In vitro characterization and in vivo comparison of the pulmonary outcomes of Poractant alfa and Calsurf in ventilated preterm rabbits. by Xiaojing Guo, Siwei Luo, Davide Amidani, Claudio Rivetti, Giuseppe Pieraccini, Barbara Pioselli, Silvia Catinella, Xabi Murgia, Fabrizio Salomone, Yaling Xu, Ying Dong, Bo Sun

“…Poractant alfa and Calsurf are two natural surfactants widely used in China for the treatment of neonatal respiratory distress syndrome, which are extracted from porcine and calf lungs, respectively. …”
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Poractant alfa (Curosurf^®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo by Willems Coen HMP, Urlichs Florian, Seidenspinner Silvia, Kunzmann Steffen, Speer Christian P, Kramer Boris W

“…In this study, we assessed the influence of exogenous poractant alfa (Curosurf^®) instillation on the in vivo phagocytosis of apoptotic neutrophils by alveolar macrophages.…”
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Dose Effect of Poractant Alfa in Neonatal RDS: Analysis of Combined Data from Three Prospective Studies by Barbara Królak-Olejnik, Roman Hożejowski, Tomasz Szczapa

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In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome by Francesca Ricci, Fabrizio Salomone, Elke Kuypers, Daan Ophelders, Maria Nikiforou, Monique Willems, Tobias Krieger, Xabier Murgia, Matthias Hütten, Boris W. Kramer, Federico Bianco

“…BackgroundPoractant alfa (Curosurf®) and Bovactant (Alveofact®) are two animal-derived pulmonary surfactants preparations approved for the treatment of neonatal respiratory distress syndrome (nRDS). …”
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Poractant alfa versus bovine lipid extract surfactant for infants 24+0 to 31+6 weeks gestational age: A randomized controlled trial. by Brigitte Lemyre, Christoph Fusch, Georg M Schmölzer, Nicole Rouvinez Bouali, Deepti Reddy, Nicholas Barrowman, Nicole Huneault-Purney, Thierry Lacaze-Masmonteil

“…OBJECTIVES:To compare the efficacy and safety of poractant alfa and bovine lipid extract surfactant in preterm infants. …”
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A Randomized, Single-blind, Comparison Trial of Beractant (BeraksurfTM) versus Poractant Alfa (Curosurf®) in the Treatment of Respiratory Distress Syndrome in Preterm Infants by Manizheh Mostafa Gharehbaghi, Parvin Sarbakhsh, Hossein Mohammadbager, Safoora Gharibzadeh, Elnaz Shaseb

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MORTALITY OF PREMATURELY BORN NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME RECEIVED PORACTANT ALPHA by S. N. Mamedova

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Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future by Ga Won Jeon

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From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy by F. Bianco, F. Ricci, C. Catozzi, X. Murgia, M. Schlun, A. Bucholski, U. Hetzer, S. Bonelli, M. Lombardini, E. Pasini, M. Nutini, M. Pertile, S. Minocchieri, M. Simonato, B. Rosa, G. Pieraccini, G. Moneti, L. Lorenzini, S. Catinella, G. Villetti, M. Civelli, B. Pioselli, P. Cogo, V. Carnielli, C. Dani, F. Salomone

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Surfactant-Assisted Distal Pulmonary Distribution of Budesonide Revealed by Mass Spectrometry Imaging by Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Fabrizio Salomone, Giuseppe Pieraccini, Haruo Usada, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp, Alan H. Jobe

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Preclinical Assessment of Nebulized Surfactant Delivered through Neonatal High Flow Nasal Cannula Respiratory Support by Francesca Ricci, Arianna Mersanne, Matteo Storti, Marcello Nutini, Giulia Pellicelli, Angelo Carini, Ilaria Milesi, Marta Lombardini, Raffaele L. Dellacà, Merran A. Thomson, Xabier Murgia, Anna Lavizzari, Federico Bianco, Fabrizio Salomone

Subjects: “…<i>Poractant alfa</i>…”
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New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs. by Matthias Seehase, Jennifer J P Collins, Elke Kuypers, Reint K Jellema, Daan R M G Ophelders, Olga L Ospina, J Perez-Gil, Federico Bianco, Raffaella Garzia, Roberta Razzetti, Boris W Kramer

