Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia by Lissette C. Sánchez-Aranguren, Lissette C. Sánchez-Aranguren, Cindy T. Espinosa-González, Laura M. González-Ortiz, Laura M. González-Ortiz, Sandra M. Sanabria-Barrera, Sandra M. Sanabria-Barrera, Carlos E. Riaño-Medina, Carlos E. Riaño-Medina, Andrés F. Nuñez, Asif Ahmed, Asif Ahmed, Jeannette Vasquez-Vivar, Marcos López, Marcos López

“…Preeclampsia is a maternal hypertensive disorder that affects up to 1 out of 12 pregnancies worldwide. It is characterized by proteinuria, endothelial dysfunction, and elevated levels of the soluble form of the vascular endothelial growth factor receptor-1 (VEGFR-1, known as sFlt-1). sFlt-1 effects are mediated in part by decreasing VEGF signaling. …”
Get full text

Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors by Teppei Takeshima, Noboru Mimura, Shun Aoki, Tomoki Saito, Tomoki Saito, Jurii Karibe, Jurii Karibe, Kimitsugu Usui, Kimitsugu Usui, Shinnosuke Kuroda, Shinnosuke Kuroda, Mitsuru Komeya, Mitsuru Komeya, Yasushi Yumura

“…Among these 12 patients, eight retained viable spermatozoa, and two successfully achieved spontaneous pregnancies resulting in live births. In one of the remaining four cases where no sperm were detected in ejaculate, a live birth was achieved through intracytoplasmic sperm injection using cryopreserved sperm.Discussion: While ifosfamide, the primary chemotherapy drug for patients with malignant bone and soft tissue tumors, was associated with severe impairments in spermatogenesis, recovery of spermatogenesis was observed in many cases. …”
Get full text

FGF21 negatively affects long-term female fertility in mice by Beat Moeckli, Thuy-Vy Pham, Florence Slits, Samuel Latrille, Andrea Peloso, Vaihere Delaune, Graziano Oldani, Stéphanie Lacotte, Christian Toso

“…A treatment with FGF21 leads to a reduction in the number of pregnancies (0 vs 1, p = 0.019) and no viable pup was born to a mother previously treated with FGF21. …”
Get full text

Management of twin reversed arterial perfusion sequence: one center's experience by Saud Alshanafey, Maha Al-Nemer, Maha Tulbah, Rubina MA Khan, Nada Al Sahan, Maisoon Al Mugbel, Fahad Al-Hazzani, Gawaher Almutairi, Wesam Kurdi

“…BACKGROUND: Twin reversed arterial perfusion (TRAP) sequence is a rare condition that affects primarily monozygotic monochorionic twin pregnancies in which a normal twin acts as a pump (donor) for an acardiac recipient (perfuse) twin. …”
Get full text

Maternity Waiting Home Use by HIV-positive Pregnant Women in Zambia: Opportunity for Improved Prevention of Maternal to Child Transmission of HIV by Rachael Bonawitz, MD, Kathleen Lucy McGlasson, MPH, Jeanette L. Kaiser, MPH, Thandiwe Ngoma, MPH, Jody Lori, PhD, MS, Carol Boyd, PhD, MSN, Godfrey Biemba, MD, Davidson H. Hamer, MD, Nancy A. Scott, DrPH, MPH

“…HIV-positive women were older and had more pregnancies and children than HIV-negative women (p<0.001). …”
Get full text

Prevalence of osteoporosis among North Korean women refugees living in South Korea: a comparative cross-sectional study by Nam Hoon Kim, Sin Gon Kim, Ji Hee Yu, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyeong Jin Kim, Jee Hyun An, Kyoung Jin Kim, Hee Young Kim

“…The median age of the NORNS participants was 46 years (IQR, 40–60 years) with 52 women (42.6%) being postmenopausal.Results Among the postmenopausal women, NORNS participants had a higher body mass index and number of pregnancies and lower physical activity than the KUMC participants. …”
Get full text

Identification of MicroRNA Profiles in Fetal Spina Bifida: The Role in Pathomechanism and Diagnostic Significance by Angelika Buczyńska, Iwona Sidorkiewicz, Magdalena Niemira, Adam Jacek Krętowski, Piotr Węgrzyn, Przemysław Kosiński, Monika Zbucka-Krętowska

