Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets by Kelsie M Rodriguez, Sara C Buch-Larsen, Ilsa T Kirby, Ivan Rodriguez Siordia, David Hutin, Marit Rasmussen, Denis M Grant, Larry L David, Jason Matthews, Michael L Nielsen, Michael S Cohen

“…What remains unclear is the mechanism by which PARP-7 regulates this process, namely because the protein targets of PARP-7 mono-ADP-ribosylation (MARylation) are largely unknown. …”
Get full text

Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses by Katarina Z. Doctor, Elizabeth Gilmour, Marilyn Recarte, Trinity R. Beatty, Intisar Shifa, Michaela Stangel, Jacob Schwisow, Dagmar H. Leary, Patricia M. Legler

Get full text

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. by Law, M, Lower, K, Voon, H, Hughes, J, Garrick, D, Viprakasit, V, Mitson, M, De Gobbi, M, Marra, M, Morris, A, Abbott, A, Wilder, S, Taylor, S, Santos, G, Cross, J, Ayyub, H, Jones, S, Ragoussis, J, Rhodes, D, Dunham, I, Higgs, D, Gibbons, R

Systematic multi‐level analysis of an organelle proteome reveals new peroxisomal functions by Eden Yifrach, Duncan Holbrook‐Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo WT van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz, Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar

Subjects: Get full text

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex by Rebecca M Voorhees, Ramanujan S Hegde

Subjects: Get full text

Targeted protein degradation by Trim-Away using cell resealing coupled with microscopic image-based quantitative analysis by Rina Kunishige, Rina Kunishige, Masayuki Murata, Masayuki Murata, Masayuki Murata, Fumi Kano, Fumi Kano

Subjects: Get full text

A Photosensitized Singlet Oxygen (¹O₂) Toolbox for Bio-Organic Applications: Tailoring ¹O₂ Generation for DNA and Protein Labelling, Tar... by Dorien Aerssens, Enrico Cadoni, Laure Tack, Annemieke Madder

Subjects: Get full text

CANDI: a web server for predicting molecular targets and pathways of cannabis-based therapeutics by Srinivasan Ekambaram, Jian Wang, Nikolay V. Dokholyan

Subjects: Get full text

Editorial: Chemosensory receptor systems of invertebrates, from expression to function: protein targeting, interactions with ligands, pharmacology, and pest management strategies by Alberto Maria Cattaneo, William B. Walker

Get full text

SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response by Soo Jin Oh, Ok Sarah Shin

Get full text

Mechanistic Insights of Polyphenolic Compounds from Rosemary Bound to Their Protein Targets Obtained by Molecular Dynamics Simulations and Free-Energy Calculations by Samo Lešnik, Marko Jukič, Urban Bren

“…In our earlier research, we carried out an inverse molecular docking at the proteome scale to determine possible protein targets of the mentioned compounds. Here, we subjected the previously identified ligand–protein complexes with HIV-1 protease, K-RAS, and factor X to molecular dynamics simulations coupled with free-energy calculations. …”
Get full text

Recombinant VAR2CSA malaria protein-targeted exosome-mediated DACT2 gene therapy for effective glioma treatment by Jiaming Xu, Jie Zhang, Qifeng Li

Get full text

SARS-CoV-2 spike-protein targeted serology test results and their association with subsequent COVID-19-related outcomes by Harvey W. Kaufman, Stanley Letovsky, William A. Meyer, Laura Gillim, Magdalene M. Assimon, Carly A. Kabelac, John W. Kroner, Shannon L. Reynolds, Marcia Eisenberg

“…Follow-up for outcomes began after each eligible individual's first SARS-CoV-2 semiquantitative spike-protein targeted antibody test, from 16 November 2020 to 30 December 2021.ExposuresExposure is defined as having SARS-CoV-2 spike-protein targeted antibody testing.Main outcomes and measuresStudy outcomes were SARS-CoV-2 infection and a serious composite outcome (hospitalization with an associated SARS-CoV-2 infection or all-cause death). …”
Get full text

A computational study on the molecular mechanisms of panduratin A as a potential inhibitor on SARS-CoV-2 protein targets by Patamalai Boonserm, Pongsak Khunrae, Thana Sutthibutpong

Get full text

Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer by Alfred Zippelius, Petra Herzig, Heinz Läubli, Vaios Karanikas, Gieri Cathomas, Christian Klein, Marta Trüb, Franziska Uhlenbrock, Christina Claus, Martin Thelen, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Abhishek S Kashyap

Get full text

Retraction: Proteomics Approaches for Identification of Tumor Relevant Protein Targets in Pulmonary Squamous Cell Carcinoma by 2D-DIGE-MS

Get full text

Correction: Proteomic Identification of Protein Targets for 15-Deoxy-Δ12,14-Prostaglandin J2 in Neuronal Plasma Membrane

Get full text

Retraction: Proteomics Approaches for Identification of Tumor Relevant Protein Targets in Pulmonary Squamous Cell Carcinoma by 2D-DIGE-MS. by PLOS ONE Editors

Get full text

Mapping Protein Targets of Carnosol, a Molecule Identified in <i>Rosmarinus officinalis</i>: In Silico Docking Studies and Network Pharmacology by María Taboada-Alquerque, Danilo Pajaro-Valenzuela, Karina Caballero-Gallardo, Alejandro Cifuentes, Elena Ibáñez, Maicol Ahumedo-Monterrosa, Elena E. Stashenko, Jesus Olivero-Verbel

Get full text

The HPV8 E6 protein targets the Hippo and Wnt signaling pathways as part of its arsenal to restrain keratinocyte differentiation by Sharon C. Wu, Miranda Grace, Karl Munger

Get full text