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Overcoming barriers to membrane protein structure determination.
Published 2011“…After decades of slow progress, the pace of research on membrane protein structures is beginning to quicken thanks to various improvements in technology, including protein engineering and microfocus X-ray diffraction. …”
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Membrane protein structure determination - the next generation.
Published 2014“…The field of Membrane Protein Structural Biology has grown significantly since its first landmark in 1985 with the first three-dimensional atomic resolution structure of a membrane protein. …”
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Biophysical studies of membrane protein structure and function
Published 2014“…In summary, this thesis demonstrates the potential of biophysical techniques to study various aspects of membrane protein structure and function in native-like lipid systems, complementing <em>e.g.…”
Thesis -
26
Effect of one point mutation on protein structure
Published 2012Get full text
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Improving biologically inspired protein structure prediction using satisfied predicted contacts
Published 2018Subjects:Thesis -
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Conditional Graphical Models for Protein Structural Motif Recognition
Published 2011“…Determining protein structures is crucial to understanding the mechanisms of infection and designing drugs. …”
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Protein knot server: detection of knots in protein structures
Published 2012“…KNOTS (http://knots.mit.edu) is a web server that detects knots in protein structures. Several protein structures have been reported to contain intricate knots. …”
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Get full text
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Protein structure prediction using bidirectional neural networks
Published 2010Get full text
Thesis -
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Molecular dynamics simulations and membrane protein structure quality.
Published 2008“…Despite a growing repertoire of membrane protein structures (currently approximately 120 unique structures), considerations of low resolution and crystallization in the absence of a lipid bilayer require the development of techniques to assess the global quality of membrane protein folds. …”
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Probing environmental effects on gas-phase protein structure
Published 2017“…<p>Growth in the use of mass spectrometry as an analytical tool for studying protein structure and functionality has posed questions regarding correlation of native structures and observed gas-phase conformations for proteins. …”
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Membrane protein structure quality in molecular dynamics simulation.
Published 2005“…The results were compared to membrane protein structures, solved at various resolution, by either X-ray or electron diffraction techniques. …”
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Phasing statistics for alpha helical membrane protein structures.
Published 2013“…In this report we highlight the latest trends in phasing methods used to solve alpha helical membrane protein structures and analyze the use of heavy atom metals for the purpose of experimental phasing. …”
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A generative angular model of protein structure evolution
Published 2017“…We present a generative, evolutionary model of protein structure and sequence that is valid on a local length scale. …”
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Protein structure prediction begins well but ends badly.
Published 2010“…The accurate prediction of protein structure, both secondary and tertiary, is an ongoing problem. …”
Journal article