“…METHODOLOGY/PRINCIPAL FINDINGS: Nineteen preterm lambs of 127 days gestational age (term = 150 days) received CHF 5633 or Poractant alfa and were ventilated for 48 hours. Ninety minutes after birth, the animals received albumin with CHF 5633 or Poractant alfa. …”
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Effects of Two Different Exogenous Surfactant Preparations on Serial Peripheral Perfusion Index and Tissue Carbon Monoxide Measurements in Preterm Infants with Severe Respiratory D... by Demet Terek, Deniz Gonulal, Ozge Altun Koroglu, Mehmet Yalaz, Mete Akisu, Nilgun Kultursay

“…TCO declined in both groups, showing lung improvement and decreased oxidative/inflammatory stress, and it was normalized earlier with poractant alfa.…”
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Structural and haemodynamic evaluation of less invasive surfactant administration during nasal intermittent positive pressure ventilation in surfactant-deficient newborn piglets. by Victoria Mielgo, Elena Gastiasoro, Fabrizio Salomone, Francesca Ricci, Miguel A Gomez-Solaetxe, Lara Olazar, Begoña Loureiro, Carmen Rey-Santano

“…For this, we used five groups of spontaneously breathing newborn piglets (n = 6/group) with bronchoalveolar lavage (BAL)-induced respiratory distress which received NIPPV only (controls), poractant-alfa using the INSURE-like method (bolus delivery) followed by NIPPV, or poractant-alfa using one of three LISA devices, 1) a nasogastric tube (NT), 2) a vascular catheter (VC) or 3) the LISAcath® catheter. …”
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Comparison of Efficacy of Beractant and Poractant Treatment Performed with Minimal Invasive Technique by Selahattin Akar, Sevilay Topcuoglu, Emre Dincer, Elif Ozalkaya, Guner Karatekin, Tulin Gokmen Yildirim

“…The cases were divided into two groups of beractant (BG) and poractant alfa (PG). While the BG (n=24) consisted of patients receiving beractant treatment with MIST during nCPAP, the PG (n=34) were those subjected to poractant alfa treatment. …”
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Behavior of microbubbles on air-aqueous interfaces by Min, HJ, Bau, L, Payne, SJ, Stride, EP

“…Three different formulations of microbubbles (DPPC with/out PEG40-stearate and poractant alfa) were prepared, and their equilibrium and dynamic surface tensions were tested on a clean air-saline interface or a simulated air-lung fluid interface using a Langmuir-Blodgett trough. …”

Synthetic surfactant with a recombinant surfactant protein C analogue improves lung function and attenuates inflammation in a model of acute respiratory distress syndrome in adult... by J. Zebialowicz Ahlström, F. Massaro, P. Mikolka, R. Feinstein, G. Perchiazzi, O. Basabe-Burgos, T. Curstedt, A. Larsson, J. Johansson, A. Rising

“…The animals were treated with two intratracheal boluses of 2.5 mL/kg of 2% rSP-C33Leu in DPPC/egg PC/POPG, 50:40:10 or poractant alfa (Curosurf®), both surfactants containing 80 mg phospholipids/mL, or air as control. …”
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Early Immunomodulatory Effects of Different Natural Surfactant Preparations in Preterms With Respiratory Distress by Mehmet Yalaz, Sema Tanriverdi, Özgün Uygur, Özge Altun Köroğlu, Elif Azarsiz, Guzide Aksu, Nilgün Kültürsay

“…Newborns were randomly divided into three groups and Beractant 100 mg/kg (B-100), Poractant alfa 100 mg/kg (Pα-100) and Poractant alfa 200 mg/kg (Pα-200) were administered intratracheally. …”
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Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international... by Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath, Brett J Manley

“…The intervention is budesonide (0.25 mg/kg) mixed with poractant alfa (200 mg/kg first intervention, 100 mg/kg if second intervention), administered intratracheally via an endotracheal tube or thin catheter. …”
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Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicent... by Brett J. Manley, C. Omar F. Kamlin, Susan Donath, Li Huang, Pita Birch, Jeanie L. Y. Cheong, Peter A. Dargaville, Jennifer A. Dawson, Lex W. Doyle, Susan E. Jacobs, Rodney Wilson, Peter G. Davis, Christopher J. D. McKinlay

“…The intervention is budesonide (0.25 mg/kg) mixed with poractant alfa (200 mg/kg first intervention, 100 mg/kg if second intervention), administered intratracheally via an endotracheal tube or thin catheter. …”
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