Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal by Stephen F. Schaffner, Aida Badiane, Akanksha Khorgade, Medoune Ndiop, Jules Gomis, Wesley Wong, Yaye Die Ndiaye, Younouss Diedhiou, Julie Thwing, Mame Cheikh Seck, Angela Early, Mouhamad Sy, Awa Deme, Mamadou Alpha Diallo, Ngayo Sy, Aita Sene, Tolla Ndiaye, Djiby Sow, Baba Dieye, Ibrahima Mbaye Ndiaye, Amy Gaye, Aliou Ndiaye, Katherine E. Battle, Joshua L. Proctor, Caitlin Bever, Fatou Ba Fall, Ibrahima Diallo, Seynabou Gaye, Doudou Sene, Daniel L. Hartl, Dyann F. Wirth, Bronwyn MacInnis, Daouda Ndiaye, Sarah K. Volkman

“…Abstract We here analyze data from the first year of an ongoing nationwide program of genetic surveillance of Plasmodium falciparum parasites in Senegal. The analysis is based on 1097 samples collected at health facilities during passive malaria case detection in 2019; it provides a baseline for analyzing parasite genetic metrics as they vary over time and geographic space. …”
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Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study by Erin D. Lewis, Edwin F. Ortega, Maria Carlota Dao, Kathryn Barger, Joel B. Mason, John M. Leong, Marcia S. Osburne, Loranne Magoun, Felix J. Nepveux V, Athar H. Chishti, Christopher Schwake, Anh Quynh, Cheryl H. Gilhooly, Gayle Petty, Weimin Guo, Gregory Matuszek, Dora Pereira, Manju Reddy, Jifan Wang, Dayong Wu, Simin N. Meydani, Gerald F. Combs

“…The study was powered to detect effects on primary endpoints: susceptibility of participant erythrocytes to infection by Plasmodium falciparum, the proliferation potential of selected pathogenic bacteria in sera, and markers of gut inflammation. …”
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Effectiveness of joint 3 + 1 malaria strategy along China–Myanmar cross border areas by Zu-rui Lin, Shi-gang Li, Xiao-dong Sun, Xiang-rui Guo, Zhi Zheng, Jie Yang, Hong-ru Pian, Peng Tian, Qi-yan Chen, Xiao-ying Sun, Chun-li Ding, Kai-xia Duan, Hong-wei Chen, Dakhidam Yaw Bee, Hong-ning Zhou

“…Results In + 1 area of Myanmar from 2015 to 2019, the averaged annual parasite incidence was (59.11 ± 40.73)/1000 and Plasmodium vivax accounted for 96.27% of the total confirmed cases. …”
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Metagenomic Investigation of Ticks From Kenyan Wildlife Reveals Diverse Microbial Pathogens and New Country Pathogen Records by Koray Ergunay, Koray Ergunay, Koray Ergunay, Koray Ergunay, Mathew Mutinda, Brian Bourke, Brian Bourke, Brian Bourke, Silvia A. Justi, Silvia A. Justi, Silvia A. Justi, Laura Caicedo-Quiroga, Laura Caicedo-Quiroga, Laura Caicedo-Quiroga, Joseph Kamau, Samson Mutura, Irene Karagi Akunda, Elizabeth Cook, Francis Gakuya, Patrick Omondi, Suzan Murray, Dawn Zimmerman, Dawn Zimmerman, Dawn Zimmerman, Dawn Zimmerman, Yvonne-Marie Linton, Yvonne-Marie Linton, Yvonne-Marie Linton

“…The vector-borne filarial pathogens (Brugia malayi, Dirofilaria immitis, Loa loa), protozoa (Plasmodium spp., Trypanosoma cruzi), and environmental and water-/food-borne pathogens (Entamoeba histolytica, Encephalitozoon intestinalis, Naegleria fowleri, Schistosoma spp., Toxoplasma gondii, and Trichinella spiralis) were detected. …”
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Strengthening therapeutic adherence and pharmacovigilance to antimalarial treatment in Manaus, Brazil: a multicomponent strategy using mHealth by Diego Macías Saint-Gerons, Sheila Rodovalho, Ádila Liliane Barros Dias, André Lacerda Ulysses de Carvalho, Andrea Beratarrechea, Wuelton Marcelo Monteiro, Myrna Barata Machado, Cristiano Fernandes da Costa, Marcelo Yoshito Wada, Márcia Helena Maximiano Faria de Almeida, Rayanne Silva de Matos Fonseca, Jady Shayenne Mota Cordeiro, Alinne Paula Rodrigues Antolini, João Altecir Nepomuceno, Karen Fleck, Fernanda Simioni Gasparotto, Marcus Lacerda, Robin Rojas-Cortés, Shanthi Narayan Pal, Analía I. Porrás, María de la Paz Ade, José Luis Castro

