Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro by Sen Wang, Sen Wang, Muxiao Li, Muxiao Li, Xiaoying Luo, Xiaoying Luo, Long Yu, Long Yu, Zheng Nie, Zheng Nie, Qin Liu, Qin Liu, Xiaomeng An, Xiaomeng An, Yangsiqi Ao, Yangsiqi Ao, Qin Liu, Jiaxu Chen, Yu Tian, Junlong Zhao, Junlong Zhao, Junlong Zhao, Lan He, Lan He, Lan He

“…The methylerythritol 4-phosphate (MEP) pathway, a unique pathway in apicomplexan parasites, was shown to play a crucial function in the growth of Plasmodium falciparum. In the MEP pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is a rate-limiting enzyme and fosmidomycin (FSM) is a reported inhibitor for this enzyme. …”
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LINFOHISTIOCITOSE HEMOFAGOCÍTICA SECUNDÁRIA A LEISHMANIOSE VISCERAL: RELATO DE CASO EM PEDIATRIA by EO Braga, ACA Mendes, JBB Macedo, MEFD Santos, NT Carmo, RS Guerra, RQS Póvoas, TCC Fonseca

“…Em sua forma secundária, a infecção é o gatilho mais frequente, destacando-se o vírus Epstein-Barr, a Leishmania sp. e o Plasmodium. Na Bahia, a Leishmaniose visceral é uma doença endêmica, sendo um diagnóstico diferencial importante nos casos de febre, hepatoesplenomegalia, anemia e imunossupressão. …”
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Insecticide resistance of Anopheles sinensis after elimination of malaria in Henan Province, China by Zhi-quan He, Ya-bo Hu, Dan Wang, Yu-ting Liu, Cheng-yun Yang, Dan Qian, Rui-min Zhou, De-ling Lu, Su-hua Li, Ying Liu, Hong-wei Zhang

“…Abstract Background Historically, malaria due to Plasmodium vivax has been epidemic in Henan Province, China, with Anopheles sinensis as the main vector. …”
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A single Haemoproteus plataleae haplotype is widespread in white ibis (Eudocimus albus) from urban and rural sites in southern Florida by Michael J. Yabsley, Sarah M. Coker, Catharine N. Welch, Kayla B. Garrett, Maureen Murray, Ryan Grunert, Julia S. Seixas, Whitney M. Kistler, Shannon E. Curry, Henry C. Adams, Charlie S. Nakatsu, Liandrie Swanepoel, Seth T. Wyckoff, Troy M. Koser, Elizabeth Kurimo-Beechuk, Ellen Haynes, Sonia M. Hernandez

“…Sequences of 302 positives revealed a single haplotype of Haemoproteus (EUDRUB01), which was previously reported from white ibis in South Florida and captive scarlet ibis (E. ruber) in Brazil. No Plasmodium or Leucocytozoon infections were detected. …”
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Mapping malaria seasonality in Madagascar using health facility data by Michele Nguyen, Rosalind E. Howes, Tim C.D. Lucas, Katherine E. Battle, Ewan Cameron, Harry S. Gibson, Jennifer Rozier, Suzanne Keddie, Emma Collins, Rohan Arambepola, Su Yun Kang, Chantal Hendriks, Anita Nandi, Susan F. Rumisha, Samir Bhatt, Sedera A. Mioramalala, Mauricette Andriamananjara Nambinisoa, Fanjasoa Rakotomanana, Peter W. Gething, Daniel J. Weiss

“…Abstract Background Many malaria-endemic areas experience seasonal fluctuations in case incidence as Anopheles mosquito and Plasmodium parasite life cycles respond to changing environmental conditions. …”
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Health care provider practices in diagnosis and treatment of malaria in rural communities in Kisumu County, Kenya by Wilfred Ouma Otambo, Julius O. Olumeh, Kevin O. Ochwedo, Edwin O. Magomere, Isaiah Debrah, Collins Ouma, Patrick Onyango, Harrysone Atieli, Wolfgang R. Mukabana, Chloe Wang, Ming-Chieh Lee, Andrew K. Githeko, Guofa Zhou, John Githure, James Kazura, Guiyun Yan

