Comparison of frequency domain parameters of heart rate variability between women with polycystic ovarian disease and apparently healthy women by Ritu Tiwari, Manish Bajpai, Sunita Tiwari, Smriti Agrawal

“…Background: Polycystic ovary syndrome (PCOS) patients shows common features like increased insulin resistance and adiposity, which have been known to correlate with sympathetic hyperactivity. …”
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Mental health, Reproductive health and contraception: pharmacological interaction, current evidence and challenges by C. Pinto Osório, P. Macedo

“…Treatment with valproic acid in women of childbearing age has been discouraged because of its association with polycystic ovary syndrome, elevated testosterone concentrations and menstrual irregularities, in addition to the risk of fetal malformations. …”
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Significance of the pineal gland hormone melatonin in maintaining the health of women of reproductive age (a review) by M. V. Danilova, E. N. Usoltseva

“…More and more studies address the role of the pineal gland (epiphysis) hormone melatonin (МТ) in the functioning of the reproductive system, as well as the impact of МТ deficiency on the women’s health.Aim: to analyze and summarize the available literature about the role of the pineal gland hormone МТ in the pathogenesis of gynecological diseases in women of reproductive age (infertility, endometriosis, polycystic ovary syndrome, premenstrual syndrome), and also about the impact of МТ deficiency on the health of women working night shifts.Materials and methods. …”
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Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles: a prospective cohort study by A. Abdelmagied, Alaa A. Makhlouf, Ahmed A. Abdel-Aleem, Safwat A. Mohamed, Ahmed Nasr, Azza Abo Elfadl, Mohammed K. Ali

“…This is a prospective cohort study that enrolled infertile women without polycystic ovary syndrome scheduled for ICSI. At baseline, women had an assessment of obesity using different metrics: clinical, serum biochemical, and sonographic. …”
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Role of gut microbiota derived short chain fatty acid metabolites in modulating female reproductive health by Ashwitha Acharya, Shilpa S. Shetty, Suchetha Kumari N

“…Therefore, SCFAs exhibit anti-inflammatory, anti-obesity, immunoregulatory, anti-diabetes, anti-cancer, hepatoprotective, cardiovascular protective and neuroprotective properties.This review highlights recent findings on SCFA and gynaecological pathologies such as preeclampsia, gestational diabetes, pregnancy complications, polycystic ovary syndrome, bacterial vaginosis, and endometriosis to describe current knowledge of the relationship between SCFA and reproductive health and disease in women.…”
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Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases by Maria Mirabelli, Eusebio Chiefari, Biagio Arcidiacono, Domenica Maria Corigliano, Francesco Saverio Brunetti, Valentina Maggisano, Diego Russo, Daniela Patrizia Foti, Antonio Brunetti

“…Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide spectrum of pathological conditions, such as non-alcoholic fatty liver disease (NAFLD), cognitive impairment, endothelial dysfunction, chronic kidney disease (CKD), polycystic ovary syndrome (PCOS), and some endocrine tumors, including breast cancer. …”
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Abstract Number ‐ 236: Pure Arterial Malformations: A Case Report by Rashid A Ahmed, Robert W Regenhardt, Justin E Vranic, Adam A Dmytriw, James D Rabinov

“…Results A 28‐year‐old female with a history of infantile hemangiomas, polycystic ovary syndrome, and hyperprolactinemia presented with acne, mild hirsutism, and galactorrhea. …”
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The effects of weight loss on health-related quality of life in obese women with PCOS and controls by Farnaz Shishehgar, Fahimeh Ramezani Tehrani, Setareh Vahidi

“…Abstract Background Polycystic ovary syndrome (PCOS) is a complicated endocrine disorder with widespread symptoms that reduce women’s quality of life. …”
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Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study by Yan Li, Yiwen Wang, Hai Liu, Shaodi Zhang, Cuilian Zhang

“…IntroductionInsulin resistance (IR) may play a central role in the pathophysiology of polycystic ovary syndrome (PCOS). Controlled ovarian stimulation (COS) in PCOS women in the setting of assisted reproductive technology (ART) is always a challenge for clinicians. …”
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Potential health benefits of curcumin on female reproductive disorders: A review by Datu Agasi Mohd Kamal, Norizam Salamt, Allia Najmie Muhammad Yusuf, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar

“…This review aims to provide an overview of the potential health benefits of curcumin to treat female reproductive disorders, including polycystic ovary syndrome (PCOS), ovarian failure and endometriosis. …”
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Cloning, expression, purification, crystallization and X-ray crystallographic analysis of recombinant human C1ORF123 protein by A. Rahaman, Siti Nurulnabila, Mat Yusop, Jastina, Mohamed Hussein, Zeti Azura, Ho, Kok Lian, Teh, Aik Hong, Waterman, Jitka, Ng, Chyan Leong

“…Recent proteomic and bioinformatic analyses identified the presence of C1ORF123 in brain, frontal cortex and synapses, as well as its involvement in endocrine function and polycystic ovary syndrome (PCOS), indicating the importance of its biological role. …”
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Obesity and risk of female reproductive conditions: A Mendelian randomisation study. by Samvida S Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M Becker, Ingrid Granne, Krina T Zondervan, Michael V Holmes, Cecilia M Lindgren, Laura B L Wittemans