“…The mean age of patients was 37.36 years (SD 13.65), 61.24% were male, 98.54% were infected with. Plasmodium vivax and 95.90% received a short regimen of chloroquine plus primaquine (CQ + PQ 7 days), as per malaria case management guidelines in Brazil. …”
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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study by Hakan Erdem, Jaffar A. Al-Tawfiq, Maha Abid, Wissal Ben Yahia, George Akafity, Manar Ezzelarab Ramadan, Fatma Amer, Amani El-Kholy, Atousa Hakamifard, Bilal Ahmad Rahimi, Farouq Dayyab, Hulya Caskurlu, Reham Khedr, Muhammad Tahir, Lysien Zambrano, Mumtaz Ali Khan, Aun Raza, Nagwa Mostafa El-Sayed, Magdalena Baymakova, Aysun Yalci, Yasemin Cag, Umran Elbahr, Aamer Ikram

“…The most common infectious syndromes were tuberculosis (TB) (n=27, 16.9%), infective endocarditis (n=25, 15.6%), malaria (n=21, 13.1%), brucellosis (n=15, 9.4%), and typhoid fever (n=9, 5.6%). Plasmodium falciparum, Mycobacterium tuberculosis, Brucellae, Staphylococcus aureus, Salmonella typhi, and Rickettsiae were the leading infectious agents in this study. …”
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The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysi... by Michael T. Bretscher, Prabin Dahal, Jamie Griffin, Kasia Stepniewska, Quique Bassat, Elisabeth Baudin, Umberto D’Alessandro, Abdoulaye A. Djimde, Grant Dorsey, Emmanuelle Espié, Bakary Fofana, Raquel González, Elizabeth Juma, Corine Karema, Estrella Lasry, Bertrand Lell, Nines Lima, Clara Menéndez, Ghyslain Mombo-Ngoma, Clarissa Moreira, Frederic Nikiema, Jean B. Ouédraogo, Sarah G. Staedke, Halidou Tinto, Innocent Valea, Adoke Yeka, Azra C. Ghani, Philippe J. Guerin, Lucy C. Okell

“…Abstract Background The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal malaria chemoprevention programs combined with sulfadoxine-pyrimethamine. …”
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Molecular Epidemiology of G6PD Genotypes in Different Ethnic Groups Residing in Saharan and Sahelian Zones of Mauritania by Oum Kelthoum Mamadou Djigo, Mohamed Salem Ould Ahmedou Salem, Sileye Mamadou Diallo, Mohamed Abdallahi Bollahi, Boushab Mohamed Boushab, Aymeric Garre, Nasserdine Papa Mze, Leonardo Basco, Sébastien Briolant, Ali Ould Mohamed Salem Boukhary

“…<i>Plasmodium vivax</i> malaria is endemic in Mauritania. …”
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Insecticide Resistance Profiling of <i>Anopheles coluzzii</i> and <i>Anopheles gambiae</i> Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechan... by Oumou. K. Gueye, Magellan Tchouakui, Abdoulaye K. Dia, Mouhamed B. Faye, Amblat A. Ahmed, Murielle J. Wondji, Daniel N. Nguiffo, Leon. M. J. Mugenzi, Frederic Tripet, Lassana Konaté, Abdoulaye Diabate, Ibrahima Dia, Oumar Gaye, Ousmane Faye, El Hadji A. Niang, Charles S. Wondji

