Is There an Added Neonatal Risk in Vacuum-Assisted Deliveries with Nuchal Cord? by Hanoch Schreiber, Gal Cohen, Nir Mevorach, Maya Shavit, Michal Kovo, Tal Biron-Shental, Ofer Markovitch

“…Women with singleton pregnancies, 34–41-weeks gestation, who underwent VAD, from 2014 to 2020 were included. …”
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Contraceptive use among HIV-infected women and men receiving antiretroviral therapy in Lusaka, Zambia: a cross-sectional survey by Nancy L. Hancock, Carla J. Chibwesha, Samuel Bosomprah, Jonathan Newman, Mwangelwa Mubiana-Mbewe, Elizabeth Siyama Sitali, Carolyn Bolton-Moore, Clara Mbwili-Muleya, Benjamin H. Chi

“…Conclusions While FP-ART integration may be a promising strategy for increasing FP service uptake, such services must focus on assessing sexual activity and advocating for dual method use to increase effective contraceptive use and prevent unintended pregnancies.…”
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Effects of Different Indications for Forceps Delivery on Pelvic Floor Muscle Surface Electromyography and Early Postpartum Pelvic Floor Function in Primiparas by Xiaolei Chi, Shushu Yu, Kun Zhu, Chuangchuang Xu, Xiaohan Su, Xinliang Chen

“…Methods: Four hundred primiparas whose pregnancies had been terminated by forceps delivery were divided into three groups based on the indication for forceps delivery: fetal distress (FD) (n = 260), prolonged second stage of labor (PSSL) (n = 30), and intrapartum fever combined with fetal distress (IFFD) (n = 110). …”
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Estrogens and endocrine-disrupting chemicals differentially impact the bioenergetic fluxes of mammary epithelial cells in two- and three-dimensional models by Aurélie Lacouture, Yann Breton, Cindy Weidmann, Sarah-Maude Goulet, Lucas Germain, Martin Pelletier, Étienne Audet-Walsh

“…Finally, we demonstrate that mammary organoids can be used for long-term studies on EDC exposure to study alterations in organogenesis/morphogenesis and that past pregnancies can modulate the sensitivity of mammary epithelial organoids to specific EDCs. …”
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Placental thickness in 2D prenatal ultrasonographic examination by Iwona Strzelecka, Filip F. Karuga, Bartosz Szmyd, Aleksandra Walter, Gabriela Daszkiewicz, Maria Respondek-Liberska

“…Material and methods In this retrospective study, we analysed the results of foetal ECHO examination of 2833 foetuses performed between June 2016 and December 2019 in our single unit. 596 healthy foetuses older than 12 weeks of gestation from singleton pregnancies were enrolled in the study. The following parameters were used in the further analysis: placental implantation site, gestational age according to the last menstrual period (LMP) and foetal biometry (FB); maternal weight, height, and body mass index (BMI) at the time of examination; and PTh. …”
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Lack of detection of a human placenta microbiome in samples from preterm and term deliveries by Jacob S. Leiby, Kevin McCormick, Scott Sherrill-Mix, Erik L. Clarke, Lyanna R. Kessler, Louis J. Taylor, Casey E. Hofstaedter, Aoife M. Roche, Lisa M. Mattei, Kyle Bittinger, Michal A. Elovitz, Rita Leite, Samuel Parry, Frederic D. Bushman

“…Abstract Background Historically, the human womb has been thought to be sterile in healthy pregnancies, but this idea has been challenged by recent studies using DNA sequence-based methods, which have suggested that the womb is colonized with bacteria. …”
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Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study by Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, The Japan Environment and Children’s Study Group

“…This study aimed to investigate the association between maternal birth weight (MBW) and the prevalence of congenital malformations in offspring using data from a nationwide birth cohort study in Japan including 103,060 pregnancies. A binary logistic regression model with adjustment for various covariates revealed that an MBW of <2500 g (low MBW) was associated with an increased risk of congenital heart disease (adjusted odds ratio: 1.388, [95% confidence interval: 1.075–1.792]), angioma (1.491 [1.079–2.059]), and inguinal hernia (1.746, [1.189–2.565]), while those with an MBW of ≥4000 g (high MBW) were associated with congenital anomalies of the urinary tract (2.194, [1.261–3.819]) and arrhythmia (1.775, [1.157–2.725]) compared with those with an MBW of 3000–3499 g. …”
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“It was my own decision”: the transformational shift that influences a woman's decision to use contraceptives covertly by Jenna Hoyt, Jessie K. Hamon, Shari Krishnaratne, Emmanuel Houndekon, Dora Curry, Miriam Mbembe, Seth Marcus, Misozi Kambanje, Shannon Pryor, Ariko Angela Barbra, Herbert Muhumuza, Nathaly Spilotros, Jayne Webster

