Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: <it>in vitro </it>and <it>in vivo </it>studies by Sun Samuel SM, Liu Qiao-quan, Lan Lin-lin, Liu Li-zhong, Cheung Stanley CK, Chan Juliana CN, Tong Peter CY

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Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Ta... by Pratiti Bhadra, Stefan Schorr, Monika Lerner, Duy Nguyen, Johanna Dudek, Friedrich Förster, Volkhard Helms, Sven Lang, Richard Zimmermann

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The evolution of the plant organellar proteome by Costello, RMO

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Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer by Makoto Ueno, Masafumi Ikeda, Do-Youn Oh, Masatoshi Kudo, Christoph Helwig, Changhoon Yoo, Hye Jin Choi, Shunsuke Kondo, Li-Tzong Chen, Motonobu Osada, Isabelle Dussault

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Case Report: Keratoacanthoma and type I diabetes secondary to treatment with PM8001, a bifunctional fusion protein targeting TGF-β and PD-L1 by Rongbin Qi, Hailing Xu, Xinyu Fu, Yingying Yu, Dongqing Lv, Yujing Li, Susu He

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'Targeting' the search: An upgraded structural and functional repository of antimicrobial peptides for biofilm studies (B-AMP v2.0) with a focus on biofilm protein targets by Shashank Ravichandran, SaiSupriya Avatapalli, Yatindrapravanan Narasimhan, Karishma S. Kaushik, Ragothaman M. Yennamalli

“…B-AMP v2.0 hosts a curated collection of 2502 biofilm protein targets across 473 bacterial species, with structural protein models and functional annotations from PDB, UniProt, and PubMed databases. …”
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Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation. by Jordan M Meyers, Aayushi Uberoi, Miranda Grace, Paul F Lambert, Karl Munger

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Virtual screening and molecular dynamic simulations of the antimalarial derivatives of 2-anilino 4-amino substituted quinazolines docked against a Pf-DHODH protein target by Zakari Ya’u Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Sulaiman Isyaku

“…Research highlights The research aimed at screening of the antimalarial derivatives of 2-anilino 4-amino substituted quinazolines docked against a Pf-DHODH protein target. Hence, some of the highlights are listed below: 1. …”
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728 A phase 1/2 study of JK08, an IL-15 antibody fusion protein targeting CTLA-4, in patients with advanced solid tumors by Sylvie Rottey, Valentina Boni, Naimish Pandya, Elena Garralda, Shalabh Singhal, Vladimir Galvao, Nuria Kotecki, Maria de Miguel, Brant Delafontaine, Omar Saavedra, Amanda McEwen, Samuel L Murphy

Discovery of new naphthyridine hybrids against enoyl-ACP reductase (inhA) protein target of Mycobacterium tuberculosis: Molecular docking, molecular dynamics simulations studies by Govindaraj Sabarees, Vadivel Velmurugan, Viswas Raja Solomon

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Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors by Fiona O’Neill, Taylor-Jade Allen-Coyle, Sandra Roche, Justine Meiller, Neil T. Conlon, Niall Swan, Robert M. Straubinger, Justin Geoghegan, Ninfa L. Straubinger, Kevin Conlon, Ray McDermott, Finbarr O’Sullivan, Michael Henry, Paula Meleady, Gerard McVey, Robert O’Connor, Michael Moriarty, Martin Clynes

“…Prominent among the protein targets are enzymes involved in aldehyde metabolism and membrane transport and trafficking. …”
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Immune Responses to Orally Administered Recombinant <i>Lactococcus lactis</i> Expressing Multi-Epitope Proteins Targeting M Cells of Foot-and-Mouth Disease Virus by Fudong Zhang, Zhongwang Zhang, Xian Li, Jiahao Li, Jianliang Lv, Zhongyuan Ma, Li Pan

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<i>Cymbopogon citratus</i> Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS by Ana G. Cortes-Torres, Guiee N. López-Castillo, Josefina L. Marín-Torres, Roberto Portillo-Reyes, Felix Luna, Beatriz E. Baca, Jesús Sandoval-Ramírez, Alan Carrasco-Carballo