“…A RT-qPCR (Reverse Transcriptase-quantitative Polymerase Chaine Reaction) was performed to estimate the level of genes expression belonging to the CYP450 (Cytochrome P450) family. <i>Plasmodium</i> infection rate was investigated using TaqMan method. …”
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Persistently high estimates of late night, indoor exposure to malaria vectors despite high coverage of insecticide treated nets by M Nabie Bayoh, Edward D Walker, Jackline Kosgei, Maurice Ombok, George B Olang, Andrew K Githeko, Gerry F Killeen, Peter Otieno, Meghna Desai, Neil F Lobo, John M Vulule, Mary J Hamel, Simon Kariuki, John E Gimnig

“…Collections were separated by hour of the night, and mosquitoes were identified to species and tested for sporozoite infection with Plasmodium falciparum. A subset was dissected to determine parity. …”
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Investigating the contribution of peri-domestic transmission to risk of zoonotic malaria infection in humans by Manin, Benny O., Ferguson, Heather M., Indra Vythilingam, Fornace, Kim, William, Timothy, Torr, Steve J., Drakeley, Chris, Chua, Tock Hing

“…Background: In recent years, the primate malaria Plasmodium knowlesi has emerged in human populations throughout South East Asia, with the largest hotspot being in Sabah, Malaysian Borneo. …”
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Surveillance to achieve malaria elimination in eastern Myanmar: a 7-year observational study by Jade D. Rae, Suphak Nosten, Ladda Kajeechiwa, Jacher Wiladphaingern, Daniel M. Parker, Jordi Landier, Aung Myint Thu, Hsa Dah, Aye Be, Win Cho Cho, K.’Nyaw Paw, Eh Shee Paw, Paw Bway Shee, Christ Poe, Chit Nu, Baw Nyaw, Julie A. Simpson, Angela Devine, Richard J. Maude, Ku Ler Moo, Myo Chit Min, May Myo Thwin, Saw Win Tun, François H. Nosten

“…Conclusions Surveillance data collected by the METF programme demonstrate that despite significant changes in the context in which the programme operates, malaria posts have remained accessible and continue to provide early diagnosis and treatment contributing to an 89.3% decrease in Plasmodium falciparum incidence between 2014 and 2021.…”
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Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their... by Abdouramane Traoré, Merepen A. Guindo, Drissa Konaté, Bourama Traoré, Seidina A. Diakité, Salimata Kanté, Assitan Dembélé, Abdourhamane Cissé, Nathan C. Incandela, Mamoudou Kodio, Yaya I. Coulibaly, Ousmane Faye, Andrey V. Kajava, Federico Pratesi, Paola Migliorini, Anna Maria Papini, Lorenzo Pacini, Paolo Rovero, Fosca Errante, Mahamadou Diakité, Myriam Arevalo-Herrera, Myriam Arevalo-Herrera, Socrates Herrera, Socrates Herrera, Giampietro Corradin, Saidou Balam, Saidou Balam

“…Cross-reactive antibody responses to RBM were mostly associated (p &lt; 0.01) with the absence of current Plasmodium falciparum infection, warranting further study.…”
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Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003‒2020: a case study by Hui Liu, Yaowu Zhou, Yan Deng, Zurui Lin, Canglin Zhang, Qiyan Chen, Chun Wei, Kaixia Duan, Peng Tian, Hongning Zhou, Jianwei Xu

“…Movement of both the human population and anopheline mosquitoes infected with Plasmodium spp. can cause cross-border malaria transmission. …”
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Current malaria infection, previous malaria exposure, and clinical profiles and outcomes of COVID-19 in a setting of high malaria transmission: an exploratory cohort study in Ugand... by Jane Achan, PhD, Asadu Serwanga, MSc, Humphrey Wanzira, PhD, Tonny Kyagulanyi, MSc, Anthony Nuwa, PhD, Godfrey Magumba, MPH, Stephen Kusasira, MD, Isaac Sewanyana, PhD, Kevin Tetteh, PhD, Chris Drakeley, PhD, Fredrick Nakwagala, MD, Helen Aanyu, MD, Jimmy Opigo, MPH, Prudence Hamade, MD, Madeleine Marasciulo, MSc, Byarugaba Baterana, MD, James K Tibenderana, PhD