“…Results Women recognised that although they suffered the negative consequences of frequent pregnancies and of raising large families, they lacked overt decision-making power over their fertility. …”
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Induction of labour for predicted macrosomia: study protocol for the ‘Big Baby’ randomised controlled trial by Martin Underwood, Sara Wood, Stavros Petrou, Jaclyn Brown, Simon Gates, Ceri Jones, Mandy Williams, Hema Mistry, Anne-Marie Slowther, Katie Booth, Ranjit Lall, Debra Bick, Siobhan Quenby, SANJEEV DESHPANDE, Joanne D Fisher, Jason Gardosi, Adam Gornall, Adrian Willis, Lauren Jade Ewington, Ryan Griffin, Kirsten Harris, Emily Butler, Kelly Fowler, Jackie Dewdney, Karen Hillyer

“…The Big Baby Trial aims to find if induction of labour at 38+0–38+4 weeks’ gestation, in pregnancies with suspected LGA fetuses, reduces the incidence of shoulder dystocia.Methods and analysis The Big Baby Trial is a multicentre, prospective, individually randomised controlled trial of induction of labour at 38+0 to 38+4 weeks’ gestation vs standard care as per each hospital trust (median gestation of delivery 39+4) among women whose fetuses have an estimated fetal weight &gt;90th customised centile according to ultrasound scan at 35+0 to 38+0 weeks’ gestation. …”
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Surgical-PEARL protocol: a multicentre prospective cohort study exploring aetiology, management and outcomes for patients with congenital anomalies potentially requiring surgical i... by Clare Skerritt, Massimo Caputo, Andrew Mumford, Karen Luyt, Mai Baquedano, Andrew R Bamber, Catherine Bradshaw, Deborah Lawlor, Samantha E de Jesus, Stuart Mires, Beverley Power, Hannah Gill, Tim Overton

“…Introduction Congenital anomalies affect over 2% of pregnancies. Surgical advances have reduced mortality and improved survival for patients with congenital anomalies potentially requiring surgical (CAPRS) intervention. …”
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Reprogramming of the developing heart by Hif1a-deficient sympathetic system and maternal diabetes exposure by Hana Kolesova, Hana Kolesova, Petra Hrabalova, Petra Hrabalova, Romana Bohuslavova, Pavel Abaffy, Valeria Fabriciova, David Sedmera, David Sedmera, Gabriela Pavlinkova

“…Abnormalities in the cardiac sympathetic system are implicated in conditions such as sudden infant death syndrome, cardiac arrhythmic death, heart failure, and certain congenital heart defects in children from diabetic pregnancies. However, the mechanisms by which maternal diabetes affects the development of the cardiac sympathetic system and, consequently, heightens health risks and predisposes to cardiovascular disease remain poorly understood.Methods and resultsIn the mouse model, we performed a comprehensive analysis of the combined impact of a Hif1a-deficient sympathetic system and the maternal diabetes environment on both heart development and the formation of the cardiac sympathetic system. …”
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Maternal mortality during the COVID-19 pandemic in Mexico: a preliminary analysis during the first year by Nina Mendez-Dominguez, Karen Santos-Zaldívar, Salvador Gomez-Carro, Sudip Datta-Banik, Genny Carrillo

“…Abstract Background In Mexico, the COVID-19 pandemic led to preventative measures such as confinement and social interaction limitations that paradoxically may have aggravated healthcare access disparities for pregnant women and accentuated health system weaknesses addressing high-risk patients’ pregnancies. Our objective is to estimate the maternal mortality ratio in 1 year and analyze the clinical course of pregnant women hospitalized due to acute respiratory distress syndrome and COVID-19. …”
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Prenatal ultrasonographic findings of esophageal atresia: potential diagnostic role of the stomach shape by Chi-Son Chang, Yunsun Choi, Seo-yeon Kim, Cheonga Yee, Mina Kim, Ji-Hee Sung, Sanghoon Lee, Suk-Joo Choi, Soo-young Oh, Jeong-Meen Seo, Cheong-Rae Roh

