Effect of probiotics on mother-to-neonate vertical transmission of group B streptococci: A prospective open-label randomized study by Yuriha Kasai, Mitsutaka Komatsu, Yudai Toyama, Saki Nakano, Ken Hisata, Mie Yamada, Toshiaki Shimizu

“…Conclusion: No statistically significant difference was found; however, the consumption of L. reuteri by women with GBS-positive pregnancies may inhibit the MTCT of GBS.…”
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Microvillus Inclusion Disease: Prenatal Ultrasound Findings, Molecular Diagnosis and Genetic Counseling of Congenital Diarrhea by Chih-Ping Chen, Ming-Chou Chiang, Tzu-Hao Wang, Chuen Hsueh, Shueen-Dyh Chang, Fuu-Jen Tsai, Chao-Ning Wang, Schu-Rern Chern, Wayseen Wang

“…Molecular analysis of the MYO5B gene is helpful in genetic counseling and prenatal diagnosis of recurrent microvillus inclusion disease in subsequent pregnancies.…”
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Clinical exome sequencing for fetuses with ultrasound abnormalities and a suspected Mendelian disorder by Elizabeth A. Normand, Alicia Braxton, Salma Nassef, Patricia A. Ward, Francesco Vetrini, Weimin He, Vipulkumar Patel, Chunjing Qu, Lauren E. Westerfield, Samantha Stover, Avinash V. Dharmadhikari, Donna M. Muzny, Richard A. Gibbs, Hongzheng Dai, Linyan Meng, Xia Wang, Rui Xiao, Pengfei Liu, Weimin Bi, Fan Xia, Magdalena Walkiewicz, Ignatia B. Van den Veyver, Christine M. Eng, Yaping Yang

“…Out of 146 cases, a prenatal trio exome option designed for ongoing pregnancies was performed on 62 fetal specimens, resulting in a diagnostic yield of 35% with an average TAT of 14 days for initial reporting (excluding tissue culture time). …”
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Two cases of placental trisomy 21 mosaicism causing false-negative NIPT results by Qinfei Zhao, Jing Chen, Ling Ren, Huijuan Zhang, Dedong Liu, Xuxiang Xi, Xiangsheng Wu, Chunyun Fang, Ping Ye, Shaoying Zeng, Tianyu Zhong

“…However, in the second case, of all the placental biopsies, percentage of total chimerism was less than 30%; and placental biopsies taken at the middle of maternal side and middle of fetal side, also had variable trisomy 2 mosaicism levels of 10% and 8%, respectively. Ultimately, the pregnancies were interrupted at 30 gestational age (GA) and 27GA, respectively. …”
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Study protocol for a randomised trial for atosiban versus placebo in threatened preterm birth: the APOSTEL 8 study by Ben W Mol, Fionnuala McAuliffe, Martijn A Oudijk, Christiana A Naaktgeboren, Jim Thornton, Ewoud Schuit, Job Klumper, Wouter Breebaart, Carolien Roos, Joris van der Post, Judith Bosmans, Anton van Kaam, Jelle Baalman, Marjolein Kok

“…Introduction Preterm birth complicates >15 million pregnancies annually worldwide. In many countries, women who present with signs of preterm labour are treated with tocolytics for 48 hours. …”
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Accelerated Wound Border Closure Using a Microemulsion Containing Non-Inhibitory Recombinant α1-Antitrypsin by Alon Gimmon, Lior Sherker, Lena Kojukarov, Melodie Zaknoun, Yotam Lior, Tova Fadel, Ronen Schuster, Eli C. Lewis, Eldad Silberstein

“…Human α1-antitrypsin (hAAT), a circulating glycoprotein that rises during acute-phase responses and during healthy pregnancies, is tissue-protective and tolerance-inducing; although anti-inflammatory, hAAT enhances revascularization. hAAT blocks tissue-degrading enzymes, including neutrophil elastase; it is, therefore, unclear how wound healing might improve under hAAT-rich conditions. …”
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Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark by Bjørn AM, Nørgaard M, Hundborg HH, Nohr EA, Ehrenstein V

