Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndr... by Kailu Liu, Xi He, Jingyu Huang, Simin Yu, Meiting Cui, Mengya Gao, Li Liu, Yu Qian, Ying Xie, Miao Hui, Yanli Hong, Xiaowei Nie

“…Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. …”
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Inositols: pharmacology and findings of clinical trials. Current evidence and prospects by Yu.E. Dobrokhotova, O.A. Gromova, A.S. Dukhanin, Z.Kh. Kumykova, E.V. Sheremetyeva, G.I. Tabeeva

“…</p> <p> <b>Keywords</b>: reproductive function, metabolism, inositol, myoinositol, D-chiroinositol, polycystic ovary syndrome, ovarian reserve, menopause, metabolic syndrome, manganese, folic acid. …”
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Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study by Elena Vasyukova, Ekaterina Zaikova, Olga Kalinina, Inga Gorelova, Irina Pyanova, Elena Bogatyreva, Elena Vasilieva, Elena Grineva, Polina Popova

“…Background: it has been suggested that chronic low-grade inflammation plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). According to previous studies, it remains unclear which cytokines influence the development of this syndrome and whether their increase is associated with the presence of excess weight/obesity or is an independent factor. …”
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NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation by Jiayu Lin, Yuting Xiang, Yuting Xiang, Jiana Huang, Haitao Zeng, Yanyan Zeng, Jiawen Liu, Taibao Wu, Qiqi Liang, Xiaoyan Liang, Jingjie Li, Chuanchuan Zhou

“…It is an important technique for patients with polycystic ovary syndrome and, especially, those young patients with the need of fertility preservation. …”
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Mitochondrial Function in Modulating Human Granulosa Cell Steroidogenesis and Female Fertility by Dilip Bhargava Sreerangaraja Urs, Wen-Han Wu, Katerina Komrskova, Pavla Postlerova, Yung-Feng Lin, Chii-Ruey Tzeng, Shu-Huei Kao

“…The patients who provided the granulosa cells were further classified into four groups: endometriosis, ovarian endometrioma, endometriosis without ovarian endometrioma, and polycystic ovary syndrome (PCOS); patients with other female factor infertility and male factor infertility were used as controls. …”
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Obesity, obesity-related metabolic conditions, and risk of thyroid cancer in women: results from a prospective cohort study (Sister Study)Research in context by Elisa Pasqual, Katie O’Brien, Sabina Rinaldi, Dale P. Sandler, Cari M. Kitahara

“…Body mass index (BMI) (hazard ratio [HR]per-5 kg/m2 = 1.25, 95% CI = 1.14–1.37), waist circumference (HRper-5 cm increase = 1.11, 95% CI = 1.06–1.15), and waist-to-hip ratio (HR ≥0.85-versus-<0.85 = 1.49, 95% CI = 1.14–1.94) were positively associated with thyroid cancer incidence, as were metabolic syndrome (HR = 1.67, 95% CI = 1.24–2.25), dyslipidemia (HR = 1.46, 95% CI = 1.13–1.90), borderline diabetes (HR = 2.06, 95% CI = 1.15–3.69), hypertension (HR = 1.49, 95% CI = 1.12–1.96), and polycystic ovary syndrome (PCOS, HR = 2.10, 95% CI = 1.20–3.67). …”
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Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Traits in a Hyperandrogenic PCOS Mouse Model by Valentina RODRIGUEZ PARIS, Stephanie J. ALEXOPOULOS, Ying HU, Divya P. SHAH, Ali AFLATOUNIAN, Melissa C. EDWARDS, Michael J. BERTOLDO, Robert B. GILCHRIST, Kyle L. HOEHN, Kirsty A. WALTERS

“…Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition characterized by endocrine, reproductive and metabolic abnormalities. …”
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A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (<i>Nigella sativa</... by Muhammad Abdul Rahim, Aurbab Shoukat, Waseem Khalid, Afaf Ejaz, Nizwa Itrat, Iqra Majeed, Hyrije Koraqi, Muhammad Imran, Mahr Un Nisa, Anum Nazir, Wafa S. Alansari, Areej A. Eskandrani, Ghalia Shamlan, Ammar AL-Farga

