Cervera, Ralph T. Schwarz, Ralph T. Schwarz, Tony Lefebvre

“…A form of OGT was predicted for Toxoplasma and recently we were the first to show evidence of O-GlcNAcylation in the apicomplexans Toxoplasma gondii and Plasmodium falciparum. Numerous studies have explored the O-GlcNAcome in a wide variety of biological models but very few focus on protists. …”
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Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and tr... by Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K. Singh, James G. Beeson, Kevin K. A. Tetteh, Immo Kleinschmidt, Umberto D’Alessandro, Chris Drakeley

“…Antigen-specific antibody responses to eight Plasmodium falciparum (P. falciparum) antigens—Etramp5.Ag1, GEXP18, HSP40.Ag1, Rh2.2030, EBA175 RIII-V, PfMSP119, PfAMA1, and PfGLURP.R2—were quantified using a multiplexed bead-based assay. …”
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HEMÓLISE INDUZIDA POR ARTESUNATO USADO PARA TRATAMENTO DE MALÁRIA GRAVE: RELATO DE CASO by Ana Carolina de O. Mota, Frederico Martins Oliveira, Ana Paula F.B. dos Santos, Andrey Biff Sarris, Matheus D.G. Rocha, Gilberto Gambero Gaspar, Cinara Silva Feliciano, Benedito A. Lopes da Fonseca

“…Introdução: A espécie Plasmodium falciparum é responsável por 90% dos casos de malária grave. …”
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Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria by Fernanda de Moura Alves, Jessica Correa Bezerra Bellei, Camila de Souza Barbosa, Caíque Lopes Duarte, Amanda Luisa da Fonseca, Ana Claudia de Souza Pinto, Felipe Oliveira Raimundo, Bárbara Albuquerque Carpinter, Ari Sérgio de Oliveira Lemos, Elaine Soares Coimbra, Alex Gutterres Taranto, Vinícius Novaes Rocha, Fernando de Pilla Varotti, Gustavo Henrique Ribeiro Viana, Kézia K. G. Scopel

“…The most severe form of infection is caused by <i>Plasmodium falciparum</i>, which can lead to development of cerebral malaria (CM) and is responsible for deaths and significant neurocognitive sequelae throughout life. …”
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Prevalence and risk factors associated with malaria infection in children under two years of age in southern Togo prior to perennial malaria chemoprevention implementation by Shino Arikawa, Martin Kouame Tchankoni, Fifonsi A. Gbeasor-Komlanvi, Somiabalo P. Atekpe, Tinah Atcha-Oubou, Antía Figueroa-Romero, Augustin E. Fombah, Francisco Saute, Mohamed Samai, Clara Menendez, Raquel Gonzalez, Valérie Briand, Didier K. Ekouevi, the MULTIPLY consortium

“…A three-stage random sampling method was used to select study participants aged 10–23 months whose caretakers gave informed consent. The prevalence of Plasmodium infection, defined as a positive rapid diagnostic test (RDT), was estimated with 95% confidence interval (CI). …”
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The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study by Silvia N Kariuki, Alexander W Macharia, Johnstone Makale, Wilfred Nyamu, Stephen L Hoffman, Melissa C Kapulu, Philip Bejon, Julian C Rayner, Thomas N Williams, On behalf of for the CHMI-SIKA Study Team

“…Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. …”
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Babesia microti Infection Inhibits Melanoma Growth by Activating Macrophages in Mice by Xiang Shu, Xiang Shu, Zheng Nie, Zheng Nie, Wanxin Luo, Wanxin Luo, Yaxin Zheng, Yaxin Zheng, Zhen Han, Zhen Han, Hongyan Zhang, Hongyan Zhang, Yingjun Xia, Yingjun Xia, Han Deng, Han Deng, Fangjie Li, Fangjie Li, Sen Wang, Sen Wang, Junlong Zhao, Junlong Zhao, Lan He, Lan He

“…Infections caused by protozoa, including Plasmodium yoelii and Toxoplasma gondii, are shown to inhibit tumor development by activating immune responses. …”
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Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial by Hans de Graaf, Ruth O. Payne, Iona Taylor, Kazutoyo Miura, Carol A. Long, Sean C. Elias, Marija Zaric, Angela M. Minassian, Sarah E. Silk, Lee Li, Ian D. Poulton, Megan Baker, Simon J. Draper, Diane Gbesemete, Nathan J. Brendish, Filipa Martins, Arianna Marini, David Mekhaiel, Nick J. Edwards, Rachel Roberts, Johan Vekemans, Sarah Moyle, Saul N. Faust, Eleanor Berrie, Alison M. Lawrie, Fergal Hill, Adrian V. S. Hill, Sumi Biswas

“…BackgroundTransmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria. The Plasmodium falciparum Pfs25 protein (Pfs25) is the most clinically advanced candidate sexual-stage antigen. …”
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B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens by Theresa Bock, Moritz Bewarder, Onur Cetin, Natalie Fadle, Evi Regitz, Eva C. Schwarz, Jana Held, Sophie Roth, Stefan Lohse, Thorsten Pfuhl, Rabea Wagener, Sigrun Smola, Sören L. Becker, Rainer Maria Bohle, Lorenz Trümper, Reiner Siebert, Martin‐Leo Hansmann, Michael Pfreundschuh, Hans G. Drexler, Markus Hoth, Boris Kubuschok, Klaus Roemer, Klaus‐Dieter Preuss, Sylvia Hartmann, Lorenz Thurner

“…To explore this hypothesis, BCRs of BL cell lines and cases were screened for reactivities against a panel of bacterial lysates, lysates of Plasmodium falciparum, a custom‐made virome array and against self‐antigens, including post‐translationally modified antigens. …”
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