“…The overall positivity rate for Plasmodium falciparum was 28% (257/936). The odds of slide positivity was higher in public hospitals, 30% (186/624, OR:1.44, 95% CI = 1.05–1.98, p < 0.05) than the private hospital 23% (71/312, OR:0.69, 95% CI = 0.51–0.95, p < 0.05). …”
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Hypothesis-free detection of genome-changing events in pedigree sequencing by Garimella, K

“…</p> <p>We applied our caller to real datasets: 115 progeny across four previously analyzed experimental crosses of Plasmodium falciparum. We demonstrate our ability to access subtelomeric compartments of the genome, regions harboring antigenic genes under tremendous selective pressure, thus highly divergent between geographically distinct isolates and routinely masked and ignored in reference-based analyses. …”

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data by Anstey, N, Price, R, Davis, T, Karunajeewa, H, Mueller, I, Karunajeewa, H, D'Alessandro, U, Massougbodji, A, Nikiema, F, Ouedraogo, J, Tinto, H, Zongo, I, Ouedraogo, J, Tinto, H, Same-Ekobo, A, Kone, M, Menan, H, Toure, A, Yavo, W, Yavo, W, Kofoed, P, Alemayehu, B, Jima, D, Baudin, E, Espie, E, Nabasumba, C, Pinoges, L, Schramm, B, Cot, M, Deloron, P, Faucher, J, Cot, M, Deloron, P, Faucher, J, Faucher, J, Guthmann, J, Lell, B, Borrmann, S, Lell, B, Adjei, G, Kofoed, P, Ursing, J, Tjitra, E, Borrmann, S, Marsh, K, Peshu, J, Juma, E, Ogutu, B, Omar, SA, Sawa, P, Talisuna, A, Talisuna, A, Khanthavong, M, Mayxay, M, Newton, P, Mayxay, M, Piola, P, Djimde, A, Doumbo, O, Fofana, B, Sagara, I, Bassat, Q, Gonzalez, R, Menendez, C, Smithuis, F, Smithuis, F, Bousema, T, Kager, P, Mens, P, Mens, P, Schallig, H, Van den Broek, I, Van Vugt, M, Ibrahim, M, Falade, C, Meremikwu, M, Meremikwu, M, Gil, J, Karema, C, Ba, MS, Faye, B, Faye, O, Gaye, O, Ndiaye, J, Pene, M, Sow, D, Sylla, K, Tine, R, Penali, L, Barnes, K, Workman, L, Barnes, K, Workman, L, Bassat, Q, Gonzalez, R, Menendez, C, Mueller, I, Lima, A, Adam, I, Gadalla, N, Malik, E, Bjorkman, A, Gil, J, Martensson, A, Ngasala, B, Ursing, J, Rombo, L, Rombo, L, Rombo, L, Aliu, P, Duparc, S, Filler, S, Genton, B, Genton, B, Hodel, E, Olliaro, P, Abdulla, S, Kamugisha, E, Ngasala, B, Premji, Z, Shekalaghe, SA, Shekalaghe, SA, Ashley, E, Carrara, V, McGready, R, Nosten, F, Ashley, E, Faiz, A, Lee, S, White, N, Carrara, V, Dondorp, A, Smith, J, D'Alessandro, U, Tarning, J, Achan, J, Bukirwa, H, Yeka, A, Arinaitwe, E, Staedke, S, Kamya, MR, Kironde, F, Nabasumba, C, Bousema, T, Drakeley, C, Gadalla, N, Oguike, M, Sutherland, C, Checchi, F, Dahal, P, Flegg, J, Guerin, P, Moreira, C, Newton, P, Nsanzabana, C, Price, R, Sibley, C, Stepniewska, K, Tarning, J, Dahal, P, Dondorp, A, Flegg, J, Guerin, P, Lee, S, Marsh, K, McGready, R, Moreira, C, Newton, P, Nosten, F, Nsanzabana, C, Olliaro, P, Price, R, Tarning, J, White, N, Gething, P, Hay, S, Greenwood, B, Hodel, E, Ward, SA, Staedke, S, Van den Broek, I, Winstanley, P, Dorsey, G, Greenhouse, B, Rosenthal, P, Gadalla, N, Gil, J, Grivoyannis, A, Hamed, K, Hwang, J, Kachur, P, Hwang, J, Sibley, C, Nambozi, M, Resistance, W

