Noninvasive prenatal testing for fetal subchromosomal copy number variations and chromosomal aneuploidy by low‐pass whole‐genome sequencing by Dongyi Yu, Kai Zhang, Meiyan Han, Wei Pan, Ying Chen, Yunfeng Wang, Hongyan Jiao, Ling Duan, Qiying Zhu, Xiaojie Song, Yan Hong, Chen Chen, Juan Wang, Feng Hui, Linzhou Huang, Chongjian Chen, Yang Du

“…Abstract Background Expanding noninvasive prenatal testing (NIPT) to include the detection of fetal subchromosomal copy number variations (CNVs) significantly decreased the sensitivity and specificity. …”
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Realizing responsibility. Institutional routines, critical intervention, and the “big” questions in the controversy over non-invasive prenatal testing in Germany by Kathrin Braun, Sabine Könninger

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Peripheral Blood Microbiome Analysis via Noninvasive Prenatal Testing Reveals the Complexity of Circulating Microbial Cell-Free DNA by Xunliang Tong, Xiaowei Yu, Yang Du, Fei Su, Ye Liu, Hexin Li, Yunshan Liu, Kai Mu, Qingsong Liu, Hui Li, Jiansheng Zhu, Hongtao Xu, Fei Xiao, Yanming Li

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Noninvasive Prenatal Testing of Methylmalonic Acidemia cblC Type Using the cSMART Assay for MMACHC Gene Mutations by Weigang Lv, Lili Liang, Xin Chen, Zhuo Li, Desheng Liang, Huimin Zhu, Yanling Teng, Weijuan Wu, Lingqian Wu, Lianshu Han

Subjects: “…noninvasive prenatal testing…”
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Current view of the application of non-invasive prenatal testing of cell-free circulating fetal DNA from maternal blood by Ana Tadić, Anita Barišić, Jadranka Vraneković

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Non-invasive prenatal testing for the diagnosis of congenital abnormalities: Insights from a large multicenter study in southern China by Meiying Cai, Na Lin, Xuemei Chen, Ying Li, Min Lin, Xianguo Fu, Hailong Huang, Shuqiong He, Liangpu Xu

“…Although non-invasive prenatal testing (NIPT) is widely used to detect fetal abnormalities, the results of NIPT vary by population, and data for the screening efficiency of NIPT positive predictive value (PPV) from different populations is limited. …”
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Could Digital PCR Be an Alternative as a Non-Invasive Prenatal Test for Trisomy 21: A Proof of Concept Study. by Laïla Allach El Khattabi, Christelle Rouillac-Le Sciellour, Dominique Le Tessier, Armelle Luscan, Audrey Coustier, Raphael Porcher, Rakia Bhouri, Juliette Nectoux, Valérie Sérazin, Thibaut Quibel, Laurent Mandelbrot, Vassilis Tsatsaris, François Vialard, Jean-Michel Dupont

“…CONCLUSION:Our results demonstrate that digital PCR can meet the requirements for non-invasive prenatal testing of trisomy 21. This approach is technically simple, relatively cheap, easy to implement in a diagnostic setting and compatible with ethical concerns regarding access to nucleotide sequence information. …”
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Non-invasive prenatal testing for the detection of trisomy 13, 18, and 21 and sex chromosome aneuploidies in 68,763 cases by Yanchun Zhang, Yanchun Zhang, Hongyan Xu, Hongyan Xu, Wen Zhang, Wen Zhang, Kaibo Liu, Kaibo Liu

Subjects: “…noninvasive prenatal testing…”
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Positive Attitudes towards Non-Invasive Prenatal Testing (NIPT) in a Swedish Cohort of 1,003 Pregnant Women. by Ellika Sahlin, Magnus Nordenskjöld, Peter Gustavsson, Josephine Wincent, Susanne Georgsson, Erik Iwarsson

“…OBJECTIVE:The clinical utilization of non-invasive prenatal testing (NIPT) for identification of fetal aneuploidies is expanding worldwide. …”
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A novel noninvasive prenatal testing method for chromosomal rearrangements using maternal circulating cell‐free foetal DNA by Shuo Zhang, Zhenle Pei, Caixia Lei, Yixuan Bai, Junping Wu, Min Xiao, Jing Zhou, Bin Hu, Songchang Chen, Yiming Wu, Jingmin Yang, Xiaoxi Sun, Daru Lu, Chenming Xu, Congjian Xu