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A Synthetic Biology Workflow Reveals Variation in Processing and Solubility of Nitrogenase Proteins Targeted to Plant Mitochondria, and Differing Tolerance of Targeting Sequences in a Bacterial Nitrogenase Assay by Shoko Okada, Christina M. Gregg, Robert Silas Allen, Amratha Menon, Dawar Hussain, Vanessa Gillespie, Ema Johnston, Keren Byrne, Michelle Lisa Colgrave, Michelle Lisa Colgrave, Craig C. Wood

“…Here we present our workflow assessing the mitochondrial processing, solubility and relative abundance of 16 Klebsiella oxytoca Nif proteins targeted to the mitochondrial matrix in Nicotiana benthamiana leaf. …”
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Prediction of Protein Targets in Ovarian Cancer Using a Ru-Complex and Carbon Dot Drug Delivery Therapeutic Nanosystems: A Bioinformatics and µ-FTIR Spectroscopy Approach by Maja D. Nešić, Tanja Dučić, Branislava Gemović, Milan Senćanski, Manuel Algarra, Mara Gonçalves, Milutin Stepić, Iva A. Popović, Đorđe Kapuran, Marijana Petković

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An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockade by Miaomiao Sun, Michael Weller, Tobias Weiß, Dario Neri, Emanuele Puca, Thomas Look, Cesare Di Nitto, Eleonora Prodi, Roberto De Luca, Markus G. Manz, Ettore Gilardoni, Christian Pellegrino, Domenico Ravazza, Vlad Moisoiu

“…Extradomain A-fibronectin (EDA-FN), which is expressed in most solid and hematological tumors but is virtually undetectable in healthy adult tissues, is an attractive target for the delivery of cytokine at the site of the disease.Methods In this work, we describe the generation and characterization of a novel interleukin-7-based fusion protein targeting EDA-FN termed F8(scDb)-IL7. The product consists of the F8 antibody specific to the alternatively spliced EDA of FN in the single-chain diabody (scDb) format fused to human IL-7.Results F8(scDb)-IL7 efficiently stimulates human peripheral blood mononuclear cells in vitro. …”
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Study on the Chemical Composition and Anti-Tumor Mechanisms of <i>Clausena lansium</i> Fruit By-Products: Based on LC-MS, Network Pharmacology Analysis, and Protein Target Validation by Ziyue Zhang, Liangqian Zhang, Pengfei Wu, Yuan Tian, Yao Wen, Meina Xu, Peihao Xu, Ying Jiang, Nan Ma, Qi Wang, Wei Dai

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Pharmacoscreening, molecular dynamics, and quantum mechanics of inermin from Panax ginseng: a crucial molecule inhibiting exosomal protein target associated with coronary artery disease progression by Janakiraman V, Sudhan M, Abubakar Wani, Sheikh F. Ahmad, Ahmed Nadeem, Ashutosh Sharma, Shiek S. S. J. Ahmed

“…Methods This study uses a systems biological approach that integrates differential gene expression in the CAD, exosomal cargo assessment, protein network construction, and functional enrichment to identify the crucial exosomal cargo protein target. Meanwhile, absorption, distribution, metabolism, and excretion (ADME) screening of Panax ginseng-derived compounds was conducted and then docked against the protein target to identify potential inhibitors and then subjected to molecular dynamics simulation (MDS) to understand the behavior of the protein-ligand complex till 100 nanoseconds. …”
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PhyteByte: identification of foods containing compounds with specific pharmacological properties by Kenneth E. Westerman, Sean Harrington, Jose M. Ordovas, Laurence D. Parnell

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Antioxidant, Cytotoxic Activity and Protein Target Inhibition of Ethyl Acetate Fraction Melinjo Seed (Gnetum gnemon L.) by In Vitro and In Silico Studies on HeLa Cervical Cancer Cells by Rawi Ingra Savitri, Nuha Haifa Arifin, Rifki Febriansah

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