Guiding the Clinical Nurse Specialist role in oncology within Princess Margaret Cancer Centre by Verna Cheung, Jocelyn Brown, Anet Julius, Laura Mitchell, Shari Moura, Rana Jin

“…In response to the CNA publication, the CNS Community of Practice (CoP) at Princess Margaret Cancer Centre (PM) reviewed how the oncology CNS roles at PM aligned with the CNA competencies. …”
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P548: Universal germline genetic testing for breast cancer at the Princess Margaret Cancer Centre by Larissa Peck, Maria Carolina Sanabria-Salas, Sarah Ridd, Helia Purnaghshband, Wes Morrison, C. Anne Koch, Raymond Kim

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Pivoting the Provision of Smoking Cessation Education in a Virtual Clinical World: The Princess Margaret Cancer Centre Experience by Naa Kwarley Quartey, Janet Papadakos, Ben Umakanthan, Meredith Elana Giuliani

“…Here, we describe how the Princess Margaret Cancer Centre implemented innovative solutions to improve the delivery of education during the COVID-19 pandemic to better support patients and healthcare providers.…”
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The Survival Outcomes of the Metastatic Nonclear Cell Renal Cell Carcinoma in the Immunotherapy Era: Princess Margaret Cancer Centre Experience by Esmail Al-Ezzi, Abhenil Mittal, Zachary W. Veitch, Amer Zahralliyali, Nely Mercy Diaz Mejia, Osama Abdeljalil, Husam Alqaisi, Vikaash Kumar, Aaron R. Hansen, Nazanin Fallah-Rad, Srikala S. Sridhar

“…Here, we report survival outcomes for patients with metastatic nccRCC treated with IO and/or TT at the Princess Margaret Cancer Centre, Toronto, ON, Canada. Demographics, disease characteristics, and survival outcomes were collected retrospectively. …”
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Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre by Michael Yan, Tzen S. Toh, Patricia E. Lindsay, Jessica Weiss, Katrina Hueniken, Christy Yeung, Vijithan Sugumar, Dixon Pinto, Tony Tadic, Alexander Sun, Andrea Bezjak, John Cho, Srinivas Raman, Meredith Giuliani, Fabio Ynoe Moraes, Geoffrey Liu, Andrew J. Hope, Benjamin H. Lok

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P385: COMPARISON OF CLINICAL OUTCOMES AND ADVERSE EVENTS IN OLDER ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH NATIVE VS PEGYLATED ASPARAGINASE by Maria Agustina Perusini, Vikas Gupta, Aniket Bankar, Jad Sibai, Mark Minden, Dawn Maze, Marta Davidson, Guillaume Richard-Carpentier, Steven M Chan, Andre Schuh, Karen Yee, Eshetu Atenafu, Hassan Sibai

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Fcmr regulates mononuclear phagocyte control of anti-tumor immunity by Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak

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An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE) by Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu

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Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes by Oliver A. Kent, Manipa Saha, Etienne Coyaud, Helen E. Burston, Napoleon Law, Keith Dadson, Sujun Chen, Estelle M. Laurent, Jonathan St-Germain, Ren X. Sun, Yoshinori Matsumoto, Justin Cowen, Aaryn Montgomery-Song, Kevin R. Brown, Charles Ishak, Jose La Rose, Daniel D. De Carvalho, Housheng Hansen He, Brian Raught, Filio Billia, Peter Kannu, Robert Rottapel

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Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer by Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien

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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity by S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh

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First impressions: A prospective evaluation of patient–physician concordance and satisfaction following the initial medical oncology consultation by Yvonne Bach, Elan Panov, Osvaldo Espin‐Garcia, Eric Chen, Monika Krzyzanowska, Grainne O'Kane, Malcolm Moore, Rebecca M. Prince, Jennifer Knox, Robert Grant, Lucy X. Ma, Michael J. Allen, Lawson Eng, Ekaterina Kosyachkova, Thais Baccili Cury Megid, Carly Barron, Xin Wang, Marie‐Philippe Saltiel, Abdul Rehman Rehman Farooq, Raymond W. Jang, Elena Elimova

“…Methods Between January and August 2021, patients without prior systemic treatment of their gastrointestinal malignancy (GI) attending the Princess Margaret Cancer Centre (PMCC) were approached within 24 h of their initial consultation to complete a paper‐based questionnaire assessing understanding of their disease (diagnosis, treatment plan/intent, and prognosis) and satisfaction with the consultation. …”
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P1040: FACTORS ASSOCIATED WITH THROMBOSIS IN MYELOFIBROSIS by Aniket Bankar, Gopila Gupta, Verna Cheung, Jaime O. Claudio, Andrea Arruda, Hubert Tsui, Jose-Mario Capo-Chichi, Hassan Sibai, Marta Davidson, Dawn Maze, Vikas Gupta

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P500: A REAL WORLD MULTI CENTRE STUDY OF CPX-351 REVEALS NO DIFFERENCE IN OVERALL SURVIVAL WHEN COMPARED WITH FLAG-IDA AND 3 + 7 IN HIGH RISK AML. by C. Andrews, I. AlNabhani, T. Young, E. G. Atenafu, S. E. Assouline, J. M. Brandwein, S. M. Chan, S. Chow, D. Khalaf, V. Gupta, D. D. H. Kim, D. Maze, M. M. Minden, T. Murphy, D. Sanford, A. D. Schimmer, A. C. Schuh, J. Sibai, K. Yee, H. Sibai

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ONECUT2 is a driver of neuroendocrine prostate cancer by Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He

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Biological and therapeutic implications of a unique subtype of NPM1 mutated AML by Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains

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Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro by Zhaleh Safikhani, Petr Smirnov, Kelsie L. Thu, Jennifer Silvester, Nehme El-Hachem, Rene Quevedo, Mathieu Lupien, Tak W. Mak, David Cescon, Benjamin Haibe-Kains

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Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells by Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John E. Dick, Eric R. Lechman

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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes by Shideh Mirhadi, Shirley Tam, Quan Li, Nadeem Moghal, Nhu-An Pham, Jiefei Tong, Brian J. Golbourn, Jonathan R. Krieger, Paul Taylor, Ming Li, Jessica Weiss, Sebastiao N. Martins-Filho, Vibha Raghavan, Yasin Mamatjan, Aafaque A. Khan, Michael Cabanero, Shingo Sakashita, Kugeng Huo, Sameer Agnihotri, Kota Ishizawa, Thomas K. Waddell, Gelareh Zadeh, Kazuhiro Yasufuku, Geoffrey Liu, Frances A. Shepherd, Michael F. Moran, Ming-Sound Tsao

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Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient by Scott C. Lien, Dalam Ly, S. Y. Cindy Yang, Ben X. Wang, Derek L. Clouthier, Michael St. Paul, Ramy Gadalla, Babak Noamani, Carlos R. Garcia-Batres, Sarah Boross-Harmer, Philippe L. Bedard, Trevor J. Pugh, Anna Spreafico, Naoto Hirano, Albiruni R. A. Razak, Pamela S. Ohashi

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