Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers by Sasithon Pukrittayakamee, Podjanee Jittamala, James A Watson, Borimas Hanboonkunupakarn, Pawanrat Leungsinsiri, Kittiyod Poovorawan, Kesinee Chotivanich, Germana Bancone, Cindy S Chu, Mallika Imwong, Nicholas PJ Day, Walter RJ Taylor, Nicholas J White

“…It is the only widely available treatment to prevent relapses of Plasmodium vivax malaria. The 8-aminoquinolines cause dose-dependent haemolysis in glucose-6-phosphate dehydrogenase deficiency (G6PDd). …”
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ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) by Edison J. OSORIO D., Guillermo L. MONTOYA P., Katalina MUÑOZ D., Gabriel J. ARANGO A.

“…Of the alkaloids, liriodenine exhibited the highest activity against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum (CI50 = 8.0-10.0 μg/ml). In addition, inhibition of β-hematin formation (If????…”
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Topical repellents for malaria prevention by Gabaldón Figueira, JC, Wagah, MG, Adipo, LB, Wanjiku, C, Maia, MF

“…We only included data on <i>Plasmodium falciparum</i> infections in the meta‐analysis.…”

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…<p><strong>Background:</strong> A blood-stage Plasmodium falciparum malaria vaccine would provide a second line of defence to complement partially effective or waning immunity conferred by the approved pre-erythrocytic vaccines. …”

Causes of non-malarial fever in Laos: a prospective study by Mayfong Mayxay, MD, Josée Castonguay-Vanier, MSc, Vilada Chansamouth, MD, Audrey Dubot-Pérès, PhD, Daniel H Paris, MD, Rattanaphone Phetsouvanh, MD, Jarasporn Tangkhabuanbutra, MSc, Phouvieng Douangdala, MD, Saythong Inthalath, MD, Phoutthalavanh Souvannasing, MD, Günther Slesak, MD, Narongchai Tongyoo, MPhil, Anisone Chanthongthip, Phonepasith Panyanouvong, Bountoy Sibounheuang, Koukeo Phommasone, MD, Michael Dohnt, Darouny Phonekeo, MD, Bouasy Hongvanthong, MD, Sinakhone Xayadeth, Pakapak Ketmayoon, MSc, Stuart D Blacksell, PhD, Catrin E Moore, PhD, Scott B Craig, PhD, Mary-Anne Burns, Prof. Frank von Sonnenburg, MD, Andrew Corwin, PhD, Prof. Xavier de Lamballerie, MD, Iveth J González, MD, Eva Maria Christophel, MD, Amy Cawthorne, MSc, David Bell, MRCP, Dr. Paul N Newton, MRCP

“…Background: Because of reductions in the incidence of Plasmodium falciparum malaria in Laos, identification of the causes of fever in people without malaria, and discussion of the best empirical treatment options, are urgently needed. …”
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Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma by Zhiwei Liu, Yang Luo, Samuel Kirimunda, Murielle Verboom, Olusegun O. Onabajo, Mateus H. Gouveia, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Nathan Cole, Wen Luo, Jia Liu, Michelle Manning, Belynda Hicks, Ludmila Prokunina-Olsson, George Chagaluka, W. Thomas Johnston, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Ann W. Hsing, James E. Mensah, Anthony A. Adjei, Amy Hutchinson, Mary Carrington, Meredith Yeager, Rainer Blasczyk, Stephen J. Chanock, Soumya Raychaudhuri, Sam M. Mbulaiteye

“…Abstract Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymorphisms, which regulate immune response, are associated with BL has not been well investigated, which limits our understanding of BL etiology. …”
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G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials by Nuno Sepúlveda, Nuno Sepúlveda, Lynn Grignard, Jonathan Curry, Laleta Mahey, Guido J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Sam A. Coulibaly, Bronner P. Gonçalves, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, Kjerstin Lanke, Sodiomon B. Sirima, Alassane Dicko, Umberto d’Alessandro, Umberto d’Alessandro, Taane G. Clark, Taane G. Clark, Susana Campino, Ingrid Chen, Alice C. Eziefula, Alice C. Eziefula, Roly Gosling, Teun Bousema, Teun Bousema, Chris Drakeley

“…Primaquine (PQ) is an antimalarial drug with the potential to reduce malaria transmission due to its capacity to clear mature Plasmodium falciparum gametocytes in the human host. …”
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Scientific advances of scorpion venom by Pérez-Delgado Orlando