“…We noted changes in patterns of use of anti-infective drugs and antidepressants.Keywords: drug utilization, epidemiology, pregnancy…”
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Icterícia neonatal: fatores associados à necessidade de fototerapia em alojamento conjunto by Vitória Silva Souza Dias, Simone Manso de Carvalho Pelicia, José Eduardo Corrente, Ligia Maria Suppo de Souza Rugolo

“…Clinical data relative to the mothers, pregnancies, newborns, and care practices were analyzed. …”
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Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following He... by Rachel L. Gibbs, James A. Wilson, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Ty B. Schmidt, Jessica L. Petersen, Dustin T. Yates

“…IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from pair-fed thermoneutral pregnancies. As juveniles, IUGR lambs exhibited systemic inflammation and robust metabolic dysfunction, including greater (<i>p</i> < 0.05) circulating TNFα, IL-6, and non-esterified fatty acids, increased (<i>p</i> < 0.05) intramuscular glycogen, reduced (<i>p</i> < 0.05) circulating IGF-1, hindlimb blood flow, glucose-stimulated insulin secretion, and muscle glucose oxidation. …”
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Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study by Nádia Calvo Martins Okuyama, Fernando Cezar-dos-Santos, Érica Romão Pereira, Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Michelle Mota Sena, Ana Paula Lombardi Pereira, Adriano Martin Felis Aranome, Luis Fernando Lasaro Mangieri, Rodolfo Sanches Ferreira, Maria Angelica Ehara Watanabe, Karen Brajão de Oliveira

“…Results HPV infection was more incident in women who had more than 4 sexual partners during lifetime (p = 0.007), among those who presented lower number of pregnancies (p = 0.017). HPV was more prevalent among allele A carriers confirmed by logistic regression analysis adjusted for several confounding factors [ORADJ = 4.985; CI95% (2.85–8.72), p < 0.001]. …”
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Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity by Juan-Antonio Garcia-Santillan, Maria-Luisa Lazo-de-la-Vega-Monroy, Gloria-Celina Rodriguez-Saldaña, Miguel-Angel Solis-Barbosa, Maria-Angelica Corona-Figueroa, Martha-Isabel Gonzalez-Dominguez, Hector-Manuel Gomez-Zapata, Juan-Manuel Malacara, Gloria Barbosa-Sabanero

“…Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.…”
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Using Fetal Fibronectin Test to Reduce Hospital Admissions with Diagnosis of Preterm Labor: An Economic Evaluation Study by Bedayah Amro, Iman Alhalabi, Anila George, Hanan Haroun, Amar Hassan Khamis, Nadia Al Sawalhi

“…<b>Methods:</b> A retrospective cohort study of singleton pregnancies between 24 and 34 weeks of gestation who attended Latifa Hospital in the period of September 2015–December 2016, complaining of threatened preterm labor after the availability of an FFN test, and a historical cohort study for those who attended with threatened preterm labor before the availability of an FFN test. …”
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Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia by Fieke Terstappen, Sinéad M. Clarke, Jaap A. Joles, Courtney A Ross, Michael R. Garrett, Magdalena Minnion, Martin Feelisch, Harry van Goor, Jennifer M. Sasser, A. Titia Lely

“…While these data suggest a promising antihypertensive effect that could imply prolongation of preeclamptic pregnancies, the unfavorable effects on proteinuria, kidney weight, and fetal/placental weight ratio implies that clinical implementation of STS is contra-indicated until safety for mother and child can be verified.…”
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Placental Pathology Contributes to Impaired Volumetric Brain Development in Neonates With Congenital Heart Disease by Maaike Nijman, Lotte E. van der Meeren, Peter G. J. Nikkels, Raymond Stegeman, Johannes M. P. J. Breur, Nicolaas J. G. Jansen, Henriette ter Heide, Trinette J. Steenhuis, Roel de Heus, Mireille N. Bekker, Nathalie H. P. Claessens, Manon J. N. L. Benders