“…The primary endpoint was the PCR-adjusted risk of Plasmodium falciparum recrudescence by day 28. Secondary endpoints consisted of the PCR-adjusted risk of P falciparum recurrence by day 42, PCR-unadjusted risk of P falciparum recurrence by day 42, early parasite clearance, and gametocyte carriage. …”

Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis by Pfeffer, DA, Ley, B, Howes, RE, Adu, P, Alam, MS, Bansil, P, Boum, Y, Brito, M, Charoenkwan, P, Clements, A, Cui, L, Deng, Z, Egesie, OJ, Espino, FE, von Fricken, ME, Hamid, MMA, He, Y, Henriques, G, Khan, WA, Khim, N, Kim, S, Lacerda, M, Lon, C, Mekuria, AH, Menard, D, Monteiro, W, Nosten, F, Oo, NN, Pal, S, Palasuwan, D, Parikh, S, Pitaloka Pasaribu, A, Poespoprodjo, JR, Price, DJ, Roca-Feltrer, A, Roh, ME, Saunders, DL, Spring, MD, Sutanto, I, Ley-Thriemer, K, Weppelmann, TA, von Seidlein, L, Satyagraha, AW, Bancone, G, Domingo, GJ, Price, RN

“…<p><strong>Background:</strong><br /> The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. …”

Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of <em>Antrocaryon klaineanum</em> Pierre (Anacardiaceae) by Gabrielle Ange Amang à Ngnoung, Lazare S. Sidjui, Peron B. Leutcha, Yves O. Nganso Ditchou, Lauve R. Y. Tchokouaha, Gaëtan Herbette, Beatrice Baghdikian, Theodora K. Kowa, Desire Soh, Raoul Kemzeu, Madan Poka, Patrick H. Demana, Xavier Siwe Noundou, Alembert T. Tchinda, Fabrice Fekam Boyom, Alain M. Lannang, Barthélemy Nyassé

“…</i> The methanol crude extract (<b>AK-MeOH</b>), the <i>n-</i>hexane fraction (<b>AK-Hex</b>), the dichloromethane fraction (<b>AK-DCM</b>), the ethyl acetate fraction (<b>AK-EtOAc</b>), and compounds <b>1</b>–<b>6</b> were all evaluated for their antiparasitic effects against <i>Plasmodium falciparum</i> strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of <i>Leishmania donovani</i> (MHOM/SD/62/1S). …”
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Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis. by Daniel A Pfeffer, Benedikt Ley, Rosalind E Howes, Patrick Adu, Mohammad Shafiul Alam, Pooja Bansil, Yap Boum, Marcelo Brito, Pimlak Charoenkwan, Archie Clements, Liwang Cui, Zeshuai Deng, Ochaka Julie Egesie, Fe Esperanza Espino, Michael E von Fricken, Muzamil Mahdi Abdel Hamid, Yongshu He, Gisela Henriques, Wasif Ali Khan, Nimol Khim, Saorin Kim, Marcus Lacerda, Chanthap Lon, Asrat Hailu Mekuria, Didier Menard, Wuelton Monteiro, François Nosten, Nwe Nwe Oo, Sampa Pal, Duangdao Palasuwan, Sunil Parikh, Ayodhia Pitaloka Pasaribu, Jeanne Rini Poespoprodjo, David J Price, Arantxa Roca-Feltrer, Michelle E Roh, David L Saunders, Michele D Spring, Inge Sutanto, Kamala Thriemer, Thomas A Weppelmann, Lorenz von Seidlein, Ari Winasti Satyagraha, Germana Bancone, Gonzalo J Domingo, Ric N Price