“…Lourival Possani, han aislado y patentado un péptido denominado Hadrurina del escorpión Hadrurus aztecus con actividad bactericida sobre un gran número de microorganismos de importancia clínica tales como Escherichia coli, Enterococcus cloacae, Klebsiella pneumoniae, Salmonella typhiy Pseudomonas aeruginosa13, además por otro lado se ha reportado de un escorpión asiático Scorpiops tibetanus del péptido StCT2 con efecto frente a Staphylococcus aureus, incluyendo cepas resistentes a los antibióticos como a la meticilina (MRSA).14 Inclusive a partir del veneno de la especie Pandinus imperator, también se ha reportado del péptido denominado escorpina con capacidad inhibitoria frente a etapas sexuales de ooquinetos y gametos de Plasmodium berghei15, como también del veneno de Tityus gonzalespongai con acción leishmanicida sobre promastigotes de Leishmania mexicana.16 En los últimos años, diferentes enfoques como las "ómicas" se han convertido en una herramienta muy poderosa para la comprensión de la complejidad de animales venenosos, utilizando técnicas de biología molecular, tales como RT-PCR, ADNc se ha amplificado a partir de ARNm total purificado de telsones (último segmento del postabdomen de los escorpiones) macerados. …”
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Serological evaluation of the effectiveness of reactive focal mass drug administration and reactive vector control to reduce malaria transmission in Zambezi Region, Namibia: Result... by Lindsey Wu, Michelle S. Hsiang, Lisa M. Prach, Leah Schrubbe, Henry Ntuku, Mi-Suk Kang Dufour, Brooke Whittemore, Valerie Scott, Joy Yala, Kathryn W. Roberts, Catriona Patterson, Joseph Biggs, Tom Hall, Kevin K.A. Tetteh, Cara Smith Gueye, Bryan Greenhouse, Adam Bennett, Jennifer L. Smith, Stark Katokele, Petrina Uusiku, Davis Mumbengegwi, Roly Gosling, Chris Drakeley, Immo Kleinschmidt

“…Antibody responses were measured on a multiplex immunoassay, using a panel of eight serological markers of Plasmodium falciparum infection - Etramp5.Ag1, GEXP18, HSP40.Ag1, Rh2.2030, EBA175, PfMSP119, PfAMA1, and PfGLURP.R2. …”
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond by Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Yesmalie, Alemán Resto, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Cassera, Maria Belen, Ken, Chih-Chien Cheng, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H. Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R. Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy, Willis, Paul A., Bhatia, Sangeeta N

“…The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two years, with the only stipulation that information from the screens is deposited in the public domain. …”
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Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes by Yann Le Gal, Agathe Filatre-Furcate, Dominique Lorcy, Olivier Jeannin, Thierry Roisnel, Vincent Dorcet, Diana Fontinha, Denise Francisco, Miguel Prudncio, Marta Martins, Catarina Soeiro, Sílvia A. Sousa, Jorge H. Leitão, Tnia S. Morais, Ins Bártolo, Nuno Taveira, Joana F. Guerreiro, Fernanda Marques

“…Most complexes containing the [<span style="color: #ff1b00;"><b>P</b></span>] counter ion exhibited exceptional antiplasmodial activity against the <i>Plasmodium berghei</i> parasite liver stages, with submicromolar IC₅₀ values ranging from 400–700 nM. …”
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Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria by Benoît Henry, Geoffroy Volle, Hilaire Akpovi, Laure Gineau, Camille Roussel, Papa Alioune Ndour, Félicien Tossou, Felipe Suarez, Friso Palstra, Aurélie Fricot, Charlotte Chambrion, Julien Solinc, Julie Nguyen, Mathilde Garé, Florentin Aussenac, Charles-Henry Cottart, Christine Keyser, Rafiou Adamou, Magali Tichit, David Hardy, Nadine Fievet, Jérôme Clain, André Garcia, David Courtin, Olivier Hermine, Audrey Sabbagh, Pierre Buffet

“…This phenotype was observed in individuals displaying markers of Plasmodium falciparum infection. The heritability of this new trait was high, with a strong multigenic component. …”
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A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection by Gigliola Zanghì, Shruthi S. Vembar, Sebastian Baumgarten, Shuai Ding, Julien Guizetti, Jessica M. Bryant, Denise Mattei, Anja T.R. Jensen, Laurent Rénia, Yun Shan Goh, Robert Sauerwein, Cornelus C. Hermsen, Jean-François Franetich, Mallaury Bordessoulles, Olivier Silvie, Valérie Soulard, Olivier Scatton, Patty Chen, Salah Mecheri, Dominique Mazier, Artur Scherf

“…Summary: Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection. …”
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Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study by Katherine O’Flaherty, Jo-Anne Chan, Jo-Anne Chan, Jo-Anne Chan, Julia C. Cutts, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Arjen M. Dondorp, Nicholas P. Day, Nicholas P. Day, Mehul Dhorda, Mehul Dhorda, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, Mayfong Mayxay, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Caterina Fanello, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Michael Theisen, Francois Nosten, Francois Nosten, Francois Nosten, James G. Beeson, James G. Beeson, James G. Beeson, James G. Beeson, Julie A. Simpson, Nicholas J. White, Nicholas J. White, Freya J. I. Fowkes, Freya J. I. Fowkes, Freya J. I. Fowkes

