A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome by Amal F. Alshammary, Abdulrahman M. Alshammari, Raed Farzan, Sarah F. Alsobaie, Arwa A. Alageel, Imran Ali Khan

“…Introduction: Polycystic ovary syndrome (PCOS) is an ovarian health condition as well as a long-term endocrine dysfunction that affects reproductive-aged women. …”
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Effects of Selected Metal Nanoparticles (Ag, ZnO, TiO₂) on the Structure and Function of Reproductive Organs by Lucia Dianová, Filip Tirpák, Marko Halo, Tomáš Slanina, Martin Massányi, Robert Stawarz, Grzegorz Formicki, Roberto Madeddu, Peter Massányi

“…Metal nanoparticles most likely induce polycystic ovary syndrome and follicular atresia, inflammation, apoptosis, and necrosis also occurred.…”
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تقييم الخطورة القلبية الوعائية بالاعتماد على الصيغة الشحمية لدى مجموعة من مريضات متلازمة المبيض متعدد الكيسات... by zeinab ibrahim, Remal Assad, Faisal Radwan

“… مقدمة: تعد متلازمة المبيض متعدد الكيسات Polycystic ovary syndrome (PCOs) إحدى أكثر الاضطرابات الصَّماوية شيوعاً ومن المعروف أنَّ اضطراب الشحوم يشكّل عامل مؤهب لتطوُّر الداء السُّكري من النمط الثاني وزيادة خطورة الإصابة القلبية الوعائية هدف البحث: تقييم مستويات الشحوم لدى مريضات المتلازمة ومن ثم تحديد المجموعات ذات الخطورة العالية ومن ثم تقييم الخطورة القلبية الوعائية لدى مريضات متلازمة المبيض متعدد الكيسات من خلال معايرة الصيغة الشحمية بالاعتماد على مشعر التصلب العصيدي Atherogenic index of plasma (AIP)  المواد والطرائق:  شملت الدراسة الوصفية 59 مريضة من المريضات المراجعات لمشفى تشرين الجامعي في اللاذقية ، بالمقارنة مع مجموعة شواهد مكونة من 20 من الإناث الأصحاء، تراوحت أعمار المريضات بين 18و 38 عاماً، تم إجراء تحاليل مخبرية للمريضات تضم معايرة عناصر الصيغة اللبيدية وتحديد مشعر الخطورة التصلب العصيدي(AIP)  الذي يُحسب من اللوغاريتم العشري لنسبة ثلاثيات الغليسريد إلى الليبوبروتين الشحمي عالي الكثافة. …”
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The complex metabolic interactions of liver tissue and hepatic exosome in PCOS mice at young and middle age by ShanHu Gao, Fei Long, Zheng Jiang, Jun Shi, DongXue Ma, Yang Yang, Jin Bai, Ting-Li Han, Ting-Li Han

“…Polycystic ovary syndrome (PCOS) is a common age-related endocrinopathy that promotes the metabolic disorder of the liver. …”
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Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver dis... by Alessandro D. Genazzani, Christian Battipaglia, Laura Rusce, Greta Prampolini, Claudia Aio, Francesco Ricciardiello, Martina Foschi, Alessandra Sponzilli, Elisa Semprini, Tabatha Petrillo

“…AbstractObjective To evaluate the effects of alpha lipoic acid (ALA) on hormonal and metabolic parameters in a group of overweight/obese Polycystic Ovary Syndrome (PCOS) patients.Methods This was a retrospective study in which thirty-two overweight/obese patients with PCOS (n = 32) not requiring hormonal treatment were selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Italy. …”
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Metformin Treatment Regulates the Expression of Molecules Involved in Adiponectin and Insulin Signaling Pathways in Endometria from Women with Obesity-Associated Insulin Resistance... by Maria Lorena Oróstica, Isis Astorga, Francisca Plaza-Parrochia, Cristian Poblete, Rodrigo Carvajal, Víctor García, Carmen Romero, Margarita Vega

“…Polycystic ovary syndrome (PCOS) is an endocrine/metabolic disorder associated with insulin resistance (IR) and obesity. …”
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Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients by Jingwen Gan, Jie Chen, Rui-lin Ma, Yan Deng, Xue-song Ding, Shi-yang Zhu, Ai-jun Sun

“…Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age, whose clinical characteristics are hyperandrogenism (HA), ovulatory dysfunction, and polycystic ovary, often accompanied by insulin resistance (IR) and metabolic abnormalities. …”
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Performance Analysis of a Novel Hybrid Segmentation Method for Polycystic Ovarian Syndrome Monitoring by Asma’ Amirah Nazarudin, Noraishikin Zulkarnain, Siti Salasiah Mokri, Wan Mimi Diyana Wan Zaki, Aini Hussain, Mohd Faizal Ahmad, Ili Najaa Aimi Mohd Nordin

“…Experts have used ultrasound imaging to manually determine follicle count and perform measurements, especially in cases of polycystic ovary syndrome (PCOS). However, due to the laborious and error-prone process of manual diagnosis, researchers have explored and developed medical image processing techniques to help with diagnosing and monitoring PCOS. …”
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The Effect of Age on Clinical and Laboratory Parameters in Reproductive Age Women with Endometrial Polyps by Aytekin Tokmak, Ebru Ersoy, Ali Özgür Ersoy, Esra Yaşar Çelik, Ali İrfan Güzel, Mustafa Uğur