“…<h4>Background</h4>The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. …”
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Ontogenia de los estróbilos, desarrollo de los esporangios y esporogénesis de Equisetum giganteum (Equisetaceae) en los Andes de Colombia by Edgar Javier Rincón Barón, Helkin Giovani Forero Ballesteros, Leidy Viviana Gélvez Landazábal, Gerardo Andrés Torres, Cristina Hilda Rolleri

“…The tapetum retains its histological integrity, but subsequently the cell walls break down and form a plasmodium that invades the sporangial cavity, partially surrounding the tetrads, and then the spores. …”
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Can the intake of antiparasitic secondary metabolites explain the low prevalence of hemoparasites among wild Psittaciformes? by Juan F. Masello, Javier Martínez, Luciano Calderón, Michael Wink, Petra Quillfeldt, Virginia Sanz, Jörn Theuerkauf, Luis Ortiz-Catedral, Igor Berkunsky, Dianne Brunton, José A. Díaz-Luque, Mark E. Hauber, Valeria Ojeda, Antoine Barnaud, Laura Casalins, Bethany Jackson, Alfredo Mijares, Romel Rosales, Gláucia Seixas, Patricia Serafini, Adriana Silva-Iturriza, Elenise Sipinski, Rodrigo A. Vásquez, Peter Widmann, Indira Widmann, Santiago Merino

“…We investigated the presence of avian malaria parasites (Plasmodium), intracellular haemosporidians (Haemoproteus, Leucocytozoon), unicellular flagellate protozoans (Trypanosoma) and microfilariae in 19 Psittaciformes species from a range of habitats in the Indo-Malayan, Australasian and Neotropical regions. …”
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The Effect of Previous Exposure to Malaria Infection and Clinical Malaria Episodes on the Immune Response to the Two-Dose Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen by Daniela Manno, Catriona Patterson, Abdoulie Drammeh, Kevin Tetteh, Mattu Tehtor Kroma, Godfrey Tuda Otieno, Bolarinde Joseph Lawal, Seyi Soremekun, Philip Ayieko, Auguste Gaddah, Abu Bakarr Kamara, Frank Baiden, Muhammed Olanrewaju Afolabi, Daniel Tindanbil, Kwabena Owusu-Kyei, David Ishola, Gibrilla Fadlu Deen, Babajide Keshinro, Yusupha Njie, Mohamed Samai, Brett Lowe, Cynthia Robinson, Bailah Leigh, Chris Drakeley, Brian Greenwood, Deborah Watson-Jones

“…Previous malaria exposure in participants in an Ebola vaccine trial in Sierra Leone (ClinicalTrials.gov: NCT02509494) was classified as low, intermediate, and high according to their antibody responses to a panel of <i>Plasmodium falciparum</i> antigens detected using a Luminex MAGPIX platform. …”
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Resisting and tolerating P. falciparum in pregnancy under different malaria transmission intensities by Nicaise Tuikue Ndam, Emmanuel Mbuba, Raquel González, Pau Cisteró, Simon Kariuki, Esperança Sevene, María Rupérez, Ana Maria Fonseca, Anifa Vala, Sonia Maculuve, Alfons Jiménez, Llorenç Quintó, Peter Ouma, Michael Ramharter, John J. Aponte, Arsenio Nhacolo, Achille Massougbodji, Valerie Briand, Peter G. Kremsner, Ghyslain Mombo-Ngoma, Meghna Desai, Eusebio Macete, Michel Cot, Clara Menéndez, Alfredo Mayor

“…Abstract Background Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. …”
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Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade of using artemisinin-based... by Deus S. Ishengoma, Celine I. Mandara, Filbert Francis, Eldin Talundzic, Naomi W. Lucchi, Billy Ngasala, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Erasmus Kamugisha, Reginald A. Kavishe, Florida Muro, Ally Mohamed, Renata Mandike, Sigsbert Mkude, Frank Chacky, Lynn Paxton, George Greer, Chonge A. Kitojo, Ritha Njau, Troy Martin, Meera Venkatesan, Marian Warsame, Eric S. Halsey, Venkatachalam Udhayakumar