“…Summary: Background: The potential effects of SARS-CoV-2 and Plasmodium falciparum co-infection on host susceptibility and pathogenesis remain unknown. …”
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Biology, Bionomics and Molecular Biology of Anopheles sinensis Wiedemann 1828 (Diptera: Culicidae), Main Malaria Vector in China by Xinyu Feng, Xinyu Feng, Xinyu Feng, Xinyu Feng, Xinyu Feng, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Shaosen Zhang, Fang Huang, Fang Huang, Fang Huang, Fang Huang, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Jun Feng, Jun Feng, Jun Feng, Jun Feng, Zhigui Xia, Zhigui Xia, Zhigui Xia, Zhigui Xia, Hejun Zhou, Hejun Zhou, Hejun Zhou, Hejun Zhou, Wei Hu, Wei Hu, Wei Hu, Wei Hu, Wei Hu, Wei Hu, Shuisen Zhou, Shuisen Zhou, Shuisen Zhou, Shuisen Zhou

“…Sporozoite analysis demonstrated An. sinensis efficacy on Plasmodium vivax transmission. An. sinensis was not stringently refractory to P. falciparum under experimental conditions, however, sporozoite was not found in salivary glands of field collected An. sinensis. …”
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Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-<i>Bis</i>[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaff... by Jean Guillon, Anita Cohen, Clotilde Boudot, Sarah Monic, Solène Savrimoutou, Stéphane Moreau, Sandra Albenque-Rubio, Camille Lafon-Schmaltz, Alexandra Dassonville-Klimpt, Jean-Louis Mergny, Luisa Ronga, Mikel Bernabeu de Maria, Jeremy Lamarche, Cristina Dal Lago, Eric Largy, Valérie Gabelica, Serge Moukha, Pascale Dozolme, Patrice Agnamey, Nadine Azas, Catherine Mullié, Bertrand Courtioux, Pascal Sonnet

“…A series of novel 2,9-<i>bis</i>[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives was designed, synthesized, and evaluated in vitro against three protozoan parasites (<i>Plasmodium falciparum</i>, <i>Leishmania donovani</i> and <i>Trypanosoma brucei brucei</i>). …”
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2,4-disubstituted 6-fluoroquinolines as potent antiplasmodial agents: QSAR, homology modeling, molecular docking and ADMET studies by Gideon A. Shallangwa, PhD, Aliyu W. Mahmud, MSc, Adamu Uzairu, PhD, Muhmmad T. Ibrahim, PhD

“…Abstract: Objective: This work was designed to study 2,4-disubstituted 6-fluoroquinolines as antiplasmodial agents by using in silico techniques, to aid in the design of novel analogs with high potency against malaria and high inhibition of Plasmodium falciparum translation elongation factor 2 (PfeEF2), a novel drug target. …”
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Malaria mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites by P. Kim Streatfield, Wasif A. Khan, Abbas Bhuiya, Syed M.A. Hanifi, Nurul Alam, Eric Diboulo, Ali Sié, Maurice Yé, Yacouba Compaoré, Abdramane B. Soura, Bassirou Bonfoh, Fabienne Jaeger, Eliezer K. Ngoran, Juerg Utzinger, Yohannes A. Melaku, Afework Mulugeta, Berhe Weldearegawi, Pierre Gomez, Momodou Jasseh, Abraham Hodgson, Abraham Oduro, Paul Welaga, John Williams, Elizabeth Awini, Fred N. Binka, Margaret Gyapong, Shashi Kant, Puneet Misra, Rahul Srivastava, Bharat Chaudhary, Sanjay Juvekar, Abdul Wahab, Siswanto Wilopo, Evasius Bauni, George Mochamah, Carolyne Ndila, Thomas N. Williams, Mary J. Hamel, Kim A. Lindblade, Frank O. Odhiambo, Laurence Slutsker, Alex Ezeh, Catherine Kyobutungi, Marylene Wamukoya, Valérie Delaunay, Aldiouma Diallo, Laetitia Douillot, Cheikh Sokhna, F. Xavier Gómez-Olivé, Chodziwadziwa W. Kabudula, Paul Mee, Kobus Herbst, Joël Mossong, Nguyen T.K. Chuc, Samuelina S. Arthur, Osman A. Sankoh, Marcel Tanner, Peter Byass

“…Childhood malaria mortality rates were strongly correlated with Malaria Atlas Project estimates of Plasmodium falciparum parasite rates for the same locations. …”
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Common virulence gene expression in adult first-time infected malaria patients and severe cases by J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schöllhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, Anna Bachmann

“…Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis. …”
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