Email recruitment for chronic pain clinical trials: results from the LAMP trial by John E. Ferguson, Emily Hagel Campbell, Ann Bangerter, Lee J. S. Cross, Kelli D. Allen, Kimberly Behrens, Mariah Branson, Collin Calvert, Jessica K. Friedman, Sierra Hennessy, Laura A. Meis, Brent C. Taylor, Diana J. Burgess

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Trial participant representativeness compared to ordinary service users in a work rehabilitation setting by Simon Øverland, Astrid Grasdal, Silje Endresen Reme

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Justice and equity in pragmatic clinical trials: Considerations for pain research within integrated health systems by Joseph Ali, Alison F. Davis, Diana J. Burgess, Daniel I. Rhon, Robert Vining, Stacey Young‐McCaughan, Sean Green, Robert D. Kerns

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Symptom-driven inhaled corticosteroid/long-acting beta-agonist therapy for adult patients with asthma who are non-adherent to daily maintenance inhalers: a study protocol for a pra... by James G. Krings, Kaitlyn M. Wojcik, Vanessa Chen, Tejas C. Sekhar, Kelly Harris, Abigail Zulich, Kaharu Sumino, Ross Brownson, Eric Lenze, Mario Castro

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Overcoming challenges in real‐world evidence generation: An example from an Adult Medical Care Coordination program by Samuel T. Savitz, Michelle A. Lampman, Shealeigh A. Inselman, Ruchita Dholakia, Vicki L. Hunt, Angela B. Mattson, Robert J. Stroebel, Pamela J. McCabe, Stephanie G. Witwer, Bijan J. Borah

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Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pra... by Kevin J. Anstrom, Imre Noth, Kevin R. Flaherty, Rex H. Edwards, Joan Albright, Amanda Baucom, Maria Brooks, Allan B. Clark, Emily S. Clausen, Michael T. Durheim, Dong-Yun Kim, Jerry Kirchner, Justin M. Oldham, Laurie D. Snyder, Andrew M. Wilson, Stephen R. Wisniewski, Eric Yow, Fernando J. Martinez, For the CleanUP-IPF Study Team

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Coordinated Health Care Interventions for Childhood Asthma Gaps in Outcomes (CHICAGO) plan by Jerry A. Krishnan, MD, PhD, Helen Margellos-Anast, MPH, Rajesh Kumar, MD, Joel J. Africk, JD, Michael Berbaum, PhD, Nina Bracken, MSN, NP, Yi-Fan Chen, PhD, Julie DeLisa, MA, Kim Erwin, MDes, Stacy Ignoffo, MSW, Sai Dheeraj Illendula, MS, Hajwa Kim, MS, Cortland Lohff, MD, MPH, Tom MacTavish, MLIS, Molly A. Martin, MD, MAPP, Giselle S. Mosnaim, MD, MS, Hannah Nguyen, MPH, Sarah Norell, MDes, MFA, Sharmilee M. Nyenhuis, MD, S. Margaret Paik, MD, Zachary Pittsenbarger, MD, Valerie G. Press, MD, MPH, Jennifer Sculley, MDes, Trevonne M. Thompson, MD, Leslie Zun, MD, MBA, Lynn B. Gerald, PhD, MSPH, Michael McDermott, MD, Sana Ali, Janet Flores, Shahina Gantiwala, Carmen Goralski, Rajesh Kumar, Jacqueline Ortega, Zachary Pittsenbarger, Isabelle Wilson, Cortland Lohff, Michael McDermott, Kim Erwin, Thomas MacTavish, Sarah Norell, Maureen Damitz, David Massaquoi, Kenneth Soyemi, Thomas Senko, Trevonne Thompson, Kate McMahon, Joel Africk, Amy O’Rourke, Christopher Codispoti, Jane Kramer, Rabia Malik, Pamela Manning, Giselle Mosnaim, Jeanette Avila, Helen Margellos-Anast, Fatima Padron, Jessica Ramsay, Nazia Saiyed, Tala Schwindt, Gloria Seals, Leslie Zun, Susannah Butters, Ashley Hull, John Kim, S. Margaret Paik, Valerie Press, Crystal Stevenson, Nicole Twu, Nicole Woodrick, Michael Berbaum, Nina Bracken, Jennifer Buenrostro, Lauren Castro, Yi-Fan Chen, Julie DeLisa, David De La Torre-Dorado, Dameka Edwards, Alexander Frye, Maciej Grabarek, Sai Dheeraj Illendula, Hajwa Kim, Jerry Krishnan, Molly Martin, Melissa Morales- Perez, Hannah Nguyen, Sharmilee Nyenhuis, Jennifer Sculley, Bruce Bender, PhD, Francine Ducharme, MD, Sheri Hurdle, Xue Li, PhD, Sande Okelo, MD, PhD