“…Thirty seven women older than 40 years of age (study group), and 113 women younger than 40 years (control group) were compared in terms of various clinical and laboratory parameters including age, body mass index (BMI), gravidity, parity, abortion, basal hormone levels, tumor markers, complete blood count values, smoking status, presence of polycystic ovary syndrome (PCOS), infertility status, co-morbidities, and number and size of endometrial polyps. …”
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Assessment of Nutritional Status and Its Influence on Ovarian Reserve: A Systematic Review by Laura Prieto-Huecas, Clara Ángela Piera-Jordán, Verónica Serrano De La Cruz-Delgado, Ana Zaragoza-Martí, María Belén García-Velert, Cristina Tordera-Terrades, Miriam Sánchez-Sansegundo, Laura Martín-Manchado

“…In seven publications (31.8%), the increased body mass index (BMI) led to a decrease in ovarian reserve, two of them (0.9%) in patients with polycystic ovary syndrome, showing a decrease only if BMI > 25. …”
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Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. by Taponen, S, Martikainen, H, Järvelin, MR, Sovio, U, Laitinen, J, Pouta, A, Hartikainen, A, McCarthy, M, Franks, S, Paldanius, M, Ruokonen, A

“…The metabolic cardiovascular disease (CVD) risk factors of women with self-reported oligomenorrhea and/or hirsutism, which are symptoms of polycystic ovary syndrome (PCOS), were investigated in a general population-based Northern Finland Birth Cohort 1966 Study to determine whether women with PCOS symptoms at 31 yr would be distinguishable from asymptomatic controls in terms of CVD risk factors. …”

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5. by Quinkler, M, Sinha, B, Tomlinson, J, Bujalska, I, Stewart, P, Arlt, W

“…Women with polycystic ovary syndrome (PCOS) have high circulating androgens, thought to originate from ovaries and adrenals, and frequently suffer from the metabolic syndrome including obesity. …”

Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhoea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. by Taponen, S, Ahonkallio, S, Martikainen, H, Koivunen, R, Ruokonen, A, Sovio, U, Hartikainen, A, Pouta, A, Laitinen, J, King, V, Franks, S, McCarthy, M, Järvelin, MR

“…METHODS: The ultrasonographic ovarian morphology and the hormonal and metabolic profile of female cases with self-reported symptoms typical of polycystic ovary syndrome (PCOS) (n = 196) and asymptomatic controls (n = 67) at the age of 31 years were examined in a general population-based Northern Finland Birth Cohort 1966. …”

Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptome by Lingbin Qi, Yumei Li, Lina Zhang, Shuyue Li, Xunyi Zhang, Wanqiong Li, Jiaying Qin, Xian Chen, Yazhong Ji, Zhigang Xue, Bo Lv

“…Although the impact of immune cells in human reproduction has been widely investigated, systematic understanding of the changes of the immune atlas under female ovulation remain less understood.MethodsHere, we generated single cell transcriptomic profiles of 80,689 PBMCs in three representative statuses of ovulation dysfunction, i.e., polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and menopause (MENO), and identified totally 7 major cell types and 25 subsets of cells.ResultsOur study revealed distinct cluster distributions of immune cells among individuals of ovulation disorders and health. …”
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Evaluation of socio-demographic and clinical characteristics of PCOS patients attending a tertiary care institute in Colombo by I. Ranathunga, T. G. Athukorala, M. R. Sumanatilleke, N. P. Somasundaram

“…Abstract Background and objectives Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogeneous aetiology. …”
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Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis by Gita Pratama, Budi Wiweko, Asmarinah, Indah S. Widyahening, Trinovita Andraini, Hartanto Bayuaji, Andon Hestiantoro

“…Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. …”
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Familial Diabetes in Obese PCOS Predisposes Individuals to Compensatory Hyperinsulinemia and Insulin Resistance (IR) Also for Reduced Hepatic Insulin Extraction (HIE) by Alessandro D. Genazzani, Christian Battipaglia, Elisa Semprini, Melania Arnesano, Fedora Ambrosetti, Alessandra Sponzilli, Veronica Tomatis, Tabatha Petrillo

“…<b>Background:</b> Polycystic ovary syndrome (PCOS) is a frequent reproductive disease characterized by hyperandrogenism, oligo /anovulation, and polycystic aspects at ultrasound. …”
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Which Ovarian Reserve Marker is More Reliable in IVF Patients with AMH and AFC Discordance? by Eun Hee Yu, Hyun Joo Lee, Jong Kil Joo, Yong Jin Na

“…In the logistic regression analysis, age was not a significant patient factor affecting the ART outcomes; however, the patient’s status of polycystic ovary syndrome (PCOS) was significantly associated with the AMH-AFC discordance, with an odds ratio (OR) of 1.24. …”
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The effects of serum concentration of androgens, LH and IGF1 in early follicular phase on follicular growth parameters and pregnancy rate by Zahra Raoofi, Farzaneh Hosseini, Seyedeh Pegah Parvar, Seyedeh Paniz Parvar

“…Patients were excluded if they had polycystic ovary syndrome (PCOS) or endometriosis. The serum concentration of androgens (testosterone, dehydroepiandrosterone and androstenedione), LH and IGF1 was measured on the third day of menstruation. …”
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Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice by Giovanna Di Emidio, Martina Placidi, Francesco Rea, Giulia Rossi, Stefano Falone, Loredana Cristiano, Stefania Nottola, Anna Maria D’Alessandro, Fernanda Amicarelli, Maria Grazia Palmerini, Carla Tatone

“…Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility. …”
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