“…IntroductionUnderstanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates.MethodsIn a multi-national clinical efficacy trial of artemisinin therapies (13 sites of varying transmission over South-East Asia and Africa), we measured Immunoglobulin G (IgG) responses to recombinant P. falciparum gametocyte antigens expressed on the gametocyte plasma membrane and leading transmission blocking vaccine candidates Pfs230 (Pfs230c and Pfs230D1M) and Pfs48/45 at enrolment in 1,114 participants with clinical falciparum malaria. …”
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Prevalence of glucose 6-phosphate dehydrogenase deficiency in highly malaria-endemic municipalities in the Brazilian Amazon: A region-wide screening study by Joabi Rocha Nascimento, Jose Diego Brito-Sousa, Anne Cristine Gomes Almeida, Marly M Melo, Monica Regina Farias Costa, Laila Rowena Albuquerque Barbosa, Reinaldo Nery Ramos, Alexandre Vilhena Silva-Neto, Patricia Carvalho da Silva Balieiro, Erick Frota Gomes Figueiredo, Emanuelle Lira Silva, Djane Clarys Baia-da-Silva, Quique Bassat, Gustavo Romero, Gisely Cardoso Melo, Vanderson Souza Sampaio, Marcus Lacerda, Wuelton Monteiro

“…Summary: Background: Difficulties associated with the assessment of glucose-6-phosphate dehydrogenase deficiency (G6PDd), particularly in remote areas, hinders the safe use of 8-aminoquinolines such as primaquine (PQ) and tafenoquine against Plasmodium vivax malaria due to the risk of haemolysis. …”
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Editorial by David Alcantara, Joe Blois, Carlos Juan Ceacero

“…The paper highlights the plasmodium genes of interest playing a role in resistance to first line therapies such as chloroquine and sulfadoxine-pyrimethanine. …”
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Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia by Geraldine M Clarke, Kirk Rockett, Katja Kivinen, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Muminatou Jallow, David J Conway, Kalifa A Bojang, Margaret Pinder, Stanley Usen, Fatoumatta Sisay-Joof, Giorgio Sirugo, Ousmane Toure, Mahamadou A Thera, Salimata Konate, Sibiry Sissoko, Amadou Niangaly, Belco Poudiougou, Valentina D Mangano, Edith C Bougouma, Sodiomon B Sirima, David Modiano, Lucas N Amenga-Etego, Anita Ghansah, Kwadwo A Koram, Michael D Wilson, Anthony Enimil, Jennifer Evans, Olukemi K Amodu, Subulade Olaniyan, Tobias Apinjoh, Regina Mugri, Andre Ndi, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Norbert Peshu, Thomas N Williams, Alphaxard Manjurano, Nuno Sepúlveda, Taane G Clark, Eleanor Riley, Chris Drakeley, Hugh Reyburn, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Sarah J Dunstan, Nguyen Hoan Phu, Nguyen Ngoc Quyen, Cao Quang Thai, Tran Tinh Hien, Laurens Manning, Moses Laman, Peter Siba, Harin Karunajeewa, Steve Allen, Angela Allen, Timothy ME Davis, Pascal Michon, Ivo Mueller, Síle F Molloy, Susana Campino, Angeliki Kerasidou, Victoria J Cornelius, Lee Hart, Shivang S Shah, Gavin Band, Chris CA Spencer, Tsiri Agbenyega, Eric Achidi, Ogobara K Doumbo, Jeremy Farrar, Kevin Marsh, Terrie Taylor, Dominic P Kwiatkowski, MalariaGEN Consortium

“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effect has proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. …”
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Some Ethical Paradigms In View Of Equipoise and Randomized Clinical Trials by Emmanuel Kornyo

“…For example, a study was carried out comparing Artesunate-Cotrimoxazole and Artesunate-amodiaquine in view of treating asexual and sexual stages of Plasmodium Falciparum malaria in a West African Country where malaria has been consistently prevalent in epidemic proportions.[5] While there are many known medications for treating malaria, it is equally true that the parasite has developed resistance to some drugs such as Chloroquine. …”
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Symposium - De la recherche à la production industrielle des produits de santé (Présentations d'expériences réussies) Expérience n°1 : Médicaments Traditionnels Améliorés (MTA) sou... by Rokia SANOGO, Daouda DEMBELE, Sékou DOUMBIA, Aichata B. A. MARIKO, Mohamed Yacine FOFANA

“…De ces extraits ceux présentant les meilleures inhibitions de croissance du Plasmodium selon les critères de Wilcox, ont été retenues pour la mise au point de phytomédicaments de catégorie 2 OMS. …”
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Neurological manifestations of falciparum malaria. by Newton, C, Warrell, D

“…Plasmodium falciparum remains one of the most common causes of central nervous system infection worldwide. …”