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Evaluating India’s Position in Pragmatic Clinical Trial for Public Healthcare: A Key to Real World Healthcare Solutions by Smruti Besekar, Sangita Jogdand, Satyawan Singh Patel

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Pragmatic clinical trials in the context of regulation of medicines by Rolf Gedeborg, Charles Cline, Björn Zethelius, Tomas Salmonson

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Using preliminary data and prospective power analyses for mid-stream revision of projected group and subgroup sizes in pragmatic patient-centered outcomes research by Elizabeth A. Tolley, Satya Surbhi, James E. Bailey

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Effectiveness and Safety of Acupotomy on Lumbar Spinal Stenosis: A Pragmatic, Pilot, Randomized Controlled Trial [Letter] by Wei W, Peng X, Su X

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Practice based research in dentistry: an alternative to deal with clinical questions by Flávio Fernando DEMARCO, Marcos Britto CORREA, Maximiliano Sérgio CENCI, Frederick James Trevor BURKE, Niek Johannes Maria OPDAM, Andre Luis FARIA-E-SILVA

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Effect of thumbtack needle on functional constipation: A pragmatic randomized controlled trial by Li Dan, Zhang Guilin, Zhang Linxue, Tang Yao, Wang Li, Xu Ying, Cao Jinkui, Zhao Wenqian, Zuo Guanchao, Li Hang, Li Dehua

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The Effectiveness of Pharmacopuncture in Patients with Lumbar Spinal Stenosis: A Protocol for a Multi-Centered, Pragmatic, Randomized, Controlled, Parallel Group Study by Lee JY, Park KS, Kim S, Seo JY, Cho HW, Nam D, Park Y, Kim EJ, Lee YJ, Ha IH

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Effectiveness and Safety of Acupotomy on Lumbar Spinal Stenosis: A Pragmatic, Pilot, Randomized Controlled Trial by Lee JH, Lee HJ, Woo SH, Park YK, Han JH, Choi GY, Heo ES, Kim JS, Park CA, Lee WD, Yang CS, Kim AR, Han CH

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Early use of corticosteroids in non-critical patients with COVID-19 pneumonia (PREDCOVID): a structured summary of a study protocol for a randomised controlled trial by Mauricio Salinas, Paulette Andino, Leonor Palma, Javiera Valencia, Elizabeth Figueroa, Jhonatan Ortega

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Improving the relevance of randomised trials to primary care: a qualitative study investigating views towards pragmatic trials and the PRECIS-2 tool by Gordon Forbes, Kirsty Loudon, Megan Clinch, Stephanie J. C. Taylor, Shaun Treweek, Sandra Eldridge

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Bridging Recovery Initiative Despite Gaps in Entry (BRIDGE): study protocol for a randomized controlled trial of a bridge clinic compared with usual care for patients with opioid u... by David E. Marcovitz, Katie D. White, William Sullivan, Heather M. Limper, Mary Lynn Dear, Reagan Buie, David A. Edwards, Cody Chastain, Kristopher A. Kast, Christopher J. Lindsell, Vanderbilt Learning Health System Investigators

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A patient activation intervention in primary care for patients with chronic pain on long term opioid therapy: results from a randomized control trial by Monique B. Does, Sara R. Adams, Andrea H. Kline-Simon, Catherine Marino, Nancy Charvat-Aguilar, Constance M. Weisner, Andrea L. Rubinstein, Murtuza Ghadiali, Penney Cowan, Kelly C. Young-Wolff, Cynthia I. Campbell

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Optimizing data integration in trials that use EHR data: lessons learned from a multi-center randomized clinical trial by Sudha R. Raman, Laura G. Qualls, Bradley G. Hammill, Adam J. Nelson, Ester Kim Nilles, Keith Marsolo, Emily C. O’Brien

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