“…Moreover, the maternal plasma expression of miR-320e was increased in pregnancies with SB, and this marker could serve as a valuable non-invasive screening tool. …”
Get full text

Diagnostic Performance of Ultrasonography for Detection of Abruption and Its Clinical Correlation and Maternal and Foetal Outcome by Gauri Raghunath Shinde, Babita Prakash Vaswani, R.P. Patange, Manisha Manish Laddad, Rajashree Babasaheb Bhosale

“…Introduction: Placental abruption complicates about 1% of singleton pregnancies and is an important cause of perinatal mortality and morbidity. …”
Get full text

Immediate Pre-Partum SARS-CoV-2 Status and Immune Profiling of Breastmilk: A Case-Control Study by Laura Sánchez García, Natalia Gómez-Torres, Fernando Cabañas, Raquel González-Sánchez, Manuela López-Azorín, M. Teresa Moral-Pumarega, Diana Escuder-Vieco, Esther Cabañes-Alonso, Irma Castro, Claudio Alba, Juan Miguel Rodríguez Gómez, Adelina Pellicer

“…ObjetiveTo address the prevalence of SARS-CoV-2 and the evolutionary profile of immune compounds in breastmilk of positive mothers according to time and disease state.MethodsForty-five women with term pregnancies with confirmed non-severe SARS-CoV-2 infection (case group), and 96 SARS-CoV-2 negative women in identical conditions (control group) were approached, using consecutive sample. …”
Get full text

Paternal occupational exposure to chemicals and secondary sex ratio: results from the Japan Environment and Children's Study by Sho Adachi, PhD, Junko Sawaki, PhD, Narumi Tokuda, MS, Hiroyuki Tanaka, ProfPhD, Hideaki Sawai, ProfPhD, Yasuhiro Takeshima, ProfPhD, Hiroaki Shibahara, ProfPhD, Masayuki Shima, ProfPhD

“…Findings: The JECS study gathered data on 103 062 pregnancies, 104 065 fetuses, and 51 898 partners of pregnant women. …”
Get full text

Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger by Denise Baratti-Mayer, MD, Angèle Gayet-Ageron, MD, Stéphane Hugonnet, MD, Patrice François, PhD, Brigitte Pittet-Cuenod, MD, Antoine Huyghe, PhD, Jacques-Etienne Bornand, MD, Prof Alain Gervaix, MD, Denys Montandon, MD, Jacques Schrenzel, MD, Prof Andrea Mombelli, DMD, Prof Didier Pittet, MD

“…Independent risk factors associated with noma were: severe stunting (odds ratio [OR] 4·87, 95% CI 2·35–10·09) or wasting (2·45, 1·25–4·83); a high number of previous pregnancies in the mother (1·16, 1·04–1·31); the presence of respiratory disease, diarrhoea, or fever in the past 3 months (2·70, 1·35–5·40); and the absence of chickens at home (1·90, 0·93–3·88). …”
Get full text

The Change of Perinatal Mortality Over Three Decades in a Reference Centre in the Aegean Region: Neonatal Mortality has decreased but Foetal Mortality Remains Unchanged by Nilgün Kültürsay, Niyazi Aşkar, Demet Terek, Ahmet Özgür Yeniel, Özge Altun Köroğlu, Mehmet Yalaz, Ferda Özkınay, Mete Akısü

“…In order to decrease foetal and perinatal mortality rates more efficiently, reducing consanguineous marriages and providing better antenatal care for high risk pregnancies are needed…”
Get full text

New insights regarding origin of monosomy occurrence in early developing embryos as demonstrated in preimplantation genetic testing by N. Samara, S. Peleg, T. Frumkin, V. Gold, H. Amir, Einat Haikin Herzberger, A. Reches, Y. Kalma, Dalit Ben Yosef, F. Azem, M. Malcov

“…Mitotic errors and paternal involvement in chemical pregnancies and IVF failure should be re-evaluated. …”
Get full text