“…Methods and Results Placentas from 96 term singleton pregnancies with severe fetal congenital heart disease were prospectively analyzed for macroscopic and microscopic pathology. …”
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Nurses and midwives’ experience in providing fertility awareness-based methods, including natural family planning methods in Rwanda by Pauline Uwajeneza, Marilyn Evans, Pamela Meharry, Donatilla Mukamana, Yolanda Babenko-Mould, Patrick Munezero, Agnes Mukabaramba Kanimba

“…Access to effective and acceptable family planning services in developing countries is an essential reproductive health intervention to reduce maternal deaths and prevent unwanted pregnancies. The purpose of this qualitative descriptive study was to gain an in-depth understanding of nurses' and midwives' experiences in providing information related to fertility awareness-based methods, including natural family planning, to clients in Rwanda. …”
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Delivery of antiretroviral therapy to HIV-infected women during the postpartum period: The Postpartum Adherence Clubs for Antiretroviral Therapy (PACART) trial by Jasantha Odayar, Thokozile R. Malaba, Joanna Allerton, Maia Lesosky, Landon Myer

“…Keywords: Adherence clubs, Antiretroviral therapy, HIV, Option B+, Postpartum, Pregnancy…”
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Newborn Screening for Sickle Cell Disease Among Tribal Populations in the States of Gujarat and Madhya Pradesh in India: Evaluation and Outcome Over 6 Years by Pallavi Thaker, Roshan B. Colah, Jignisha Patel, Bhavesh Raicha, Abhishek Mistry, Vishal Mehta, Yazdi Italia, Shrey Desai, Kapilkumar Dave, Rajasubramaniam Shanmugam, Kanjaksha Ghosh, Malay B. Mukherjee

“…Genetic counseling to the affected families has increased the awareness and acceptance for prenatal diagnosis and 18 couples opted for prenatal diagnosis in subsequent pregnancies. SCD is not always mild among tribal groups in India. …”
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Diagnostic implications of associated defects in patients with typical orofacial clefts by Isabella L. Monlleó, Amanda G.R. de Barros, Marshall I.B. Fontes, Ana K.M. de Andrade, Gisele de M. Brito, Diogo L.L. do Nascimento, Vera L. Gil‐da‐Silva‐Lopes

“…There was no statistical difference between syndromic and non‐syndromic groups regarding gender (p < 0.55), maternal age of 35 years and above (p < 0.50), alcohol (p < 0.50) and tobacco consumption (p < 0.11), consanguinity (p < 0.59), recurrence (p < 0.08), average number of pregnancies (p < 0.32), and offspring (p < 0.35). Conclusions: There is a lack of information on syndromic clefts. …”
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Efficacy of Phase I and Phase II <i>Coxiella burnetii</i> Bacterin Vaccines in a Pregnant Ewe Challenge Model by Sarah E. Williams-Macdonald, Mairi Mitchell, David Frew, Javier Palarea-Albaladejo, David Ewing, William T. Golde, David Longbottom, Alasdair J. Nisbet, Morag Livingstone, Clare M. Hamilton, Stephen F. Fitzgerald, Søren Buus, Emil Bach, Annemieke Dinkla, Hendrik-Jan Roest, Ad P. Koets, Tom N. McNeilly

“…Both vaccines provided protection against <i>C. burnetii</i> challenge as measured by reductions in bacterial shedding in faeces, milk and vaginal mucus, and reduced abnormal pregnancies, compared to unvaccinated controls. This work highlights that the phase I vaccine Coxevac^® can protect ewes against <i>C. burnetii</i> infection. …”
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Reproductive intentions and corresponding use of safer conception methods and contraception among Ugandan HIV clients in serodiscordant relationships by Glenn J. Wagner, Deborah Mindry, Emily A. Hurley, Jolly Beyeza-Kashesya, Violet Gwokyalya, Sarah Finocchario-Kessler, Rhoda K. Wanyenze, Mastula Nanfuka, Mahlet G. Tebeka, Kathy Goggin

“…Abstract Context Among people living with HIV in Uganda, desires to have a child and unplanned pregnancies are both common, while utilization of safer conception methods (SCM) and modern contraceptives are low. …”
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