“…These include polycystic ovary syndrome (PCOS), abnormal uterine bleeding, endometriosis, infertility, and pregnancy-related disorders. …”
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Are plasma Brain-Derived Neurotrophic Factor or reproductive hormones related to depression in PCOS patients?: a prospective cohort study by Gyung-Mee Kim, Jung Ahn Lee, Sung Woo Park, Jung Goo Lee, Gyun-Ho Jeon

“…Background: Brain-derived neurotrophic factor (BDNF) is involved both in the ovarian dysfunctions such as Polycystic Ovary Syndrome (PCOS) and in the pathogenesis of depressive disorders. …”
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Identification of novel differentially expressed genes in type 1 diabetes mellitus complications using transcriptomic profiling of UAE patients: a multicenter study by Bashair M. Mussa, Thenmozhi Venkatachalam, Ankita Srivastava, Abeer Al-Habshi, Elamin Abdelgadir, Alaaeldin Bashier, Fatheya Al Awadi, Khadija Hafidh, Rifat Hamoudi, Salah Abusnana

“…Five groups of complications associated with the latter were identified including hyperlipidemia, neuropathy, ketoacidosis, hypothyroidism and polycystic ovary syndrome (PCOS). A comprehensive whole transcriptomic analysis using NGS was conducted. …”
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Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China by Qingfang Li, Yimiao Sang, Qingqing Chen, Bingru Ye, Xiaoqian Zhou, Yimin Zhu

“…Abstract Background Polycystic ovary syndrome (PCOS) is a common reproductive, neuroendocrine, and metabolic disorder in women of reproductive age that affects up to 5–10% of women of reproductive age. …”
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Circulating follistatin concentrations in adolescent PCOS: Divergent effects of randomized treatments by Marta Díaz, Marta Díaz, Francis de Zegher, Lourdes Ibáñez, Lourdes Ibáñez

“…Higher follistatin levels have been associated with an increased risk for type 2 diabetes and with polycystic ovary syndrome (PCOS). In non-obese adolescent girls with PCOS, insulin sensitization results in a healthier endocrine-metabolic outcome than oral contraception (OC); we assessed whether those differences are underscored by changes in serum follistatin concentrations.MethodsCirculating follistatin, endocrine-metabolic markers and hepato-visceral fat were measured longitudinally in 72 girls with PCOS [age, 16 years; body mass index (BMI), 23 Kg/m2] randomized to receive PioFluMet [pioglitazone (7.5 mg/d), metformin (850 mg/d) and flutamide (62.5 mg/d), n=17]; EE-CA [an OC containing 35 µg ethinylestradiol (EE) and 2 mg cyproterone acetate (CA), n=17]; SPIOMET [Spironolactone (50 mg/d), pioglitazone (7.5 mg/d) and metformin (850 mg/d), n=18], or EE-LNG [an OC containing 20 µg EE and 100 mg levonorgestrel (LNG), n=20]. …”
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Urinary Metabolites Reveal Hyperinsulinemia and Insulin Resistance in Polycystic Ovarian Syndrome (PCOS) by Anna Maria Fulghesu, Cristina Piras, Angelica Dessì, Claudia Succu, Luigi Atzori, Roberta Pintus, Cecilia Gentile, Stefano Angioni, Vassilios Fanos

“…The identification of insulin resistance and hyperinsulinemia in polycystic ovary syndrome (PCOS) is not a minor issue. The homeostasis model assessment of insulin resistance index (HOMA) is the most used index of IR (Insulin Resistance), validated in overweight and obese patients but not in normal-weight PCOS subjects, who can still present with increased insulin secretion by an oral glucose tolerance test (OGTT). …”
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Integral assessment of lipoperoxidation processes in women with ovarian hyperandrogenism by L. I. Kolesnikova, O. V. Krusko, L. V. Belenkaya, L. V. Sholokhov, L. A. Grebenkina, N. A. Kurashova, S. I. Kolesnikov

“…During an annual preventive medical examination at the Scientific Сentre for Family Health and Human Reproduction Problems, 92 women of reproductive age (18–45 years old) were divided into a group of women with polycystic ovary syndrome (PCOS) (n = 47) and a control group of healthy women (n = 45). …”
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To Assess the Frequency and Risk Factors of Type 2 Diabetes Mellitus in Adult Population of District Peshawar Pakistan by Romana Ayub, Adeela Mustafa, Junaid Ahsan, Manal Gohar Qureshi, Shahid Ali, Mahnoor Inamullah, Fatima Afaq

“…Conclusion: We found some other factors which also affected type 2 diabetes mellitus, like sedentary life style, taking mixed meal and polycystic ovary syndrome. The study results also showed no difference in DM prevalence if someone is on medications for other diseases. …”
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Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway by Ming-Qi Yan, Bing-Hong Zhu, Xiao-Hong Liu, Yu-Meng Yang, Xiu-Yun Duan, Yong Wang, Hui Sun, Mei Feng, Tao Li, Xiao-Man Liu

“…Briefly, we demonstrated that the mitochondrial MIGA1 and MIGA2, especially MIGA2, promoted cellular proliferation by activating AKT and regulating the Hippo/YAP1 signaling pathway in ovarian granulosa cells, which may contribute to the molecular pathogenesis of reproductive endocrine diseases, such as polycystic ovary syndrome (PCOS).…”
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