Factors affecting cell-free DNA fetal fraction: statistical analysis of 13,661 maternal plasmas for non-invasive prenatal screening by Yaping Hou, Jiexia Yang, Yiming Qi, Fangfang Guo, Haishan Peng, Dongmei Wang, Yixia Wang, Xiaohui Luo, Yi Li, Aihua Yin

“…Results A total of 13,661 pregnant subjects with singleton pregnancies who undertook NIPS were included in the study. …”
Get full text

Prevalence of Group B Streptococcus Recto-Vaginal Colonization, Vertical Transmission, and Antibiotic Susceptibility Among Pregnant Women in Ethiopia: A Systematic Review and Meta-... by Habtamu Bekele, Adera Debella, Tamirat Getachew, Bikila Balis, Dawit Tamiru, Addis Eyeberu, Getahun Tiruye, Mohammed Abdurke Kure, Sisay Habte, Bajrond Eshetu, Lemma Demissie Regassa, Sinetibeb Mesfin, Adisu Alemu, Yadeta Dessie, Kasiye Shiferaw

“…As a result, half of the pregnancies end with vertical transmission of GBS. Hence, the review emphasizes that policy and programs should consider planning and implementing prophylactic programs.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
Get full text

Clinical Outcome of Postplacental Copper T 380A Insertion in Women Delivering by Caesarean Section by Sunita Singal, Rekha Bharti, Rupali Dewan, Divya, Anjali Dabral, Achla Batra, Manjula Sharma, Pratima Mittal

“…At the end of one year, there were 16 expulsions, 21 removals, and 2 pregnancies with gross cumulative expulsion, removal, failure and continuation rates of 5.33%, 7%, 0.67% and 91%, respectively. …”
Get full text

Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro... by Hiromitsu Hattori, Yuko Atsumi, Yukiko Nakajo, Nobuya Aono, Masae Koizumi, Mayumi Toya, Hideki Igarashi, Koichi Kyono

“…Background: To evaluate obstetrical and neonatal outcomes of singletons conceived after advanced assisted reproductive technology (ART) techniques: conventional IVF pregnancies (C-IVF), ejaculated sperm intracytoplasmic sperm injection (ICSI), assisted oocyte activation (AOA), in vitro maturation (IVM), and testicular sperm extraction (TESE). …”
Get full text

Effects of Different Drug Therapies and COVID-19 mRNA Vaccination on Semen Quality in a Man with Ankylosing Spondylitis: A Case Report by Katerina Chatzimeletiou, Alexandra Fleva, Antonia Sioga, Ioannis Georgiou, Theodoros-Thomas Nikolopoulos, Maria Markopoulou, Nikos Petrogiannis, George Anifandis, Antonios Patrikiou, Efstratios Kolibianakis, Anastasia Giannakou, Grigoris Grimbizis

“…<i>Conclusion:</i> The anti-inflamatory drugs celecoxib and sulphasalazine had no adverse effect on sperm quality as all parameters were within normal limits and the patient achieved under that treatment 2 pregnancies following natural conception that lead to the birth of a healthy boy and girl respectively. …”
Get full text

Profile of Nucleotides in Chinese Mature Breast Milk from Six Regions by Lutong Yang, Zhiheng Guo, Miao Yu, Xiaokun Cai, Yingyi Mao, Fang Tian, Wenhui Xu, Guoliang Liu, Xiang Li, Yanrong Zhao, Lin Xie

“…A total of 631 breast milk samples were collected from healthy, lactating women with singleton, full-term pregnancies between 40 and 45 days postpartum in Changchun, Chengdu, Lanzhou, Shanghai, Tianjin, and Guangzhou. …”
Get full text

Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia by Alex Chao, Jarod Grossman, Celeste Carberry, Yunjia Lai, Antony J. Williams, Jeffrey M. Minucci, S. Thomas Purucker, John Szilagyi, Kun Lu, Kim Boggess, Rebecca C. Fry, Jon R. Sobus, Julia E. Rager

“…Methods: A non-targeted analysis based on high-resolution mass spectrometry was used to analyze placental tissues from a cohort of 35 patients with preeclampsia (n = 18) and normotensive (n = 17) pregnancies. Molecular feature data were prioritized for confirmation based on association with preeclampsia case status and confidence of chemical identification. …”
Get full text