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Validation of a non-invasive prenatal test for fetal RhD, C, c, E, K and Fya antigens by Brian Alford, Brian P. Landry, Sarah Hou, Xavier Bower, Anna M. Bueno, Drake Chen, Brooke Husic, David E. Cantonwine, Thomas F. McElrath, Jacqueline A. Carozza, Julia Wynn, Jennifer Hoskovec, Kathryn J. Gray

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A two-year experience of non-invasive prenatal testing (NIPT) at an urban tertiary medical center in South Korea by Joseph J. Noh, Hyun Mee Ryu, Soo-young Oh, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim

“…Objective: To report our experience of implementing non-invasive prenatal testing (NIPT) in a tertiary urban academic medical center in South Korea. …”
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GenomeMixer and TRUST: Novel bioinformatics tools to improve reliability of Non-Invasive Prenatal Testing (NIPT) for fetal aneuploidies by David Pratella, Véronique Duboc, Marco Milanesio, John Boudjarane, Stéphane Descombes, Véronique Paquis-Flucklinger, Silvia Bottini

Subjects: “…Non-invasive prenatal testing…”
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When Is Non-Invasive Prenatal Testing Reliable in Pregnancies with a Vanishing Twin? - A Systematic Review of Case Reports by Somayeh Khanjani, Sedigheh hantoushzadeh, Leyla sahebi, Mohsen Vigeh, Mamak Shariat, mahdieh saeri

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Decision-making about non-invasive prenatal testing: women’s moral reasoning in the absence of a risk of miscarriage in Germany by Stefan Reinsch, Anika König, Christoph Rehmann-Sutter

“…This paper examines women’s experiences with decision-making about non-invasive prenatal testing (NIPT). Such tests offer knowledge about chromosomal disorders early in pregnancy, without the risk of miscarriage associated with invasive procedures such as amniocentesis. …”
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Targeted capture enrichment assay for non-invasive prenatal testing of large and small size sub-chromosomal deletions and duplications. by Maria C Neofytou, Kyriakos Tsangaras, Elena Kypri, Charalambos Loizides, Marios Ioannides, Achilleas Achilleos, Petros Mina, Anna Keravnou, Carolina Sismani, George Koumbaris, Philippos C Patsalis

“…Noninvasive prenatal testing (NIPT) using whole genome and targeted sequencing has become increasingly accepted for clinical detection of Trisomy 21 and sex chromosome aneuploidies. …”
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Knowledge and attitude of pregnant women in the Kingdom of Saudi Arabia toward Noninvasive prenatal testing: A single center study by Maaged A. Akiel, Mohamud S. Mohamud, Emad M. Masuadi, Hassan S. Alamri

“…Abstract Background Noninvasive prenatal testing (NIPT) is a screening tool for chromosomal aneuploidies. …”
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Strategy for Use of Genome-Wide Non-Invasive Prenatal Testing for Rare Autosomal Aneuploidies and Unbalanced Structural Chromosomal Anomalies by Pascale Kleinfinger, Laurence Lohmann, Armelle Luscan, Detlef Trost, Laurent Bidat, Véronique Debarge, Vanina Castaigne, Marie-Victoire Senat, Marie-Pierre Brechard, Lucie Guilbaud, Gwenaël Le Guyader, Véronique Satre, Hélène Laurichesse Delmas, Hakima Lallaoui, Marie-Christine Manca-Pellissier, Aicha Boughalem, Mylene Valduga, Farah Hodeib, Alexandra Benachi, Jean Marc Costa

Subjects: “…non-invasive prenatal test…”
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Women’s perspectives on the ethical implications of non-invasive prenatal testing: a qualitative analysis to inform health policy decisions by Meredith Vanstone, Alexandra Cernat, Jeff Nisker, Lisa Schwartz

Subjects: “…Non-invasive prenatal testing…”
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Whole genome non-invasive prenatal testing in prenatal screening algorithm: clinical experience from 12,700 pregnancies by Elena E. Baranova, Olesya V. Sagaydak, Alexandra M. Galaktionova, Ekaterina S. Kuznetsova, Madina T. Kaplanova, Maria V. Makarova, Maxim S. Belenikin, Anton S. Olenev, Ekaterina N. Songolova

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