“…The main outcomes were PCR corrected cure rates, day 3 positivity rates, safety of AL, and prevalence of single nucleotide polymorphisms in Plasmodium falciparum kelch 13 (Pfk13) (codon positions: 440–600) and P. falciparum multi-drug resistance 1 (Pfmdr1) genes (codons: N86Y, Y184F and D1246Y), markers of artemisinin and lumefantrine resistance, respectively. …”
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Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans by Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn

“…Although atypical B cells have previously been associated with disease states, the alternative lineage is common in healthy controls, as well as malaria-exposed individuals. We further track Plasmodium-specific B cells after malaria vaccination in naive volunteers. …”
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Comparative Genome Analysis of Three Eukaryotic Parasites with Differing Abilities To Transform Leukocytes Reveals Key Mediators of <italic toggle="yes">Theileria</italic>-Induced... by Kyoko Hayashida, Yuichiro Hara, Takashi Abe, Chisato Yamasaki, Atsushi Toyoda, Takehide Kosuge, Yutaka Suzuki, Yoshiharu Sato, Shuichi Kawashima, Toshiaki Katayama, Hiroyuki Wakaguri, Noboru Inoue, Keiichi Homma, Masahito Tada-Umezaki, Yukio Yagi, Yasuyuki Fujii, Takuya Habara, Minoru Kanehisa, Hidemi Watanabe, Kimihito Ito, Takashi Gojobori, Hideaki Sugawara, Tadashi Imanishi, William Weir, Malcolm Gardner, Arnab Pain, Brian Shiels, Masahira Hattori, Vishvanath Nene, Chihiro Sugimoto

“…Gene families that are present only in T. parva and T. annulata and not in T. orientalis, Babesia bovis, or Plasmodium were also identified. Identification of differences between the genome sequences of Theileria species with different abilities to transform and immortalize bovine leukocytes will provide insight into proteins and mechanisms that have evolved to induce and regulate this process. …”
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The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under... by Sarah Charital, Serena Shunmugam, Sheena Dass, Anna Maria Alazzi, Christophe-Sébastien Arnold, Nicholas J. Katris, Samuel Duley, Nyamekye A. Quansah, Fabien Pierrel, Jérôme Govin, Yoshiki Yamaryo-Botté, Cyrille Y. Botté

“…We further demonstrate that TgACS1 is critical for gliding motility of extracellular parasite facing low nutrient conditions, by relocating to peroxisomal-like area.IMPORTANCEToxoplasma gondii, causing human toxoplasmosis, is an Apicomplexa parasite and model within this phylum that hosts major infectious agents, such as Plasmodium spp., responsible for malaria. The diseases caused by apicomplexans are responsible for major social and economic burdens affecting hundreds of millions of people, like toxoplasmosis chronically present in about one-third of the world’s population. …”
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Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa [version 1; referees: 2 approved, 1 approved with reservations] by Claire L. Jeffries, Gena G. Lawrence, George Golovko, Mojca Kristan, James Orsborne, Kirstin Spence, Eliot Hurn, Janvier Bandibabone, Luciano M. Tantely, Fara N. Raharimalala, Kalil Keita, Denka Camara, Yaya Barry, Francis Wat’senga, Emile Z. Manzambi, Yaw A. Afrane, Abdul R. Mohammed, Tarekegn A. Abeku, Shivanand Hedge, Kamil Khanipov, Maria Pimenova, Yuriy Fofanov, Sebastien Boyer, Seth R. Irish, Grant L. Hughes, Thomas Walker

“…As there are numerous Anopheles species that have the capacity to transmit malaria, we analysed a range of species to determine Wolbachia prevalence rates, characterise novel Wolbachia strains and determine any correlation between the presence of Plasmodium, Wolbachia and the competing endosymbiotic bacterium Asaia. …”
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