“…Many clinical and experimental studies have indicated that the black seed and their by-products can be used to reduce the risk of cardiovascular diseases, chronic cancer, diabetes, oxidative stress, polycystic ovary syndrome, metabolic disorders, hypertension, asthma, and skin disorders. …”
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Androgen Actions in Adipose Tissue, But Not Skeletal Muscle, are Involved in the Development of Metabolic PCOS Features in a Mouse Model by Ting XIONG, Valentina RODRIGUEZ PARIS, Melissa C. EDWARDS, Blake J. COCHRAN, Kerry-Anne RYE, William L. LEDGER, Vasantha PADMANABHAN, David J. HANDELSMAN, Robert B. GILCHRIST, Kirsty A. WALTERS

“…Background: Polycystic ovary syndrome (PCOS) is a common disorder characterised by endocrine, reproductive and metabolic dysfunction. …”
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Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis by Xin-Le Lai, Wen-Jie Xiong, Li-Shu Li, Meng-Fan Lan, Jin-Xin Zhang, Yu-Ting Zhou, Dong Niu, Xing Duan

“…Serum zinc concentrations are reduced in patients with polycystic ovary syndrome (PCOS). However, the underlying mechanism of the effects of zinc deficiency on the female reproductive system, especially oocyte quality, has not been fully elucidated. …”
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PLANT PIGMENTS IN PSYCHIATRY AND NEUROLOGY: HISTORICAL AND MODERN USES. PART II. A LITERATURE REVIEW WITH A CLINICAL CASE PRESENTATION by Roman A. Bekker, Yuriy V. Bykov

“…In the aforementioned case, the combined use of a low-calorie diet, exercise, metformin, chromium picolinate, thermogenic fat burners (caffeine and synephrine) and several different plant pigments and antioxidants — made it possible to achieve remission, both in terms of the mental state and in terms of endocrine and metabolic status in a young woman with obesity, polycystic ovary syndrome, depression, hyperuricemia, and an initial stage of urate-based urolithiasis, without the use of traditional psychopharmacotherapy. …”
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Participant characteristics in the prevention of gestational diabetes as evidence for precision medicine: a systematic review and meta-analysis by Siew Lim, Wubet Worku Takele, Kimberly K. Vesco, Leanne M. Redman, Wesley Hannah, Maxine P. Bonham, Mingling Chen, Sian C. Chivers, Andrea J, Fawcett, Jessica A. Grieger, Nahal Habibi, Gloria K. W. Leung, Kai Liu, Eskedar Getie Mekonnen, Maleesa Pathirana, Alejandra Quinteros, Rachael Taylor, Gebresilasea G. Ukke, Shao J. Zhou, ADA/EASD PMDI, Jami Josefson

“…Combined diet and physical activity interventions result in greater GDM reduction in participants without polycystic ovary syndrome (PCOS) than those with PCOS (0.62 [0.47, 0.82] vs 1.12 [0.78–1.61]) and in those without a history of GDM than those with unspecified GDM history (0.62 [0.47, 0.81] vs 0.85 [0.76, 0.95]). …”
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A novel nonsense mutation in the insulin receptor gene in a patient with HAIR-AN syndrome and endometrial cancer by Dalia Cuenca, Jose Luis Ventura-Gallegos, Paloma Almeda-Valdes, María Teresa Tusié-Luna, Alfredo Reza-Albarran, Laura Ventura-Ayala, Ma. Luisa Ordoñez-Sánchez, Yayoi Segura-Kato, Francisco Javier Gomez-Perez, Michelle De Puy Conte, Lizbet Ruilova Gonzalez, Alejandro Zentella-Dehesa

“…Among those is the HAIR-AN an extreme subtype of polycystic ovary syndrome (PCOS). We present a case of a 29-year-old woman with amenorrhea, severe insulin resistance, hirsutism, and acanthosis nigricans who also developed endometrial cancer. …”
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Effects of a New Group of Antidiabetic Drugs in Metabolic Diseases by Jaime Sanz-Cánovas, Michele Ricci, Lidia Cobos-Palacios, Almudena López-Sampalo, Halbert Hernández-Negrín, María Vázquez-Márquez, Juan José Mancebo-Sevilla, Elena Álvarez-Recio, María Dolores López-Carmona, Miguel Ángel Pérez-Velasco, Luis Miguel Pérez-Belmonte, Ricardo Gómez-Huelgas, Maria-Rosa Bernal-López

“…Some of these entities are arterial hypertension, dyslipidemia, hyperuricemia, obesity, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), vascular aging, respiratory diseases, or osteoporosis and fractures. …”
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مقایسه‌ی اثر آنتی‌اکسیدانی نانوذرات پلی‌لاکتیک کوگلیکولیک اسید (PLGA) حاوی عصاره‌ی جینسینگ قرمز کره‌ای (KRGE) نسبت به عصاره‌ی جینسینگ قرمز کره‌ای در درمان سندرم تخمدان پلی‌کیستیک ن... by ماندانا امام دوست, سعیده ظفر بلانژاد, خدیجه شاهرخ آبادی, مسعود همایونی

