Exploring trypanosoma brucei brucei protein targets for drug discovery. by Cheong, Yue Sheng.

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Flagellar morphogenesis: protein targeting and assembly in the paraflagellar rod of trypanosomes. by Bastin, P, MacRae, T, Francis, S, Matthews, K, Gull, K

Roles of cofactors and chromatin accessibility in hox protein target specificity by Beh, C.Y., El-Sharnouby, S., Chatzipli, A., Russell, S., Choo, S.W., White, R.

“…Conclusions: Our experiments demonstrate a strong role for chromatin accessibility in Hox protein binding and suggest that Hox protein competition with nucleosomes has a major role in Hox protein target specificity in vivo.…”
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Systematic Approaches to Study Eclipsed Targeting of Proteins Uncover a New Family of Mitochondrial Proteins by Maayan Mark, Ofir Klein, Yu Zhang, Koyeli Das, Adi Elbaz, Reut Noa Hazan, Michal Lichtenstein, Norbert Lehming, Maya Schuldiner, Ophry Pines

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Optimizing NMR fragment-based drug screening for membrane protein targets by Geoffrey C. Li, Manuel A. Castro, Thilini Ukwaththage, Charles R. Sanders

“…Fragment-based screening by NMR has been successfully applied to many soluble protein targets, but only to a limited number of membrane proteins, despite the fact that many drug targets are membrane proteins. …”
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Deep generative model for drug design from protein target sequence by Yangyang Chen, Zixu Wang, Lei Wang, Jianmin Wang, Pengyong Li, Dongsheng Cao, Xiangxiang Zeng, Xiucai Ye, Tetsuya Sakurai

“…Abstract Drug discovery for a protein target is a laborious and costly process. Deep learning (DL) methods have been applied to drug discovery and successfully generated novel molecular structures, and they can substantially reduce development time and costs. …”
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Extending in Silico Protein Target Prediction Models to Include Functional Effects by Lewis H. Mervin, Avid M. Afzal, Lars Brive, Ola Engkvist, Andreas Bender

“…In silico protein target deconvolution is frequently used for mechanism-of-action investigations; however existing protocols usually do not predict compound functional effects, such as activation or inhibition, upon binding to their protein counterparts. …”
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Protein folding as a driving force for dual protein targeting in eukaryotes by Bella eKalderon, Ophry ePines, Ophry ePines

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Candidate Single Nucleotide Polymorphism Markers for Arsenic Responsiveness of Protein Targets by Barbara E. Graham-Evans, Udensi K. Udensi, Paul B. Tchounwou, Rajendram V. Rajnarayanan, Matthew N. Anyanwu, Hari H.P. Cohly, Raphael D. Isokpehi

“…In summary, our analysis identified non-synonymous SNPs that could be used to evaluate responsiveness of a protein target to arsenic. In particular, an epidermal expressed serine protease with crucial function in normal skin physiology was prioritized on the basis of abundance of vicinal cysteines for further research on arsenic-induced keratinocyte carcinogenesis.…”
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Endothelial Cell Protein Targeting by Myeloperoxidase-Derived 2-Chlorofatty Aldehyde by Shubha Shakya, Roger A. Herr, Haley L. Carlson, Raphael A. Zoeller, Carolyn J. Albert, David A. Ford

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The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets by Otávio Augusto Chaves, Francisco Mainardi Martins, Carlos Serpa, Davi Fernando Back

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Structures and Dynamics of Native-State Transmembrane Protein Targets and Bound Lipids by Michael Overduin, Catharine Trieber, R. Scott Prosser, Louis-Philippe Picard, Joey G. Sheff

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Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes by E. Ruchti, P.J. Roach, A.A. DePaoli-Roach, P.J. Magistretti, I. Allaman

“…Glycogen synthesis is regulated by Protein Targeting to Glycogen (PTG), a member of specific glycogen-binding subunits of protein phosphatase-1 (PPP1). …”
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Protein targeting and flagellum assembly dynamics revealed by paralysed mutant trypanosomes. by Bastin, P, Gull, K

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment by Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng

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Preclinical Study of Diagnosing Liver Fibrosis by Fibroblast Activation Protein Targeted Radiopharmaceuticals by XU Mengxin1, CAI Jie2, CHEN Junyi1, SONG Hanbo2, LIU Yu3, LIU Zhibo1, 2, 3

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GLUT4 as A Protein Target for T2DM Therapy with Natural Compounds by Vivi Hendra Sutandar, Mgs. Irsan Saleh, Ziske Maritska

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Multiple selection filters ensure accurate tail-anchored membrane protein targeting by Meera Rao, Voytek Okreglak, Un Seng Chio, Hyunju Cho, Peter Walter, Shu-ou Shan

Subjects: “…protein targeting and translocation…”
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Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets by Kaixi Ding, Juejue Zhangwang, Ming Lei, Chunping Xiong

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Beyond Small Molecules: Antibodies and Peptides for Fibroblast Activation Protein Targeting Radiopharmaceuticals by Xiaona Sun, Yuxuan Wu, Xingkai Wang, Xin Gao, Siqi Zhang, Zhicheng Sun, Ruping Liu, Kuan Hu

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