“…Both groups included only singleton pregnancies. Amniotic fluid index (AFI) and width/length (W/L) ratio as well as the product of width and length (W×L) of stomach were serially assessed during gestation and compared between the 2 groups. …”
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Bioinformatics analysis combined with clinical sample screening reveals that leptin may be a biomarker of preeclampsia by Yajuan Wang, Yajuan Wang, Xuening Bai, Xuening Bai, Xin Guo, Xin Guo, Xiaoli Gao, Xiaoli Gao, Yuanyuan Chen, Yuanyuan Chen, Huanrong Li, Huanrong Li, Wenjun Fan, Wenjun Fan, Cha Han, Cha Han

“…Immune cell infiltration analysis showed that M1 and M2 macrophages differed between normal pregnancies and those in PE patients. A competing endogenous RNA (ceRNA) network was constructed, and proteins interacting with LEP were identified. …”
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Effect of 3D Spheroid Culturing on NF-κB Signaling Pathway and Neurogenic Potential in Human Amniotic Fluid Stem Cells by Giedrė Valiulienė, Aistė Zentelytė, Elizabet Beržanskytė, Rūta Navakauskienė

“…For this purpose, hAFSCs were obtained from amniotic fluid of healthy pregnancies and cultivated in vitro, either in 2D, or 3D under untreated or neuro-differentiated conditions. …”
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Performance comparison of ultrasonography and magnetic resonance imaging in their diagnostic accuracy of placenta accreta spectrum disorders: a systematic review and meta-analysis by Shibin Hong, Yiping Le, Ka U. Lio, Ting Zhang, Yu Zhang, Ning Zhang

“…Results A total of 18 articles comprising 861 pregnancies were included in the study. The overall diagnostic accuracy of US for identification of PAS was as follows: sensitivity [0.90 (0.86–0.93)], specificity [0.83 (0.79–0.86)], DOR [39.5 (19.6–79.7)]. …”
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Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours by Shuang-zheng Jia, Jun-ji Zhang, Zhi-yong Liang, Jun-jun Yang, Yang Xiang, Cong-wei Jia, Jin-hua Leng

“…Of 20 patients who attempted to conceive, three pregnancies among two patients (10.0%) resulted in two live births. …”
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A Multicenter Cohort Study in Patients With Primary Empty Sella: Hormonal and Neuroradiological Features Over a Long Follow-Up by Giulia Carosi, Giulia Carosi, Alessandro Brunetti, Alessandro Brunetti, Alessandra Mangone, Alessandra Mangone, Roberto Baldelli, Alberto Tresoldi, Giulia Del Sindaco, Giulia Del Sindaco, Elisabetta Lavezzi, Elisa Sala, Roberta Mungari, Letizia Maria Fatti, Elena Galazzi, Emanuele Ferrante, Rita Indirli, Rita Indirli, Emilia Biamonte, Maura Arosio, Maura Arosio, Renato Cozzi, Andrea Lania, Andrea Lania, Gherardo Mazziotti, Gherardo Mazziotti, Giovanna Mantovani, Giovanna Mantovani

“…Hypopituitarism was associated with male sex (p=0.02), suspected endocrinopathy (p&lt;0.001), traumatic brain injury (p=0.003) and not with age, BMI, number of pregnancies and neuroradiological grade. A longitudinal assessment was possible in 166/402 (median follow-up=58 months). …”
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“Words are too small”: exploring artmaking as a tool to facilitate dialogues with young South African women about their sexual and reproductive health experiences by Felicity Hartley, Felicity Hartley, Lucia Knight, Lucia Knight, Hilton Humphries, Hilton Humphries, Jill Trappler, Katherine Gill, Katherine Gill, Linda-Gail Bekker, Linda-Gail Bekker, Virginia MacKenny, Jo-Ann S. Passmore, Jo-Ann S. Passmore, Jo-Ann S. Passmore

“…BackgroundAdolescents and young women are at high risk for sexually transmitted infections (STIs) and unintended pregnancies. However, conversations about sexual and reproductive health (S&amp;RH) are difficult and stigmatised. …”
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Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women by Gabriela Baldeon-Vaca, Jai G. Marathe, Joseph A. Politch, Emilie Mausser, Jeffrey Pudney, James Doud, Ellena Nador, Larry Zeitlin, Michael Pauly, Thomas R. Moench, Miles Brennan, Kevin J. Whaley, Deborah J. Anderson

“…Background: Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. …”
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