“…مقدمه: پژوهش حاضر با هدف ارزیابی و مقایسه‌ی اثرات عصاره‌ی جینسینگ قرمز کره‌ای (Korean red ginseng extract یا KRGE) و نانوذرات پلی‌لاکتیک کوگلیکولیک اسید [Poly(lactic-co-glycolic acid) یا PLGA] حاوی KRGE در درمان موش‌‌های مبتلا به سندرم تخمدان پلی‌کیستیک (Polycystic ovary syndrome یا PCOS) ناشی از تستوسترون انجام شد.روش‌ها: موش‌های ماده‌ی Naval Medical Research Institute (NMRI) پس از بلوغ به سه گروه شاهد منفی (10 سر موش سالم)، شاهد مثبت (10 سر موش تحت درمان با دارونما) و بیمار (60 سر موش) تقسیم شدند. …”
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The effect and mechanism of rapamycin on the ovarian tissue of rats with PCOS induced by dehydroepiandrosterone by Chen Wenli, Wang Huiling, Yang Jun

“…Objective To evaluate the effect and unravel the mechanism of rapamycin on the ovarian tissues in rat models with polycystic ovary syndrome （PCOS） induced by dehydroepiandrosterone （DHEA）. …”
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Comparison of exenatide alone or combined with metformin versus metformin in the treatment of polycystic ovaries: a systematic review and meta-analysis by Yan Hu, Xiangxin Song, Shaila Hamiti, Yanyong Ma, Mainu Yusufu, Xing Wang, Kaidi Zhang, Yanying Guo

“…Abstract Background Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of childbearing age. …”
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Effects of half-dose spiomet treatment in girls with early puberty and accelerated bone maturation: a multicenter, randomized, placebo-controlled study protocol by Judit Bassols, Francis de Zegher, Marta Diaz, Gemma Carreras-Badosa, Cristina Garcia-Beltran, Elsa Puerto-Carranza, Cora Oliver-Vila, Paula Casano, Céline Alicia Franco, Rita Malpique, Abel López-Bermejo, Lourdes Ibáñez

“…Abstract Background A “mismatch” sequence of less prenatal weight gain and more postnatal weight gain may lead to ectopic lipid accumulation, and trigger the development of early adrenarche/pubarche and the activation of the gonadotropic axis resulting in early puberty and ending up in full-blown adolescent polycystic ovary syndrome (PCOS). In the present study, we assess whether a low-dose combination of generics that collectively reduce ectopic fat through different pathways can slow down the accelerated maturation in “mismatch” girls with early puberty. …”
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Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study by Shuyi Ling, Yuqing Dai, Ruoxin Weng, Yuan Li, Wenbo Wu, Ziqiong Zhou, Zhisheng Zhong, Yuehui Zheng

“…Our aim was to establish a causal relationship between genetically predicted depression and the risk of various female reproductive pathological conditions, such as ovarian dysfunction, polycystic ovary syndrome(PCOS), ovarian cysts, abnormal uterine and vaginal bleeding(AUB), endometriosis, leiomyoma of the uterus, female infertility, spontaneous abortion, eclampsia, pregnancy hypertension, gestational diabetes, excessive vomiting in pregnancy, cervical cancer, and uterine/endometrial cancer. …”
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Gender-differences in antithrombotic therapy across the spectrum of ischemic heart disease: Time to tackle the Yentl syndrome? by Renzo Laborante, Josip Andjelo Borovac, Mattia Galli, Mattia Galli, Daniele Rodolico, Giuseppe Ciliberti, Attilio Restivo, Luigi Cappannoli, Alessandra Arcudi, Rocco Vergallo, Andrea Zito, Giuseppe Princi, Antonio Maria Leone, Cristina Aurigemma, Enrico Romagnoli, Rocco Antonio Montone, Francesco Burzotta, Francesco Burzotta, Carlo Trani, Carlo Trani, Domenico D’Amario, Domenico D’Amario

“…Compared with men, women feature an increased thrombotic risk, probably related to an increased platelet reactivity, higher level of coagulation factors, and sex-associated unique cardiovascular risk factors, such as pregnancy-related (i.e., pre-eclampsia and gestational diabetes), gynecological disorders (i.e., polycystic ovary syndrome, early menopause) and autoimmune or systemic inflammatory diseases. …”
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